Jacqueline P. Williams, Ph.D.

Jacqueline P. Williams, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester, NY 14642

Books

2008
Constine L, Milano M, Friedman D, Morris M, Williams JP, Rubin P, Okunieff P. "Late effects of cancer treatment on normal tissues". Principles and Practice of Radiation Oncology. Halperin EC, Perez CA, Brady LW. Philadelphia, PA: Lippincott Williams & Wilkins, 2008. 320-355
2006
J. Allalunis-Turner, E.K. Balcer-Kubiczek, K.A. Camphausen, T.L. DeWeese, A. Haimovitz-Friedman, D.E. Hallahan, M. Hauer-Jensen, R.P. Hill, R.K. Jain, A. Kronenberg, W.F. Morgan, J.P. Mornane, P.L. Olive, M.E. Robbins, J.L. Roti-Roti, J. Sweasy, G.E. Woloschak. 2006 ASTRO Radiation/Cancer Biology Practice Examination and Study Guide. B. Rosenstein, K. Held, S. Rockwell, J. Williams, E. Zeman. : American Society for Therapeutic Radiology and Oncology, 2006.
2005
J. Allalunis-Turner, E.K. Balcer-Kubiczek, K.A. Camphausen, T.L. DeWeese, A. Haimovitz-Friedman, D.E. Hallahan, M. Hauer-Jensen, R.P. Hill, R.K. Jain, A. Kronenberg, W.F. Morgan, J.P. Mornane, P.L. Olive, M.E. Robbins, J.L. Roti-Roti, J. Sweasy, G.E. Woloschak. Radiation and Cancer Biology Practice Exam (RABEX). B.S. Rosenstein, K. Held, J.P. Williams, E. Zeman. : Advanced Medical Publishing, 2005.
2003
Constine, L., Williams, J.P., Morris, M., Rubin, P., Okunieff, P.. "Late effects of cancer treatment on normal tissues". Principles and Practice of Radiation Oncology. Perez, C.A., Brady, L.W., Halperin, E.C., Schmidt-Ullrich, R.K.. Philadelphia: Lippincott Williams & Wilkins, 2003. 357-390
2002
Rubin, P., Williams, J.P., Okunieff, P.. "A paradigm shift for the radiation prophylaxis of arterial restenosis". Vascular Brachytherapy. Waksman, R.. armonk, NY: futura Publishing, 2002.
2002
Sandhu, A., Williams, J. Constine, L.. "Late Effects of Radiation Therapy". Encyclopedia of Cancer. Bertino, J.R.. Philadelphia: Elsevier Science (USA), 2002. 7-19
2001
Rubin, P., Williams, J.P.. "Principles of radiation oncology". Clinical Oncology. A Multidisciplinary Approach for Physicians and Students. Rubin, P., Williams, J.P.. Philadelphia: WB Saunders, 2001. 1-33
2001
Williams, J.P., Keng, P, Sutherland, R.. "Basic principles of radiobiology". Clinical Oncology. A Multidisciplinary Approach for Physicians and Students. Rubin, P., Williams, J.P.. Philadelphia: WB Saunders, 2001. 75-98
2001
Williams, J.P., Lord, E., Order, S.E.. "Basic concepts of tumor immunology and principles of immunotherapy". Clinical Oncology. A Multidisciplinary Approach for Physicians and Students. Rubin, P., Williams, J.P.. Philadelphia: WB Saunders, 2001. 185-198
2001
Rubin, P., Williams, J.P., Constine, L.S., Slovik, F.. "Late effects of cancer treatment: Radiation and chemotherapy toxicity". Clinical Oncology. A Multidisciplinary Approach for Physicians and Students. Rubin, P., Williams, J.P.. Philadelphia: WB Saunders, 2001. 897-936
2001
McDonald, S., Dombrowski, J., Williams, J. Rubin, P.. "Combined-modality (chemotherapy/ radiation therapy) pneumonitis and esophagitis: characteristics and management". Lung Cancer: Controversies and Dilemmas. Movsas, B., Langer, C.J., Goldberg, M.. New York, NY: Dekker, 2001.
1999
Rubin, P., Williams, J.P., Finkelstein, J.N., Pomerantz, R., Okunieff, P.. "Radiation inhibition vs induction of vascular restenosis: the role of the monocyte-derived macrophage". Vascular Brachytherapy. Waksman, R.. Armonk, NY: Futura Publishing, 1999. 103-125
1998
Rubin, P., Constine, L.S., Williams, J.P.. "Late effects of cancer treatment: Radiation and drug toxicity". Principles and Practice of Radiation Oncology. Perez, C.A., Brady, L.W.. Philadelphia: Lippincott-Raven, 1998. 155-212
1998
Rubin, P., Finkelstein, J.N., Williams, J.P.. "Paradigm shifts in the radiation pathophysiology of late effects in normal tissues: molecular vs classic concepts". Current Radiation Oncology. Tobias, J.S., Thomas, P.R.M.. London, U.K.: Arnold, 1998. 1-26

Journal Articles

Showing all 68 journal articles available.

