Randy N. Rosier, M.D., Ph.D.

Randy N. Rosier, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester, NY 14642

Administrative: (585) 341-9236
Office: (585) 341-9236
Fax: (585) 340-3051

Journal Articles

Showing all 131 journal articles available.

2008 Jun 5
Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis." Oncogene.. 2008 Jun 5; 27(25):3605-14. Epub 2008 Jan 28.
2008 May
Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. "Regulation of embryonic endochondral ossification by Smurf2." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 May; 26(5):704-12.
2007 Oct
Eliseev RA, Filippov G, Velos J, VanWinkle B, Goldman A, Rosier RN, Gunter TE. "Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition." Neurobiology of aging.. 2007 Oct; 28(10):1532-42. Epub 2006 Jul 31.
2007
Wu,Q.; Chen,D.; Zuscik,M. J.; O'Keefe,R. J.; Rosier,R. N.;. "Overexpression of Smurf2 Stimulates Endochondral Ossification Through Upregulation of beta-Catenin". J.Bone Miner.Res.. 2007; .
2006 Aug
Rosier RN. "Continuing competency in orthopaedics: the future of recertification." Clinical orthopaedics and related research.. 2006 Aug; 449:72-5.
2006 Aug
Rosier RN. "Institutional barriers to the orthopaedic clinician-scientist." Clinical orthopaedics and related research.. 2006 Aug; 449:159-64.
2006 Mar
Garrett WE, Swiontkowski MF, Weinstein JN, Callaghan J, Rosier RN, Berry DJ, Harrast J, Derosa GP. "American Board of Orthopaedic Surgery Practice of the Orthopaedic Surgeon: Part-II, certification examination case mix." The Journal of bone and joint surgery. American volume.. 2006 Mar; 88(3):660-7.
2006 Jan 1
Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN. "Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB." Experimental cell research.. 2006 Jan 1; 312(1):40-50. Epub 2005 Nov 02.
2006 Jan
Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ. "Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2006 Jan; 21(1):4-16. Epub 2005 Sep 19.
2005 Nov
Evans CH, Rosier RN. "Molecular biology in orthopaedics: the advent of molecular orthopaedics." The Journal of bone and joint surgery. American volume.. 2005 Nov; 87(11):2550-64.
2005 Jun
Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. "Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency." Environmental health perspectives.. 2005 Jun; 113(6):749-55.
2005 May
Courville XF, Cort├ęs Z, Katzman PJ, Rosier RN. "Case report: Bone metastases from fallopian tube carcinoma." Clinical orthopaedics and related research.. 2005 May; (434):278-81.
2005 Apr 15
Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE. "Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone." Cancer research.. 2005 Apr 15; 65(8):3209-17.
2005 Mar 14
Andela VB, Altuwaijri S, Wood J, Rosier RN. "Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists." FEBS letters.. 2005 Mar 14; 579(7):1765-9.
2005 Mar
Andela VB, Siddiqui F, Groman A, Rosier RN. "An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma." Journal of clinical pathology.. 2005 Mar; 58(3):328-30.
2005
Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN. "A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival." FEBS letters.. 2005 579(30):6814-20. Epub 2005 Nov 28.
2005
Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. "Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase." Journal of cellular biochemistry.. 2005 96(6):1262-73.
2004 Nov 5
Eliseev RA, Vanwinkle B, Rosier RN, Gunter TE. "Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB." The Journal of biological chemistry.. 2004 Nov 5; 279(45):46748-54. Epub 2004 Aug 23.
2004 Oct 15
Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ. "PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling." Experimental cell research.. 2004 Oct 15; 300(1):159-69.
2004 Sep 10
Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. "Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway." Experimental cell research.. 2004 Sep 10; 299(1):128-36.
2004 Aug
Campbell JR, Rosier RN, Novotny L, Puzas JE. "The association between environmental lead exposure and bone density in children." Environmental health perspectives.. 2004 Aug; 112(11):1200-3.
2004 May 15
Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. "5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes." Journal of cellular biochemistry.. 2004 May 15; 92(2):316-31.
2004 May
Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. "Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation." Bone.. 2004 May; 34(5):809-17.
