Hartmut K. Land, Ph.D.

Hartmut K. Land, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, NY 14642

Office: (585) 273-1441
Lab: (585) 273-1445
Administrative: (585) 273-1441
Fax: (585) 273-1450

Journal Articles

Showing all 65 journal articles available.

2014 Aug 15
McCall MN, McMurray H, Land H, Almudevar A. "On non-detects in qPCR data." Bioinformatics. 2014 Aug 15; 30(16):2310-6. Epub 2014 Apr 23.
2014 May 22
Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H. "Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression." Cell reports. 2014 May 22; 7(4):1143-55. Epub 2014 May 01.
2013 Aug 15
Sampson ER, McMurray HR, Hassane DC, Newman L, Salzman P, Jordan CT, Land H. "Gene signature critical to cancer phenotype as a paradigm for anticancer drug discovery." Oncogene. 2013 Aug 15; 32(33):3809-18. Epub 2012 Sep 10.
2013 Jun 18
Hu X, Dutta P, Tsurumi A, Li J, Wang J, Land H, Li WX. "Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth." Proceedings of the National Academy of Sciences of the United States of America. 2013 Jun 18; 110(25):10213-8. Epub 2013 Jun 03.
2013 Jan 15
Gaur K, Li J, Wang D, Dutta P, Yan SJ, Tsurumi A, Land H, Wu G, Li WX. "The Birt-Hogg-Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis." Human molecular genetics. 2013 Jan 15; 22(2):284-99. Epub 2012 Oct 16.
2012 Sep 27
Smith B, Land H. "Anticancer activity of the cholesterol exporter ABCA1 gene." Cell reports. 2012 Sep 27; 2(3):580-90. Epub 2012 Sep 13.
2012 Sep 7
Ashton JM, Balys M, Neering SJ, Hassane DC, Cowley G, Root DE, Miller PG, Ebert BL, McMurray HR, Land H, Jordan CT. "Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells." Cell stem cell. 2012 Sep 7; 11(3):359-72. Epub 2012 Aug 02.
2012 Mar 15
O'Dell MR, Huang JL, Whitney-Miller CL, Deshpande V, Rothberg P, Grose V, Rossi RM, Zhu AX, Land H, Bardeesy N, Hezel AF. "Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma." Cancer research. 2012 Mar 15; 72(6):1557-67. Epub 2012 Jan 20.
2011
Almudevar A, McCall MN, McMurray H, Land H. "Fitting Boolean networks from steady state perturbation data." Statistical applications in genetics and molecular biology. 2011 10(1)Epub 2011 Oct 05.
2008 Jun 19
McMurray HR, Sampson ER, Compitello G, Kinsey C, Newman L, Smith B, Chen SR, Klebanov L, Salzman P, Yakovlev A, Land H. "Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype." Nature. 2008 Jun 19; 453(7198):1112-6. Epub 2008 May 25.
2007 Mar
Xia M, Land H. "Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility." Nature structural & molecular biology. 2007 Mar; 14(3):215-23. Epub 2007 Feb 18.
2005
Klebanov, L.; Gordon, A.; Xiao, Y.; Land, H.; Yakovlev, A. "A permutation test motivated by microarray data analysis". Computational Statistics and Data Analysis. 2005; 50: 3619-3628.
2001 Feb
Roper E, Weinberg W, Watt FM, Land H. "p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes." EMBO reports. 2001 Feb; 2(2):145-50.
2001
Deleu L, Shellard S, Alevizopoulos K, Amati B, Land H. "Recruitment of TRRAP required for oncogenic transformation by E1A." Oncogene. 2001 20(57):8270-5.
1999 Oct 1
Perez-Roger I, Kim SH, Griffiths B, Sewing A, Land H. "Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1)." The EMBO journal. 1999 Oct 1; 18(19):5310-20.
1997 Sep
Sewing A, Wiseman B, Lloyd AC, Land H. "High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1." Molecular and cellular biology. 1997 Sep; 17(9):5588-97.
1997 May 22
Pérez-Roger I, Solomon DL, Sewing A, Land H. "Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes." Oncogene. 1997 May 22; 14(20):2373-81.
1997 Mar 1
Lloyd AC, Obermüller F, Staddon S, Barth CF, McMahon M, Land H. "Cooperating oncogenes converge to regulate cyclin/cdk complexes." Genes & development. 1997 Mar 1; 11(5):663-77.
1996 Oct 15
Bhakoo KK, Williams SR, Florian CL, Land H, Noble MD. "Immortalization and transformation are associated with specific alterations in choline metabolism." Cancer research. 1996 Oct 15; 56(20):4630-5.
1995 Nov 2
Solomon DL, Philipp A, Land H, Eilers M. "Expression of cyclin D1 mRNA is not upregulated by Myc in rat fibroblasts." Oncogene. 1995 Nov 2; 11(9):1893-7.
1995
