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Jacob J. Schlesinger, M.D.

Contact Information

11 Cavan Way
Pittsford, NY 14534

Office: (585) 275-0526
Fax: (585) 442-9328

Journal Articles

Showing all 49 journal articles available.

2012 Apr
Thibodeaux BA, Garbino NC, Liss NM, Piper J, Schlesinger JJ, Blair CD, Roehrig JT. "A humanized IgG but not IgM antibody is effective in prophylaxis and therapy of yellow fever infection in an AG129/17D-204 peripheral challenge mouse model." Antiviral research. 2012 Apr; 94(1):1-8. Epub 2012 Feb 15.
2011 Feb 5
Kou Z, Lim JY, Beltramello M, Quinn M, Chen H, Liu SN, Martnez-Sobrido L, Diamond MS, Schlesinger JJ, de Silva A, Sallusto F, Jin X. "Human antibodies against dengue enhance dengue viral infectivity without suppressing type I interferon secretion in primary human monocytes." Virology. 2011 Feb 5; 410(1):240-7. Epub 2010 Dec 04.
2010 Nov 29
Block OK, Rodrigo WW, Quinn M, Jin X, Rose RC, Schlesinger JJ. "A tetravalent recombinant dengue domain III protein vaccine stimulates neutralizing and enhancing antibodies in mice." Vaccine. 2010 Nov 29; 28(51):8085-94. Epub 2010 Oct 16.
2009 Nov 25
Rodrigo WW, Block OK, Lane C, Sukupolvi-Petty S, Goncalvez AP, Johnson S, Diamond MS, Lai CJ, Rose RC, Jin X, Schlesinger JJ. "Dengue virus neutralization is modulated by IgG antibody subclass and Fcgamma receptor subtype." Virology. 2009 Nov 25; 394(2):175-82. Epub 2009 Oct 14.
2009 Mar
Arévalo MT, Simpson-Haidaris PJ, Kou Z, Schlesinger JJ, Jin X. "Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infection." Journal of medical virology. 2009 Mar; 81(3):519-28.
2009 Feb
Rodrigo WW, Alcena DC, Kou Z, Kochel TJ, Porter KR, Comach G, Rose RC, Jin X, Schlesinger JJ. "Difference between the abilities of human Fcgamma receptor-expressing CV-1 cells to neutralize American and Asian genotypes of dengue virus 2." Clinical and vaccine immunology : CVI. 2009 Feb; 16(2):285-7. Epub 2008 Nov 26.
2009 Jan
Shanaka WW, Rodrigo I, Alcena DC, Rose RC, Jin X, Schlesinger JJ. "An automated Dengue virus microneutralization plaque assay performed in human Fc{gamma} receptor-expressing CV-1 cells." The American journal of tropical medicine and hygiene. 2009 Jan; 80(1):61-5.
2009
Jin X, Block OT, Rose R, Schlesinger J. "Dengue vaccine development and dengue viral neutralization and enhancement assays." Antiviral therapy. 2009 14(6):739-49.
2008 Apr 10
Sapinoro R, Volcy K, Rodrigo WW, Schlesinger JJ, Dewhurst S. "Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells." Virology. 2008 Apr 10; 373(2):274-86. Epub 2008 Jan 14.
2008 Jan
Kou Z, Quinn M, Chen H, Rodrigo WW, Rose RC, Schlesinger JJ, Jin X. "Monocytes, but not T or B cells, are the principal target cells for dengue virus (DV) infection among human peripheral blood mononuclear cells." Journal of medical virology. 2008 Jan; 80(1):134-46.
2007
Sukupolvi-Petty S, Austin SK, Purtha WE, Oliphant T, Nybakken GE, Schlesinger JJ, Roehrig JT, Gromowski GD, Barrett AD, Fremont DH, Diamond MS. "Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes." Journal of virology. 2007 81(23):12816-26. Epub 2007 Sep 19.
2007
Blackley S, Kou Z, Chen H, Quinn M, Rose RC, Schlesinger JJ, Coppage M, Jin X. "Primary human splenic macrophages, but not T or B cells, are the principal target cells for dengue virus infection in vitro." Journal of virology. 2007 81(24):13325-34. Epub 2007 Oct 10.
2006 Oct
Rodrigo WW, Jin X, Blackley SD, Rose RC, Schlesinger JJ. "Differential enhancement of dengue virus immune complex infectivity mediated by signaling-competent and signaling-incompetent human Fcgamma RIA (CD64) or FcgammaRIIA (CD32)." Journal of virology. 2006 Oct; 80(20):10128-38.
2006
Schlesinger JJ. "Flavivirus nonstructural protein NS1: complementary surprises." Proceedings of the National Academy of Sciences of the United States of America. 2006 103(50):18879-80. Epub 2006 Dec 04.
2003 Mar
Chambers TJ, Liang Y, Droll DA, Schlesinger JJ, Davidson AD, Wright PJ, Jiang X. "Yellow fever virus/dengue-2 virus and yellow fever virus/dengue-4 virus chimeras: biological characterization, immunogenicity, and protection against dengue encephalitis in the mouse model." Journal of virology. 2003 Mar; 77(6):3655-68.
