Shu-Yuan Yeh, Ph.D.

Shu-Yuan Yeh, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 656
Rochester, NY 14642

Office: (585) 273-2750
Lab: (585) 273-2749

Research Bio

Dr. Yeh's research projects focus mainly on studying the roles of the estrogen receptor (ER) and androgen receptor (AR) in urological diseases, including prostate cancer, bladder cancer, benign prostatic hyperplasia (BPH), and in male fertility. Dr. Yeh's lab has successfully utilized a broad range of research strategies, with in vitro biochemistry and molecular biology and in vivo animal models, to delineate the biological roles of the AR and ER. In the earlier stages of her career, Dr. Yeh focused on the mechanistic study of the roles of AR and AR associated proteins in androgen responsive and hormonal refractory prostate cancer. Dr. Yeh was the first scientist to clone AR associated protein in 1996, and to create and report on AR knockout (ARKO) mice using the cre-loxP strategy in 2002. The floxed AR mouse has now been successfully applied to knock out the AR gene in selective types of cells, including cells in prostate, testis, bladder, liver, brain, and others. Continuing with her success, Dr. Yeh's lab now has established genetically engineered ERalpha knockout (ERaKO) mice using this cre-loxP strategy.



Dr. Yeh has published papers to validate the usage of Cre-LoxP ERaKO mice and found the defects of prostate ductal morphogenesis and male fertility in this established ERaKO mice model. This cre-loxP ERaKO model represents a more complete ERaKO mouse model and is being used to delineate ERa roles in urological diseases in Dr. Yeh's lab. Furthermore, the lab has identified new ER binding proteins and ER target genes involved in disease progression.

Overall, Dr. Yeh's research strength is in hormone receptors, mechanisms of tumor suppressor and animal model-related studies in prostate cancer and urological disorders. To date, Dr. Yeh has published 78 peer-reviewed papers and 17 review articles on urological diseases. Currently, Dr. Yeh's research projects are supported by the NCI and the Department of Defense.

Recent Journal Articles

Showing the 5 most recent journal articles. 93 available »

2014 Jun 19
Chang C, Lee SO, Yeh S, Chang TM. "Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver." Oncogene. 2014 Jun 19; 33(25):3225-34. Epub 2013 Jul 22.
2014 Jun
Slavin S, Yeh CR, Jun D, Yu S, Miyamoto H, Messing EM, Yeh S. "Estrogen receptor ? in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3." Carcinogenesis. 2014 Jun; 35(6):1301-9. Epub 2013 Dec 28.
2014 Mar
Hsu I, Chuang KL, Slavin S, da J, Lim WX, Pang ST, O'Brien JH, Yeh S. "Suppression of ER? signaling via ER? knockout or antagonist protects against bladder cancer development." Carcinogenesis. 2014 Mar; 35(3):651-61. Epub 2013 Oct 22.
2014 Jan
Guancial EA, Bellmunt J, Yeh S, Rosenberg JE, Berman DM. "The evolving understanding of microRNA in bladder cancer." Urologic oncology. 2014 Jan; 32(1):41.e31-40. Epub 2013 Aug 02.
2013 Jun
Hsu I, Vitkus S, Da J, Yeh S. "Role of oestrogen receptors in bladder cancer development." Nature reviews. Urology. 2013 Jun; 10(6):317-26. Epub 2013 Apr 16.

Current Appointments

Professor - Department of Urology (SMD) - Primary
Professor - Department of Pathology and Laboratory Medicine (SMD)

Education

PhD | Endocrinology/Molecular Oncology | Univ Wisconsin-Madison1996
MS | Biochemical Science | National Taiwan University1991
BS | Medical Biotechnology/Immunology | National Taiwan University1988