Yi-Fen Lee, Ph.D.

Yi-Fen Lee, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 656
Rochester, NY 14642

Office: (585) 275-9702
Lab: (585) 275-9703

Journal Articles

Showing all 51 journal articles available.

2014 Aug
Beckham CJ, Olsen J, Yin PN, Wu CH, Ting HJ, Hagen FK, Scosyrev E, Messing EM, Lee YF. "Bladder Cancer Exosomes Contain EDIL-3/Del1 and Facilitate Cancer Progression." The Journal of urology.. 2014 Aug; 192(2):583-92. Epub 2014 Feb 14.
2013 Jan 4
Ting HJ, Messing J, Yasmin-Karin S, Lee YF. "Identification of microRNA-98 as a therapeutic target inhibiting prostate cancer growth and a biomarker induced by vitamin D." The Journal of biological chemistry.. 2013 Jan 4; 288(1):1-9. Epub 2012 Nov 27.
2012 Jun
Yan SJ, Lee YF, Ting HJ, Liu NC, Liu S, Lin SJ, Yeh SD, Li G, Chang C. "Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation." Cellular & molecular biology letters. 2012 Jun; 17(2):309-22. Epub 2012 Mar 07.
2012 Feb 15
Ting HJ, Yasmin-Karim S, Yan SJ, Hsu JW, Lin TH, Zeng W, Messing J, Sheu TJ, Bao BY, Li W, Messing E, Lee YF. "A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D." Cancer research.. 2012 Feb 15; 72(4):958-68. Epub 2011 Dec 29.
2012
Lin SJ, Ho HC, Lee YF, Liu NC, Liu S, Li G, Shyr CR, Chang C. "Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis." Reproductive biology and endocrinology : RB&E.. 2012 10:43. Epub 2012 Jun 07.
2011 Nov 4
Liu S, Yan SJ, Lee YF, Liu NC, Ting HJ, Li G, Wu Q, Chen LM, Chang C. "Testicular nuclear receptor 4 (TR4) regulates UV light-induced responses via Cockayne syndrome B protein-mediated transcription-coupled DNA repair." The Journal of biological chemistry.. 2011 Nov 4; 286(44):38103-8. Epub 2011 Sep 14.
2011 Aug
Liu S, Lee YF, Chou S, Uno H, Li G, Brookes P, Massett MP, Wu Q, Chen LM, Chang C. "Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I." Molecular endocrinology.. 2011 Aug; 25(8):1301-10. Epub 2011 May 26.
2011 Jul
Lee YF, Liu S, Liu NC, Wang RS, Chen LM, Lin WJ, Ting HJ, Ho HC, Li G, Puzas EJ, Wu Q, Chang C. "Premature aging with impaired oxidative stress defense in mice lacking TR4." American journal of physiology. Endocrinology and metabolism.. 2011 Jul; 301(1):E91-8. Epub 2011 Apr 26.
2011 Jun 17
Xie S, Ni J, Lee YF, Liu S, Li G, Shyr CR, Chang C. "Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation." The Journal of biological chemistry.. 2011 Jun 17; 286(24):21129-36. Epub 2011 Apr 22.
2011 May
Kim E, Liu NC, Yu IC, Lin HY, Lee YF, Sparks JD, Chen LM, Chang C. "Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity." Diabetes.. 2011 May; 60(5):1493-503. Epub 2011 Apr 08.
2011 Feb
Hsu JW, Yasmin-Karim S, King MR, Wojciechowski JC, Mickelsen D, Blair ML, Ting HJ, Ma WL, Lee YF. "Suppression of prostate cancer cell rolling and adhesion to endothelium by 1?,25-dihydroxyvitamin D3." The American journal of pathology.. 2011 Feb; 178(2):872-80.
2011
Collins LL, Lee YF, Ting HJ, Lin WJ, Liu NC, Meshul CK, Uno H, Bao BY, Chen YT, Chang C. "The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice." Reproductive biology and endocrinology : RB&E.. 2011 9:138. Epub 2011 Oct 13.
2010 May
Bao BY, Ting HJ, Hsu JW, Yasmin-Karim S, Messing E, Lee YF. "Down-regulation of NF-kappaB signals is involved in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness." The Journal of steroid biochemistry and molecular biology.. 2010 May; 120(1):11-21. Epub 2010 Mar 04.
2009 Oct
Liu NC, Lin WJ, Yu IC, Lin HY, Liu S, Lee YF, Chang C. "Activation of TR4 orphan nuclear receptor gene promoter by cAMP/PKA and C/EBP signaling." Endocrine.. 2009 Oct; 36(2):211-7. Epub 2009 Jul 18.
2009 Aug 11
Xie S, Lee YF, Kim E, Chen LM, Ni J, Fang LY, Liu S, Lin SJ, Abe JI, Berk B, Ho FM, Chang C. "TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation." Proceedings of the National Academy of Sciences of the United States of America.. 2009 Aug 11; 106(32):13353-8. Epub 2009 Jul 28.
2008 Jul 1