2004 Mar 22
Andela VB, Rosier RN. "The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids." Molecular cancer. 2004 Mar 22; 3:8. Epub 2004 Mar 22.
2004 Mar
Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. "CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter." Journal of cellular physiology.. 2004 Mar; 198(3):428-40.
2004 Jan
Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. "PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 Jan; 22(1):6-12.
2003 Oct
Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN. "The mevalonate synthesis pathway as a therapeutic target in cancer." Clinical orthopaedics and related research.. 2003 Oct; (415 Suppl):S59-66.
2003 Oct
Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ. "NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone." Clinical orthopaedics and related research.. 2003 Oct; (415 Suppl):S75-85.
2003 Sep
Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. "Smad6 is induced by BMP-2 and modulates chondrocyte differentiation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 Sep; 21(5):908-13.
2003 Sep
Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. "ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2003 Sep; 18(9):1593-604.
2003 Aug 1
Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ. "ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation." Experimental cell research.. 2003 Aug 1; 288(1):198-207.
2003 Jul
Zuscik MJ, Rosier RN, Schwarz EM. "Altered negative regulation of transforming growth factor beta signaling in scleroderma: potential involvement of SMURF2 in disease." Arthritis and rheumatism.. 2003 Jul; 48(7):1779-80.
2003 Jun
Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. "Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5." Endocrinology.. 2003 Jun; 144(6):2514-23.
2003 May 8
Andela VB, Gingold BI, Souza MD, O'Keefe RJ, Puzas EJ, Schwarz EM, Rosier RN. "Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB." Cancer letters.. 2003 May 8; 194(1):37-43.
2003 Jan 3
Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. "A phage display technique identifies a novel regulator of cell differentiation." The Journal of biological chemistry.. 2003 Jan 3; 278(1):438-43. Epub 2002 Oct 25.
2003
Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. "Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes." Journal of cellular biochemistry.. 2003 90(6):1287-98.
2002 Oct
Pateder DB, Gish MW, O'Keefe RJ, Hicks DG, Teot LA, Rosier RN. "Parathyroid hormone-related Peptide expression in cartilaginous tumors." Clinical orthopaedics and related research.. 2002 Oct; (403):198-204.
2002 Sep 20
Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN. "Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB." Biochemical and biophysical research communications.. 2002 Sep 20; 297(2):237-41.
2002 Sep
Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN. "Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Sep; 20(5):1079-90.
2002 Jul
Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ. "The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jul; 20(4):714-22.
2002 Jul
Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ. "Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jul; 20(4):811-8.
2002 Jun 10
Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN. "Growth plate chondrocyte maturation is regulated by basal intracellular calcium." Experimental cell research.. 2002 Jun 10; 276(2):310-9.
2002 Jun
Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. "Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair." The Journal of clinical investigation.. 2002 Jun; 109(11):1405-15.
2002 May
Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE. "Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 May; 17(5):915-22.
2002 May
Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. "Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles." Arthritis and rheumatism.. 2002 May; 46(5):1298-308.
2002 Apr
Andela VB, Rosenblatt JD, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosier RN. "Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis." Clinical orthopaedics and related research.. 2002 Apr; (397):228-39.
2002 Mar
Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN. "Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors." Journal of surgical oncology. 2002 Mar; 79(3):174-9.
2002 Mar
Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. "Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Mar; 20(2):169-73.
2002 Feb
Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM. "In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 Feb; 17(2):192-9.
2002 Feb
Zhang D, Ferguson CM, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. "A role for the BMP antagonist chordin in endochondral ossification." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 Feb; 17(2):293-300.
2002 Jan
Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN. "Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes." Radiation research.. 2002 Jan; 157(1):62-8.
2002 Jan
Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. "COX-1 and COX-2 expression in osteoid osteomas." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 Jan; 20(1):159-62.
2001 Sep
Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ. "PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling." Journal of cellular physiology.. 2001 Sep; 188(3):343-51.
2001 Aug
Buckwalter JA, Callaghan JJ, Rosier RN. "From oranges and lemons to glucosamine and chondroitin sulfate: clinical observations stimulate basic research." The Journal of bone and joint surgery. American volume.. 2001 Aug; 83-A(8):1266-8.
