Barry M. Goldstein, M.D., Ph.D.

Barry M. Goldstein, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 275-5095
Fax: (585) 275-6007


Journal Articles

Showing all 53 journal articles available.

2005 Oct
Gruswitz F, Frishman M, Goldstein BM, Wedekind JE. "Coupling of MBP fusion protein cleavage with sparse matrix crystallization screens to overcome problematic protein solubility." BioTechniques. 2005 Oct; 39(4):476, 478, 480.
2004 Sep 1
Nogami K, Wakabayashi H, Ansong C, Fay PJ. "Localization of a pH-dependent, A2 subunit-interactive surface within the factor VIIIa A1 subunit." Biochimica et biophysica acta.. 2004 Sep 1; 1701(1-2):25-35.
2004 May 11
Ceccarelli C, Liang ZX, Strickler M, Prehna G, Goldstein BM, Klinman JP, Bahnson BJ. "Crystal structure and amide H/D exchange of binary complexes of alcohol dehydrogenase from Bacillus stearothermophilus: insight into thermostability and cofactor binding." Biochemistry.. 2004 May 11; 43(18):5266-77.
2003 Oct 21
Strickler M, Goldstein BM, Maxfield K, Shireman L, Kim G, Matteson DS, Jones JP. "Crystallographic studies on the complex behavior of nicotine binding to P450cam (CYP101)." Biochemistry.. 2003 Oct 21; 42(41):11943-50.
2002 Apr
Pankiewicz KW, Watanabe KA, Lesiak-Watanabe K, Goldstein BM, Jayaram HN. "The chemistry of nicotinamide adenine dinucleotide (NAD) analogues containing C-nucleosides related to nicotinamide riboside." Current medicinal chemistry. 2002 Apr; 9(7):733-41.
2002 Feb 15
French KJ, Rock DA, Rock DA, Manchester JI, Goldstein BM, Jones JP. "Active site mutations of cytochrome p450cam alter the binding, coupling, and oxidation of the foreign substrates (R)- and (s)-2-ethylhexanol." Archives of biochemistry and biophysics.. 2002 Feb 15; 398(2):188-97.
2002 Jan 31
Pankiewicz KW, Lesiak-Watanabe KB, Watanabe KA, Patterson SE, Jayaram HN, Yalowitz JA, Miller MD, Seidman M, Majumdar A, Prehna G, Goldstein BM. "Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia." Journal of medicinal chemistry.. 2002 Jan 31; 45(3):703-12.
2001 Aug 14
French KJ, Strickler MD, Rock DA, Rock DA, Bennett GA, Wahlstrom JL, Goldstein BM, Jones JP. "Benign synthesis of 2-ethylhexanoic acid by cytochrome P450cam: enzymatic, crystallographic, and theoretical studies." Biochemistry.. 2001 Aug 14; 40(32):9532-8.
2001 Jan 8
Franchetti P, Marchetti S, Cappellacci L, Yalowitz JA, Jayaram HN, Goldstein BM, Grifantini M. "A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin)." Bioorganic & medicinal chemistry letters. 2001 Jan 8; 11(1):67-9.
2000 Apr 6
Franchetti P, Marchetti S, Cappellacci L, Jayaram HN, Yalowitz JA, Goldstein BM, Barascut JL, Dukhan D, Imbach JL, Grifantini M. "Synthesis, conformational analysis, and biological activity of C-thioribonucleosides related to tiazofurin." Journal of medicinal chemistry.. 2000 Apr 6; 43(7):1264-70.
Goldstein BM, Colby TD. "Conformational constraints in NAD analogs: implications for dehydrogenase binding and specificity." Advances in enzyme regulation. 2000 40:405-26.
1999 Jul
Goldstein BM, Colby TD. "IMP dehydrogenase : structural aspects of inhibitor binding." Current medicinal chemistry. 1999 Jul; 6(7):519-36.
1999 Mar 30
Colby TD, Vanderveen K, Strickler MD, Markham GD, Goldstein BM. "Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design." Proceedings of the National Academy of Sciences of the United States of America.. 1999 Mar 30; 96(7):3531-6.
