Gloria S. Pryhuber, M.D.

Gloria S. Pryhuber, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-5948
Fax: (585) 461-3614
Lab: (585) 275-1496
Administrative: (585) 275-2972

Lab Information

Pryhuber Lab

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Research Bio

Dr. Pryhhuber's research interests are:
1) Inflammatory Lung Disease
2) Interstitial Fibrosis
3) Silicosis
4) Bronchopulmonary Dysplasia.



Up to 300,000 adults and infants per year in the U.S. suffer from acute inflammatory lung diseases such as pneumonia, acute respiratory distress syndrome (ARDS) and respiratory distress of prematurity, while many times that number suffer from chronic, fibrotic lung disease. The proinflammatory cytokine, tumor necrosis factor-a (TNF), is a major pathogenic factor in these acute and chronic lung diseases. Recent discoveries advanced understanding of TNF signaling mechanisms that account for the highly pleiotropic and cell type specific effects of the cytokine. Dr. Pryhuber's laboratory is applying these advances in molecular biology to study how TNF and oxidant stress interact to alter pulmonary cell survival, gene expression and function, with an ultimate goal of improving therapy for inflammatory lung disease.

In her laboratory, cell culture and whole animal models are being utilized to determine signaling mechanisms by which members of the NGF/TNF receptor superfamily, of which TNF receptor I and II (TNFRI and TNFRII) are representative, regulate gene expression, inflammation and apoptosis in the lung. They recently demonstrated marked induction of TNF receptor associated factors (TRAF) and Inhibitor of Apoptosis Proteins (IAPs) by TNF in pulmonary epithelial cells in vitro, in mouse lung following intratracheal TNF treatment and in inflamed human and baboon lung tissue. They are pursing studies to establish cellular and developmental localization, regulation and function of the TRAF-1 and cIAP proteins in lung, as well as their role in TNF-induced proliferation, programmed cell death and transcription factor AP-1 and NFkB activation. Effects of TNF on pulmonary cell function are also being studied in whole animal models. Structural and biochemical abnormalities are measured following exposure of "knock-out" transgenic mice, in which gene expression of either of the TNF receptors or of a signal transduction intermediate protein, such as TRAF1, is prevented, to intratracheal administration of TNF, silica or hyperoxia, in order to understand mechanisms of TNF mediated injury and repair.

Patents

A Role for Connective Tissue-Type Mast Cells in Chronic Lung Disease of the Premature

United States Serial NO.: 14/118,042
Filed Date: May 16, 2012
Title: Detecting, Preventing and Treating Bronchopulmonary Dysplasia
Invented by: Thomas Mariani, Gloria Pryhuber

Awards & Honors (National)

Best Doctors in America Database 2006 - Present

Awards & Honors (Local)

Ruth A. Lawrence Academic Faculty Service Award for Excellence in Training, Department of Pediatrics, University of Rochester, R 2005
University of Rochester Environmental Health Sciences Center, Pulmonary Core - Member 2001
Society for Pediatric Research - Member 1999
Chief Fellow in Neonatology, University of Cincinnati, Cincinnati, OH 1989
Resident Teaching Award 1986 - 1987
Resident Teaching Award 1985 - 1986
Janet M. Glascow Memorial Achievement Award | American Medical Women's Association | SUNY Health Science Center at Syracuse 1985
Annual Clinical Campus Pediatric Award | SUNY Health Science Center at Syracuse 1984

Recent Journal Articles

Showing the 5 most recent journal articles. 46 available »

2013 Jun
Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ, Bhandari V. "Hyperoxia and interferon-?-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway." American journal of respiratory cell and molecular biology.. 2013 Jun; 48(6):749-57.
2012 Nov
Scheible K, Secor-Socha S, Wightman T, Wang H, Mariani TJ, Topham DJ, Pryhuber G, Quataert S. "Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection." Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2012 Nov; 81(11):937-49. Epub 2012 Oct 01.
2012 Sep
Popova AP, Bentley JK, Anyanwu AC, Richardson MN, Linn MJ, Lei J, Wong EJ, Goldsmith AM, Pryhuber GS, Hershenson MB. "Glycogen synthase kinase-3?/?-catenin signaling regulates neonatal lung mesenchymal stromal cell myofibroblastic differentiation." American journal of physiology. Lung cellular and molecular physiology.. 2012 Sep; 303(5):L439-48. Epub 2012 Jul 06.
2012 Aug 15
Bhattacharya S, Go D, Krenitsky DL, Huyck HL, Solleti SK, Lunger VA, Metlay L, Srisuma S, Wert SE, Mariani TJ, Pryhuber GS. "Genome-wide transcriptional profiling reveals connective tissue mast cell accumulation in bronchopulmonary dysplasia." American journal of respiratory and critical care medicine.. 2012 Aug 15; 186(4):349-58. Epub 2012 Jun 21.
2012
Bozyk PD, Bentley JK, Popova AP, Anyanwu AC, Linn MD, Goldsmith AM, Pryhuber GS, Moore BB, Hershenson MB. "Neonatal periostin knockout mice are protected from hyperoxia-induced alveolar simplication." PloS one. 2012 7(2):e31336. Epub 2012 Feb 17.

Current Appointments

George Washington Goler Chair in Pediatrics - Department of Pediatrics (SMD)
Professor - Department of Pediatrics, Neonatology (SMD) - Primary
Professor - Department of Environmental Medicine (SMD)

Specialties

Pediatrics - American Board of Pediatrics
Neonatal-Perinatal Medicine - American Board of Pediatrics

Education

M.D., Cum Laude, | Medicine | SUNY at Upstate Medical Center1985
B.S. with Distinction, | Arts and Sciences | Cornell University1981

Post-Doctoral Training & Residency

Fellowship in Neonatology at University of Cincinnati College of Medicine07/01/1988 - 06/30/1991
Residency in Pediatrics at SUNY Health Science Center at Syracuse07/01/1986 - 06/30/1988
Internship in Pediatrics at SUNY Health Science Center at Syracuse07/01/1985 - 06/30/1986