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Patricia J. Simpson-Haidaris, Ph.D.

Patricia J. Simpson-Haidaris, Ph.D.

Contact

Call Center (585) 276-3000

About Me

Faculty Appointments

Professor Emeritus - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Credentials

Post-doctoral Training & Residency

Post-doctoral Fellow. Dept of Microbiology and Immunology, University of North Carolina. Research Mentor: Kenneth Bott, Ph.D.: "Molecular cloning and expression in prokaryotes.

Graduate Research Assistant, Dept of Microbiology, University of Notre Dame. Dissertation research performed under the direction of Dr. Charles Kulpa. Ph.D. Thesis: "Characterization and evaluation of large unilamellar liposomes as carriers of synthetic, single-stranded polyribonucleotides to affect RNA virus replication in culture. 1979 - 1981

Associate Development Scientist: Miles, Inc., Ames Division. Developed and implemented quality assurance control systems to define quality of new products from raw materials through in-process production, finished product and clinical trials following GMP, GLP and FDA regulations for new clinical diagnostic products in immunochemistry test systems. 1976 - 1979

Assistant Development Scientist: Miles Inc., Ames Division. Developed quality assurance control systems to define quality of new products for thyroid function, hepatitis B and urine chemistry test systems. Elkhart, IN 46515 1973 - 1976

Education

Certificate | Rochester Institute of Technology. Deaf Studies. 2000

PhD | University of Notre Dame. Microbiology. 1981

MS | University of Notre Dame. Microbiology. 1980

BA, double major | Indiana University. Chemistry & Biology. 1973

Awards

Miles Inc., Post-doctoral Fellowship (Salary and Supplies) 1981

American Society for Microbiology Garner Award for Oral Presentation 1980

Miles Inc., Pre-doctoral Fellowship (Stipend and Tuition) 1979 - 1981

Indiana University Merit Scholarship 1970 - 1973

Research

The role of fibrinogen in the pathogenesis of disease progression and resolution in the lung, the vasculature, and in prostate and breast carcinoma.

Patents

Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof

Issue date: October 19, 2010

Patent #: 7,815,918

Country: United States

Inventors: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Jesse Wells, Terry W Wright

Optimized Antigens of Pneumocystis and Use Thereof

Issue date: December 06, 2016

Patent #: 9,512,189

Country: United States

Inventors: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Terry W Wright

Publications

Journal Articles

A review of mentoring deaf and hard-of-hearing scholars.

Lynn MA, Butcher E, Cuculick JA, Barnett S, Martina CA, Smith SR, Pollard RQ, Simpson-Haidaris PJ

Mentoring & tutoring.. 2020 28 (2):211-228. Epub 04/13/2020.

Parasitoid wasp venom elevates sorbitol and alters expression of metabolic genes in human kidney cells.

Siebert AL, Doucette LA, Simpson-Haidaris PJ, Werren JH

Toxicon : official journal of the International Society on Toxinology.. 2019 March 1 Epub 03/01/2019.

Heterologous expression of Streptococcus mutans Cnm in Lactococcus lactis promotes intracellular invasion, adhesion to human cardiac tissues and virulence.

Freires IA, Avilés-Reyes A, Kitten T, Simpson-Haidaris PJ, Swartz M, Knight PA, Rosalen PL, Lemos JA, Abranches J

Virulence.. 2017 January 28 (1):18-29. Epub 06/03/2016.

Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus.

Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Lemos JA, Abranches J

Molecular oral microbiology.. 2014 February 29 (1):11-23. Epub 10/30/2013.

The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells.

Abranches J, Miller JH, Martinez AR, Simpson-Haidaris PJ, Burne RA, Lemos JA

Infection and immunity.. 2011 June 79 (6):2277-84. Epub 03/21/2011.

A putative role for platelet-derived PPAR? in vascular homeostasis demonstrated by anti-PPAR? induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis.

Simpson-Haidaris PJ, Seweryniak KE, Spinelli SL, Garcia-Bates TM, Murant TI, Pollock SJ, Sime PJ, Phipps RP

Journal of biotechnology.. 2010 November 150 (3):417-27. Epub 10/01/2010.