2013 Jul
Ryan JL, Heckler CE, Ling M, Katz A, Williams JP, Pentland AP, Morrow GR. "Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients." Radiation research.. 2013 Jul; 180(1):34-43. Epub 2013 Jun 07.
2013 May 1
Manning CM, Johnston CJ, Reed CK, Lawrence BP, Williams JP, Finkelstein JN. "Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure." International journal of radiation oncology, biology, physics.. 2013 May 1; 86(1):128-35. Epub 2012 Nov 27.
2013 Apr
Johnston CJ, Manning CM, Rangel-Moreno J, Randall TD, Hernady E, Finkelstein JN, Williams JP. "Neonatal irradiation sensitizes mice to delayed pulmonary challenge." Radiation research.. 2013 Apr; 179(4):475-84. Epub 2012 Mar 15.
2012 Jul
Johnson MD, O'Connell M, Iqbal MA, Williams JP. "Radiation effects on human leptomeningeal cell response to cerebrospinal fluid and PDGF-BB." International journal of radiation biology. 2012 Jul; 88(7):547-55. Epub 2012 May 25.
2012 May
Williams JP, Jackson IL, Shah JR, Czarniecki CW, Maidment BW, Dicarlo AL. "Animal models and medical countermeasures development for radiation-induced lung damage: report from an NIAID Workshop." Radiation research.. 2012 May; 177(5):e0025-39. Epub 2012 Apr 02.
2012 May
Dicarlo AL, Jackson IL, Shah JR, Czarniecki CW, Maidment BW, Williams JP. "Development and licensure of medical countermeasures to treat lung damage resulting from a radiological or nuclear incident." Radiation research.. 2012 May; 177(5):717-21. Epub 2012 Apr 02.
2012 Apr
Janelsins MC, Mustian KM, Palesh OG, Mohile SG, Peppone LJ, Sprod LK, Heckler CE, Roscoe JA, Katz AW, Williams JP, Morrow GR. "Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research." Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2012 Apr; 20(4):831-9. Epub 2011 May 01.
2012
Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK. "Galactic cosmic radiation leads to cognitive impairment and increased a? plaque accumulation in a mouse model of Alzheimer's disease." PloS one. 2012 7(12):e53275. Epub 2012 Dec 31.
2011 Oct
Moravan MJ, Olschowka JA, Williams JP, O'Banion MK. "Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain." Radiation research.. 2011 Oct; 176(4):459-73. Epub 2011 Jul 25.
2011 Aug
Williams JP, McBride WH. "After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS)." International journal of radiation biology. 2011 Aug; 87(8):851-68. Epub 2011 Mar 21.
2011 Aug
Johnston CJ, Manning C, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. "Effect of total body irradiation on late lung effects: hidden dangers." International journal of radiation biology. 2011 Aug; 87(8):902-13. Epub 2011 May 17.
2011 Aug
Williams JP, Huser AK, Brenner DJ. "Introduction." International journal of radiation biology. 2011 Aug; 87(8):747.
2011 Jun
Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'keefe RJ, Langstein HN. "The impact of Smad3 loss of function on TGF-? signaling and radiation-induced capsular contracture." Plastic and reconstructive surgery. 2011 Jun; 127(6):2263-9.
2011 Jun
Janelsins MC, Davis PG, Wideman L, Katula JA, Sprod LK, Peppone LJ, Palesh OG, Heckler CE, Williams JP, Morrow GR, Mustian KM. "Effects of Tai Chi Chuan on insulin and cytokine levels in a randomized controlled pilot study on breast cancer survivors." Clinical breast cancer. 2011 Jun; 11(3):161-70. Epub 2011 Apr 20.
2011 Apr
Marples B, Downing L, Sawarynski KE, Finkelstein JN, Williams JP, Martinez AA, Wilson GD, Sims MD. "Pulmonary injury after combined exposures to low-dose low-LET radiation and fungal spores." Radiation research.. 2011 Apr; 175(4):501-9. Epub 2011 Jan 28.
2011 Apr
Peslak SA, Wenger J, Bemis JC, Kingsley PD, Frame JM, Koniski AD, Chen Y, Williams JP, McGrath KE, Dertinger SD, Palis J. "Sublethal radiation injury uncovers a functional transition during erythroid maturation." Experimental hematology.. 2011 Apr; 39(4):434-45. Epub 2011 Feb 01.
