Harris A. Gelbard, M.D., Ph.D.

Harris A. Gelbard, M.D., Ph.D.

Contact Information

919 Westfall Road, Clinton Crossings Bldg C, Suite 220
Rochester, NY 14618

Appointment: (585) 275-1200

  • Accepting New Patients Accepting New Patients
  • Admits to Strong Memorial Hospital Admits to Strong Memorial Hospital

Patient Care Bio

Dr. Gelbard is the Director of the Center for Neural Development and Disease and Professor of Neurology, Pediatrics and Microbiology & Immunology at the University of Rochester Medical Center. Dr. Gelbard has 25 years of experience as a molecular neuropharmacologist, working in experimental models of neuroAIDS and HIV-1 neuroinflammation since 1992. As the leader of the NeuroAIDS research group in the UR's NIH-funded Development Center for AIDS Research and PO1 MH64570, in collaboration with Drs. Steve Dewhurst and Sanjay Maggirwar from the Department of Microbiology and Immunology, Dr. Gelbard has worked to develop new therapies for HIV-associated neurocognitive disorders (HAND) over the past several years with a programmatic effort funded by the NIMH for over 10 years.

Our approach is to develop strategies to target mixed lineage kinase (MLK)-3, an upstream kinase that regulates neuroinflammation and neuronal function/fate through effects on downstream kinases, including Jun N-terminal kinase (JNK). Working with our industry partner, Califia Bio (San Diego, CA), we have developed novel, brain-penetrant small molecules that efficiently inhibit MLK-3, Dr. Gelbard's lab is in the process of testing these new inhibitors in in vitro and in vivo models for HAND. Dr. Gelbard serves on numerous advisory boards of Center, U-level and P-level grants investigating the pathogenesis and treatment of HAND. He is the chair of the external advisory committee to the CNS HIV Anti-Retroviral Therapy Effects Research ("CHARTER," NIMH and NINDS N01 MH22005, 2002-2015), and a member of the Neurology Scientific Advisory Board to the Pediatric HIV/AIDS Cohort Study (PHACS) network (NICHD U01 HD052104, 2009-2014). Dr. Gelbard is the associate editor for the 3rd edition of The Neurology of AIDS (Oxford Press).

Awards & Honors (National)

National Merit Scholar 1972

Awards & Honors (Local)

Child Neurology Young Investigator Award 1990
Buswell Memorial Fellowship, University of Rochester 1990
First Prize, Wyeth-Ayerst Award or New Psychiatric Research, VIII World Congress of Psychiatry, Athens, Greece 1989
Sigma Xi, Thesis Research 1980


A Selectively Non-Selective Mixed Lineage Kinase 3 Inhibitor Potentiates the Effectiveness of Antiretroviral Therapy for HIV/AIDS

United States Serial NO.: 14/648,404
Filed Date: November 30, 2013
Title: MIxed Lineage Kinase Inhibitors for HIV/AIDS Therapies
Invented by: Harris Gelbard, Stephen Dewhurst, Howard Gendelman

Current Appointments

Director - Center for Neural Development & Disease - Primary Administrative
Professor - Department of Neurology, Center for Neural Development & Disease (SMD) - Primary
Professor - Department of Microbiology and Immunology (SMD)
Professor - Department of Pediatrics (SMD)


Neurology with Special Qualifications in Child Neurology - American Board of Psychiatry and Neurology


MD | Medicine | Northwestern Univ Medical Sch1983
PhD | Pharmacology | Northwestern Univ-Chicago Cmp1983
BS | Arts & Sciences | Northwestern Univ-Chicago Cmp1976

Post-Doctoral Training & Residency

Fellowship in Developmental Neuropharmacology at McLean Hospital09/01/1988 - 06/30/1990
Fellowship in Neurology at Children s Hospital09/01/1988 - 06/30/1990
Residency in Neurology at Children s Hospital07/01/1985 - 06/30/1988
Residency in Pediatrics at Children s Memorial Hospital, Northwestern University07/01/1984 - 06/30/1985
Internship in Pediatrics at Children s Memorial Hospital, Northwestern University07/01/1983 - 6/30/1984