Fibrin-specific beta(15-42) domain is exposed in cell-associated intact fibrinogen: Response to Weijers et al comment on the study by A. Sahni et al.

Simpson-Haidaris PJ, Sahni A

International journal of cancer.. 2010 March 2 Epub 3/2/2010.

Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes.

Simpson-Haidaris PJ, Pollock SJ, Ramon S, Guo N, Woeller CF, Feldon SE, Phipps RP

PPAR research. 2010 2010 :814609. Epub 02/28/2010.

Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation.

Garcia-Bates TM, Baglole CJ, Bernard MP, Murant TI, Simpson-Haidaris PJ, Phipps RP

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 December 1183 (11):6903-12. Epub 11/13/2009.

The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells.

Sahni A, Arévalo MT, Sahni SK, Simpson-Haidaris PJ

International journal of cancer.. 2009 August 1125 (3):577-84. Epub 1900 01 01.

Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175.

Abranches J, Zeng L, Bélanger M, Rodrigues PH, Simpson-Haidaris PJ, Akin D, Dunn WA, Progulske-Fox A, Burne RA

Oral microbiology and immunology.. 2009 April 24 (2):141-5. Epub 1900 01 01.

Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infection.

Arévalo MT, Simpson-Haidaris PJ, Kou Z, Schlesinger JJ, Jin X

Journal of medical virology.. 2009 March 81 (3):519-28. Epub 1900 01 01.

Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2).

Sahni A, Simpson-Haidaris PJ, Sahni SK, Vaday GG, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2008 January 6 (1):176-83. Epub 10/22/2007.

Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies.

Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP

PPAR research. 2008 2008 :834612. Epub 1900 01 01.

Plasma fibrinogen gamma' chain content in the thrombotic microangiopathy syndrome.

Mosesson MW, Hernandez I, Raife TJ, Medved L, Yakovlev S, Simpson-Haidaris PJ, Uitte DE Willige S, Bertina RM

Journal of thrombosis and haemostasis : JTH.. 2007 January 5 (1):62-9. Epub 10/13/2006.

Cell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6.

Duan HO, Simpson-Haidaris PJ

The Journal of biological chemistry.. 2006 May 5281 (18):12451-7. Epub 03/08/2006.

Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells.

Sahni A, Sahni SK, Simpson-Haidaris PJ, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2004 September 2 (9):1629-36. Epub 1900 01 01.

Regulated de novo biosynthesis of fibrinogen in extrahepatic epithelial cells in response to inflammation.

Lawrence SO, Simpson-Haidaris PJ

Thrombosis and haemostasis.. 2004 August 92 (2):234-43. Epub 1900 01 01.

Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA.

Wells J, Gigliotti F, Simpson-Haidaris PJ, Haidaris CG

Infection and immunity.. 2004 March 72 (3):1548-56. Epub 1900 01 01.

Regulated de novo biosynthesis of fibrinogen in lung alveolar epithelial cells

Lawrence SO, Simpson-Haidaris PJ.

(Thromb Haemost 92) Chosen as Journal Club Highlights. Clin Lab. 2004; 50: 715-30.

Matrix-fibrinogen enhances wound closure by increasing both cell proliferation and migration.

Rybarczyk BJ, Lawrence SO, Simpson-Haidaris PJ

Blood.. 2003 December 1102 (12):4035-43. Epub 08/14/2003.

Functional analysis of interleukin 6 response elements (IL-6REs) on the human gamma-fibrinogen promoter: binding of hepatic Stat3 correlates negatively with transactivation potential of type II IL-6REs.

Duan HO, Simpson-Haidaris PJ

The Journal of biological chemistry.. 2003 October 17278 (42):41270-81. Epub 08/04/2003.

The incorporation of fibrinogen into extracellular matrix is dependent on active assembly of a fibronectin matrix.

Pereira M, Rybarczyk BJ, Odrljin TM, Hocking DC, Sottile J, Simpson-Haidaris PJ

Journal of cell science.. 2002 February 1115 (Pt 3):609-17. Epub 1900 01 01.

Fibrinogen naples I (B beta A68T) nonsubstrate thrombin-binding capacities.

