Laura M. Calvi, M.D.

Laura M. Calvi, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 693
Rochester, NY 14642

Office: (585) 275-2901
Fax: (585) 273-1288

Research Bio

RESEARCH
Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow



To survive throughout the life of an individual, hematopoietic stem cells (or HSC), which continuously give rise to all cellular blood components, must strictly regulate their behavioral choices. These choices include self-renewal, differentiation, quiescence or death. This essential regulation of stem cells is thought to be determined at least in part by the environment, or niche, in which these cells reside. The bone forming cells, osteoblasts, have been known to support and expand HSC in vitro and co-transplantation of osteoblasts with HSC can increase engraftment rate. Work in our laboratory and others first identified osteoblastic cells as a regulatory component in the HSC niche through genetic means. A number of molecules have since been implicated in HSC-osteoblastic interaction. In fact, it has recently become evident that osteoblasts can both stimulate and limit HSC expansion, promote quiescence, coordinate HSC mobilization and, when destroyed or mutated, initiate hematopoietic dysfunction. Therefore, increasing evidence points to osteoblasts as key regulators of HSC behavior. While the HSC niche is still poorly understood, we and others have begun to demonstrate the therapeutic potential of its manipulation in animal models. Our laboratory has demonstrated that osteoblastic activation by Parathyroid Hormone (PTH) expands HSC, and improves recovery from myeloablation. Thus, the central hypothesis pursued by my laboratory is that osteoblastic cells play a central role in orchestrating microenvironmental control of the behavior of both benign and malignant HSC, and that they can be targeted for therapeutic benefit. My laboratory therefore uniquely uses techniques that bridge bone and stem cell biology to discover the regulatory components of the bone marrow microenvironment, with the long term goal of identifying targets for therapeutic manipulation.

Current areas of research include:
1) Molecular mechanisms of osteoblastic regulation of hematopoietic stem cells,

2) Role of osteoblasts in coordinating the actions of other bone marrow cellular components (osteoclasts, endothelial cells and adipocytes) for HSC regulation,

3) Regulation of malignant stem cells by bone microenvironmental factors,

4) Role of HSC niche components in response to toxic or irradiation injury,

5) Therapeutic targeting of the HSC niche to improve HSC expansion (in vivo and in vitro), response to toxic injury and malignant stem cell eradication.

Individuals working in the laboratory can expect to learn flow cytometric analysis, pharmacologic and immunohistochemical methods for studying microenvironmental interactions in several animal and in vitro models, and the necessary computational techniques for analyzing these data.

CAREERS
We are currently accepting applications for graduate students and post-doctoral fellow positions in Calvi Lab at the University of Rochester Medical Center. Individuals interested in conducting research on the physiology and stem cell biology within the bone marrow microenvironment are encouraged to apply. Interested candidates, please e-mail your CV and a cover letter detailing your scientific background and skills to Dr. Calvi (laura_calvi@urmc.rochester.edu )

Patents

Modulation of CCL3 Expression to Accelerate Hematopoietic Recovery in the Setting of Myeloid Leukemia

United States Serial NO.: 14/194,344
Filed Date: February 28, 2014
Title: Compositions and Methods for Inhibiting CCL3
Invented by: Benjamin Frisch, Laura Calvi

Recent Journal Articles

Showing the 5 most recent journal articles. 35 available »

2014 Aug 1
Hoffman CM, Calvi LM. "Minireview: Complexity of Hematopoietic Stem Cell Regulation in the Bone Marrow Microenvironment." Molecular endocrinology.. 2014 Aug 1; :me20141079. Epub 2014 Aug 01.
2014 Jul 15
Hutchinson K, Jahangiri S, Calvi LM, Barr P, Friedberg JW, Kelly JL. "Impact of dietary supplements, obesity and treatment initiation on serum vitamin D levels in patients with lymphoma." Leukemia & lymphoma.. 2014 Jul 15; :1-4. Epub 2014 Jul 15.
2014 Jan
Calvi LM, Link DC. "Cellular complexity of the bone marrow hematopoietic stem cell niche." Calcified tissue international.. 2014 Jan; 94(1):112-24. Epub 2013 Oct 08.
2013 Jun
Smith JN, Calvi LM. "Concise review: Current concepts in bone marrow microenvironmental regulation of hematopoietic stem and progenitor cells." Stem cells.. 2013 Jun; 31(6):1044-50.
2013 Jun
Yeaney GA, Brathwaite JM, Dashnaw ML, Vates GE, Calvi LM. "Pituitary adenoma with mucin cells in a man with an unusual presentation of Carney complex." Endocrine pathology. 2013 Jun; 24(2):106-9.

Current Appointments

Dean's Professorship - Department of Medicine (SMD)
Professor - Department of Medicine, Endocrine/Metabolism (SMD) - Primary
Professor - Department of Neurosurgery (SMD)
Professor - Department of Pharmacology and Physiology (SMD)

Specialties

Internal Medicine - American Board of Internal Medicine
Endocrinology, Diabetes and Metabolism - American Board of Internal Medicine

Education

MD | Medicine | Harvard Medical School1995
BA | Biological Science | Union College1990

Post-Doctoral Training & Residency

Fellowship in Endocrinology and Metabolism at Massachusetts General Hospital07/01/1998 - 06/30/2000
Residency in Internal Medicine at Massachusetts General Hospital06/01/1996 - 06/30/1998
Internship in Internal Medicine at Massachusetts General Hospital06/24/1995 - 05/31/1996