Michael A. O'Reilly, Ph.D.

Michael A. O'Reilly, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-5948
Lab: (585) 275-1450
Lab: (585) 273-4831
Lab: (585) 273-3118
Administrative: (585) 275-5948

Lab Information

O'Reilly Lab

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Research Bio

Dr. O¹Reilly¹s laboratory investigates mechanisms controlling lung epithelial cell survival and differentiation in response to oxidative stress caused by exposure to high oxygen (hyperoxia). Although hyperoxia is often used to treat patients with respiratory distress, it stimulates cell death in adults and permanently disrupts lung development in neonates. Research in the laboratory focuses on two major lines of investigation. First, understand how hyperoxia activates the p53-dependent expression of the cell cycle inhibitor p21 and how p21 controls cell growth, survival, and inflammation.

Second, understand how neonatal exposure to hyperoxia stimulates differentiation of alveolar epithelial progenitor cells and why this leads to long-term susceptibility to subsequent respiratory insults. These studies will allow us to develop novel therapies for treating patients requiring oxygen, as well as provide valuable information on other conditions involving persistent oxidative stress, including inflammation, neurodegeneration, cancer, and the aging process. Research funding comes from an NIH R01, the March of Dimes and participation in other NIH grants.

Awards & Honors (Local)

Dean's Research Incentive Award University of Rochester Medical Center 2005
Ruth A. Lawrence Academic Faculty Service Award Department of Pediatrics 2005
Dean's Research Incentive Award University of Rochester 2004
National Research Council NICHD, NIH 1993 - 1995
NIH Training Grant, University of Cincinnati 1986 - 1988

Recent Journal Articles

Showing the 5 most recent journal articles. 85 available »

2014 Jul 15
Kalifa L, Gewandter JS, Staversky RJ, Sia EA, Brookes PS, O'Reilly MA. "DNA Double-Strand Breaks Activate ATM Independent of Mitochondrial Dysfunction in A549 Cells." Free radical biology & medicine.. 2014 Jul 15; Epub 2014 Jul 15.
2014 May 22
Maduekwe ET, Buczynski BW, Yee M, Rangasamy T, Stevens TP, Lawrence BP, O'Reilly MA. "Cumulative neonatal oxygen exposure predicts response of adult mice infected with influenza A virus." Pediatric pulmonology.. 2014 May 22; Epub 2014 May 22.
2014 Apr
Yee M, Buczynski BW, O'Reilly MA. "Neonatal hyperoxia stimulates the expansion of alveolar epithelial type II cells." American journal of respiratory cell and molecular biology.. 2014 Apr; 50(4):757-66.
2013 Nov 1
Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW. "Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis." The Journal of immunology : official journal of the American Association of Immunologists.. 2013 Nov 1; 191(9):4720-30. Epub 2013 Sep 27.
2013 Sep 15
Zhao L, Yee M, O'Reilly MA. "Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-? and BMP signaling." American journal of physiology. Lung cellular and molecular physiology.. 2013 Sep 15; 305(6):L409-18. Epub 2013 Jul 05.

Current Appointments

Professor - Department of Pediatrics, Neonatology (SMD) - Primary
Professor - Department of Environmental Medicine (SMD)

Education

PhD | Developmental Biology | University of Cincinnati1989
BS | Biology | SUNY at Stony Brook1984

Post-Doctoral Training & Residency

NRC Fellow, Lab. Mamm. Genes and Develop., NICHD, NIH Dr. Heiner Westphal 1995
Senior Staff Fellow, Laboratory of Chemoprevention, NCI, NIH 1993
Staff Fellow, Laboratory of Chemoprevention, NCI, NIH Drs. Michael B. Sporn and Anita B. Roberts 1992