Robert A. Mooney, Ph.D.

Robert A. Mooney, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 608
Rochester, NY 14642

Office: (585) 275-8181
Fax: (585) 756-4468

Journal Articles

Showing all 74 journal articles available.

2014 Apr
Barry CT, Hah Z, Partin A, Mooney RA, Chuang KH, Augustine A, Almudevar A, Cao W, Rubens DJ, Parker KJ. "Mouse liver dispersion for the diagnosis of early-stage Fatty liver disease: a 70-sample study." Ultrasound in medicine & biology.. 2014 Apr; 40(4):704-13. Epub 2014 Jan 10.
2014
David MA, Jones KH, Inzana JA, Zuscik MJ, Awad HA, Mooney RA. "Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes." PloS one. 2014 9(3):e91234. Epub 2014 Mar 21.
2014
Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ. "Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus." PloS one. 2014 9(6):e99656. Epub 2014 Jun 09.
2013 Nov
Shi J, Liang Q, Wang Y, Mooney R, Boyce B, Xing L. "Use of a whole-slide imaging system to assess the presence and alteration of lymphatic vessels in joint sections of arthritic mice." Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2013 Nov; 88(8):428-39. Epub 2012 Nov 23.
2013 Nov
Inzana JA, Kung M, Shu L, Hamada D, Xing LP, Zuscik MJ, Awad HA, Mooney RA. "Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur." Bone.. 2013 Nov; 57(1):174-83. Epub 2013 Aug 14.
2013 Oct
Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ. "RBP-J?-dependent Notch signaling is required for murine articular cartilage and joint maintenance." Arthritis and rheumatism. 2013 Oct; 65(10):2623-33.
2013
Curtin WM, Menegus MA, Patru MM, Peterson CJ, Metlay LA, Mooney RA, Stanwood NL, Scheible AL, Dorgan A. "Midtrimester fetal herpes simplex-2 diagnosis by serology, culture and quantitative polymerase chain reaction." Fetal diagnosis and therapy.. 2013 33(2):133-6. Epub 2012 Oct 11.
2012 Feb
Barry CT, Mills B, Hah Z, Mooney RA, Ryan CK, Rubens DJ, Parker KJ. "Shear wave dispersion measures liver steatosis." Ultrasound in medicine & biology.. 2012 Feb; 38(2):175-82. Epub 2011 Dec 16.
2011 Nov
Clementi AH, Gaudy AM, Zimmers TA, Koniaris LG, Mooney RA. "Deletion of interleukin-6 improves pyruvate tolerance without altering hepatic insulin signaling in the leptin receptor-deficient mouse." Metabolism: clinical and experimental. 2011 Nov; 60(11):1610-9. Epub 2011 May 31.
2011 Sep 21
Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. "Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis." Science translational medicine. 2011 Sep 21; 3(101):101ra93.
2011 Jun
Gough MS, Morgan MA, Mack CM, Darling DC, Frasier LM, Doolin KP, Apostolakos MJ, Stewart JC, Graves BT, Arning E, Bottiglieri T, Mooney RA, Frampton MW, Pietropaoli AP. "The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis." Critical care medicine.. 2011 Jun; 39(6):1351-8.
2011
Mooney RA, Sampson ER, Lerea J, Rosier RN, Zuscik MJ. "High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury." Arthritis research & therapy. 2011 13(6):R198. Epub 2011 Dec 07.
2010 Nov
Galloway CA, Ashton J, Sparks JD, Mooney RA, Smith HC. "Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes." Biochimica et biophysica acta.. 2010 Nov; 1802(11):976-85. Epub 2010 Jun 09.
2010
Gaudy AM, Clementi AH, Campbell JS, Smrcka AV, Mooney RA. "Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes." The Journal of biological chemistry.. 2010 285(53):41356-65. Epub 2010 Oct 26.
2009 Nov
Clementi AH, Gaudy AM, Rooijen NV, Pierce RH, Mooney RA. "Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling." Biochimica et biophysica acta.. 2009 Nov; 1792(11):1062-72. Epub 2009 Aug 20.
2008 Aug
Thornburg LL, Knight KM, Peterson CJ, McCall KB, Mooney RA, Pressman EK. "Maternal serum alpha-fetoprotein values in type 1 and type 2 diabetic patients." American journal of obstetrics and gynecology.. 2008 Aug; 199(2):135.e1-5. Epub 2008 May 02.
2008
Navaneethan, SD; Mooney, RA; James Sloand, J. "Pseudo-anion gap acidosis". NDT Plus. 2008; 1(2): 94-96.
2007 Feb
Mooney RA. "Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis." Journal of applied physiology.. 2007 Feb; 102(2):816-8; discussion 818-9.
