Research Bio
Dr. O¹Reilly¹s laboratory investigates mechanisms controlling lung epithelial cell survival and differentiation in response to oxidative stress caused by exposure to high oxygen (hyperoxia). Although hyperoxia is often used to treat patients with respiratory distress, it stimulates cell death in adults and permanently disrupts lung development in neonates. Research in the laboratory focuses on two major lines of investigation. First, understand how hyperoxia activates the p53-dependent expression of the cell cycle inhibitor p21 and how p21 controls cell growth, survival, and inflammation.
Second, understand how neonatal exposure to hyperoxia stimulates differentiation of alveolar epithelial progenitor cells and why this leads to long-term susceptibility to subsequent respiratory insults. These studies will allow us to develop novel therapies for treating patients requiring oxygen, as well as provide valuable information on other conditions involving persistent oxidative stress, including inflammation, neurodegeneration, cancer, and the aging process. Research funding comes from an NIH R01, the March of Dimes and participation in other NIH grants.
2013 Apr
Buczynski BW, Maduekwe ET, O'Reilly MA. "The role of hyperoxia in the pathogenesis of experimental BPD." Seminars in perinatology. 2013 Apr 0; 37(2):69-78. |
2013 Feb
Yee M, Buczynski BW, Lawrence BP, O'Reilly MA. "Neonatal hyperoxia increases sensitivity of adult mice to bleomycin-induced lung fibrosis." American journal of respiratory cell and molecular biology. 2013 Feb 0; 48(2):258-66. Epub 2012 Dec 20. |
2012 Oct 1
O'Reilly MA. "Angiotensin II: tapping the cell cycle machinery to kill endothelial cells." American journal of physiology. Lung cellular and molecular
physiology. 2012 Oct 1; 303(7):L575-6. Epub 2012 Aug 10. |
2012 Sep
Giannandrea M, Yee M, O'Reilly MA, Lawrence BP. "Memory CD8+ T cells are sufficient to alleviate impaired host resistance to influenza A virus infection caused by neonatal oxygen supplementation." Clinical and vaccine immunology : CVI. 2012 Sep 0; 19(9):1432-41. Epub 2012 Jul 11. |
2012 Aug
O'Reilly MA, Yee M, Buczynski BW, Vitiello PF, Keng PC, Welle SL, Finkelstein N, Dean DA, Lawrence BP. "Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1." The American journal of pathology. 2012 Aug 0; 181(2):441-51. Epub 2012 Jun 05. |
