David I. Yule, Ph.D.

David I. Yule, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester, NY 14642

Office: (585) 273-2154
Lab: (585) 275-6128
Fax: (585) 273-2652

Journal Articles

Showing all 104 journal articles available.

2013 Apr 19
Alzayady KJ, Chandrasekhar R, Yule DI. "Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels." The Journal of biological chemistry.. 2013 Apr 19; 288(16):11122-34. Epub 2013 Mar 11.
2013 Apr 12
Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W. "Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity." The Journal of biological chemistry.. 2013 Apr 12; 288(15):10567-77. Epub 2013 Mar 01.
2013 Mar 28
Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. "Phospholipase C? hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy." Cell.. 2013 Mar 28; 153(1):216-27.
2013 Jan
Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, Yule DI. "Manganese transport via the transferrin mechanism." Neurotoxicology.. 2013 Jan; 34:118-27. Epub 2012 Nov 09.
2012 Nov 15
Patterson K, Catalán MA, Melvin JE, Yule DI, Crampin EJ, Sneyd J. "A quantitative analysis of electrolyte exchange in the salivary duct." American journal of physiology. Gastrointestinal and liver physiology.. 2012 Nov 15; 303(10):G1153-63. Epub 2012 Aug 16.
2012 Jul 21
Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ. "Modelling the effects of calcium waves and oscillations on saliva secretion." Journal of theoretical biology.. 2012 Jul 21; 305:45-53. Epub 2012 Apr 14.
2012 Jul 15
Wagner LE, Yule DI. "Differential regulation of the InsP? receptor type-1 and -2 single channel properties by InsP?, Ca²? and ATP." The Journal of physiology.. 2012 Jul 15; 590(Pt 14):3245-59. Epub 2012 Apr 30.
2012 Jun 1
Bhattacharya S, Verrill DS, Carbone KM, Brown S, Yule DI, Giovannucci DR. "Distinct contributions by ionotropic purinoceptor subtypes to ATP-evoked calcium signals in mouse parotid acinar cells." The Journal of physiology.. 2012 Jun 1; 590(Pt 11):2721-37. Epub 2012 Mar 25.
2012 Feb
Almassy J, Won JH, Begenisich TB, Yule DI. "Apical Ca2+-activated potassium channels in mouse parotid acinar cells." The Journal of general physiology. 2012 Feb; 139(2):121-33.
2012 Jan 1
Park HS, Betzenhauser MJ, Zhang Y, Yule DI. "Regulation of Ca²? release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells." American journal of physiology. Gastrointestinal and liver physiology.. 2012 Jan 1; 302(1):G97-G104. Epub 2011 Sep 29.
2011 Feb 1
Won JH, Zhang Y, Ji B, Logsdon CD, Yule DI. "Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis." Molecular biology of the cell.. 2011 Feb 1; 22(3):421-36.
2010 Nov 26
Masuda W, Betzenhauser MJ, Yule DI. "InsP3R-associated cGMP kinase substrate determines inositol 1,4,5-trisphosphate receptor susceptibility to phosphoregulation by cyclic nucleotide-dependent kinases." The Journal of biological chemistry.. 2010 Nov 26; 285(48):37927-38. Epub 2010 Sep 27.
2010 Nov
Yule DI. "Pancreatic acinar cells: molecular insight from studies of signal-transduction using transgenic animals." The international journal of biochemistry & cell biology. 2010 Nov; 42(11):1757-61. Epub 2010 Jul 15.
2010 Oct 21
Palk L, Sneyd J, Shuttleworth TJ, Yule DI, Crampin EJ. "A dynamic model of saliva secretion." Journal of theoretical biology.. 2010 Oct 21; 266(4):625-40. Epub 2010 Jun 25.
2010 Jun
Yule DI, Betzenhauser MJ, Joseph SK. "Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis." Cell calcium. 2010 Jun; 47(6):469-79. Epub 2010 May 26.
2010 Feb
Brown DA, Yule DI. "Protein kinase A regulation of P2X(4) receptors: requirement for a specific motif in the C-terminus." Biochimica et biophysica acta.. 2010 Feb; 1803(2):275-87. Epub 2009 Dec 21.