2001 Jul
Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ. "Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components." The Journal of bone and joint surgery. American volume.. 2001 Jul; 83-A(7):1057-61.
2001 Jun
Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN. "The role of autocrine growth factors in radiation damage to the epiphyseal growth plate." Radiation research.. 2001 Jun; 155(6):847-57.
2001 Apr
Buckwalter JA, Stanish WD, Rosier RN, Schenck RC, Dennis DA, Coutts RD. "The increasing need for nonoperative treatment of patients with osteoarthritis." Clinical orthopaedics and related research.. 2001 Apr; (385):36-45.
2001 Apr
Rosier RN. "Expanding the role of the orthopaedic surgeon in the treatment of osteoporosis." Clinical orthopaedics and related research.. 2001 Apr; (385):57-67.
2001 Apr
Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM. "Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 Apr; 16(4):660-70.
2000 Nov
Schwarz EM, Benz EB, Lu AP, Goater JJ, Mollano AV, Rosier RN, Puzas JE, Okeefe RJ. "Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 Nov; 18(6):849-55.
2000 Sep
Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR. "Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo." Molecular and cellular biology.. 2000 Sep; 20(17):6496-507.
2000 May 2
Reynolds SD, Zhang D, Puzas JE, O'Keefe RJ, Rosier RN, Reynolds PR. "Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues." Gene.. 2000 May 2; 248(1-2):233-43.
2000 May 1
Pateder DB, Rosier RN, Schwarz EM, Reynolds PR, Puzas JE, D'Souza M, O'Keefe RJ. "PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes." Experimental cell research.. 2000 May 1; 256(2):555-62.
2000 May
Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ. "Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 May; 18(3):472-80.
2000
Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN. "Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB." Cancer research.. 2000 60(23):6557-62.
2000
Rosier RN, O'Keefe RJ. "Hyaluronic acid therapy." Instructional course lectures. 2000 49:495-502.
2000
Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ. "Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation." Endocrinology.. 2000 141(12):4728-35.
1999 May
Vena VE, Hsu J, Rosier RN, O'Keefe RJ. "Pelvic reconstruction for severe periacetabular metastatic disease." Clinical orthopaedics and related research.. 1999 May; (362):171-80.
1999 Apr
Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Reynolds PR, Rosier RN, O'Keefe RJ. "BMP-6 is an autocrine stimulator of chondrocyte differentiation." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1999 Apr; 14(4):475-82.
1999 Mar 15
Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR. "Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19." Genomics.. 1999 Mar 15; 56(3):324-36.
1998 Nov
Pollice PF, Hsu J, Hicks DG, Bukata S, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. "Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1998 Nov; 16(6):697-704.
1998 Oct
Serletti JM, Carras AJ, O'Keefe RJ, Rosier RN. "Functional outcome after soft-tissue reconstruction for limb salvage after sarcoma surgery." Plastic and reconstructive surgery.. 1998 Oct; 102(5):1576-83; discussion 1584-5.
1998 Oct
Rosier RN, O'Keefe RJ, Hicks DG. "The potential role of transforming growth factor beta in fracture healing." Clinical orthopaedics and related research.. 1998 Oct; (355 Suppl):S294-300.
1998 Oct
Rosier RN. "Breakout session. 6: Regional gene therapy." Clinical orthopaedics and related research.. 1998 Oct; (355 Suppl):S361-3.
1998 Jul
Ishibe M, Ishibashi T, Kaneda K, Koda T, Rosier RN, Puzas JE. "Stimulation of bone formation in vivo by insulin-like growth factor-II in rats." Calcified tissue international.. 1998 Jul; 63(1):36-8.
1998 May
Rapoport AP, Constine LS, Packman CH, Rosier RN, O'Keefe R, Hicks DG, Rubin SJ, Rowe JM. "Treatment of multifocal lymphoma of bone with intensified ProMACE-CytaBOM chemotherapy and involved field radiotherapy." American journal of hematology.. 1998 May; 58(1):1-7.
1998 Mar
Romano PR, Wang J, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. "HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation." Journal of cell science.. 1998 Mar; 111 ( Pt 6):803-13.
