Gloria S. Pryhuber, M.D.

Gloria S. Pryhuber, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-5948
Fax: (585) 461-3614
Lab: (585) 275-1496
Administrative: (585) 275-2972

Lab Information

Pryhuber Lab

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Research Bio

Research interests:
1) Chronic Lung Disease of Prematurity
2) Lung Development



Dr. Pryhuber trained as a post-doctoral Proctor Research Scholar and participant in the University of Cincinnati Program of Excellence in Molecular Biology of the Heart and Lung. She has since accumulated > 20 years as independent researcher and author in lung injury and immunology. She serves on NIH study sections and as reviewer for journals in her area of expertise, manages an active laboratory, supervises students in pulmonary biology and epithelial cell research and has received awards recognizing both teaching and original research accomplishments. She teaches regularly for the UofR Toxicology graduate program, Medical School and Pediatric Residency.
An NIH-funded physician-scientist with expertise in human perinatal lung injury and repair, Dr. Pryhuber also served nine years as Perinatal-Neonatal Fellowship Associate Director and mentors undergraduate, graduate and post-doctural students. She is honored to be a member of the American Pediatric Society, the Perinatal Research Society, and the Society for Pediatric Research, the American Thoracic Society, the American Academy of Pediatrics, the International Cytokine Society and the American Physiological Society. As Professor in the Departments of Pediatrics and Environmental Medicine, Dr. Pryhuber also acts as communicating PI for the UofR / University at Buffalo Center for the Prematurity and Respiratory Outcomes Program (PROP, NHLBI U01), as Lead Site Investigator for the UR-Respiratory Pathogens Research Center Clinical Study I (NIAID / DMID Contract), PI for the Lung Molecular Atlas Program Human Tissue Core (NHLBI U01) and remains active as clinical academic Neonatologist and Pulmonary Hypertension Team member. Dr. Pryhuber directs the UofR Pediatric and Environmental Health Sciences Center Histology Facility since 2009 and Pediatric Processing Lab since 2011, providing, through the work of talented technicians and University resources, technical support and training for preparation and analysis of tissues and cells of organisms ranging from human to drosophila. Dr. Pryhuber has also provided access to an archive of neonatal lung tissue acquired by expedited autopsy at gestational ages varying from 24 to 43 weeks. In collaboration with investigators in multiple centers, subsets of the archive are published, contributing novel observations pertaining to vascular development, epithelial cell abnormalities and inflammation in bronchopulmonary dysplasia. This repository is expanded by the LungMAP to collect donated human lung across the developmental spectrum from pseudoglandular through alveologenesis. These successful clinical and research programs demonstrate particular interests and strengths in creating multi-disciplinary teams of investigators, coordinators, nurses, technicians, and information specialists. They create and foster active collaborations of investigators and clinicians in neonatology, pulmonology, infectious disease, obstetrics/perinatology, immunology, microbiology, pathology, toxicology and genomics, as well as extramural collaborations around perinatal development and disease.
Clinically, preterm infant cohorts are enrolled in longitudinal studies. In the laboratory, fresh isolated cells, cell lines and whole animal models are utilized to understand cellular interactions during development and inflammation. Specific studies determined parenchymal TNF receptor signaling mechanisms that regulate gene expression, inflammation and apoptosis in the lung. More recently, high-dimensional flow cytometry, cell sorting, transcriptomic and genomic techniques are applied to understand the effects of in utero environment, premature birth and microbial colonization on the adaptive immune system and lung. The impact on respiratory morbidity and mortality of alterations in CD4 and CD8 lymphocyte responses to stimuli are the focus of active studies.

Awards & Honors (National)

American Pediatric Society Membe 2013
Best Doctors in America Database 2006 - Present
Society for Pediatric Research - Member 1999

Awards & Honors (Local)

Ruth A. Lawrence Academic Faculty Service Award for Excellence in Research | Department of Pediatrics, Univ of Rochester 2014
George Washington Goler Professor of Pediatrics | University of Rochester 2011 - 2014
Ruth A. Lawrence Academic Faculty Service Award for Excellence in Training, Department of Pediatrics, University of Rochester, R 2005
University of Rochester Environmental Health Sciences Center, Pulmonary Core - Member 2001
Chief Fellow in Neonatology, University of Cincinnati, Cincinnati, OH 1989
Resident Teaching Award 1986 - 1987
Resident Teaching Award 1985 - 1986
Janet M. Glascow Memorial Achievement Award | American Medical Women's Association | SUNY Health Science Center at Syracuse 1985
Annual Clinical Campus Pediatric Award | SUNY Health Science Center at Syracuse 1984

Patents

A Role for Connective Tissue-Type Mast Cells in Chronic Lung Disease of the Premature

United States Serial NO.: 14/118,042
Filed Date: May 16, 2012
Title: Detecting, Preventing and Treating Bronchopulmonary Dysplasia
Invented by: Thomas Mariani, Gloria Pryhuber

Recent Journal Articles

Showing the 5 most recent journal articles. 46 available »

2015 May
Misra R, Shah S, Fowell D, Wang H, Scheible K, Misra S, Huyck H, Wyman C, Ryan RM, Reynolds AM, Mariani T, Katzman PJ, Pryhuber GS. "Preterm cord blood CD4(+) T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4(+) T cells in bronchopulmonary dysplasia." Human immunology. 2015 May; 76(5):329-38. Epub 2015 Mar 20.
2014 Aug 1
Popova AP, Bentley JK, Cui TX, Richardson MN, Linn MJ, Lei J, Chen Q, Goldsmith AM, Pryhuber GS, Hershenson MB. "Reduced platelet-derived growth factor receptor expression is a primary feature of human bronchopulmonary dysplasia." American journal of physiology. Lung cellular and molecular physiology. 2014 Aug 1; 307(3):L231-9. Epub 2014 Jun 06.
2014 Aug
Dardas M, Gill SR, Grier A, Pryhuber GS, Gill AL, Lee YH, Guillet R. "The impact of postnatal antibiotics on the preterm intestinal microbiome." Pediatric research. 2014 Aug; 76(2):150-8. Epub 2014 May 12.
2013 Jun
Choo-Wing R, Syed MA, Harijith A, Bowen B, Pryhuber G, Janér C, Andersson S, Homer RJ, Bhandari V. "Hyperoxia and interferon-?-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway." American journal of respiratory cell and molecular biology. 2013 Jun; 48(6):749-57.
2012 Nov
Scheible K, Secor-Socha S, Wightman T, Wang H, Mariani TJ, Topham DJ, Pryhuber G, Quataert S. "Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection." Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2012 Nov; 81(11):937-49. Epub 2012 Oct 01.

Current Appointments

Professor - Department of Pediatrics, Neonatology (SMD) - Primary
Professor - Department of Environmental Medicine (SMD)

Specialties

Pediatrics - American Board of Pediatrics
Neonatal-Perinatal Medicine - American Board of Pediatrics

Education

M.D., Cum Laude, | Medicine | SUNY at Upstate Medical Center1985
B.S. with Distinction, | Arts and Sciences | Cornell University1981

Post-Doctoral Training & Residency

Fellowship in Neonatology at University of Cincinnati College of Medicine07/01/1988 - 06/30/1991
Residency in Pediatrics at SUNY Health Science Center at Syracuse07/01/1986 - 06/30/1988
Internship in Pediatrics at SUNY Health Science Center at Syracuse07/01/1985 - 06/30/1986