Research Bio
My research focuses on mechanisms of therapeutic resistance in cancer in general and in bone cancer, in particular. One such mechanism is suppression of programmed cell death or apoptosis. We are studying 1) signaling pathways, such as NF-kB, leading to prevalence of anti-apoptotic factors; and 2) processes leading to specific glycolytic phenotype found in cancer cells.
| CTSI KL2 Career Award | NCRR/NIH |
2009 - 2011 |
| Wilmot Cancer Research Fellowship | Wilmot Foundation |
2004 - 2007 |
| NIH TRavel Scholarship | Keystone Symposia |
2002 |
| Graduate Student Society Research Award | University of Rochester SMD |
2001 |
| Young Investigator Award | Frontiers in Mitochondrial Research |
2000 |
| Young Investigator Award | Frontiers of Mitochondrial Research |
1998 |
| Moscow Mayor's Honorary Scholarship | Russian State Medical University |
1993 - 1995 |
| Freshman Competitive Scholarship | Russian State Medical University |
1987 - 1988 |
2012 Apr
Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA. "Targeting radioresistant osteosarcoma cells with parthenolide." Journal of cellular biochemistry. 2012 Apr 0; 113(4):1282-91. |
2011 Jun 24
Shapovalov Y, Hoffman D, Zuch D, de Mesy Bentley KL, Eliseev RA. "Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication." The Journal of biological chemistry. 2011 Jun 24; 286(25):22331-8. Epub 2011 May 02. |
2010 Jul 1
Shapovalov Y, Benavidez D, Zuch D, Eliseev RA. "Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma." International journal of cancer. Journal international du
cancer. 2010 Jul 1; 127(1):67-76. |
2009 Apr 10
Eliseev RA, Malecki J, Lester T, Zhang Y, Humphrey J, Gunter TE. "Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect." The Journal of biological chemistry. 2009 Apr 10; 284(15):9692-9. Epub 2009 Feb 19. |
2008 Jun 5
Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis." Oncogene. 2008 Jun 5; 27(25):3605-14. Epub 2008 Jan 28. |