1998 Jun 30
Colby TD, Bahnson BJ, Chin JK, Klinman JP, Goldstein BM. "Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes." Biochemistry.. 1998 Jun 30; 37(26):9295-304.
1998 Feb 12
Lesiak K, Watanabe KA, Majumdar A, Powell J, Seidman M, Vanderveen K, Goldstein BM, Pankiewicz KW. "Synthesis of a methylenebis(phosphonate) analogue of mycophenolic adenine dinucleotide: a glucuronidation-resistant MAD analogue of NAD." Journal of medicinal chemistry.. 1998 Feb 12; 41(4):618-22.
1997 Nov 25
Bahnson BJ, Colby TD, Chin JK, Goldstein BM, Klinman JP. "A link between protein structure and enzyme catalyzed hydrogen tunneling." Proceedings of the National Academy of Sciences of the United States of America.. 1997 Nov 25; 94(24):12797-802.
1997 Aug 1
Lesiak K, Watanabe KA, Majumdar A, Seidman M, Vanderveen K, Goldstein BM, Pankiewicz KW. "Synthesis of nonhydrolyzable analogues of thiazole-4-carboxamide and benzamide adenine dinucleotide containing fluorine atom at the C2' of adenine nucleoside: induction of K562 differentiation and inosine monophosphate dehydrogenase inhibitory activity." Journal of medicinal chemistry.. 1997 Aug 1; 40(16):2533-8.
1997 May 23
Franchetti P, Cappellacci L, Sheikha GA, Jayaram HN, Gurudutt VV, Sint T, Schneider BP, Jones WD, Goldstein BM, Perra G, De Montis A, Loi AG, La Colla P, Grifantini M. "Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin." Journal of medicinal chemistry.. 1997 May 23; 40(11):1731-7.
1997 Apr 11
Pankiewicz KW, Lesiak K, Zatorski A, Goldstein BM, Carr SF, Sochacki M, Majumdar A, Seidman M, Watanabe KA. "The practical synthesis of a methylenebisphosphonate analogue of benzamide adenine dinucleotide: inhibition of human inosine monophosphate dehydrogenase (type I and II)." Journal of medicinal chemistry.. 1997 Apr 11; 40(8):1287-91.
1996 Jun 7
Zatorski A, Watanabe KA, Carr SF, Goldstein BM, Pankiewicz KW. "Chemical synthesis of benzamide adenine dinucleotide: inhibition of inosine monophosphate dehydrogenase (types I and II)." Journal of medicinal chemistry.. 1996 Jun 7; 39(12):2422-6.
1995 Sep 15
Franchetti P, Cappellacci L, Grifantini M, Barzi A, Nocentini G, Yang H, O'Connor A, Jayaram HN, Carrell C, Goldstein BM. "Furanfurin and thiophenfurin: two novel tiazofurin analogues. Synthesis, structure, antitumor activity, and interactions with inosine monophosphate dehydrogenase." Journal of medicinal chemistry.. 1995 Sep 15; 38(19):3829-37.
1995 Mar 31
Zatorski A, Goldstein BM, Colby TD, Jones JP, Pankiewicz KW. "Potent inhibitors of human inosine monophosphate dehydrogenase type II. Fluorine-substituted analogues of thiazole-4-carboxamide adenine dinucleotide." Journal of medicinal chemistry.. 1995 Mar 31; 38(7):1098-105.
Cappellacci, L.; Franchetti, P.; Grifantini, M.; Messini, L.; Abu Sheikha, G.; Nocenti, G.; Moraca, R.; Goldstein, B.M.;. "Synthesis, Antitumor Activity and Crystallographic Studies of Analogues of Tiazofurin". Nucleosides and Nucleotides. 1995; 14(3): 637-640. Link
1994 Oct 4
Li H, Hallows WH, Punzi JS, Pankiewicz KW, Watanabe KA, Goldstein BM. "Crystallographic studies of isosteric NAD analogues bound to alcohol dehydrogenase: specificity and substrate binding in two ternary complexes." Biochemistry.. 1994 Oct 4; 33(39):11734-44.
