Constantine G. Haidaris, Ph.D.

Constantine G. Haidaris, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Office: (585) 275-0678
Lab: (585) 275-0657

Research Bio

Research Description:



Research in my lab focuses on infections in the immunocompromised host. We examine mechanisms of pathogenesis, host-microbe interactions and approaches to therapy. Much of our recent work centers on a novel approach to treat of infections termed photodynamic therapy, in which a chemical agent termed a photosensitizer is activated by light to convert molecular oxygen to reactive oxygen species that are toxic for the target cell. In collaboration with colleagues in the Departments of Physics and Imaging Sciences, we are exploring mechanisms to increase the sensitivity of pathogens to antimicrobial photodynamic therapy and developing methods to treat experimental infections using this technology.

Patents

Passive Intranasal Monoclonal Antibody Prophylaxis Against Murine Pneumocystis Carinii Pneumonia

United States Serial NO.: 10/584,871
Filed Date: December 31, 2004
Title: Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof
Invented by: Francis Gigliotti, Terry Wright, Constantine Haidaris, Patricia Simpson-Haidaris

Recent Journal Articles

Showing the 5 most recent journal articles. 59 available »

2012
Snell SB, Foster TH, Haidaris CG. "Miconazole induces fungistasis and increases killing of Candida albicans subjected to photodynamic therapy." Photochemistry and photobiology.. 2012 88(3):596-603. Epub 2011 Dec 20.
2010 Jun 1
Chabrier-Roselló Y, Giesselman BR, De Jesús-Andino FJ, Foster TH, Mitra S, Haidaris CG. "Inhibition of electron transport chain assembly and function promotes photodynamic killing of Candida." Journal of photochemistry and photobiology. B, Biology. 2010 Jun 1; 99(3):117-25. Epub 2010 Mar 21.
2009 Oct
Van Alst NE, Wellington M, Clark VL, Haidaris CG, Iglewski BH. "Nitrite reductase NirS is required for type III secretion system expression and virulence in the human monocyte cell line THP-1 by Pseudomonas aeruginosa." Infection and immunity.. 2009 Oct; 77(10):4446-54. Epub 2009 Aug 03.
2009 Oct
Van Alst NE, Sherrill LA, Iglewski BH, Haidaris CG. "Compensatory periplasmic nitrate reductase activity supports anaerobic growth of Pseudomonas aeruginosa PAO1 in the absence of membrane nitrate reductase." Canadian journal of microbiology. 2009 Oct; 55(10):1133-44.
2008
Chabrier-Roselló Y, Foster TH, Mitra S, Haidaris CG. "Respiratory deficiency enhances the sensitivity of the pathogenic fungus Candida to photodynamic treatment." Photochemistry and photobiology.. 2008 84(5):1141-8. Epub 2008 Jan 29.

Current Appointments

Associate Professor - Department of Microbiology and Immunology (SMD) - Primary
Associate Professor - Center for Oral Biology

Education

PhD | Microbiology | Univ Cincinnati Coll Medicine1982
MS | Microbiology | Miami University1976
BA | Biology | Wittenberg University1974