Patricia J. Simpson-Haidaris, Ph.D.

Patricia J. Simpson-Haidaris, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 610
Rochester, NY 14642

Journal Articles

Showing all 71 journal articles available.

2014 Feb
Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Lemos JA, Abranches J. "Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus." Molecular oral microbiology. 2014 Feb; 29(1):11-23. Epub 2013 Oct 30.
2011 Jun
Abranches J, Miller JH, Martinez AR, Simpson-Haidaris PJ, Burne RA, Lemos JA. "The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells." Infection and immunity.. 2011 Jun; 79(6):2277-84. Epub 2011 Mar 21.
2010 Nov
Simpson-Haidaris PJ, Seweryniak KE, Spinelli SL, Garcia-Bates TM, Murant TI, Pollock SJ, Sime PJ, Phipps RP. "A putative role for platelet-derived PPAR? in vascular homeostasis demonstrated by anti-PPAR? induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis." Journal of biotechnology. 2010 Nov; 150(3):417-27. Epub 2010 Oct 01.
2010 Mar 2
Simpson-Haidaris PJ, Sahni A. "Fibrin-specific beta(15-42) domain is exposed in cell-associated intact fibrinogen: Response to Weijers et al comment on the study by A. Sahni et al." International journal of cancer. Journal international du cancer.. 2010 Mar 2; Epub 2010 Mar 02.
2010
Simpson-Haidaris PJ, Pollock SJ, Ramon S, Guo N, Woeller CF, Feldon SE, Phipps RP. "Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes." PPAR research. 2010 2010:814609. Epub 2010 Feb 28.
2009 Aug 1
Sahni A, Arévalo MT, Sahni SK, Simpson-Haidaris PJ. "The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells." International journal of cancer. Journal international du cancer.. 2009 Aug 1; 125(3):577-84.
2009 Apr
Abranches J, Zeng L, Bélanger M, Rodrigues PH, Simpson-Haidaris PJ, Akin D, Dunn WA, Progulske-Fox A, Burne RA. "Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175." Oral microbiology and immunology. 2009 Apr; 24(2):141-5.
2009 Mar
Arévalo MT, Simpson-Haidaris PJ, Kou Z, Schlesinger JJ, Jin X. "Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infection." Journal of medical virology. 2009 Mar; 81(3):519-28.
2009
Garcia-Bates TM, Baglole CJ, Bernard MP, Murant TI, Simpson-Haidaris PJ, Phipps RP. "Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation." The Journal of immunology : official journal of the American Association of Immunologists.. 2009 183(11):6903-12. Epub 2009 Nov 13.
2008 Jan
Sahni A, Simpson-Haidaris PJ, Sahni SK, Vaday GG, Francis CW. "Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2)." Journal of thrombosis and haemostasis : JTH.. 2008 Jan; 6(1):176-83. Epub 2007 Oct 22.
2008
Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP. "Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies." PPAR research. 2008 2008:834612.
2007 Jan
Mosesson MW, Hernandez I, Raife TJ, Medved L, Yakovlev S, Simpson-Haidaris PJ, Uitte DE Willige S, Bertina RM. "Plasma fibrinogen gamma' chain content in the thrombotic microangiopathy syndrome." Journal of thrombosis and haemostasis : JTH.. 2007 Jan; 5(1):62-9. Epub 2006 Oct 13.
2006 May 5
Duan HO, Simpson-Haidaris PJ. "Cell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6." The Journal of biological chemistry.. 2006 May 5; 281(18):12451-7. Epub 2006 Mar 08.
2004 Sep
Sahni A, Sahni SK, Simpson-Haidaris PJ, Francis CW. "Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells." Journal of thrombosis and haemostasis : JTH.. 2004 Sep; 2(9):1629-36.
2004 Aug
Lawrence SO, Simpson-Haidaris PJ. "Regulated de novo biosynthesis of fibrinogen in extrahepatic epithelial cells in response to inflammation." Thrombosis and haemostasis.. 2004 Aug; 92(2):234-43.
2004 Mar
Wells J, Gigliotti F, Simpson-Haidaris PJ, Haidaris CG. "Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA." Infection and immunity.. 2004 Mar; 72(3):1548-56.
2004
Lawrence SO, Simpson-Haidaris PJ. "Regulated de novo biosynthesis of fibrinogen in lung alveolar epithelial cells". (Thromb Haemost 92) Chosen as Journal Club Highlights. Clin Lab. 2004; 50: 715-30. Link
2003 Oct 17
Duan HO, Simpson-Haidaris PJ. "Functional analysis of interleukin 6 response elements (IL-6REs) on the human gamma-fibrinogen promoter: binding of hepatic Stat3 correlates negatively with transactivation potential of type II IL-6REs." The Journal of biological chemistry.. 2003 Oct 17; 278(42):41270-81. Epub 2003 Aug 04.