1998 Mar
Grimsrud CD, Rosier RN, Puzas JE, Reynolds PR, Reynolds SD, Hicks DG, O'Keefe RJ. "Bone morphogenetic protein-7 in growth-plate chondrocytes: regulation by retinoic acid is dependent on the stage of chondrocyte maturation." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1998 Mar; 16(2):247-55.
1998
Rosier RN, O'Keefe RJ. "Autocrine regulation of articular cartilage." Instructional course lectures. 1998 47:469-75.
1998
O'Keefe RJ, Rosier RN, Teot LA, Stewart JM, Hicks DG. "Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction." The Iowa orthopaedic journal. 1998 18:26-34.
1997 Oct
Blaine TA, Pollice PF, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. "Modulation of the production of cytokines in titanium-stimulated human peripheral blood monocytes by pharmacological agents. The role of cAMP-mediated signaling mechanisms." The Journal of bone and joint surgery. American volume.. 1997 Oct; 79(10):1519-28.
1997 Jun
Rosier RN, O'Keefe RJ, Teot LA, Fox EJ, Nester TA, Puzas JE, Reynolds PR, Hicks DG. "P-glycoprotein expression in cartilaginous tumors." Journal of surgical oncology. 1997 Jun; 65(2):95-105.
1997 May 19
Zuscik MJ, Gunter TE, Puzas JE, Rosier RN. "Characterization of voltage-sensitive calcium channels in growth plate chondrocytes." Biochemical and biophysical research communications.. 1997 May 19; 234(2):432-8.
1997 Apr
O'Keefe RJ, Teot LA, Singh D, Puzas JE, Rosier RN, Hicks DG. "Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study." Laboratory investigation; a journal of technical methods and pathology.. 1997 Apr; 76(4):457-65.
1997 Mar
O'Keefe RJ, Loveys LS, Hicks DG, Reynolds PR, Crabb ID, Puzas JE, Rosier RN. "Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1997 Mar; 15(2):162-74.
1996 Sep
Hicks DG, O'Keefe RJ, Reynolds KJ, Cory-Slechta DA, Puzas JE, Judkins A, Rosier RN. "Effects of lead on growth plate chondrocyte phenotype." Toxicology and applied pharmacology.. 1996 Sep; 140(1):164-72.
1996 Aug
Blaine TA, Rosier RN, Puzas JE, Looney RJ, Reynolds PR, Reynolds SD, O'Keefe RJ. "Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles." The Journal of bone and joint surgery. American volume.. 1996 Aug; 78(8):1181-92.
1996 Jul 10
Reynolds SD, Johnston C, Leboy PS, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. "Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy." Experimental cell research.. 1996 Jul 10; 226(1):197-207.
1996 Jul
Teot LA, O'Keefe RJ, Rosier RN, O'Connell JX, Fox EJ, Hicks DG. "Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation." Human pathology.. 1996 Jul; 27(7):625-32.
1996 Jun 8
Reynolds PR, Reynolds SD, O'Keefe RJ, Puzas JE, Rosier RN. "Alternative splicing of a chondrocyte-specific gene." Annals of the New York Academy of Sciences.. 1996 Jun 8; 785:321-4.
1996 Apr
Hicks DG, Judkins AR, Sickel JZ, Rosier RN, Puzas JE, O'Keefe RJ. "Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages." The Journal of bone and joint surgery. American volume.. 1996 Apr; 78(4):482-96.
1996
Delsignore JL, Dvoretsky PM, Hicks DG, O'Keefe RJ, Rosier RN. "Mastocytosis presenting as a skeletal disorder." The Iowa orthopaedic journal. 1996 16:126-34.
1995 Oct
Martinez DA, Zuscik MJ, Ishibe M, Rosier RN, Romano PR, Cushing JE, Puzas JE. "Identification of functional insulin-like growth factor-II/mannose-6-phosphate receptors in isolated bone cells." Journal of cellular biochemistry.. 1995 Oct; 59(2):246-57.
1995 Sep
Ishibe M, Nojima T, Ishibashi T, Koda T, Rosier RN, Puzas JE, Kaneda K. "Comparison of the type-2 insulin-like growth factor receptor in normal osteoblasts and osteosarcoma-derived osteoblast-like cells." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1995 Sep; 13(5):643-8.
