Stephen Dewhurst, Ph.D.

Stephen Dewhurst, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Appointment: (585) 275-URMC (8762)

Professional Bio

Dr. Dewhurst is Dean's Professor and Chair of Microbiology & Immunology at the University of Rochester School of Medicine and Dentistry (URSMD). He received his Ph.D. from the University of Nebraska Medical Center in 1987, and performed postdoctoral training at Columbia University and at the Harvard School of Public Health, under the direction of Dr. Jim Mullins. His doctoral and postdoctoral work focussed on the pathogenesis of human and simian immunodeficiency viruses. He has been a member of the faculty at the University of Rochester since 1990, and served as Senior Associate Dean for Basic Research at the URSMD from 2007 to 2009.

He has over 20 years experience as a molecular virologist, working on both RNA and DNA viruses (including HIV-1 and human herpesviruses) and is expert in the areas of viral gene transfer vectors, HIV-1 vaccine development and neuroAIDS. He has served on many NIH special emphasis and regular grant review panels and is a former Study Section Chair as well as a past (2004-2008) member of the NIH Recombinant Advisory Committee (RAC), which oversees all recombinant DNA studies in human subjects. He serves as Director of the UR's NIH-funded Development Center for AIDS Research, and also directs a NIH-funded Predoctoral training program in HIV-1 research, in addition to his own research.

Patient Care Bio

Dr. Dewhurst is Dean's Professor and Chair of Microbiology and Immunology. He has over 20 years experience as a molecular virologist, working mainly on HIV/AIDS - with emphasis in recent years on vaccine development. He serves as Director of the UR's NIH-funded Development Center for AIDS Research, and also directs a NIH-funded Predoctoral training program in HIV-1 research, in addition to his own research.



Dr. Dewhurst is internationally recognized for his expertise, and presently serves as the President of a new vaccine company, Codevax. He is also a former NIH Study Section Chair and a former member of the NIH Recombinant Advisory Committee (RAC). Finally, he has been recognized for his mentoring and training achievements through several awards from the UR.

Awards & Honors (National)

Chair, NIH/NIAID AIDSRRC Charter Study Section 2003 - 2004
Research Career Development Award, NIH 1994 - 1999
AIDS Research Scholar | AmFAR (American Foundation for AIDS Research) 1988 - 1991

Awards & Honors (Local)

William H. Riker Award for Graduate Education | University of Rochester 2008
Member, NIH Recombinant Advisory Committee (RAC) 2004 - Present
University Dean's Award for Meritorious Service in Ph.D. Defenses | University of Rochester 2003
Graduate Alumni Award for Excellence in Graduate Education | University of Rochester 2002
Dean's Professor of Microbiology & Immunology | University of Rochester School of Medicine & Dentistry 2002 - Present
Graduate Student Soceity (GSS) Faculty Teaching Award | University of Rochester School of Medicine & Dentistry 1996
Friend of Education Award | Rochester City School District 1995

Patents

High Affinity Binding Proteins to Integrins

United States Serial NO.: 10/473,770
Filed Date: April 4, 2002
Title: avB3 Integrin-Binding Polypeptide Monobodies and Their Use
Invented by: Shohei Koide, Stephen Dewhurst, Akiko Koide, Julie Richards Gunzler, Michelle Miller
Glycoprotein Decoration of Lambda Phage Particles: Application to Vaccine Development for Influenza Virus and Other Indications

United States Serial NO.: 12/514,903
Filed Date: November 20, 2007
Title: Modified Phage for Displaying Post-Translationally Modified Proteins and Uses Thereof
Invented by: Stephen Dewhurst, John Treanor
Mixed Lineage Kinase (MLK) Inhibitors and Methods of Use

United States Serial NO.: 13/131,193
Filed Date: November 25, 2009
Title: MLK Inhibitors and Methods of Use
Invented by: Harris Gelbard, Sanjay Maggirwar, Stephen Dewhurst, Colin Loweth, Val Goodfellow, Yang Xu, Clifford John Harris
Mixed Lineage Kinase (MLK) Inhibitors and Methods of Use

United States Serial NO.: 603644
Filed Date: May 24, 2011
Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Invented by: Harris Gelbard, Sanjay Maggirwar, Stephen Dewhurst, Colin Loweth, Val Goodfellow, Yang Xu, Clifford John Harris
Mixed Lineage Kinase (MLK) Inhibitors and Methods of Use

United States Serial NO.: 13/698,829
Filed Date: May 24, 2011
Title: Bicyclic Heteroaryl Kinase Inhibitors and Methods of Use
Invented by: Harris Gelbard, Sanjay Maggirwar, Stephen Dewhurst, Colin Loweth, Val Goodfellow, Yang Xu, Clifford John Harris
Antigenic Mimics of Discontinuous HIV-1 Envelope Epitopes Recognized by Broadly Neutralizing Antibodies

United States Serial NO.: 13/577,419
Filed Date: February 14, 2011
Title: Antigenic Mimics of Discontinuous HIV-1 Envelope Epitopes Recognized by Broadly Neutralizing Antibodies
Invented by: Stephen Dewhurst, Mark Sullivan
Fibril-Targeting Microbicides for Protection Against Sexually Transmissible Microbial Pathogens Present in Semen, including HIV

United States Serial NO.: 13/643,026
Filed Date: April 22, 2011
Title: Reducing Transmission of Sexually Transmitted Infections
Invented by: Stephen Dewhurst, Bradley Nilsson, Joanna Olsen
Novel Inhibitors of SEVI-Mediated Enhancement of HIV Infection

United States Serial NO.: 14/357,037
Filed Date: November 8, 2012
Title: Reducing Transmission of Sexually Transmitted Infections
Invented by: Jerry Yang, Stephen Dewhurst, Christina Capule

Current Appointments

Vice Dean for Research, SMD - Department of Dean's Office M&D - Administration (SMD)
Associate Vice President for Health Sciences Research - Department of Office of Sr VP for Research (UR)
Chairman - Department of Microbiology and Immunology (SMD) - Primary Administrative
Dean's Professorship - Department of Microbiology and Immunology (SMD)
Professor - Department of Microbiology and Immunology (SMD) - Primary

Education

PhD | Molecular Biology | University of Nebraska1987
BS | Biochemistry | Bristol University, UK1984

Post-Doctoral Training & Residency

Postdoctoral Fellow, Department of Cancer Biology, Harvard School of Public Health, Boston, MA. 1990
Postdoctoral Fellow, Department of Medicine and Pediatrics, Columbia University, New York, NY. 1988