1999 Jul 20
Schlesinger JJ, Chapman SE. "Influence of the human high-affinity IgG receptor FcgammaRI (CD64) on residual infectivity of neutralized dengue virus." Virology. 1999 Jul 20; 260(1):84-8.
1997 Jun
Ryman KD, Ledger TN, Weir RC, Schlesinger JJ, Barrett AD. "Yellow fever virus envelope protein has two discrete type-specific neutralizing epitopes." The Journal of general virology. 1997 Jun; 78 ( Pt 6):1353-6.
1996 Jun
Schlesinger JJ, Chapman S, Nestorowicz A, Rice CM, Ginocchio TE, Chambers TJ. "Replication of yellow fever virus in the mouse central nervous system: comparison of neuroadapted and non-neuroadapted virus and partial sequence analysis of the neuroadapted strain." The Journal of general virology. 1996 Jun; 77 ( Pt 6):1277-85.
1995 Jan
Schlesinger JJ, Chapman S. "Neutralizing F(ab')2 fragments of protective monoclonal antibodies to yellow fever virus (YF) envelope protein fail to protect mice against lethal YF encephalitis." The Journal of general virology. 1995 Jan; 76 ( Pt 1):217-20.
1994 Apr
Eckels KH, Dubois DR, Summers PL, Schlesinger JJ, Shelly M, Cohen S, Zhang YM, Lai CJ, Kurane I, Rothman A. "Immunization of monkeys with baculovirus-dengue type-4 recombinants containing envelope and nonstructural proteins: evidence of priming and partial protection." The American journal of tropical medicine and hygiene. 1994 Apr; 50(4):472-8.
1993 Jan
Schlesinger JJ, Foltzer M, Chapman S. "The Fc portion of antibody to yellow fever virus NS1 is a determinant of protection against YF encephalitis in mice." Virology. 1993 Jan; 192(1):132-41.
1992 Apr
Megret F, Hugnot JP, Falconar A, Gentry MK, Morens DM, Murray JM, Schlesinger JJ, Wright PJ, Young P, Van Regenmortel MH. "Use of recombinant fusion proteins and monoclonal antibodies to define linear and discontinuous antigenic sites on the dengue virus envelope glycoprotein." Virology. 1992 Apr; 187(2):480-91.
1991 Jan
Deubel V, Bordier M, Megret F, Gentry MK, Schlesinger JJ, Girard M. "Processing, secretion, and immunoreactivity of carboxy terminally truncated dengue-2 virus envelope proteins expressed in insect cells by recombinant baculoviruses." Virology. 1991 Jan; 180(1):442-7.
1990 Oct
Barrett AD, Monath TP, Cropp CB, Adkins JA, Ledger TN, Gould EA, Schlesinger JJ, Kinney RM, Trent DW. "Attenuation of wild-type yellow fever virus by passage in HeLa cells." The Journal of general virology. 1990 Oct; 71 ( Pt 10):2301-6.
1990 Sep
Falgout B, Bray M, Schlesinger JJ, Lai CJ. "Immunization of mice with recombinant vaccinia virus expressing authentic dengue virus nonstructural protein NS1 protects against lethal dengue virus encephalitis." Journal of virology. 1990 Sep; 64(9):4356-63.
1990 Aug
Putnak JR, Schlesinger JJ. "Protection of mice against yellow fever virus encephalitis by immunization with a vaccinia virus recombinant encoding the yellow fever virus non-structural proteins, NS1, NS2a and NS2b." The Journal of general virology. 1990 Aug; 71 ( Pt 8):1697-702.
1990 Jun
Brandriss MW, Schlesinger JJ, Walsh EE. "Immunogenicity of a purified fragment of 17D yellow fever envelope protein." The Journal of infectious diseases. 1990 Jun; 161(6):1134-9.
1990 Mar
Schlesinger JJ, Brandriss MW, Putnak JR, Walsh EE. "Cell surface expression of yellow fever virus non-structural glycoprotein NS1: consequences of interaction with antibody." The Journal of general virology. 1990 Mar; 71 ( Pt 3):593-9.
1988 Aug
Henchal EA, Henchal LS, Schlesinger JJ. "Synergistic interactions of anti-NS1 monoclonal antibodies protect passively immunized mice from lethal challenge with dengue 2 virus." The Journal of general virology. 1988 Aug; 69 ( Pt 8):2101-7.
1987 Mar
Schlesinger JJ, Brandriss MW, Walsh EE. "Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1." The Journal of general virology. 1987 Mar; 68 ( Pt 3):853-7.
1987
Deubel V, Schlesinger JJ, Digoutte JP, Girard M. "Comparative immunochemical and biological analysis of African and South American yellow fever viruses." Archives of virology. 1987 94(3-4):331-8.
1987
Lobigs M, Dalgarno L, Schlesinger JJ, Weir RC. "Location of a neutralization determinant in the E protein of yellow fever virus (17D vaccine strain)." Virology. 1987 161(2):474-8.