Land H. "Transformation of primary rat embryo cells." Methods in enzymology. 1995 254:37-41.
1994 Aug 30
Evan G, Harrington E, Fanidi A, Land H, Amati B, Bennett M. "Integrated control of cell proliferation and cell death by the c-myc oncogene." Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 1994 Aug 30; 345(1313):269-75.
1994 Feb
Amati B, Land H. "Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death." Current opinion in genetics & development. 1994 Feb; 4(1):102-8.
1994
Evan,G.; Harrington,E.; Fanidi,A.; Land,H.; Amati,B.; Bennett,M.;. "Integrated control of cell proliferation and cell death by the c-myc oncogene". Philosophical transactions of the Royal Society of London. Series B: Biological sciences. 1994; 345(1313): 269-275. Link
1993 Nov 25
Solomon DL, Amati B, Land H. "Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers." Nucleic acids research. 1993 Nov 25; 21(23):5372-6.
1993 Jan 29
Amati B, Brooks MW, Levy N, Littlewood TD, Evan GI, Land H. "Oncogenic activity of the c-Myc protein requires dimerization with Max." Cell. 1993 Jan 29; 72(2):233-45.
1993
Amati B, Littlewood TD, Evan GI, Land H. "The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max." The EMBO journal. 1993 12(13):5083-7.
1992 Oct 1
Amati B, Dalton S, Brooks MW, Littlewood TD, Evan GI, Land H. "Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max." Nature. 1992 Oct 1; 359(6394):423-6.
1992 Sep
Littlewood TD, Amati B, Land H, Evan GI. "Max and c-Myc/Max DNA-binding activities in cell extracts." Oncogene. 1992 Sep; 7(9):1783-92.
1992 Apr 3
Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC. "Induction of apoptosis in fibroblasts by c-myc protein." Cell. 1992 Apr 3; 69(1):119-28.
1991
Morgenstern JP, Land H. "Choice and manipulation of retroviral vectors." Methods in molecular biology. 1991 7:181-206.
1990 Sep
Penn LJ, Brooks MW, Laufer EM, Littlewood TD, Morgenstern JP, Evan GI, Lee WM, Land H. "Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping." Molecular and cellular biology. 1990 Sep; 10(9):4961-6.
1990 Aug
Bögler O, Wren D, Barnett SC, Land H, Noble M. "Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells." Proceedings of the National Academy of Sciences of the United States of America. 1990 Aug; 87(16):6368-72.
1990 Jun 25
Morgenstern JP, Land H. "Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line." Nucleic acids research. 1990 Jun 25; 18(12):3587-96.
1990 Jun
Wiehle RD, Helftenbein G, Land H, Neumann K, Beato M. "Establishment of rat endometrial cell lines by retroviral mediated transfer of immortalizing and transforming oncogenes." Oncogene. 1990 Jun; 5(6):787-94.
1990 Apr
Penn LJ, Brooks MW, Laufer EM, Land H. "Negative autoregulation of c-myc transcription." The EMBO journal. 1990 Apr; 9(4):1113-21.
1990 Feb 25
Morgenstern JP, Land H. "A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells." Nucleic acids research. 1990 Feb 25; 18(4):1068.
1990 Feb
Penn LJ, Laufer EM, Land H. "C-MYC: evidence for multiple regulatory functions." Seminars in cancer biology. 1990 Feb; 1(1):69-80.
1990
von Deimling A, Aguzzi A, Kleihues P, Land H, Wiestler OD. "[Induction of primitive neuroectodermal tumors by oncogene complementation]." Verhandlungen der Deutschen Gesellschaft für Pathologie. 1990 74:432-6.
1990
Noble M, Barnett SC, Bögler O, Land H, Wolswijk G, Wren D. "Control of division and differentiation in oligodendrocyte-type-2 astrocyte progenitor cells." Ciba Foundation symposium. 1990 150:227-43; discussion 244-9.
1989 May
Beddington RS, Morgernstern J, Land H, Hogan A. "An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis." Development. 1989 May; 106(1):37-46.
1989 Apr
Compere SJ, Baldacci P, Sharpe AH, Thompson T, Land H, Jaenisch R. "The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors." Proceedings of the National Academy of Sciences of the United States of America. 1989 Apr; 86(7):2224-8.
1989 Mar 24
Thompson TC, Southgate J, Kitchener G, Land H. "Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ." Cell. 1989 Mar 24; 56(6):917-30.
1989
Ridley AJ, Davis JB, Stroobant P, Land H. "Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cells." The Journal of cell biology. 1989 109(6 Pt 2):3419-24.
1988 Jun