Cai Y, Lee YF, Li G, Liu S, Bao BY, Huang J, Hsu CL, Chang C. "A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor." International journal of cancer. Journal international du cancer.. 2008 Jul 1; 123(1):195-201.
2008 Jul
Li G, Lee YF, Liu S, Cai Y, Xie S, Liu NC, Bao BY, Chen Z, Chang C. "Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a." Endocrinology.. 2008 Jul; 149(7):3490-9. Epub 2008 Apr 03.
2008 Jun 15
Bao BY, Ting HJ, Hsu JW, Lee YF. "Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells." International journal of cancer. Journal international du cancer.. 2008 Jun 15; 122(12):2699-706.
2008 Apr
Chen LM, Wang RS, Lee YF, Liu NC, Chang YJ, Wu CC, Xie S, Hung YC, Chang C. "Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4." Molecular endocrinology.. 2008 Apr; 22(4):858-67. Epub 2008 Jan 03.
2007 Sep
Ting HJ, Bao BY, Reeder JE, Messing EM, Lee YF. "Increased expression of corepressors in aggressive androgen-independent prostate cancer cells results in loss of 1alpha,25-dihydroxyvitamin D3 responsiveness." Molecular cancer research : MCR.. 2007 Sep; 5(9):967-80.
2007 Apr
Zhang Y, Chen YT, Xie S, Wang L, Lee YF, Chang SS, Chang C. "Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain." Molecular endocrinology.. 2007 Apr; 21(4):908-20. Epub 2007 Jan 16.
2007 Mar 8
Ting HJ, Hsu J, Bao BY, Lee YF. "Docetaxel-induced growth inhibition and apoptosis in androgen independent prostate cancer cells are enhanced by 1alpha,25-dihydroxyvitamin D3." Cancer letters.. 2007 Mar 8; 247(1):122-9. Epub 2006 Apr 27.
2007 Mar
Chen TC, Persons KS, Zheng S, Mathieu J, Holick MF, Lee YF, Bao B, Arai MA, Kittaka A. "Evaluation of C-2-substituted 19-nor-1alpha,25-dihydroxyvitamin D3 analogs as therapeutic agents for prostate cancer." The Journal of steroid biochemistry and molecular biology.. 2007 Mar; 103(3-5):717-20. Epub 2007 Jan 04.
2007
Chen,T. C.; Persons,K. S.; Zheng,S.; Mathieu,J.; Holick,M. F.; Lee,Y. F.; Bao,B.; Arai,M. A.; Kittaka,A.;. "Evaluation of C-2-substituted 19-nor-1alpha,25-dihydroxyvitamin D(3) analogs as therapeutic agents for prostate cancer". J.Steroid Biochem.Mol.Biol.. 2007; . Link
2007
Zhang,Y.; Chen,Y. T.; Xie,S.; Wang,L.; Lee,Y. F.; Chang,S. S.; Chang,C.;. "Loss of Testicular Orphan Receptor 4 Impairs Normal Myelination in Mouse Forebrain". Mol.Endocrinol.. 2007; . Link
2007
Liu NC, Lin WJ, Kim E, Collins LL, Lin HY, Yu IC, Sparks JD, Chen LM, Lee YF, Chang C. "Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis." Diabetes.. 2007 56(12):2901-9. Epub 2007 Sep 07.
2006 Sep
Bao BY, Yao J, Lee YF. "1alpha, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis." Carcinogenesis.. 2006 Sep; 27(9):1883-93. Epub 2006 Apr 19.
2006 Jan
Bao BY, Yeh SD, Lee YF. "1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases." Carcinogenesis.. 2006 Jan; 27(1):32-42. Epub 2005 Jun 29.
2006
Wang CP, Lee YF, Chang C, Lee HJ. "Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor." Biochemical and biophysical research communications.. 2006 351(1):204-8. Epub 2006 Oct 12.
2005 May
Chuang KH, Lee YF, Lin WJ, Chu CY, Altuwaijri S, Wan YJ, Chang C. "9-cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor." Molecular endocrinology.. 2005 May; 19(5):1200-12. Epub 2005 Jan 13.
2005 Feb
Ting HJ, Bao BY, Hsu CL, Lee YF. "Androgen-receptor coregulators mediate the suppressive effect of androgen signals on vitamin D receptor activity." Endocrine.. 2005 Feb; 26(1):1-9.
2004 Oct 22
Lee YF, Bao BY, Chang C. "Modulation of the retinoic acid-induced cell apoptosis and differentiation by the human TR4 orphan nuclear receptor." Biochemical and biophysical research communications.. 2004 Oct 22; 323(3):876-83.
2004 Oct 19
Collins LL, Lee YF, Heinlein CA, Liu NC, Chen YT, Shyr CR, Meshul CK, Uno H, Platt KA, Chang C. "Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4." Proceedings of the National Academy of Sciences of the United States of America.. 2004 Oct 19; 101(42):15058-63. Epub 2004 Oct 11.
2004 Oct 15