1995 Apr
Hughes SS, Hicks DG, O'Keefe RJ, Hurwitz SR, Crabb ID, Krasinskas AM, Loveys L, Puzas JE, Rosier RN. "Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1995 Apr; 10(4):533-44.
1995 Feb 15
Hicks DG, Gokan T, O'Keefe RJ, Totterman SM, Fultz PJ, Judkins AR, Meyers SP, Rubens DJ, Sickel JZ, Rosier RN. "Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells." Cancer.. 1995 Feb 15; 75(4):973-80.
1995 Jan
Landesberg R, Proctor RL, Rosier RN, Puzas JE. "The mandibular condylar growth center: separation and characterization of the cellular elements." Calcified tissue international.. 1995 Jan; 56(1):71-7.
1995
Rosier RN, Teot LA, Hicks DG, Schwartz C, O'Keefe RJ, Puzas JE. "Multiple drug resistance in osteosarcoma." The Iowa orthopaedic journal. 1995 15:66-73.
1995
Ishibe M, Nojima T, Ishibashi T, Koda T, Kaneda K, Rosier RN, Puzas JE. "17 beta-estradiol increases the receptor number and modulates the action of 1,25-dihydroxyvitamin D3 in human osteosarcoma-derived osteoblast-like cells." Calcified tissue international.. 1995 57(6):430-5.
1994 Nov
O'Keefe RJ, Puzas JE, Loveys L, Hicks DG, Rosier RN. "Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: rapid induction of type X collagen in culture." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1994 Nov; 9(11):1713-22.
1994 Aug
Zuscik MJ, Gunter TE, Rosier RN, Gunter KK, Puzas JE. "Activation of phosphoinositide metabolism by parathyroid hormone in growth plate chondrocytes." Cell calcium.. 1994 Aug; 16(2):112-22.
1994 May
Alioto RJ, Rosier RN, Burton RI, Puzas JE. "Comparative effects of growth factors on fibroblasts of Dupuytren's tissue and normal palmar fascia." The Journal of hand surgery.. 1994 May; 19(3):442-52.
1994 May
O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. "Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1994 May; 12(3):299-310.
1994
Zuscik MJ, Puzas JE, Rosier RN, Gunter KK, Gunter TE. "Cyclic-AMP-dependent protein kinase activity is not required by parathyroid hormone to stimulate phosphoinositide signaling in chondrocytes but is required to transduce the hormone's proliferative effect." Archives of biochemistry and biophysics.. 1994 315(2):352-61.
1994
Ishibe M, Ishibe Y, Ishibashi T, Nojima T, Rosier RN, Puzas JE, Kaneda K. "Low content of estrogen receptors in human giant cell tumors of bone." Archives of orthopaedic and trauma surgery.. 1994 113(2):106-9.
1993 Nov
Loveys LS, Gelb D, Hurwitz SR, Puzas JE, Rosier RN. "Effects of parathyroid hormone-related peptide on chick growth plate chondrocytes." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1993 Nov; 11(6):884-91.
1993 Jun
Kreipe RE, Hicks DG, Rosier RN, Puzas JE. "Preliminary findings on the effects of sex hormones on bone metabolism in anorexia nervosa." The Journal of adolescent health : official publication of the Society for Adolescent Medicine.. 1993 Jun; 14(4):319-24.
1993 May 15
Kramer K, Hicks DG, Palis J, Rosier RN, Oppenheimer J, Fallon MD, Cohen HJ. "Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm." Cancer.. 1993 May 15; 71(10):2977-82.
1993 Jan
Quatela VC, Sherris DA, Rosier RN. "The human auricular chondrocyte. Responses to growth factors." Archives of otolaryngology--head & neck surgery. 1993 Jan; 119(1):32-7.
1992 Sep
Crabb ID, Hughes SS, Hicks DG, Puzas JE, Tsao GJ, Rosier RN. "Nonradioactive in situ hybridization using digoxigenin-labeled oligonucleotides. Applications to musculoskeletal tissues." The American journal of pathology.. 1992 Sep; 141(3):579-89.