2010 Jan
Ryu SY, Peixoto PM, Won JH, Yule DI, Kinnally KW. "Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry." Cell calcium. 2010 Jan; 47(1):65-76. Epub 2010 Jan 06.
2009 Oct 2
Park KM, Yule DI, Bowers WJ. "Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter." The Journal of biological chemistry.. 2009 Oct 2; 284(40):27557-66. Epub 2009 Aug 07.
2009 Sep 11
Betzenhauser MJ, Fike JL, Wagner LE, Yule DI. "Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937." The Journal of biological chemistry.. 2009 Sep 11; 284(37):25116-25. Epub 2009 Jul 16.
2009 Sep
Gin E, Wagner LE, Yule DI, Sneyd J. "Inositol trisphosphate receptor and ion channel models based on single-channel data." Chaos (Woodbury, N.Y.). 2009 Sep; 19(3):037104.
2009 Jun 12
Betzenhauser MJ, Wagner LE, Park HS, Yule DI. "ATP regulation of type-1 inositol 1,4,5-trisphosphate receptor activity does not require walker A-type ATP-binding motifs." The Journal of biological chemistry.. 2009 Jun 12; 284(24):16156-63. Epub 2009 Apr 22.
2009 May 20
Gin E, Falcke M, Wagner LE, Yule DI, Sneyd J. "A kinetic model of the inositol trisphosphate receptor based on single-channel data." Biophysical journal.. 2009 May 20; 96(10):4053-62.
2009 Apr 7
Gin E, Falcke M, Wagner LE, Yule DI, Sneyd J. "Markov chain Monte Carlo fitting of single-channel data from inositol trisphosphate receptors." Journal of theoretical biology.. 2009 Apr 7; 257(3):460-74. Epub 2008 Dec 30.
2008 Nov 28
Park KM, Yule DI, Bowers WJ. "Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor." The Journal of biological chemistry.. 2008 Nov 28; 283(48):33069-79. Epub 2008 Oct 06.
2008 Nov
Betzenhauser MJ, Wagner LE, Won JH, Yule DI. "Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation." Methods (San Diego, Calif.). 2008 Nov; 46(3):177-82. Epub 2008 Oct 16.
2008 Sep 19
Park HS, Betzenhauser MJ, Won JH, Chen J, Yule DI. "The type 2 inositol (1,4,5)-trisphosphate (InsP3) receptor determines the sensitivity of InsP3-induced Ca2+ release to ATP in pancreatic acinar cells." The Journal of biological chemistry.. 2008 Sep 19; 283(38):26081-8. Epub 2008 Jul 24.
2008 Sep
Warner JD, Peters CG, Saunders R, Won JH, Betzenhauser MJ, Gunning WT, Yule DI, Giovannucci DR. "Visualizing form and function in organotypic slices of the adult mouse parotid gland." American journal of physiology. Gastrointestinal and liver physiology.. 2008 Sep; 295(3):G629-40. Epub 2008 Jul 31.
2008 Aug 1
Betzenhauser MJ, Wagner LE, Iwai M, Michikawa T, Mikoshiba K, Yule DI. "ATP modulation of Ca2+ release by type-2 and type-3 inositol (1, 4, 5)-triphosphate receptors. Differing ATP sensitivities and molecular determinants of action." The Journal of biological chemistry.. 2008 Aug 1; 283(31):21579-87. Epub 2008 May 27.
2008 Aug 1
Wagner LE, Joseph SK, Yule DI. "Regulation of single inositol 1,4,5-trisphosphate receptor channel activity by protein kinase A phosphorylation." The Journal of physiology.. 2008 Aug 1; 586(Pt 15):3577-96. Epub 2008 Jun 05.
2008 Feb 1
Schug ZT, da Fonseca PC, Bhanumathy CD, Wagner L, Zhang X, Bailey B, Morris EP, Yule DI, Joseph SK. "Molecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment." The Journal of biological chemistry.. 2008 Feb 1; 283(5):2939-48. Epub 2007 Nov 19.