2011 Feb
Williams JP. "Assessment of radiation-induced lung disease." Clinical advances in hematology & oncology : H&O. 2011 Feb; 9(2):160-2.
2010 Nov
Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O'keefe RJ, Langstein HN. "A novel animal model for studying silicone gel-related capsular contracture." Plastic and reconstructive surgery. 2010 Nov; 126(5):1483-91.
2010 Aug 4
Travis LB, Beard C, Allan JM, Dahl AA, Feldman DR, Oldenburg J, Daugaard G, Kelly JL, Dolan ME, Hannigan R, Constine LS, Oeffinger KC, Okunieff P, Armstrong G, Wiljer D, Miller RC, Gietema JA, van Leeuwen FE, Williams JP, Nichols CR, Einhorn LH, Fossa SD. "Testicular cancer survivorship: research strategies and recommendations." Journal of the National Cancer Institute.. 2010 Aug 4; 102(15):1114-30. Epub 2010 Jun 28.
2010 Apr
Demaria S, Williams JP. "Introduction to the special BR-RIDGE issue." Radiation research.. 2010 Apr; 173(4):403-5.
2010 Apr
Johnston CJ, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. "Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure." Radiation research.. 2010 Apr; 173(4):522-35.
2010 Apr
Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB, McBride WH. "Animal models for medical countermeasures to radiation exposure." Radiation research.. 2010 Apr; 173(4):557-78.
2010 Mar 1
Bentzen SM, Parliament M, Deasy JO, Dicker A, Curran WJ, Williams JP, Rosenstein BS. "Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume effects." International journal of radiation oncology, biology, physics.. 2010 Mar 1; 76(3 Suppl):S145-50.
2010 Jan
Rubin P, Williams JP, Devesa SS, Travis LB, Constine LS. "Cancer genesis across the age spectrum: associations with tissue development, maintenance, and senescence." Seminars in radiation oncology. 2010 Jan; 20(1):3-11.
2010 Jan
Paulino AC, Constine LS, Rubin P, Williams JP. "Normal tissue development, homeostasis, senescence, and the sensitivity to radiation injury across the age spectrum." Seminars in radiation oncology. 2010 Jan; 20(1):12-20.
2010
Williams JP; Johnston CJ; Finkelstein JN. "Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?". Curr Drug Targets. 2010; 11(11): 1386-1394. Link
2009 Nov 1
Rosenstein BS, Held KD, Rockwell S, Williams JP, Zeman EM. "American Society for Radiation Oncology (ASTRO) survey of radiation biology educators in U.S. and Canadian radiation oncology residency programs." International journal of radiation oncology, biology, physics.. 2009 Nov 1; 75(3):896-905. Epub 2009 Sep 03.
2008
Okunieff P, Swarts S, Keng P, Sun W, Wang W, Kim J, Yang S, Zhang H, Liu C, Williams JP, Huser AK, Zhang L. "Antioxidants reduce consequences of radiation exposure." Advances in experimental medicine and biology. 2008 614:165-78.
2008
Veenema TG, Walden B, Feinstein N, Williams JP. "Factors affecting hospital-based nurses' willingness to respond to a radiation emergency." Disaster medicine and public health preparedness. 2008 2(4):224-9.
2006 May
Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ. "Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation." Experimental lung research. 2006 May; 32(5):181-99.
2005 May 1
Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T, Rubin P. "Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis." International journal of radiation oncology, biology, physics.. 2005 May 1; 62(1):260-6.
2005 May 1
Moore AH, Olschowka JA, Williams JP, Okunieff P, O'Banion MK. "Regulation of prostaglandin E2 synthesis after brain irradiation." International journal of radiation oncology, biology, physics.. 2005 May 1; 62(1):267-72.
2005 May 1
Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. "Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors." International journal of radiation oncology, biology, physics.. 2005 May 1; 62(1):273-8.
2004 May
Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. "Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model." Radiation research.. 2004 May; 161(5):560-7.
2004 Feb
Moore AH, Olschowka JA, Williams JP, Paige SL, O'Banion MK. "Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain." Radiation research.. 2004 Feb; 161(2):153-60.
2004 Jan 1
Singh D, Yi WS, Brasacchio RA, Muhs AG, Smudzin T, Williams JP, Messing E, Okunieff P. "Is there a favorable subset of patients with prostate cancer who develop oligometastases?" International journal of radiation oncology, biology, physics.. 2004 Jan 1; 58(1):3-10.
2004
Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. "Inflammatory cell recruitment following thoracic irradiation." Experimental lung research. 2004 30(5):369-82.
2003 Aug
Liang L, Hu D, Liu W, Williams JP, Okunieff P, Ding I. "Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor." American journal of clinical oncology.. 2003 Aug; 26(4):S114-21.