1994 May 27
Goldstein BM, Li H, Hallows WH, Langs DA, Franchetti P, Cappellacci L, Grifantini M. "C-glycosyl bond conformation in oxazofurin: crystallographic and computational studies of the oxazole analogue of tiazofurin." Journal of medicinal chemistry.. 1994 May 27; 37(11):1684-8.
1994 Feb 4
Goldstein BM, Li H, Jones JP, Bell JE, Zeidler J, Pankiewicz KW, Watanabe KA. "CNAD: a potent and specific inhibitor of alcohol dehydrogenase." Journal of medicinal chemistry.. 1994 Feb 4; 37(3):392-9.
1994 Jan 11
Li H, Hallows WH, Punzi JS, Marquez VE, Carrell HL, Pankiewicz KW, Watanabe KA, Goldstein BM. "Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin." Biochemistry.. 1994 Jan 11; 33(1):23-32.
1993 Oct 18
Zatorski A, Lipka P, Mollova N, Schram KH, Goldstein BM, Watanabe KA, Pankiewicz KW. "Synthesis of thiazole-4-carboxamide-adenine difluoromethylenediphosphonates substituted with fluorine at C-2' of the adenosine." Carbohydrate research. 1993 Oct 18; 249(1):95-108.
1993 Aug 1
Li H, Kennedy SD, Goldstein BM. "Solid-state and solution conformations of isotiazofurin: crystallographic, computational and 1H NMR studies." Acta crystallographica. Section B, Structural science. 1993 Aug 1; 49 ( Pt 4):729-38.
1993 Aug 1
Burling FT, Goldstein BM. "A database study of nonbonded intramolecular sulfur-nucleophile contacts." Acta crystallographica. Section B, Structural science. 1993 Aug 1; 49 ( Pt 4):738-44.
1993 Jun 25
Pankiewicz KW, Zeidler J, Ciszewski LA, Bell JE, Goldstein BM, Jayaram HN, Watanabe KA. "Synthesis of isosteric analogues of nicotinamide adenine dinucleotide containing C-nucleotide of nicotinamide or picolinamide." Journal of medicinal chemistry.. 1993 Jun 25; 36(13):1855-9.
Bodenteich, M.; Marquez; Barchi, J.J. Jr.; Hallows, W.H.; Goldstein, B.M.; Driscoll, J.S.;. "Synthesis of Carbocyclic Analogues of 1-beta-D-Psicoofuranosyl Nucleosides. Psico-cyclopentenyladenosine (Psicoplanocin A) and Psico-cyclopentenylcytosine". J. Org. Chem.. 1993; 58(3): 6009-6015. Link
1992 Oct 1
Burling FT, Hallows WH, Phelan MJ, Gabrielsen B, Goldstein BM. "Structures of the 4-cyano and 4-methylamidate analogs of tiazofurin." Acta crystallographica. Section B, Structural science. 1992 Oct 1; 48 ( Pt 5):677-83.
1992 Sep 18
Li H, Goldstein BM. "Carboxamide group conformation in the nicotinamide and thiazole-4-carboxamide rings: implications for enzyme binding." Journal of medicinal chemistry.. 1992 Sep 18; 35(19):3560-7.
Burling, F.T.; Goldstein, B.M.;. "Computational Studies of Nonbonded Sulfur-Oxygen and Selenium-Oxygen Interactions in the Thiazole and Selenazole Nucleosides". J. Am. Chem. Soc.. 1992; 114(3): 2313-2320. Link
Bodenteich, M.; Marquez, V.E.; Hallows, W.H.; Goldstein, B.M.;. "Synthesis and Structural characterization of (±) Neplanocin F". J. Org. Chem.. 1992; 57(3): 2071-2076. Link
1991 Oct 31
Zhen W, Jayaram HN, Marquez VE, Goldstein BM, Cooney DA, Weber G. "Cytotoxicity of tiazofurin and its arabinose and xylose analogues in K562 cells." Biochemical and biophysical research communications.. 1991 Oct 31; 180(2):933-8.
