Research Bio
Dr. Yeh's research projects focus mainly on studying the roles of the estrogen receptor (ER) and androgen receptor (AR) in urological diseases, including prostate cancer, bladder cancer, benign prostatic hyperplasia (BPH), and in male fertility. Dr. Yeh's lab has successfully utilized a broad range of research strategies, with in vitro biochemistry and molecular biology and in vivo animal models, to delineate the biological roles of the AR and ER. In the earlier stages of her career, Dr. Yeh focused on the mechanistic study of the roles of AR and AR associated proteins in androgen responsive and hormonal refractory prostate cancer. Dr. Yeh was the first scientist to clone AR associated protein in 1996, and to create and report on AR knockout (ARKO) mice using the cre-loxP strategy in 2002. The floxed AR mouse has now been successfully applied to knock out the AR gene in selective types of cells, including cells in prostate, testis, bladder, liver, brain, and others. Continuing with her success, Dr. Yeh's lab now has established genetically engineered ERalpha knockout (ERaKO) mice using this cre-loxP strategy.
Dr. Yeh has published papers to validate the usage of Cre-LoxP ERaKO mice and found the defects of prostate ductal morphogenesis and male fertility in this established ERaKO mice model. This cre-loxP ERaKO model represents a more complete ERaKO mouse model and is being used to delineate ERa roles in urological diseases in Dr. Yeh's lab. Furthermore, the lab has identified new ER binding proteins and ER target genes involved in disease progression.
Overall, Dr. Yeh's research strength is in hormone receptors, mechanisms of tumor suppressor and animal model-related studies in prostate cancer and urological disorders. To date, Dr. Yeh has published 78 peer-reviewed papers and 17 review articles on urological diseases. Currently, Dr. Yeh's research projects are supported by the NCI and the Department of Defense.
2013 Apr 16
Hsu I, Vitkus S, Da J, Yeh S. "Role of oestrogen receptors in bladder cancer development." . 2013 Apr 16; Epub 2013 Apr 16. |
2013 Jan
Vitkus S, Yeh CR, Lin HH, Hsu I, Yu J, Chen M, Yeh S. "Distinct function of estrogen receptor ? in smooth muscle and fibroblast cells in prostate development." Molecular endocrinology (Baltimore, Md.). 2013 Jan 0; 27(1):38-49. Epub 2012 Nov 30. |
2012 Jun
Miyamoto H, Yao JL, Chaux A, Zheng Y, Hsu I, Izumi K, Chang C, Messing EM, Netto GJ, Yeh S. "Expression of androgen and oestrogen receptors and its prognostic significance in urothelial neoplasm of the urinary bladder." BJU international. 2012 Jun 0; 109(11):1716-26. Epub 2012 Jan 05. |
2012 May
Lee SO, Tian J, Huang CK, Ma Z, Lai KP, Hsiao H, Jiang M, Yeh S, Chang C. "Suppressor role of androgen receptor in proliferation of prostate basal epithelial and progenitor cells." The Journal of endocrinology. 2012 May 0; 213(2):173-82. Epub 2012 Mar 05. |
2012 Jan
Chen M, Yeh CR, Chang HC, Vitkus S, Wen XQ, Bhowmick NA, Wolfe A, Yeh S. "Loss of epithelial oestrogen receptor ? inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models." The Journal of pathology. 2012 Jan 0; 226(1):17-27. Epub 2011 Nov 09. |