2007 Sep 7
Gin E, Crampin EJ, Brown DA, Shuttleworth TJ, Yule DI, Sneyd J. "A mathematical model of fluid secretion from a parotid acinar cell." Journal of theoretical biology.. 2007 Sep 7; 248(1):64-80. Epub 2007 May 03.
2007 Feb
Brown DA, Yule DI. "Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation." Biochimica et biophysica acta.. 2007 Feb; 1773(2):166-75. Epub 2006 Sep 19.
2007
Won JH, Cottrell WJ, Foster TH, Yule DI. "Ca2+ release dynamics in parotid and pancreatic exocrine acinar cells evoked by spatially limited flash photolysis." American journal of physiology. Gastrointestinal and liver physiology.. 2007 293(6):G1166-77. Epub 2007 Sep 27.
2006 Jul
Won JH, Yule DI. "Measurement of Ca2+ signaling dynamics in exocrine cells with total internal reflection microscopy." American journal of physiology. Gastrointestinal and liver physiology.. 2006 Jul; 291(1):G146-55. Epub 2006 Feb 16.
2006 Jun 23
Wagner LE, Betzenhauser MJ, Yule DI. "ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A." The Journal of biological chemistry.. 2006 Jun 23; 281(25):17410-9. Epub 2006 Apr 18.
2006 Feb 10
Khan MT, Wagner L, Yule DI, Bhanumathy C, Joseph SK. "Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors." The Journal of biological chemistry.. 2006 Feb 10; 281(6):3731-7. Epub 2005 Dec 06.
2006 Feb 7
Sneyd J, Tsaneva-Atanasova K, Reznikov V, Bai Y, Sanderson MJ, Yule DI. "A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations." Proceedings of the National Academy of Sciences of the United States of America.. 2006 Feb 7; 103(6):1675-80. Epub 2006 Jan 30.
2005 Nov
Chen Y, Warner JD, Yule DI, Giovannucci DR. "Spatiotemporal analysis of exocytosis in mouse parotid acinar cells." American journal of physiology. Cell physiology.. 2005 Nov; 289(5):C1209-19. Epub 2005 Jul 06.
2005 May 1
Mignen O, Thompson JL, Yule DI, Shuttleworth TJ. "Agonist activation of arachidonate-regulated Ca2+-selective (ARC) channels in murine parotid and pancreatic acinar cells." The Journal of physiology.. 2005 May 1; 564(Pt 3):791-801. Epub 2005 Mar 10.
2005 Mar
Tsaneva-Atanasova K, Yule DI, Sneyd J. "Calcium oscillations in a triplet of pancreatic acinar cells." Biophysical journal.. 2005 Mar; 88(3):1535-51. Epub 2004 Dec 13.
2004 Oct 29
Wagner LE, Li WH, Joseph SK, Yule DI. "Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor." The Journal of biological chemistry.. 2004 Oct 29; 279(44):46242-52. Epub 2004 Aug 11.
2004 Sep 17
Brown DA, Bruce JI, Straub SV, Yule DI. "cAMP potentiates ATP-evoked calcium signaling in human parotid acinar cells." The Journal of biological chemistry.. 2004 Sep 17; 279(38):39485-94. Epub 2004 Jul 19.
2004 Jun 1
Gunter TE, Yule DI, Gunter KK, Eliseev RA, Salter JD. "Calcium and mitochondria." FEBS letters.. 2004 Jun 1; 567(1):96-102.
2004 Mar 26
Bruce JI, Giovannucci DR, Blinder G, Shuttleworth TJ, Yule DI. "Modulation of [Ca2+]i signaling dynamics and metabolism by perinuclear mitochondria in mouse parotid acinar cells." The Journal of biological chemistry.. 2004 Mar 26; 279(13):12909-17. Epub 2003 Dec 29.
2004 Feb 3
Yule DI, Sneyd J, Thompson JL, Tsaneva-Atanasova K, Shuttleworth TJ, Yule DI, Thompson JL, Shuttleworth TJ. "Control of calcium oscillations by membrane fluxes." Proceedings of the National Academy of Sciences of the United States of America.. 2004 Feb 3; 101(5):1392-6. Epub 2004 Jan 20.