2003
Rybarczyk BJ, Lawrence SO, Simpson-Haidaris PJ. "Matrix-fibrinogen enhances wound closure by increasing both cell proliferation and migration." Blood.. 2003 102(12):4035-43. Epub 2003 Aug 14.
2002 Feb 1
Pereira M, Rybarczyk BJ, Odrljin TM, Hocking DC, Sottile J, Simpson-Haidaris PJ. "The incorporation of fibrinogen into extracellular matrix is dependent on active assembly of a fibronectin matrix." Journal of cell science.. 2002 Feb 1; 115(Pt 3):609-17.
2001 Jul 1
Meh DA, Mosesson MW, Siebenlist KR, Simpson-Haidaris PJ, Brennan SO, DiOrio JP, Thompson K, Di Minno G. "Fibrinogen naples I (B beta A68T) nonsubstrate thrombin-binding capacities." Thrombosis research.. 2001 Jul 1; 103(1):63-73.
2001
Odrljin,T. M.; Haidaris,C. G.; Lerner,N. B.; Simpson-Haidaris,P. J.;. "Integrin alphavbeta3-mediated endocytosis of immobilized fibrinogen by A549 lung alveolar epithelial cells". American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 2001; 24(1): 12-21. Link
2001
Simpson-Haidaris PJ, Rybarczyk B. "Tumors and fibrinogen. The role of fibrinogen as an extracellular matrix protein." Annals of the New York Academy of Sciences.. 2001 936:406-25.
2001
Pereira M, Simpson-Haidaris PJ. "Fibrinogen modulates gene expression in wounded fibroblasts." Annals of the New York Academy of Sciences.. 2001 936:438-43.
2000 Jul
Rybarczyk BJ, Pereira M, Simpson-Haidaris PJ. "Characterization of a monoclonal antibody, D73H, that maps to a highly conserved region on fibrinogen Bbeta chain." Thrombosis and haemostasis.. 2000 Jul; 84(1):43-8.
2000 Apr 1
Rybarczyk BJ, Simpson-Haidaris PJ. "Fibrinogen assembly, secretion, and deposition into extracellular matrix by MCF-7 human breast carcinoma cells." Cancer research.. 2000 Apr 1; 60(7):2033-9.
2000 Mar
Shi RJ, Simpson-Haidaris PJ, Marder VJ, Silverman DJ, Sporn LA. "Post-transcriptional regulation of endothelial cell plasminogen activator inhibitor-1 expression during R. rickettsii infection." Microbial pathogenesis. 2000 Mar; 28(3):127-33.
2000 Jan 25
Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG. "Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii." Gene.. 2000 Jan 25; 242(1-2):141-50.
2000
Michelsen AE, Santi C, Holme R, Lord ST, Simpson-Haidaris PJ, Solum NO, Pedersen TM, Brosstad F. "The charge-heterogeneity of human fibrinogen as investigated by 2D electrophoresis." Thrombosis research.. 2000 100(6):529-35.
2000
Nguyen,M. D.; Simpson-Haidaris,P. J.;. "Cell type-specific regulation of fibrinogen expression in lung epithelial cells by dexamethasone and interleukin-1beta". American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 2000; 22(2): 209-217. Link
1998 Oct 2
Guadiz G, Haidaris CG, Maine GN, Simpson-Haidaris PJ. "The carboxyl terminus of Pneumocystis carinii glycoprotein A encodes a functional glycosylphosphatidylinositol signal sequence." The Journal of biological chemistry.. 1998 Oct 2; 273(40):26202-9.
1998 Sep
Simpson-Haidaris PJ, Courtney MA, Wright TW, Goss R, Harmsen A, Gigliotti F. "Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia." Infection and immunity.. 1998 Sep; 66(9):4431-9.
1998 Apr 30
Haidaris CG, Medzihradsky OF, Gigliotti F, Simpson-Haidaris PJ. "Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A." DNA research : an international journal for rapid publication of reports on genes and genomes. 1998 Apr 30; 5(2):77-85.
1998 Apr
Haidaris CG, Fisher DJ, Gigliotti F, Simpson-Haidaris PJ. "Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells." Molecular biotechnology. 1998 Apr; 9(2):91-7.