Meh DA, Mosesson MW, Siebenlist KR, Simpson-Haidaris PJ, Brennan SO, DiOrio JP, Thompson K, Di Minno G

Thrombosis research.. 2001 July 1103 (1):63-73. Epub 1900 01 01.

Integrin alphavbeta3-mediated endocytosis of immobilized fibrinogen by A549 lung alveolar epithelial cells

Odrljin,T. M.; Haidaris,C. G.; Lerner,N. B.; Simpson-Haidaris,P. J.;.

American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 2001; 24(1): 12-21.

Tumors and fibrinogen. The role of fibrinogen as an extracellular matrix protein.

Simpson-Haidaris PJ, Rybarczyk B

Annals of the New York Academy of Sciences.. 2001 936 :406-25. Epub 1900 01 01.

Fibrinogen modulates gene expression in wounded fibroblasts.

Pereira M, Simpson-Haidaris PJ

Annals of the New York Academy of Sciences.. 2001 936 :438-43. Epub 1900 01 01.

The charge-heterogeneity of human fibrinogen as investigated by 2D electrophoresis.

Michelsen AE, Santi C, Holme R, Lord ST, Simpson-Haidaris PJ, Solum NO, Pedersen TM, Brosstad F

Thrombosis research.. 2000 December 15100 (6):529-35. Epub 1900 01 01.

Characterization of a monoclonal antibody, D73H, that maps to a highly conserved region on fibrinogen Bbeta chain.

Rybarczyk BJ, Pereira M, Simpson-Haidaris PJ

Thrombosis and haemostasis.. 2000 July 84 (1):43-8. Epub 1900 01 01.

Fibrinogen assembly, secretion, and deposition into extracellular matrix by MCF-7 human breast carcinoma cells.

Rybarczyk BJ, Simpson-Haidaris PJ

Cancer research.. 2000 April 160 (7):2033-9. Epub 1900 01 01.

Post-transcriptional regulation of endothelial cell plasminogen activator inhibitor-1 expression during R. rickettsii infection.

Shi RJ, Simpson-Haidaris PJ, Marder VJ, Silverman DJ, Sporn LA

Microbial pathogenesis.. 2000 March 28 (3):127-33. Epub 1900 01 01.

Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii.

Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG

Gene.. 2000 January 25242 (1-2):141-50. Epub 1900 01 01.

Cell type-specific regulation of fibrinogen expression in lung epithelial cells by dexamethasone and interleukin-1beta

Nguyen,M. D.; Simpson-Haidaris,P. J.;.

American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 2000; 22(2): 209-217.

The carboxyl terminus of Pneumocystis carinii glycoprotein A encodes a functional glycosylphosphatidylinositol signal sequence.

Guadiz G, Haidaris CG, Maine GN, Simpson-Haidaris PJ

The Journal of biological chemistry.. 1998 October 2273 (40):26202-9. Epub 1900 01 01.

Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia.

Simpson-Haidaris PJ, Courtney MA, Wright TW, Goss R, Harmsen A, Gigliotti F

Infection and immunity.. 1998 September 66 (9):4431-9. Epub 1900 01 01.

Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A.

Haidaris CG, Medzihradsky OF, Gigliotti F, Simpson-Haidaris PJ

DNA research : an international journal for rapid publication of

Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells.

Haidaris CG, Fisher DJ, Gigliotti F, Simpson-Haidaris PJ

Molecular biotechnology.. 1998 April 9 (2):91-7. Epub 1900 01 01.

Transcriptional regulation of endothelial cell tissue factor expression during Rickettsia rickettsii infection: involvement of the transcription factor NF-kappaB.

Shi RJ, Simpson-Haidaris PJ, Lerner NB, Marder VJ, Silverman DJ, Sporn LA

Infection and immunity.. 1998 March 66 (3):1070-5. Epub 1900 01 01.

Thrombin cleavage-independent deposition of fibrinogen in extracellular matrices.

Guadiz G, Sporn LA, Simpson-Haidaris PJ

Blood.. 1997 October 190 (7):2644-53. Epub 1900 01 01.

Induction of fibrinogen biosynthesis and secretion from cultured pulmonary epithelial cells.

Haidaris PJ

Blood.. 1997 February 189 (3):873-82. Epub 1900 01 01.