2004
Straub SV, Wagner LE, Bruce JI, Yule DI. "Modulation of cytosolic calcium signaling by protein kinase A-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors." Biological research.. 2004 37(4):593-602.
2003 Nov 14
Wagner LE, Li WH, Yule DI. "Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases: a mutational analysis of the functionally important sites in the S2+ and S2- splice variants." The Journal of biological chemistry.. 2003 Nov 14; 278(46):45811-7. Epub 2003 Aug 25.
2003 Nov
Brown DA, Melvin JE, Yule DI. "Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells." American journal of physiology. Gastrointestinal and liver physiology.. 2003 Nov; 285(5):G804-12. Epub 2003 Jul 03.
2003 Oct
Yule DI, Straub SV, Bruce JI. "Modulation of Ca2+ oscillations by phosphorylation of Ins(1,4,5)P3 receptors." Biochemical Society transactions. 2003 Oct; 31(Pt 5):954-7.
2003 Sep
Sneyd J, Tsaneva-Atanasova K, Bruce JI, Straub SV, Giovannucci DR, Yule DI. "A model of calcium waves in pancreatic and parotid acinar cells." Biophysical journal.. 2003 Sep; 85(3):1392-405.
2003
Bruce JI, Straub SV, Yule DI. "Crosstalk between cAMP and Ca2+ signaling in non-excitable cells." Cell calcium. 2003 34(6):431-44.
2002 Aug 30
Straub SV, Giovannucci DR, Bruce JI, Yule DI. "A role for phosphorylation of inositol 1,4,5-trisphosphate receptors in defining calcium signals induced by Peptide agonists in pancreatic acinar cells." The Journal of biological chemistry.. 2002 Aug 30; 277(35):31949-56. Epub 2002 Jun 13.
2002 Apr 15
Giovannucci DR, Bruce JI, Straub SV, Arreola J, Sneyd J, Shuttleworth TJ, Yule DI. "Cytosolic Ca(2+) and Ca(2+)-activated Cl(-) current dynamics: insights from two functionally distinct mouse exocrine cells." The Journal of physiology.. 2002 Apr 15; 540(Pt 2):469-84.
2002 Jan 11
Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI. "Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling." The Journal of biological chemistry.. 2002 Jan 11; 277(2):1340-8. Epub 2001 Nov 01.
2002
Bruce JI, Yule DI, Shuttleworth TJ. "Ca2+-dependent protein kinase--a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells." The Journal of biological chemistry.. 2002 277(50):48172-81. Epub 2002 Oct 03.
2001 Jun 15
Beutner G, Sharma VK, Giovannucci DR, Yule DI, Sheu SS. "Identification of a ryanodine receptor in rat heart mitochondria." The Journal of biological chemistry.. 2001 Jun 15; 276(24):21482-8. Epub 2001 Apr 10.
2001 May
Yule DI. "Subtype-specific regulation of inositol 1,4,5-trisphosphate receptors: controlling calcium signals in time and space." The Journal of general physiology. 2001 May; 117(5):431-4.
2000 Oct 27
Giovannucci DR, Groblewski GE, Sneyd J, Yule DI. "Targeted phosphorylation of inositol 1,4,5-trisphosphate receptors selectively inhibits localized Ca2+ release and shapes oscillatory Ca2+ signals." The Journal of biological chemistry.. 2000 Oct 27; 275(43):33704-11.
2000 Oct
Straub SV, Giovannucci DR, Yule DI. "Calcium wave propagation in pancreatic acinar cells: functional interaction of inositol 1,4,5-trisphosphate receptors, ryanodine receptors, and mitochondria." The Journal of general physiology. 2000 Oct; 116(4):547-60.
2000 Aug
Giovannucci DR, Sneyd J, Groblewski GE, Yule DI. "Modulation of InsP3 receptor properties by phosphorylation: targeting of PKA to InsP3 receptors shapes oscillatory calcium signals in pancreatic acinar cells." Journal of Korean medical science. 2000 Aug; 15 Suppl:S55-6.