2006 Jul
Chagnon MJ, Elchebly M, Uetani N, Dombrowski L, Cheng A, Mooney RA, Marette A, Tremblay ML. "Altered glucose homeostasis in mice lacking the receptor protein tyrosine phosphatase sigma." Canadian journal of physiology and pharmacology.. 2006 Jul; 84(7):755-63.
2005 Aug
Klover PJ, Clementi AH, Mooney RA. "Interleukin-6 depletion selectively improves hepatic insulin action in obesity." Endocrinology.. 2005 Aug; 146(8):3417-27. Epub 2005 Apr 21.
2004 Jul 1
LeVea CM, Reeder JE, Mooney RA. "EGF-dependent cell cycle progression is controlled by density-dependent regulation of Akt activation." Experimental cell research.. 2004 Jul 1; 297(1):272-84.
2004 May
Klover PJ, Mooney RA. "Hepatocytes: critical for glucose homeostasis." The international journal of biochemistry & cell biology. 2004 May; 36(5):753-8.
2003 Nov
Klover PJ, Zimmers TA, Koniaris LG, Mooney RA. "Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice." Diabetes.. 2003 Nov; 52(11):2784-9.
2003 Aug
Arnold GL, Hyman SL, Mooney RA, Kirby RS. "Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies." Journal of autism and developmental disorders.. 2003 Aug; 33(4):449-54.
2003 Jun
Pearce DA, McCall K, Mooney RA, Chattopadhyay S, Curran TM. "Altered amino acid levels in sera of a mouse model for juvenile neuronal ceroid lipofuscinoses." Clinica chimica acta; international journal of clinical chemistry. 2003 Jun; 332(1-2):145-8.
2003 Jun
Polliotti BM, Fry AG, Saller DN, Mooney RA, Cox C, Miller RK. "Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia." Obstetrics and gynecology.. 2003 Jun; 101(6):1266-74.
2003 Apr 18
Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA. "Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes." The Journal of biological chemistry.. 2003 Apr 18; 278(16):13740-6. Epub 2003 Jan 30.
2003
Mooney RA, LeVea CM. "The leukocyte common antigen-related protein LAR: candidate PTP for inhibitory targeting." Current topics in medicinal chemistry. 2003 3(7):809-19.
2003
Baliff JP, Mooney RA. "New developments in prenatal screening for Down syndrome." American journal of clinical pathology.. 2003 120 Suppl:S14-24.
2002 Jul 15
Symons JR, LeVea CM, Mooney RA. "Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes." The Biochemical journal.. 2002 Jul 15; 365(Pt 2):513-9.
2002
Senn JJ, Klover PJ, Nowak IA, Mooney RA. "Interleukin-6 induces cellular insulin resistance in hepatocytes." Diabetes.. 2002 51(12):3391-9.
2001 Jul 13
Mooney RA, Senn J, Cameron S, Inamdar N, Boivin LM, Shang Y, Furlanetto RW. "Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance." The Journal of biological chemistry.. 2001 Jul 13; 276(28):25889-93. Epub 2001 May 07.
2000 Nov
Levea CM, Mcgary CT, Symons JR, Mooney RA. "PTP LAR expression compared to prognostic indices in metastatic and non-metastatic breast cancer." Breast cancer research and treatment. 2000 Nov; 64(2):221-8.
1999 Oct
Bleyle LA, Peng Y, Ellis C, Mooney RA. "Dissociation of PTPase levels from their modulation of insulin receptor signal transduction." Cellular signalling. 1999 Oct; 11(10):719-25.
1999 Sep
Hostetler MA, Arnold GL, Mooney R, Bennett MJ, Rinaldo P, Roe CR. "Hypoketotic hypoglycemic coma in a 21-month-old child." Annals of emergency medicine.. 1999 Sep; 34(3):394-8.
1997 Oct
Saller DN, Canick JA, Kellner LH, Rose NC, Garza J, French CA, Mooney RA. "Maternal serum analyte levels in pregnancies with fetal Down syndrome resulting from translocations." American journal of obstetrics and gynecology.. 1997 Oct; 177(4):879-81.
1997 Aug 18
Phung TL, Mooney RA, Kulas DT, Sparks CE, Sparks JD. "Suppression of the protein tyrosine phosphatase LAR reduces apolipoprotein B secretion by McA-RH7777 rat hepatoma cells." Biochemical and biophysical research communications.. 1997 Aug 18; 237(2):367-71.
1997 Jun 27
Mooney RA, Kulas DT, Bleyle LA, Novak JS. "The protein tyrosine phosphatase LAR has a major impact on insulin receptor dephosphorylation." Biochemical and biophysical research communications.. 1997 Jun 27; 235(3):709-12.