Ridley AJ, Paterson HF, Noble M, Land H. "Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation." The EMBO journal. 1988 Jun; 7(6):1635-45.
1986 Jun
Land H, Chen AC, Morgenstern JP, Parada LF, Weinberg RA. "Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts." Molecular and cellular biology. 1986 Jun; 6(6):1917-25.
1985
Parada LF, Land H, Chen A, Morganstern J, Weinberg RA. "Cooperation between cellular oncogenes in the transformation of primary rat embryo fibroblasts." Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progrès en virologie médicale. 1985 32:115-28.
1984
Lenoir GM, Land H, Parada LF, Cunningham JM, Weinberg RA. "Activated oncogenes in Burkitt's lymphoma." Current topics in microbiology and immunology. 1984 113:6-14.
1984
Parada LF, Land H, Weinberg RA, Wolf D, Rotter V. "Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation." Nature. 1984 312(5995):649-51.
1983 Nov 18
Land H, Parada LF, Weinberg RA. "Cellular oncogenes and multistep carcinogenesis." Science. 1983 Nov 18; 222(4625):771-8.
1983 Jul
Meier F, Land H. "[Use and process evaluation of a self control program in enuresis diurna]." Praxis der Kinderpsychologie und Kinderpsychiatrie. 1983 Jul; 32(5):181-6.
1983
Land H, Grez M, Hauser H, Lindenmaier W, Schütz G. "Synthesis of ds-cDNA involving addition of dCMP tails to allow cloning of 5'-terminal m RNA sequences." Methods in enzymology. 1983 100:285-92.
1983
Land H, Parada LF, Weinberg RA. "Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes." Nature. 1983 304(5927):596-602.
1983
Land H, Grez M, Ruppert S, Schmale H, Rehbein M, Richter D, Schütz G. "Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA." Nature. 1983 302(5906):342-4.
1982 Jan 28
Land H, Schütz G, Schmale H, Richter D. "Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor." Nature. 1982 Jan 28; 295(5847):299-303.
1981 Sep
Grez M, Land H, Giesecke K, Schütz G, Jung A, Sippel AE. "Multiple mRNAs are generated from the chicken lysozyme gene." Cell. 1981 Sep; 25(3):743-52.
1981 May 25
Land H, Grez M, Hauser H, Lindenmaier W, Schütz G. "5'-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency." Nucleic acids research. 1981 May 25; 9(10):2251-66.
1981
Hauser H, Graf T, Beug H, Greiser-Wilke I, Lindenmaier W, Grez M, Land H, Giesecke K, Schütz G. "Structure of the lysozyme gene and expression in the oviduct and macrophages." Haematology and blood transfusion. 1981 26:175-8.
1980 Jan
Lindenmaier W, Nguyen-Huu MC, Stratmann LM, Blin N, Wurtz T, Hauser HJ, Giesecke K, Land H, Jeep S, Grez M, Sippel AE, Schütz G. "The isolation and characterization of the chicken lysozyme and ovomucoid gene." Journal of steroid biochemistry. 1980 Jan; 12:211-8.
1979 Nov 10
Lindenmaier W, Nguyen-Huu MC, Lurz R, Blin N, Stratmann M, Land H, Jeep S, Sippel AE, Schütz G. "Isolation and characterization of the chicken ovomucoid gene." Nucleic acids research. 1979 Nov 10; 7(5):1221-32.
1979 Jan
Nguyen-Huu MC, Stratmann M, Groner B, Wurtz T, Land H, Giesecke K, Sippel AE, Schütz G. "Chicken lysozyme gene contains several intervening sequences." Proceedings of the National Academy of Sciences of the United States of America. 1979 Jan; 76(1):76-80.
1978 Nov 2
Hofer E, Land H, Sekeris CE, Morris HP. "Messenger RNA activities for two liver enzymes, tyrosine aminotransferase and tryptophan oxygenase, in Morris hepatoma 5123C and 9618A and in HTC cells. Correlation with enzyme activities." European journal of biochemistry. 1978 Nov 2; 91(1):223-9.
1978 Sep
Sippel AE, Land H, Lindenmaier W, Nguyen-Huu MC, Wurtz T, Timmis KN, Giesecke K, Schütz G. "Cloning of chicken lysozyme structural gene sequences synthesized in vitro." Nucleic acids research. 1978 Sep; 5(9):3275-94.
1978 Jul 28
Land H, Hofer E, Sekeris CE. "Differential behavior of two dexamethasone induced mRNA activities in HTC cells in response to cordycepin and to withdrawal of hormone." Biochemical and biophysical research communications. 1978 Jul 28; 83(2):607-15.
1977
Land H, Schäfer KP. "In vitro synthesis and stability of RNA in isolated nuclei from bovine lymphocytes." Biochemical and biophysical research communications. 1977 79(3):947-57.

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