Research Bio
Toxicology of Inhaled Ultrafine Particles and Engineered Nanomaterials
Our laboratory has focused for several years on the toxicology of inhaled ultrafine particles (UFPs), the most numerous size fraction of particulate air pollution. Interests include the impacts of age, gaseous co-pollutant exposure, and health status on the response(s) to inhaled UFPs. We are also interested in determining the basis for potential adverse effects of inhaled particles in the cardiovascular and central nervous systems.
This research focus has naturally led to our work with engineered nanomaterials. The research commonalities between UFP and nanomaterials are numerous, including the kinetics of tissue distribution following exposure, mechanisms of response related to oxidative stress, particle-protein interactions, and the physicochemical characteristics of the particles that determine response. Our research aims are met by using a combination of animal and cell culture models as well as detailed particle characterization.
In addition to looking for nanosized particles in tissues via chemical and microscopic means, responses are determined by measuring markers of inflammation and oxidative stress in the lung lining fluid, lung tissue, blood, circulating inflammatory cells, and extrapulmonary tissues (e.g. heart, liver, spleen, kidney, brain regions). We also have specific projects focused on cardiovascular stability and neurodegeneration following exposures to UFPs and nanomaterials.
2013 Apr 17
Mortensen LJ, Jatana S, Gelein R, Debenedetto A, de Mesy Bentley KL, Beck L, Elder A, Delouise L. "Quantification of quantum dot murine skin penetration with UVR barrier impairment." Nanotoxicology. 2013 Apr 17; Epub 2013 Apr 17. |
2012 Jul 16
Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdörster G. "Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data." Toxicology. 2012 Jul 16; 297(1-3):1-9. Epub 2012 Apr 02. |
2012 Mar 27
Shi M, Kwon HS, Peng Z, Elder A, Yang H. "Effects of surface chemistry on the generation of reactive oxygen species by copper nanoparticles." ACS nano. 2012 Mar 27; 6(3):2157-64. Epub 2012 Mar 05. |
2011 Sep 5
Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G. "Validation of an LDH assay for assessing nanoparticle toxicity." Toxicology. 2011 Sep 5; 287(1-3):99-104. Epub 2011 Jun 23. |
2010
Kim, S.C.; Chen, D.; Qi, C.; Gelein, R.M.; Finkelstein, J.N.; Elder, A.; Bentley, K.; Oberdorster, G.; Pui, D.Y.H. "A nanoparticle dispersion method of in vitro and in vivo nanotoxicity study". Nanotoxicology. 2010; 4(1): 42-51. |