1999 Jun
LeBeau AP, Yule DI, Groblewski GE, Sneyd J. "Agonist-dependent phosphorylation of the inositol 1,4,5-trisphosphate receptor: A possible mechanism for agonist-specific calcium oscillations in pancreatic acinar cells." The Journal of general physiology. 1999 Jun; 113(6):851-72.
1999 May
Wojcikiewicz RJ, Ernst SA, Yule DI. "Secretagogues cause ubiquitination and down-regulation of inositol 1, 4,5-trisphosphate receptors in rat pancreatic acinar cells." Gastroenterology.. 1999 May; 116(5):1194-201.
1999 Jan
Yule DI, Baker CW, Williams JA. "Calcium signaling in rat pancreatic acinar cells: a role for Galphaq, Galpha11, and Galpha14." The American journal of physiology.. 1999 Jan; 276(1 Pt 1):G271-9.
1998 Sep
Giovannucci DR, Yule DI, Stuenkel EL. "Optical measurement of stimulus-evoked membrane dynamics in single pancreatic acinar cells." The American journal of physiology.. 1998 Sep; 275(3 Pt 1):C732-9.
1997 Jun 20
Ohnishi H, Ernst SA, Yule DI, Baker CW, Williams JA. "Heterotrimeric G-protein Gq/11 localized on pancreatic zymogen granules is involved in calcium-regulated amylase secretion." The Journal of biological chemistry.. 1997 Jun 20; 272(25):16056-61.
1997 May
Zhang W, Sarosi G, Barnhart D, Yule DI, Mulholland MW. "Endothelin-activated calcium signaling in enteric glia derived from neonatal guinea pig." The American journal of physiology.. 1997 May; 272(5 Pt 1):G1175-85.
1997 Apr 4
Yule DI, Ernst SA, Ohnishi H, Wojcikiewicz RJ. "Evidence that zymogen granules are not a physiologically relevant calcium pool. Defining the distribution of inositol 1,4,5-trisphosphate receptors in pancreatic acinar cells." The Journal of biological chemistry.. 1997 Apr 4; 272(14):9093-8.
1997
Ohnishi H, Samuelson LC, Yule DI, Ernst SA, Williams JA. "Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice." The Journal of clinical investigation.. 1997 100(12):3044-52.
1997
Westfall MV, Pasyk KA, Yule DI, Samuelson LC, Metzger JM. "Ultrastructure and cell-cell coupling of cardiac myocytes differentiating in embryonic stem cell cultures." Cell motility and the cytoskeleton. 1997 36(1):43-54.
1997
Williams JA, Groblewski GE, Ohnishi H, Yule DI. "Stimulus-secretion coupling of pancreatic digestive enzyme secretion." Digestion. 1997 58 Suppl 1:42-5.
1996 Oct
Yule DI, Stuenkel E, Williams JA. "Intercellular calcium waves in rat pancreatic acini: mechanism of transmission." The American journal of physiology.. 1996 Oct; 271(4 Pt 1):C1285-94.
1996 Sep
Palmer RK, Yule DI, McEwen EL, Williams JA, Fisher SK. "Intra- and intercellular calcium signaling in human neuroepithelioma cells." Journal of lipid mediators and cell signalling. 1996 Sep; 14(1-3):169-74.
1996 Jul
Palmer RK, Yule DI, Shewach DS, Williams JA, Fisher SK. "Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells." The American journal of physiology.. 1996 Jul; 271(1 Pt 1):C43-53.
1996 Apr
Kimball BC, Yule DI, Mulholland MW. "Extracellular ATP mediates Ca2+ signaling in cultured myenteric neurons via a PLC-dependent mechanism." The American journal of physiology.. 1996 Apr; 270(4 Pt 1):G587-93.
1996 Apr
Kimball BC, Yule DI, Mulholland MW. "Caffeine- and ryanodine-sensitive Ca2+ stores in cultured guinea pig myenteric neurons." The American journal of physiology.. 1996 Apr; 270(4 Pt 1):G594-603.
1995 Nov
Deutsch DE, Williams JA, Yule DI. "Halothane and octanol block Ca2+ oscillations in pancreatic acini by multiple mechanisms." The American journal of physiology.. 1995 Nov; 269(5 Pt 1):G779-88.
