Kristin M. Scheible, M.D.

Kristin M. Scheible, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester, NY 14642

Office: (585) 275-2972
Fax: (585) 461-3614

Research Bio

My research efforts focus primarily on human CD8 T cell responses to influenza virus. Influenza vaccine is highly effective at producing neutralizing antibodies when well-targeted to the given circulating strain. Unfortunately influenza virus is known to have significant genetic drift that requires annual redesign of vaccine. More importantly, major changes in hemagglutinin protein can result in pandemic and more serious disease, particularly in children. CD8 T cells may play an important role in protecting humans by recognizing more conserved, internal antigens presented by infected cells. My research seeks to understand normal naïve CD8 T cell responses to novel virus, as well as understanding the role of CD8 T cell memory responses in protecting humans from drifted or shifted influenza virus.



It is thought that NK cells likely have helper function in orchestrating a series of protective adaptive and innate responses, but it is unclear how first, NK cells recognize and activate against virus-infected cells and second, how their chemical messages are sent and interpreted by other immune cells. My research seeks to understand the aspect of how NK effector function shapes the adaptive immune response to influenza infection.

Awards & Honors (National)

Ruth L. Kirschtein National Research Service Award 2008 - Present
NIH Loan Repayment Program (NIAID) | NIH 2008 - Present

Awards & Honors (Local)

NICHD Fellows Conference (nominated/selected attendee) 2009
Clausen Fellowship | Golisano Children's Hospital, Department of Pediatrics 2008
Janet M. Glascow Memorial Achievement Award | University of Rochester School of Medicine and Dentistry | Rochester, NY 2004
Outstanding Graduate in the Faculty of Arts and Letters | SUNY Buffalo | Buffalo, NY 1993
Lucia Maria Haupt Award in Anthropology | SUNY Buffalo | Buffalo, NY 1993

Recent Journal Articles

2011 Mar 3
Scheible K, Zhang G, Baer J, Azadniv M, Lambert K, Pryhuber G, Treanor JJ, Topham DJ. "CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses." Vaccine.. 2011 Mar 3; 29(11):2159-68. Epub 2011 Jan 04.

Current Appointments

Assistant Professor - Department of Pediatrics, Neonatology (SMD) - Primary

Specialties

Neonatal-Perinatal Medicine - American Board of Pediatrics
Pediatrics - American Board of Pediatrics

Education

MD | Medicine | University of Rochester School of Medicine & Dentistry2004
BA | Anthropology and Women's Studies | State University at Buffalo1994

Post-Doctoral Training & Residency

Fellowship in Neonatology at Strong Memorial Hospital- GME Office07/01/2007 - 06/30/2010
Residency in Pediatrics at Strong Memorial Hospital- GME Office07/01/2005 - 06/30/2007
Internship in Pediatrics at Strong Memorial Hospital- GME Office06/15/2004 - 06/30/2005