1991 Aug 1
Goldstein BM, Leary JF, Farley BA, Marquez VE, Levy PC, Rowley PT. "Induction of HL60 cell differentiation by tiazofurin and its analogues: characterization and efficacy." Blood.. 1991 Aug 1; 78(3):593-8.
1991 Jun 15
Burling FT, Gabrielsen B, Goldstein BM. "Structures of the 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy analogs of tiazofurin." Acta crystallographica. Section C, Crystal structure communications. 1991 Jun 15; 47 ( Pt 6):1272-5.
Srivastava,P.C.; Knapp, F.F. Jr.; Callahan, A.P.; Goldstein, B.M.;. "Myocardial Imaging Agents: Synthesis, Characterization and Evaluation of [(Z) and (Z,E)-(1-[82Br]Bromo-1-penten-5-yl)] triphenylphosphonium Cations". J. Labeled Comp. and Radiopharm. 1991; 28(3): 1161-1169. Link
1990 Apr
Goldstein BM, Bell JE, Marquez VE. "Dehydrogenase binding by tiazofurin anabolites." Journal of medicinal chemistry.. 1990 Apr; 33(4):1123-7.
Goldstein, B.M.; Kennedy, S.D.; Hennen, W.J. ;. "77Se NMR and Crystallographic Studies of Selenazofurin and its 5-amino Derivative". J. Am. Chem.. 1990; : 8265-8268. Link
1989 Jul
Tseng CK, Marquez VE, Fuller RW, Goldstein BM, Haines DR, McPherson H, Parsons JL, Shannon WM, Arnett G, Hollingshead M. "Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities." Journal of medicinal chemistry.. 1989 Jul; 32(7):1442-6.
1988 May
Goldstein BM, Mao DT, Marquez VE. "Ara-tiazofurin: conservation of structural features in an unusual thiazole nucleoside." Journal of medicinal chemistry.. 1988 May; 31(5):1026-31.
Goldstein, B.M.;. "Introduction to the Crystallographic Literature: A Course for the Non-specialist". J. Chem. Ed.. 1988; 65(3): 508-512. Link
Banerjee A, Levy HR, Levy GC, LiMuti C, Goldstein BM, Bell JE. "A transfer nuclear Overhauser effect study of coenzyme binding to distinct sites in binary and ternary complexes in glutamate dehydrogenase." Biochemistry.. 1987 26(25):8443-50.
Goldstein, B.M.; Takusagawa, F.; Srivastava, P.C.; Knapp, F.;. "Cis/trans Disorder in (5-Bromo-4-Pentenyl) triphenylphosphonium Iodide". Acta Cryst.. 1986; C42(3): 570-573. Link
Goldstein, B.M.; Barton, J.; Berman, H.M.;. "Crystal and Molecular Structure of a Chiral-Specific DNA Binding Agent: tris(4,7-diphenylphenanthroline) ruthenium (II)". J. Inorg. Chem.. 1986; 25(3): 842-847. Link
Goldstein, B.M.; Takusagawa, F.; Berman, H.M.; Srivastava, P.C.; Robins, R.K.;. "Structural Studies of a New Antitumor and Antiviral Agent:". J. Am. Chem. Soc.. 1985; 107(3): 1394-1400. Link
1984 Apr 25
Takusagawa F, Goldstein BM, Youngster S, Jones RA, Berman HM. "Crystallization and preliminary X-ray study of a complex between d(ATGCAT) and actinomycin D." The Journal of biological chemistry.. 1984 Apr 25; 259(8):4714-5.
Goldstein, B.M.; Takusagawa, F.; Berman, H.M.; Srivastava, P.C.; Robins, R.K.;. "Structural Studies of a New Antitumor Agent: Tiazofurin and its Inactive Analogues". J. Am. Chem. Soc.. 1983; 105(3): 7416-7422. Link
Goldstein, B.M.;. "Disorder in the Structure of Trisodium Phosphorothioate Dodecahydrate". Acta. Cryst.. 1982; B38(3): 1116-1120. Link
Potter, D.I.; Epstein, H.D.; Goldstein, B.M.;. "Metastable and Equilibrium Phases in Dilute V&endash;N Alloys". Metallurgical Transactions. 1974; 5(3): 2075-2082. Link