1995 Sep
Yang J, Williams JA, Yule DI, Logsdon CD. "Mutation of carboxyl-terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization." Molecular pharmacology.. 1995 Sep; 48(3):477-85.
1995 Apr
Massa E, Kelly KM, Yule DI, MacDonald RL, Uhler MD. "Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms." Molecular pharmacology.. 1995 Apr; 47(4):707-16.
1995 Jan 26
Simeone DM, Yule DI, Logsdon CD, Williams JA. "Ca2+ signaling through secretagogue and growth factor receptors on pancreatic AR42J cells." Regulatory peptides. 1995 Jan 26; 55(2):197-206.
1994 Nov 30
Bode HP, Yule DI, Fehmann HC, Göke B, Williams JA. "Spontaneous calcium oscillations in clonal endocrine pancreatic glucagon-secreting cells." Biochemical and biophysical research communications.. 1994 Nov 30; 205(1):435-40.
1994 Aug 15
Yule DI, Kim ET, Williams JA. "Tyrosine kinase inhibitors attenuate "capacitative" Ca2+ influx in rat pancreatic acinar cells." Biochemical and biophysical research communications.. 1994 Aug 15; 202(3):1697-704.
1994 Jun
Blevins GT, van de Westerlo EM, Yule DI, Williams JA. "Characterization of cholecystokininA receptor agonist activity by a family of cholecystokininB receptor antagonists." The Journal of pharmacology and experimental therapeutics.. 1994 Jun; 269(3):911-6.
1994 Feb
Duan RD, Wagner AC, Yule DI, Williams JA. "Multiple inhibitory effects of genistein on stimulus-secretion coupling in rat pancreatic acini." The American journal of physiology.. 1994 Feb; 266(2 Pt 1):G303-10.
1994
Yule DI, Williams JA. "CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic acinar cell CCKA receptor." Peptides. 1994 15(6):1045-51.
1994
Palmer RK, Yule DI, McEwen EL, Williams JA, Fisher SK. "Agonist-specific calcium signaling and phosphoinositide hydrolysis in human SK-N-MCIXC neuroepithelioma cells." Journal of neurochemistry. 1994 63(6):2099-107.
1993 Nov
Yule DI, Tseng MJ, Williams JA, Logdson CD. "A cloned CCK-A receptor transduces multiple signals in response to full and partial agonists." The American journal of physiology.. 1993 Nov; 265(5 Pt 1):G999-1004.
1993 Jun 15
Yule DI, Wu D, Essington TE, Shayman JA, Williams JA. "Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells." The Journal of biological chemistry.. 1993 Jun 15; 268(17):12353-8.
1993 Apr
Yule DI, Essington TE, Williams JA. "Pilocarpine and carbachol exhibit markedly different patterns of Ca2+ signaling in rat pancreatic acinar cells." The American journal of physiology.. 1993 Apr; 264(4 Pt 1):G786-91.
1992 Aug 12
Yule DI, Blevins GT, Wagner AC, Williams JA. "Endothelin increases [Ca2+]i in rat pancreatic acinar cells by intracellular release but fails to increase amylase secretion." Biochimica et biophysica acta.. 1992 Aug 12; 1136(2):175-80.
1992 Jul 15
Yule DI, Williams JA. "U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells." The Journal of biological chemistry.. 1992 Jul 15; 267(20):13830-5.
1992
Wagner AC, Wishart MJ, Yule DI, Williams JA. "Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling." The American journal of physiology.. 1992 263(6 Pt 1):C1172-80.
1991 Oct
Rapoport SI, Pettigrew KD, Schapiro MB. "Discordance and concordance of dementia of the Alzheimer type (DAT) in monozygotic twins indicate heritable and sporadic forms of Alzheimer's disease." Neurology.. 1991 Oct; 41(10):1549-53.
1991 May 31
Yule DI, Williams JA. "Mastoparan induces oscillations of cytosolic Ca2+ in rat pancreatic acinar cells." Biochemical and biophysical research communications.. 1991 May 31; 177(1):159-65.
