Research Bio
Dr. Guillet's primary research focus is in the area of neonatal brain development and injury. The developing brain is at risk from the effects of centrally-acting agents, including hypoxia, seizures, and medications. This risk is due in part to the fact that the brain may be more vulnerable during times of rapid maturational change. She has an active clinical research program, focused on the neonatal brain. Dr. Guillet is the recent recipient of a 5 year multimillion dollar grant from NIH for a multicenter clinical trial to determine if treatment with phenobarbital compared with treatment with placebo for four months after resolution of neonatal seizures alters neurodevelopmental outcome or changes the incidence of recurrent seizures.
In addition, she is the overall Primary Investigator for long term follow-up of children around the world who were enrolled in the CoolCap Study (head cooling with systemic hypothermia for infants with neonatal encephalopathy). She has served as site investigator on national studies of hypothermia in the treatment of neonatal asphyxia and of phototherapy in extremely low birthweight neonates, including a substudy on the potential effect of hyperbilirubinemia and phototherapy on the maturation of the brainstem evoked response, a marker of brainstem development in premature infants.
2012 Jul 17
Shankaran S, Barnes PD, Hintz SR, Laptook AR, Zaterka-Baxter KM, McDonald SA, Ehrenkranz RA, Walsh MC, Tyson JE, Donovan EF, Goldberg RN, Bara R, Das A, Finer NN, Sanchez PJ, Poindexter BB, Van Meurs KP, Carlo WA, Stoll BJ, Duara S, Guillet R, Higgins RD, . "Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy." Archives of disease in childhood. 2012 Jul 17; Epub 2012 Jul 17. |
2012 May 31
Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, Yolton K, Gustafson KE, Leach TM, Green C, Bara R, Petrie Huitema CM, Ehrenkranz RA, Tyson JE, Das A, Hammond J, Peralta-Carcelen M, Evans PW, Heyne RJ, Wilson-Costello DE, Vaucher YE, Bauer CR, Dusick AM, Adams-Chapman I, Goldstein RF, Guillet R, Papile LA, Higgins RD, . "Childhood outcomes after hypothermia for neonatal encephalopathy." The New England journal of medicine. 2012 May 31; 366(22):2085-92. |
2012 Feb
Guillet R, Kwon JM, Chen S, McDermott MP. "Urine phenobarbital drug screening: potential use for compliance assessment in neonates." Journal of child neurology. 2012 Feb 0; 27(2):200-3. Epub 2011 Sep 27. |
2012 Feb
Guillet R, Edwards AD, Thoresen M, Ferriero DM, Gluckman PD, Whitelaw A, Gunn AJ, . "Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy." Pediatric research. 2012 Feb 0; 71(2):205-9. Epub 2011 Dec 21. |
2012 Jan
Lasky RE, Church MW, Orlando MS, Morris BH, Parikh NA, Tyson JE, McDavid GE, Oh W, Stevenson DK, Van Meurs KP, Guillet R, Phelps DL. "The effects of aggressive vs. conservative phototherapy on the brainstem auditory evoked responses of extremely-low-birth-weight infants." Pediatric research. 2012 Jan 0; 71(1):77-84. |