1998 Mar
Shi RJ, Simpson-Haidaris PJ, Lerner NB, Marder VJ, Silverman DJ, Sporn LA. "Transcriptional regulation of endothelial cell tissue factor expression during Rickettsia rickettsii infection: involvement of the transcription factor NF-kappaB." Infection and immunity.. 1998 Mar; 66(3):1070-5.
1997 Oct 1
Guadiz G, Sporn LA, Simpson-Haidaris PJ. "Thrombin cleavage-independent deposition of fibrinogen in extracellular matrices." Blood.. 1997 Oct 1; 90(7):2644-53.
1997 Feb 1
Haidaris PJ. "Induction of fibrinogen biosynthesis and secretion from cultured pulmonary epithelial cells." Blood.. 1997 Feb 1; 89(3):873-82.
1997
Guadiz,G.; Sporn,L. A.; Goss,R. A.; Lawrence,S. O.; Marder,V. J.; Simpson-Haidaris,P. J.;. "Polarized secretion of fibrinogen by lung epithelial cells". American Journal of Respiratory Cell and Molecular Biology : An Official Journal of the American Thoracic Society, Medical Section of the American Lung Association. 1997; 17(1): 60-69. Link
1997
Simpson-Haidaris PJ, Guadiz G. "Host response to inflammation elicited during Pneumocystis carinii pneumonia." The Journal of eukaryotic microbiology.. 1997 44(6):33S.
1996 Nov 14
Odrljin TM, Rybarczyk BJ, Francis CW, Lawrence SO, Hamaguchi M, Simpson-Haidaris PJ. "Calcium modulates plasmin cleavage of the fibrinogen D fragment gamma chain N-terminus: mapping of monoclonal antibody J88B to a plasmin sensitive domain of the gamma chain." Biochimica et biophysica acta.. 1996 Nov 14; 1298(1):69-77.
1996 Sep 15
Odrljin TM, Shainoff JR, Lawrence SO, Simpson-Haidaris PJ. "Thrombin cleavage enhances exposure of a heparin binding domain in the N-terminus of the fibrin beta chain." Blood.. 1996 Sep 15; 88(6):2050-61.
1996 Apr
Shi RJ, Simpson-Haidaris PJ, Marder VJ, Silverman DJ, Sporn LA. "Increased expression of plasminogen activator inhibitor-1 in R. rickettsii-infected endothelial cells." Thrombosis and haemostasis.. 1996 Apr; 75(4):600-6.
1996 Jan 1
Courtney MA, Haidaris PJ, Marder VJ, Sporn LA. "Tissue factor mRNA expression in the endothelium of an intact umbilical vein." Blood.. 1996 Jan 1; 87(1):174-9.
1996
Odrljin TM, Francis CW, Sporn LA, Bunce LA, Marder VJ, Simpson-Haidaris PJ. "Heparin-binding domain of fibrin mediates its binding to endothelial cells." Arteriosclerosis, thrombosis, and vascular biology.. 1996 16(12):1544-51.
1995
Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ. "Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA." Gene.. 1995 167(1-2):185-9.
1995
Simpson-Haidaris PJ, Wright TW, Earnest BJ, Hui Z, Neroni LA, Courtney MA. "Cloning and characterization of a lung-specific cDNA corresponding to the gamma chain of hepatic fibrinogen." Gene.. 1995 167(1-2):273-8.
1995
Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ. "Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii." DNA research : an international journal for rapid publication of reports on genes and genomes. 1995 2(2):77-88.
1994 Aug
Courtney MA, Bunce LA, Neroni LA, Simpson-Haidaris PJ. "Cloning of the complete coding sequence of rat fibrinogen B beta chain cDNA: interspecies conservation of fibrin beta 15-42 primary structure." Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 1994 Aug; 5(4):487-96.
1994 May
Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG. "Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species." Infection and immunity.. 1994 May; 62(5):1513-9.
1994 Mar 15
Sporn LA, Haidaris PJ, Shi RJ, Nemerson Y, Silverman DJ, Marder VJ. "Rickettsia rickettsii infection of cultured human endothelial cells induces tissue factor expression." Blood.. 1994 Mar 15; 83(6):1527-34.
1994
Harbol AW, Liesveld JL, Simpson-Haidaris PJ, Abboud CN. "Mechanisms of cytopenia in human immunodeficiency virus infection." Blood reviews. 1994 8(4):241-51.
1994
Thertulien R, Simpson-Haidaris PJ, Haidaris CG. "Intracellular localization of a Trypanosoma cruzi kDNA minicircle transcript using RNA: RNA in situ hybridization." The Journal of eukaryotic microbiology.. 1994 41(4):402-7.