1991 Feb
Campistol JM, Montoliu J. "Chronic renal failure: causes, diagnosis, and therapy." Comprehensive therapy. 1991 Feb; 17(2):51-62.
1991
Petersen OH, Gallacher DV, Wakui M, Yule DI, Petersen CC, Toescu EC. "Receptor-activated cytoplasmic Ca2+ oscillations in pancreatic acinar cells: generation and spreading of Ca2+ signals." Cell calcium. 1991 12(2-3):135-44.
1991
Yule DI, Lawrie AM, Gallacher DV. "Acetylcholine and cholecystokinin induce different patterns of oscillating calcium signals in pancreatic acinar cells." Cell calcium. 1991 12(2-3):145-51.
1990 Nov 12
Dunne MJ, Yule DI, Gallacher DV, Petersen OH. "Effects of alanine on insulin-secreting cells: patch-clamp and single cell intracellular Ca2+ measurements." Biochimica et biophysica acta.. 1990 Nov 12; 1055(2):157-64.
1990 Jul
Gallacher DV, Hanley MR, Petersen OH, Roberts ML, Squire-Pollard LG, Yule DI. "Substance P and bombesin elevate cytosolic Ca2+ by different molecular mechanisms in a rat pancreatic acinar cell line." The Journal of physiology.. 1990 Jul; 426:193-207.
1990 Mar
Osipchuk YV, Wakui M, Yule DI, Gallacher DV, Petersen OH. "Cytoplasmic Ca2+ oscillations evoked by receptor stimulation, G-protein activation, internal application of inositol trisphosphate or Ca2+: simultaneous microfluorimetry and Ca2+ dependent Cl- current recording in single pancreatic acinar cells." The EMBO journal. 1990 Mar; 9(3):697-704.
1990 Mar
Dunne MJ, Yule DI, Gallacher DV, Petersen OH. "Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells." The Journal of membrane biology. 1990 Mar; 114(1):53-60.
1990 Feb
Dunne MJ, Yule DI, Gallacher DV, Petersen OH. "Stimulant-evoked depolarization and increase in [Ca2+]i in insulin-secreting cells is dependent on external Na+." The Journal of membrane biology. 1990 Feb; 113(2):131-8.
1989
Martin SC, Yule DI, Dunne MJ, Gallacher DV, Petersen OH. "Vasopressin directly closes ATP-sensitive potassium channels evoking membrane depolarization and an increase in the free intracellular Ca2+ concentration in insulin-secreting cells." The EMBO journal. 1989 8(12):3595-9.
1989
Dunne MJ, Yule DI, Gallacher DV, Petersen OH. "Cromakalim (BRL 34915) and diazoxide activate ATP-regulated potassium channels in insulin-secreting cells." Pflügers Archiv : European journal of physiology.. 1989 414 Suppl 1:S154-5.
1988 Nov 7
Yule DI, Gallacher DV. "Oscillations of cytosolic calcium in single pancreatic acinar cells stimulated by acetylcholine." FEBS letters.. 1988 Nov 7; 239(2):358-62.

Books

2012
Williams, John A., and Yule, David I.. "Stimulum-secretion Coupling in Pancreatic Acinar Cells". Physiology of the Gastrointestinal Tract, Two Volume Set. Johnson L, Ghishan F, Kaunitz J, Merchant J, Said H, Wood J. : Elsevier, 2012. 1361-1398
2006
Williams, JA; and Yule, DI. "Stimulus-Scretion Coupling in the Pancreatic Acinus.". Physiology of the Gastrointestinal Tract. Johnson, LR. : Raven Press, 2006. 1337-1369
1994
Yule, DI; and Williams, JA. "Stimulus-secretion coupling in the pancreatic acinus.". Physiology of the Gastrointestinal Tract. Johnson, LR. : Raven Press, 1994. 1447-1471
1993
Williams, JA; Yule, DI; Go, VLW; Dimagn, EP. "Stimulus-secretion coupling in rat pancreatic acinar cells.". Pancreas: Biology, Pathobiology and Disease. New York: Raven Press, 1993.