1992 Apr
O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. "Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1992 Apr; 7(4):397-404.
1992 Jan
Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. "Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes." Calcified tissue international.. 1992 Jan; 50(1):61-6.
1991 Oct
Ishibe M, Rosier RN, Puzas JE. "Human prostatic acid phosphatase directly stimulates collagen synthesis and alkaline phosphatase content of isolated bone cells." The Journal of clinical endocrinology and metabolism.. 1991 Oct; 73(4):785-92.
1991 Sep
Sawyer JR, Myers MA, Rosier RN, Puzas JE. "Heterotopic ossification: clinical and cellular aspects." Calcified tissue international.. 1991 Sep; 49(3):208-15.
1991
Ishibe M, Rosier RN, Puzas JE. "Activation of osteoblast insulin-like growth factor-II/cation-independent mannose-6-phosphate receptors by specific phosphorylated sugars and antibodies induce insulin-like growth factor-II effects." Endocrine research. 1991 17(3-4):357-66.
1990 Nov
Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. "Synergistic effect of transforming growth factor beta and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes." Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1990 Nov; 5(11):1105-12.
1990 Oct
Gelb DE, Rosier RN, Puzas JE. "The production of transforming growth factor-beta by chick growth plate chondrocytes in short term monolayer culture." Endocrinology.. 1990 Oct; 127(4):1941-7.
1990 Aug
Gunter TE, Zuscik MJ, Puzas JE, Gunter KK, Rosier RN. "Cytosolic free calcium concentrations in avian growth plate chondrocytes." Cell calcium.. 1990 Aug; 11(7):445-57.
1990
O'Keefe RJ, Rosier RN, Puzas JE. "Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes." Connective tissue research.. 1990 24(1):53-66.
1989 Aug
Puzas JE, Miller MD, Rosier RN. "Pathologic bone formation." Clinical orthopaedics and related research.. 1989 Aug; (245):269-81.
1989 Apr
O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. "Countercurrent centrifugal elutriation. High-resolution method for the separation of growth-plate chondrocytes." The Journal of bone and joint surgery. American volume.. 1989 Apr; 71(4):607-20.
1989
Rosier RN, O'Keefe RJ, Crabb ID, Puzas JE. "Transforming growth factor beta: an autocrine regulator of chondrocytes." Connective tissue research.. 1989 20(1-4):295-301.
1988 Jun
O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. "Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes." Endocrinology.. 1988 Jun; 122(6):2953-61.
1988
O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. "Effect of transforming growth factor-beta on DNA synthesis by growth plate chondrocytes: modulation by factors present in serum." Calcified tissue international.. 1988 43(6):352-8.
1987
Rosier RN. "Orthopedic basic science: update." Orthopedics.. 1987 10(12):1793-805.
1984
Rosier RN, Blair WF. "Preliminary clinical evaluation of the digital electroneurometer." Biomedical sciences instrumentation. 1984 20:55-62.
1982 Feb
Gunter KK, Gunter TE, Jarkowski A, Rosier RN. "A method of resuspending small vesicles separated from suspension by protamine aggregation and centrifugation." Analytical biochemistry.. 1982 Feb; 120(1):113-24.
1981 Sep
Rosier RN, Tucker DA, Meerdink S, Jain I, Gunter TE. "Ca2+ transport against its electrochemical gradient in cytochrome oxidase vesicles reconstituted with mitochondrial hydrophobic proteins." Archives of biochemistry and biophysics.. 1981 Sep; 210(2):549-64.
1980 Jan 1
Rosier RN, Gunter TE. "Calcium uptake by cytochrome oxidase vesicles." FEBS letters.. 1980 Jan 1; 109(1):99-103.
1979 Jul 15
Rosier RN, Gunter TE, Tucker DA, Gunter KK. "A rapid method for separating small vesicles from suspension." Analytical biochemistry.. 1979 Jul 15; 96(2):384-90.
1978 Apr 28
Gunter TE, Rosier RN, Tucker DA, Gunter KK. "Uptake of calcium and manganese by rat liver submitochondrial particles." Annals of the New York Academy of Sciences.. 1978 Apr 28; 307:246-7.

Books