Lee YF, John M, Falconer A, Edwards S, Clark J, Flohr P, Roe T, Wang R, Shipley J, Grimer RJ, Mangham DC, Thomas JM, Fisher C, Judson I, Cooper CS. "A gene expression signature associated with metastatic outcome in human leiomyosarcomas." Cancer research.. 2004 Oct 15; 64(20):7201-4.
2004 Oct
Chen HH, Lee YF, Chan MH, Lo PS. "The role of N-methyl-D-aspartate receptors in neurobehavioral changes induced by toluene exposure during synaptogenesis." Annals of the New York Academy of Sciences.. 2004 Oct; 1025:552-5.
2004 Jul
Mu X, Lee YF, Liu NC, Chen YT, Kim E, Shyr CR, Chang C. "Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis." Molecular and cellular biology.. 2004 Jul; 24(13):5887-99.
2004 Apr 22
Bao BY, Hu YC, Ting HJ, Lee YF. "Androgen signaling is required for the vitamin D-mediated growth inhibition in human prostate cancer cells." Oncogene.. 2004 Apr 22; 23(19):3350-60.
2003 Nov 21
Kim E, Xie S, Yeh SD, Lee YF, Collins LL, Hu YC, Shyr CR, Mu XM, Liu NC, Chen YT, Wang PH, Chang C. "Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster." The Journal of biological chemistry.. 2003 Nov 21; 278(47):46919-26. Epub 2003 Sep 03.
2003 Mar 14
Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C. "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4." The Journal of biological chemistry.. 2003 Mar 14; 278(11):9353-60. Epub 2003 Jan 08.
2003 Feb
Inui S, Lee YF, Chang E, Shyr CR, Chang C. "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes." Journal of dermatological science. 2003 Feb; 31(1):65-71.
2002 Nov 1
Lee YF, Lin WJ, Huang J, Messing EM, Chan FL, Wilding G, Chang C. "Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells." Cancer research.. 2002 Nov 1; 62(21):6039-44.
2002 Aug
Lee YF, Lee HJ, Chang C. "Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily." The Journal of steroid biochemistry and molecular biology.. 2002 Aug; 81(4-5):291-308.
2001 Aug 3
Lee HJ, Lee YF, Chang C. "TR4 orphan receptor represses the human steroid 21-hydroxylase gene expression through the monomeric AGGTCA motif." Biochemical and biophysical research communications.. 2001 Aug 3; 285(5):1361-8.
1999 Jun 4
Lee YF, Young WJ, Lin WJ, Shyr CR, Chang C. "Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor." The Journal of biological chemistry.. 1999 Jun 4; 274(23):16198-205.
1999 Apr
Inui S, Lee YF, Haake AR, Goldsmith LA, Chang C. "Induction of TR4 orphan receptor by retinoic acid in human HaCaT keratinocytes." The Journal of investigative dermatology.. 1999 Apr; 112(4):426-31.
1999 Apr
Lee HJ, Lee YF, Chang C. "Identification of the histamine H1 receptor gene as a differentially repressed target of the human TR2 orphan receptor." Molecular and cellular biochemistry.. 1999 Apr; 194(1-2):199-207.
1999
Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C. "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily." Proceedings of the National Academy of Sciences of the United States of America.. 1999 96(26):14724-9.
1998 Aug 14
Young WJ, Lee YF, Smith SM, Chang C. "A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway." The Journal of biological chemistry.. 1998 Aug 14; 273(33):20877-85.
1998 May 29
Lee YF, Young WJ, Burbach JP, Chang C. "Negative feedback control of the retinoid-retinoic acid/retinoid X receptor pathway by the human TR4 orphan receptor, a member of the steroid receptor superfamily." The Journal of biological chemistry.. 1998 May 29; 273(22):13437-43.
1997 Jun 9
Chang C, Lee HJ, Lee YF. "Identification of the human aldolase A gene as the first induced target for the TR2 orphan receptor, a member of the steroid hormone receptor superfamily." Biochemical and biophysical research communications.. 1997 Jun 9; 235(1):205-11.
1997 May 2
Lee YF, Pan HJ, Burbach JP, Morkin E, Chang C. "Identification of direct repeat 4 as a positive regulatory element for the human TR4 orphan receptor. A modulator for the thyroid hormone target genes." The Journal of biological chemistry.. 1997 May 2; 272(18):12215-20.

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