1986 May
Rice CM, Aebersold R, Teplow DB, Pata J, Bell JR, Vorndam AV, Trent DW, Brandriss MW, Schlesinger JJ, Strauss JH. "Partial N-terminal amino acid sequences of three nonstructural proteins of two flaviviruses." Virology. 1986 May; 151(1):1-9.
1986 Feb
Brandriss MW, Schlesinger JJ, Walsh EE, Briselli M. "Lethal 17D yellow fever encephalitis in mice. I. Passive protection by monoclonal antibodies to the envelope proteins of 17D yellow fever and dengue 2 viruses." The Journal of general virology. 1986 Feb; 67 ( Pt 2):229-34.
1986 Jan
Monath TP, Hill LJ, Brown NV, Cropp CB, Schlesinger JJ, Saluzzo JF, Wands JR. "Sensitive and specific monoclonal immunoassay for detecting yellow fever virus in laboratory and clinical specimens." Journal of clinical microbiology. 1986 Jan; 23(1):129-34.
1986
Schlesinger JJ, Brandriss MW, Cropp CB, Monath TP. "Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1." Journal of virology. 1986 60(3):1153-5.
1985 Oct
Schlesinger JJ, Brandriss MW, Walsh EE. "Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48." The Journal of immunology : official journal of the American Association of Immunologists. 1985 Oct; 135(4):2805-9.
1985 Sep
Deubel V, Pailliez JP, Cornet M, Schlesinger JJ, Diop M, Diop A, Digoutte JP, Girard M. "Homogeneity among Senegalese strains of yellow fever virus." The American journal of tropical medicine and hygiene. 1985 Sep; 34(5):976-83.
1985 Mar
Walsh EE, Brandriss MW, Schlesinger JJ. "Purification and characterization of the respiratory syncytial virus fusion protein." The Journal of general virology. 1985 Mar; 66 ( Pt 3):409-15.
1984 Oct
Schlesinger JJ, Walsh EE, Brandriss MW. "Analysis of 17D yellow fever virus envelope protein epitopes using monoclonal antibodies." The Journal of general virology. 1984 Oct; 65 ( Pt 10):1637-44.
1984 Jul
Monath TP, Schlesinger JJ, Brandriss MW, Cropp CB, Prange WC. "Yellow fever monoclonal antibodies: type-specific and cross-reactive determinants identified by immunofluorescence." The American journal of tropical medicine and hygiene. 1984 Jul; 33(4):695-8.
1984 Apr
Walsh EE, Schlesinger JJ, Brandriss MW. "Purification and characterization of GP90, one of the envelope glycoproteins of respiratory syncytial virus." The Journal of general virology. 1984 Apr; 65 ( Pt 4):761-7.
1984 Apr
Brandriss MW, Schlesinger JJ. "Antibody-mediated infection of P388D1 cells with 17D yellow fever virus: effects of chloroquine and cytochalasin B." The Journal of general virology. 1984 Apr; 65 ( Pt 4):791-4.
1984 Feb
Walsh EE, Schlesinger JJ, Brandriss MW. "Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies." Infection and immunity. 1984 Feb; 43(2):756-8.
1983 Jun
Burstin SJ, Brandriss MW, Schlesinger JJ. "Infection of a macrophage-like cell line, P388D1 with reovirus; effects of immune ascitic fluids and monoclonal antibodies on neutralization and on enhancement of viral growth." The Journal of immunology : official journal of the American Association of Immunologists. 1983 Jun; 130(6):2915-9.
1983 Jun
Schlesinger JJ, Brandriss MW. "17D yellow fever virus infection of P388D1 cells mediated by monoclonal antibodies: properties of the macrophage Fc receptor." The Journal of general virology. 1983 Jun; 64 (Pt 6):1255-62.
1983 Mar
Monath TP, Kinney RM, Schlesinger JJ, Brandriss MW, Brès P. "Ontogeny of yellow fever 17D vaccine: RNA oligonucleotide fingerprint and monoclonal antibody analyses of vaccines produced world-wide." The Journal of general virology. 1983 Mar; 64 Pt 3:627-37.
1983 Feb
Schlesinger JJ, Brandriss MW, Monath TP. "Monoclonal antibodies distinguish between wild and vaccine strains of yellow fever virus by neutralization, hemagglutination inhibition, and immune precipitation of the virus envelope protein." Virology. 1983 Feb; 125(1):8-17.
1981 Aug
Schlesinger JJ, Brandriss MW. "Growth of 17D yellow fever virus in a macrophage-like cell line, U937: role of Fc and viral receptors in antibody-mediated infection." The Journal of immunology : official journal of the American Association of Immunologists. 1981 Aug; 127(2):659-65.