Polarized secretion of fibrinogen by lung epithelial cells

Guadiz,G.; Sporn,L. A.; Goss,R. A.; Lawrence,S. O.; Marder,V. J.; Simpson-Haidaris,P. J.;.

American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 1997; 17(1): 60-69.

Host response to inflammation elicited during Pneumocystis carinii pneumonia.

Simpson-Haidaris PJ, Guadiz G

The Journal of eukaryotic microbiology.. 1997 44 (6):33S. Epub 1900 01 01.

Heparin-binding domain of fibrin mediates its binding to endothelial cells.

Odrljin TM, Francis CW, Sporn LA, Bunce LA, Marder VJ, Simpson-Haidaris PJ

Arteriosclerosis, thrombosis, and vascular biology.. 1996 December 16 (12):1544-51. Epub 1900 01 01.

Calcium modulates plasmin cleavage of the fibrinogen D fragment gamma chain N-terminus: mapping of monoclonal antibody J88B to a plasmin sensitive domain of the gamma chain.

Odrljin TM, Rybarczyk BJ, Francis CW, Lawrence SO, Hamaguchi M, Simpson-Haidaris PJ

Biochimica et biophysica acta.. 1996 November 141298 (1):69-77. Epub 1900 01 01.

Thrombin cleavage enhances exposure of a heparin binding domain in the N-terminus of the fibrin beta chain.

Odrljin TM, Shainoff JR, Lawrence SO, Simpson-Haidaris PJ

Blood.. 1996 September 1588 (6):2050-61. Epub 1900 01 01.

Increased expression of plasminogen activator inhibitor-1 in R. rickettsii-infected endothelial cells.

Shi RJ, Simpson-Haidaris PJ, Marder VJ, Silverman DJ, Sporn LA

Thrombosis and haemostasis.. 1996 April 75 (4):600-6. Epub 1900 01 01.

Tissue factor mRNA expression in the endothelium of an intact umbilical vein.

Courtney MA, Haidaris PJ, Marder VJ, Sporn LA

Blood.. 1996 January 187 (1):174-9. Epub 1900 01 01.

Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA.

Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ

Gene.. 1995 December 29167 (1-2):185-9. Epub 1900 01 01.

Cloning and characterization of a lung-specific cDNA corresponding to the gamma chain of hepatic fibrinogen.

Simpson-Haidaris PJ, Wright TW, Earnest BJ, Hui Z, Neroni LA, Courtney MA

Gene.. 1995 December 29167 (1-2):273-8. Epub 1900 01 01.

Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii.

Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ

DNA research : an international journal for rapid publication of

Mechanisms of cytopenia in human immunodeficiency virus infection.

Harbol AW, Liesveld JL, Simpson-Haidaris PJ, Abboud CN

Blood reviews.. 1994 December 8 (4):241-51. Epub 1900 01 01.

Cloning of the complete coding sequence of rat fibrinogen B beta chain cDNA: interspecies conservation of fibrin beta 15-42 primary structure.

Courtney MA, Bunce LA, Neroni LA, Simpson-Haidaris PJ

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.. 1994 August 5 (4):487-96. Epub 1900 01 01.

Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species.

Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG

Infection and immunity.. 1994 May 62 (5):1513-9. Epub 1900 01 01.

Rickettsia rickettsii infection of cultured human endothelial cells induces tissue factor expression.

Sporn LA, Haidaris PJ, Shi RJ, Nemerson Y, Silverman DJ, Marder VJ

Blood.. 1994 March 1583 (6):1527-34. Epub 1900 01 01.

Intracellular localization of a Trypanosoma cruzi kDNA minicircle transcript using RNA: RNA in situ hybridization.

Thertulien R, Simpson-Haidaris PJ, Haidaris CG

The Journal of eukaryotic microbiology.. 1994 41 (4):402-7. Epub 1900 01 01.

Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma.

Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ

Blood.. 1993 October 1582 (8):2406-13. Epub 1900 01 01.

Cross-linked alpha s gamma t-chain hybrids in plasma clots studied by 1D- and 2D electrophoresis and western blotting.

Grøn B, Filion-Myklebust C, Bjørnsen S, Haidaris P, Brosstad F

Thrombosis and haemostasis.. 1993 September 170 (3):438-42. Epub 1900 01 01.