1996 Jan 12
Kulas DT, Goldstein BJ, Mooney RA. "The transmembrane protein-tyrosine phosphatase LAR modulates signaling by multiple receptor tyrosine kinases." The Journal of biological chemistry.. 1996 Jan 12; 271(2):748-54.
1996 Jan 12
Kulas DT, Freund GG, Mooney RA. "The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin receptor signaling." The Journal of biological chemistry.. 1996 Jan 12; 271(2):755-60.
1995 Feb 10
Kulas DT, Zhang WR, Goldstein BJ, Furlanetto RW, Mooney RA. "Insulin receptor signaling is augmented by antisense inhibition of the protein tyrosine phosphatase LAR." The Journal of biological chemistry.. 1995 Feb 10; 270(6):2435-8.
1995 Jan 5
Freund GG, Wittig JG, Mooney RA. "The PI3-kinase serine kinase phosphorylates its p85 subunit and IRS-1 in PI3-kinase/IRS-1 complexes." Biochemical and biophysical research communications.. 1995 Jan 5; 206(1):272-8.
1995
Mooney RA, Arvan DA, Saller DN, French CA, Peterson CJ. "Decreased maternal serum hCG levels with increasing gravidity and parity." Obstetrics and gynecology.. 1995 86(6):900-5.
1994 Oct 26
Way BA, Mooney RA. "Differential effects of phosphotyrosine phosphatase expression on hormone-dependent and independent pp60c-src activity." Molecular and cellular biochemistry.. 1994 Oct 26; 139(2):167-75.
1994 Aug
Mooney RA, Peterson CJ, French CA, Saller DN, Arvan DA. "Effectiveness of combining maternal serum alpha-fetoprotein and hCG in a second-trimester screening program for Down syndrome." Obstetrics and gynecology.. 1994 Aug; 84(2):298-303.
1994 Jun 15
Freund GG, Kulas DT, Way BA, Mooney RA. "Functional insulin and insulin-like growth factor-1 receptors are preferentially expressed in multiple myeloma cell lines as compared to B-lymphoblastoid cell lines." Cancer research.. 1994 Jun 15; 54(12):3179-85.
1993 Aug 15
Freund GG, Kulas DT, Mooney RA. "Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226." The Journal of immunology : official journal of the American Association of Immunologists.. 1993 Aug 15; 151(4):1811-20.
1993
Way BA, Mooney RA. "Activation of phosphatidylinositol-3-kinase by platelet-derived growth factor and insulin-like growth factor-1 is inhibited by a transmembrane phosphotyrosine phosphatase." The Journal of biological chemistry.. 1993 268(35):26409-15.
1992 Nov 25
Mooney RA, Freund GG, Way BA, Bordwell KL. "Expression of a transmembrane phosphotyrosine phosphatase inhibits cellular response to platelet-derived growth factor and insulin-like growth factor-1." The Journal of biological chemistry.. 1992 Nov 25; 267(33):23443-6.
1992 Jul 15
Mooney RA, Bordwell KL. "Differential dephosphorylation of the insulin receptor and its 160-kDa substrate (pp160) in rat adipocytes." The Journal of biological chemistry.. 1992 Jul 15; 267(20):14054-60.
1992 Mar
Mooney RA, Bordwell KL. "Insulin stimulates the tyrosine phosphorylation of a 61-kilodalton protein in rat adipocytes." Endocrinology.. 1992 Mar; 130(3):1533-8.
1992 Jan
Wilbur DC, Willis J, Mooney RA, Fallon MA, Moynes R, di Sant'Agnese PA. "Estrogen and progesterone receptor detection in archival formalin-fixed, paraffin-embedded tissue from breast carcinoma: a comparison of immunohistochemistry with the dextran-coated charcoal assay." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 1992 Jan; 5(1):79-84.
1991 Mar 1
Mooney RA, Bordwell KL. "Counter-regulation by insulin and isoprenaline of a prominent fat-associated phosphoprotein doublet in rat adipocytes." The Biochemical journal.. 1991 Mar 1; 274 ( Pt 2):433-8.
1990
Arvan, DA; Mooney, RA. "Maternal serum alpha-fetoprotein screening (MSAFP): A model program for clinical practice, education, and research in Pathology." Il Patologo Clinico. 1990; 9: 898-908.
1989 Sep
Davis NS, DiSant'Agnese PA, Ewing JF, Mooney RA. "The neuroendocrine prostate: characterization and quantitation of calcitonin in the human gland." The Journal of urology.. 1989 Sep; 142(3):884-8.
1989 Aug 15
Mooney RA, Green DA. "Insulin receptor dephosphorylation in permeabilized adipocytes is inhibitable by manganese and independent of receptor kinase activity." Biochemical and biophysical research communications.. 1989 Aug 15; 162(3):1200-6.
