Chawnshang Chang, Ph.D.

Chawnshang Chang, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester, NY 14642

Office: (585) 275-9994
Fax: (585) 756-4133

Lab Information

The George H. Whipple Lab for Cancer Research was established in 1997 with the recruitment of Dr. Chawnshang Chang as the Founder and current Director.

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Professional Bio

Dr.Chawnshang Chang grew up in Taiwan, receiving his Bachelor of Science degree from the National Taiwan University in 1978. Like many students before him, he made the trip across the Pacific Ocean to enter graduate school in the U.S., and earned his Ph.D. degree from the University of Chicago in 1985. As Professor Shutsung Liao's student, he cloned and characterized two androgen target genes. The first was Glutathione S-transferase, which represented the first isolated androgen-repressed gene (JBC, 1987) and the second was Spermine-binding protein, the first isolated androgen early-response gene (JBC, 1987).

With this solid training in cloning techniques and the encouragement from his mentor, Dr. Liao, he remained as a post doctorate fellow in Dr. Liao's lab to investigate what was the biggest challenge in the field of Andrology; the cloning of the androgen receptor. In 1988, Chawnshang succeeded in becoming the first scientist to clone the complete human and rat androgen receptors. (Science, 1988; PNAS, 1988). He then applied recombinant techniques to overexpress a large quantity of androgen receptor (AR) and used it to produce the first monoclonal antibody to the androgen receptor (Endo., 1989). The successful cloning of the androgen receptor and the generation of the first androgen receptor monoclonal antibody was not only truly groundbreaking, but also represented one of the most important contributions in the field of Andrology. Over the next 20 years, he continued his research and had more than 200 paper published on the fields of AR, TR2 and TR4. Want to know more about his achievement? Please go to the web site of his lab (http://www.urmc.rochester.edu/ChangARLab/chang.html) for details.

Research Bio

The George H. Whipple Lab for Cancer Research's interest is mainly in the sex hormones/nuclear receptors and Vitamin D/E effects on the prostate/bladder cancer and other hormone-related diseases.



Additional information on publications and details of Dr.Chawnshang Chang's research can be obtained from his lab website listed below.

Awards & Honors (Local)

The Milheim Award for Excellence in Cancer Research from Milheim Foundation 2003
Dr. Chien-Tien Hsu Memorial Lecture/Award at 2002 Annual Meeting of OBGYN 2002
Who's Who in America 2001
Dr. S.T.Huang-Chan memorial Lecture/Award, University of Hong Kong. 2001
President Award for Outstanding Andrology Research, The highest honor from The Chinese Andrology Association for the studies of Androgens and Androgen Receptor. 2001
President Award for Outstanding Andrology Research, The highest honor from The Taiwanese Andrology Association for the studies of Androgens and Androgen Receptor. 2000
President Award for Outstanding Urology Research, The highest honor from The Urology Association of Taiwan for the Contribution in Androgen Receptor and Prostate Cancer. 1999
Davey Memorial Award for Outstanding Cancer Research, University of Rochester. 1999
Scholar of the Year, The highest honor from The Taiwanese Osteoporosis Association for Outstanding Contribution in Sex hormones and Osteoporosis. 1998
George Hoyt Whipple Lecture, University of Rochester, Rochester, NY 1998
Jiepimg Wu Award, for Outstanding Achievement in Urology (The highest honor for Chinese-Urology Researcher). Beijing, China. 1998
Award with Honorary Fellow from The Japan Society of Andrology (The 2nd Non-Japanese ever awarded such honor) 1996
Blowity-Ridgeway Award in Andrology from Blowity-Ridgeway Foundation 1995 - 1997
Tokyo Society of Medical Science and University of Tokyo Lecturer 1992
American Cancer Society Junior Professorship in Cancer Research 1991 - 1994
CapCure Award (6 times) for Excellence in Prostate Cancer Research 1991 - 1997
Outstanding Young Investigator Award from Cancer Research Foundation 1990
Andrew Melon Award for Outstanding Young Faculty in USA from Andrew Melon Foundation 1989
The Ayerst Award for Outstanding Young Endocrinologist from the Endocrine Society 1988

Patents

Orphan Receptor Ligand-Polyunsaturated Fatty Acid Metabolites and TZD Activate TR4

United States Serial NO.: 12/842,569
Filed Date: July 23, 2010
Title: Methods and Compositions Related to TR4 Ligand
Invented by: Chawnshang Chang
A New Therapy to Target Stem-Progenitor Cells and Luminal Epithelial Cells Simultaneously to Block Castration-resistant Prostate Cancer

United States Serial NO.: 14/115,217
Filed Date: May 3, 2012
Title: Methods for Treating Prostate Cancer
Invented by: Chawnshang Chang

Recent Journal Articles

Showing the 5 most recent journal articles. 273 available »

2014 Sep 17
Park SS, Kim SJ, Choi H, Chang C, Kim E. "TR4 promotes fatty acid synthesis in 3T3-L1 adipocytes by activation of pyruvate carboxylase expression." FEBS letters.. 2014 Sep 17; Epub 2014 Sep 17.
2010 Jun 24
Niu Y, Chang TM, Yeh S, Ma WL, Wang YZ, Chang C. "Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails." Oncogene.. 2010 Jun 24; 29(25):3593-604. Epub 2010 May 03.
2010 Feb 1
Shyr CR, Tsai MY, Yeh S, Kang HY, Chang YC, Wong PL, Huang CC, Huang KE, Chang C. "Tumor suppressor PAX6 functions as androgen receptor co-repressor to inhibit prostate cancer growth." The Prostate.. 2010 Feb 1; 70(2):190-9.
2009 Oct
Liu NC, Lin WJ, Yu IC, Lin HY, Liu S, Lee YF, Chang C. "Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling." Endocrine.. 2009 Oct; 36(2):211-7. Epub 2009 Jul 18.
2009 Aug 11
Xie S, Lee YF, Kim E, Chen LM, Ni J, Fang LY, Liu S, Lin SJ, Abe JI, Berk B, Ho FM, Chang C. "TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation." Proceedings of the National Academy of Sciences of the United States of America.. 2009 Aug 11; 106(32):13353-8. Epub 2009 Jul 28.

Current Appointments

George Hoyt Whipple Professorship of Pathology - Department of Pathology and Laboratory Medicine (SMD)
Professor - Department of Pathology and Laboratory Medicine (SMD) - Primary
Professor - Department of Radiation Oncology (SMD)
Professor - Department of Urology (SMD)

Education

PhD | Biochemistry & Molecular Biology | University of Chicago1985
BS | Agriculture Chemistry | National Taiwan University1978