Role of the COOH-terminal acidic region of A1 subunit in A2 subunit retention in human factor VIIIa.

Fay PJ, Haidaris PJ, Huggins CF

The Journal of biological chemistry.. 1993 August 25268 (24):17861-6. Epub 1900 01 01.

Pneumocystis carinii is not universally transmissible between mammalian species.

Gigliotti F, Harmsen AG, Haidaris CG, Haidaris PJ

Infection and immunity.. 1993 July 61 (7):2886-90. Epub 1900 01 01.

Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction.

Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR

The Journal of infectious diseases.. 1993 July 168 (1):191-4. Epub 1900 01 01.

In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene.

Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG

Molecular microbiology.. 1993 March 7 (5):647-56. Epub 1900 01 01.

Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii.

Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG

The Journal of infectious diseases.. 1992 November 166 (5):1113-23. Epub 1900 01 01.

Liver-specific RNA processing of the ubiquitously transcribed rat fibrinogen gamma-chain gene.

Haidaris PJ, Courtney MA

Blood.. 1992 March 179 (5):1218-24. Epub 1900 01 01.

Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit.

Fay PJ, Haidaris PJ, Smudzin TM

The Journal of biological chemistry.. 1991 May 15266 (14):8957-62. Epub 1900 01 01.

Developmental expression of mRNAs encoding platelet proteins in rat megakaryocytes.

Courtney MA, Stoler MH, Marder VJ, Haidaris PJ

Blood.. 1991 February 177 (3):560-8. Epub 1900 01 01.

Molecular cloning and characterization of ferret Pneumocystis carinii gp120.

Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ

The Journal of protozoology. 1991 38 (6):5S-6S. Epub 1900 01 01.

Tissue-specific and ubiquitous expression of fibrinogen gamma-chain mRNA.

Haidaris PJ, Courtney MA

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.. 1990 October 1 (4-5):433-7. Epub 1900 01 01.

The C-terminal sequences of the gamma 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin.

Haidaris PJ, Peerschke EI, Marder VJ, Francis CW

Blood.. 1989 November 1574 (7):2437-44. Epub 1900 01 01.

Megakaryocyte and hepatocyte origins of human fibrinogen biosynthesis exhibit hepatocyte-specific expression of gamma chain-variant polypeptides.

Haidaris PJ, Francis CW, Sporn LA, Arvan DS, Collichio FA, Marder VJ

Blood.. 1989 August 174 (2):743-50. Epub 1900 01 01.

von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation.

Mayadas T, Wagner DD, Simpson PJ

Blood.. 1989 February 1573 (3):706-11. Epub 1900 01 01.

Carboxyl-terminal amino acid sequences of two variant forms of the gamma chain of human plasma fibrinogen.

Francis CW, Müller E, Henschen A, Simpson PJ, Marder VJ

Proceedings of the National Academy of Sciences of the United States of America.. 1988 May 85 (10):3358-62. Epub 1900 01 01.

Evidence for prokaryotic transcription and translation control regions in the human factor IX gene.

Simpson PJ, Chou WG, Whitbeck AA, Young FE, Zain S

Gene.. 1987 61 (3):373-83. Epub 1900 01 01.

An improved method for mRNA isolation and characterization of in vitro translation products by Western blotting.

Simpson PJ

Gene.. 1987 56 (2-3):161-71. Epub 1900 01 01.

Size exclusion HPLC as a rapid monitor for mRNA isolation.

Chan SY, Simpson PJ.

Biotechniques. 1985; 3: 114-117.

Books

Hemostasis and Thrombosis: Basic Principles and Clinical Practice. (2001)

Chapter: "Fibrinogen Structure and Physiology"

Authors: Hantgan R, Simpson-Haidaris PJ, Francis CW, Marder VJ

Publisher: Lippincott Williams & Wilkins, Philadelphia 2001

Encyclopedic Reference of Vascular Biology & Pathology. (2000)

Chapter: Fibrinogen and Fibrin.

Authors: Bini A, Simpson-Haidaris PJ, Kudryk, B.

Publisher: Springer Verlag., Berlin/Heidelberg 2000