1989 Apr 25
Mooney RA, Anderson DL. "Phosphorylation of the insulin receptor in permeabilized adipocytes is coupled to a rapid dephosphorylation reaction." The Journal of biological chemistry.. 1989 Apr 25; 264(12):6850-7.
1989 Jan
Mooney RA, Bordwell KL, Luhowskyj S, Casnellie JE. "The insulin-like effect of vanadate on lipolysis in rat adipocytes is not accompanied by an insulin-like effect on tyrosine phosphorylation." Endocrinology.. 1989 Jan; 124(1):422-9.
1989
Amatruda JM, Vallone BB, Schuster T, Mooney RA. "Importance of periodic reeducation of hospital-based nurses in capillary blood glucose monitoring and an evaluation of the usefulness of reflectance meters." The Diabetes educator. 1989 15(5):435-9.
1988 Feb 29
Mayer TK, Mooney RA. "Laboratory analyses for steroid hormone receptors, and their applications to clinical medicine." Clinica chimica acta; international journal of clinical chemistry. 1988 Feb 29; 172(1):1-33.
1988 Feb 15
Mooney RA, McGorty BL, French CA, Arvan DA. "An alpha-fetoprotein radioimmunoassay for use in maternal serum screening for Down's syndrome: limitations and improvements." Clinica chimica acta; international journal of clinical chemistry. 1988 Feb 15; 171(2-3):325-31.
1988
Mooney RA. "Use of digitonin-permeabilized adipocytes for cAMP studies." Methods in enzymology. 1988 159:193-202.
1986 Nov
Mooney RA, Swicegood CL, Marx RB. "Coupling of adenylate cyclase to lipolysis in permeabilized adipocytes: direct evidence that an antilipolytic effect of insulin is independent of adenylate cyclase." Endocrinology.. 1986 Nov; 119(5):2240-8.
1986 May
Lee LA, Mooney RA, Woolf PD. "Clinical utility of measuring free thyroxin and free triiodothyronine in serum of critically ill patients by ultrafiltration." Clinical chemistry. 1986 May; 32(5):797-800.
1986
Mooney RA, McDonald JM. "In situ analysis of adenylate cyclase activity in permeabilized rat adipocytes: sensitivity to GTP, isoproterenol, and N6-(phenylisopropyl)adenosine." The International journal of biochemistry. 1986 18(8):713-8.
1984 Jun 25
Mooney RA, Ebersohl RD, McDonald JM. "Insulin-mediated antilipolysis in permeabilized rat adipocytes." The Journal of biological chemistry.. 1984 Jun 25; 259(12):7701-4.
1984
Mooney RA, McDonald JM. "Effect of phenylephrine on lipolysis in rat adipocytes: no evidence for an alpha-adrenergic mechanism." The International journal of biochemistry. 1984 16(1):55-9.
1983 Nov 15
Mooney RA, Ebersohl RD, McDonald JM. "Novel approach to the study of the regulation of hormone-sensitive lipase in rat adipocytes. Permeabilization of cells with digitonin." European journal of biochemistry. 1983 Nov 15; 136(3):603-8.
1983 Aug
Mooney RA, Smith CH, Zarkowsky HS. "Free bilirubin measurements in a patient with Crigler-Najjar syndrome after crush injury." The Journal of pediatrics.. 1983 Aug; 103(2):262-5.
1982 Jan
Mooney RA, Lane MD. "Control of ketogenesis and fatty-acid synthesis at the mitochondrial branch-point for acetyl-CoA in the chick liver cell: effect of adenosine 3',5'-monophosphate." European journal of biochemistry. 1982 Jan; 121(2):281-7.
1982
McDonald JM, Chan KM, Goewert RR, Mooney RA, Pershadsingh HA. "The (Ca2+ +Mg2+)-ATPase of adipocyte plasma membrane: regulation by calmodulin and insulin." Annals of the New York Academy of Sciences.. 1982 402:381-401.
1981 Nov 25
Mooney RA, Lane MD. "Formation and turnover of triglyceride-rich vesicles in the chick liver cell. Effects of cAMP and carnitine on triglyceride mobilization and conversion to ketones." The Journal of biological chemistry.. 1981 Nov 25; 256(22):11724-33.
1981
Lane MD, Mooney RA. "Tricarboxylic acid cycle intermediates and the control of fatty acid synthesis and ketogenesis." Current topics in cellular regulation. 1981 18:221-42.
1975 Apr 25
Clinkenbeard KD, Reed WD, Mooney RA, Lane MD. "Intracellular localization of the 3-hydroxy-3-methylglutaryl coenzme A cycle enzymes in liver. Separate cytoplasmic and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A generating systems for cholesterogenesis and ketogenesis." The Journal of biological chemistry.. 1975 Apr 25; 250(8):3108-16.

Books