1993 Oct 15
Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ. "Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma." Blood.. 1993 Oct 15; 82(8):2406-13.
1993 Sep 1
Grøn B, Filion-Myklebust C, Bjørnsen S, Haidaris P, Brosstad F. "Cross-linked alpha s gamma t-chain hybrids in plasma clots studied by 1D- and 2D electrophoresis and western blotting." Thrombosis and haemostasis.. 1993 Sep 1; 70(3):438-42.
1993 Aug 25
Fay PJ, Haidaris PJ, Huggins CF. "Role of the COOH-terminal acidic region of A1 subunit in A2 subunit retention in human factor VIIIa." The Journal of biological chemistry.. 1993 Aug 25; 268(24):17861-6.
1993 Jul
Gigliotti F, Harmsen AG, Haidaris CG, Haidaris PJ. "Pneumocystis carinii is not universally transmissible between mammalian species." Infection and immunity.. 1993 Jul; 61(7):2886-90.
1993 Jul
Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR. "Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction." The Journal of infectious diseases.. 1993 Jul; 168(1):191-4.
1993 Mar
Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG. "In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene." Molecular microbiology. 1993 Mar; 7(5):647-56.
1992 Nov
Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG. "Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii." The Journal of infectious diseases.. 1992 Nov; 166(5):1113-23.
1992 Mar 1
Haidaris PJ, Courtney MA. "Liver-specific RNA processing of the ubiquitously transcribed rat fibrinogen gamma-chain gene." Blood.. 1992 Mar 1; 79(5):1218-24.
1991 May 15
Fay PJ, Haidaris PJ, Smudzin TM. "Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit." The Journal of biological chemistry.. 1991 May 15; 266(14):8957-62.
1991 Feb 1
Courtney MA, Stoler MH, Marder VJ, Haidaris PJ. "Developmental expression of mRNAs encoding platelet proteins in rat megakaryocytes." Blood.. 1991 Feb 1; 77(3):560-8.
1991
Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ. "Molecular cloning and characterization of ferret Pneumocystis carinii gp120." The Journal of protozoology. 1991 38(6):5S-6S.
1990 Oct
Haidaris PJ, Courtney MA. "Tissue-specific and ubiquitous expression of fibrinogen gamma-chain mRNA." Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 1990 Oct; 1(4-5):433-7.
1989 Nov 15
Haidaris PJ, Peerschke EI, Marder VJ, Francis CW. "The C-terminal sequences of the gamma 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin." Blood.. 1989 Nov 15; 74(7):2437-44.
1989 Aug 1
Haidaris PJ, Francis CW, Sporn LA, Arvan DS, Collichio FA, Marder VJ. "Megakaryocyte and hepatocyte origins of human fibrinogen biosynthesis exhibit hepatocyte-specific expression of gamma chain-variant polypeptides." Blood.. 1989 Aug 1; 74(2):743-50.
1989 Feb 15
Mayadas T, Wagner DD, Simpson PJ. "von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation." Blood.. 1989 Feb 15; 73(3):706-11.
1988 May
Francis CW, Müller E, Henschen A, Simpson PJ, Marder VJ. "Carboxyl-terminal amino acid sequences of two variant forms of the gamma chain of human plasma fibrinogen." Proceedings of the National Academy of Sciences of the United States of America.. 1988 May; 85(10):3358-62.
1987
Simpson PJ, Chou WG, Whitbeck AA, Young FE, Zain S. "Evidence for prokaryotic transcription and translation control regions in the human factor IX gene." Gene.. 1987 61(3):373-83.
1987
Simpson PJ. "An improved method for mRNA isolation and characterization of in vitro translation products by Western blotting." Gene.. 1987 56(2-3):161-71.
1985
Chan SY, Simpson PJ. "Size exclusion HPLC as a rapid monitor for mRNA isolation." Biotechniques. 1985; 3: 114-117. Link

Books

2001
Hantgan R, Simpson-Haidaris PJ, Francis CW, Marder VJ. ""Fibrinogen Structure and Physiology"". Hemostasis and Thrombosis: Basic Principles and Clinical Practice.. RW Coleman, J Hirsh, VJ Marder, AW Clowes, JN George. Philadelphia: Lippincott Williams & Wilkins, 2001. 203-232
2000
Bini A, Simpson-Haidaris PJ, Kudryk, B.. "Fibrinogen and Fibrin.". Encyclopedic Reference of Vascular Biology & Pathology.. A. Bikfalvi.. Berlin/Heidelberg: Springer Verlag., 2000. 107-125