2003 Jul
Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. "The biological basis of a comprehensive grading system for the adverse effects of cancer treatment." Seminars in radiation oncology. 2003 Jul; 13(3):182-8.
2003 Jul
Bentzen SM, Dörr W, Anscher MS, Denham JW, Hauer-Jensen M, Marks LB, Williams J. "Normal tissue effects: reporting and analysis." Seminars in radiation oncology. 2003 Jul; 13(3):189-202.
2003 Jan
Ferland RJ, Williams JP, Gross RA, Applegate CD. "The effects of brain-irradiation-induced decreases in hippocampal mitotic activity on flurothyl-induced epileptogenesis in adult C57BL/6J mice." Experimental neurology.. 2003 Jan; 179(1):71-82.
2002 Nov 15
Soni AB, Illig KA, Sternbach Y, Anthony P, Jacob P, Reddy G, Storey J, Gerety R, Williams JP, Schell M, Waldman D, Rubin P, Green R, Okunieff P. "Benefits of external beam irradiation for peripheral arterial bypass: preliminary report on a phase I study." International journal of radiation oncology, biology, physics.. 2002 Nov 15; 54(4):1174-9.
2002 Oct
Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA. "Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1)." The American journal of pathology.. 2002 Oct; 161(4):1383-93.
2002 Aug 15
Kyrkanides S, Moore AH, Olschowka JA, Daeschner JC, Williams JP, Hansen JT, Kerry O'Banion M. "Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury." Brain research. Molecular brain research. 2002 Aug 15; 104(2):159-69.
2002 Mar
Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. "Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families." Radiation research.. 2002 Mar; 157(3):256-65.
2002 Jan
Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P. "Radiation pneumonitis and early circulatory cytokine markers." Seminars in radiation oncology. 2002 Jan; 12(1 Suppl 1):26-33.
2001 Sep
Illig KA, Williams JP, Lyden SP, Hernady E, Soni A, Davies MG, Schell M, Okunieff P, Rubin P, Green RM. "External beam irradiation for inhibition of intimal hyperplasia following prosthetic bypass: preliminary results." Annals of vascular surgery.. 2001 Sep; 15(5):533-8.
2001 Mar 1
Chen Y, Rubin P, Williams J, Hernady E, Smudzin T, Okunieff P. "Circulating IL-6 as a predictor of radiation pneumonitis." International journal of radiation oncology, biology, physics.. 2001 Mar 1; 49(3):641-8.
2000 Mar
Illig KA, Soni AB, Williams J, Shortell CK, Okunieff P, Schell M, Rubin P, Green RM. "Irradiation for intimal hyperplasia: implications for peripheral arterial bypass." Journal of the American College of Surgeons. 2000 Mar; 190(3):364-70.
1999 Jun
Okunieff P, Barrett AJ, Phang SE, Li A, Constine LS, Williams JP, Rubin P, Wang X, Wu T, Chen Y, Ding I. "Circulating basic fibroblast growth factor declines during Cy/TBI bone marrow transplantation." Bone marrow transplantation. 1999 Jun; 23(11):1117-21.
1999 Apr
Rubin P, Soni A, Williams JP. "The molecular and cellular biologic basis for the radiation treatment of benign proliferative diseases." Seminars in radiation oncology. 1999 Apr; 9(2):203-14.
1999 Mar 1
Kyrkanides S, Olschowka JA, Williams JP, Hansen JT, O'Banion MK. "TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury." Journal of neuroimmunology.. 1999 Mar 1; 95(1-2):95-106.
1999
Rubin P, Williams JP, Schell MC, Okunieff P. "Radiation inhibition of arterial restenosis -- a new frontier." Acta oncologica (Stockholm, Sweden). 1999 38(4):407-24.
1999
Tallman MP, Williams JP, Eagleton MJ, Hernady E, Rubin P, Pomerantz RM. "Tolerance of normal rabbit femoral arteries to single high dose external beam irradiation." Cardiovascular radiation medicine. 1999 1(2):131-7.
1999
Williams JP, Rubin P, Soni A, Hernady E, Schell M, Green R, Illig K, Pomerantz R, Okunieff P. "Comparability of the external vs internal location of radiation in inhibiting neointimal hyperplasia." Cardiovascular radiation medicine. 1999 1(1):55-63.
1999
Williams JP, Eagleton M, Hernady E, Schell M, Illig K, Green R, Rubin P. "Effectiveness of fractionated external beam radiation in the inhibition of vascular restenosis." Cardiovascular radiation medicine. 1999 1(3):257-64.
1998 Mar 1
Rubin P, Williams JP, Riggs PN, Bartos S, Sarac T, Pomerantz R, Castano J, Schell M, Green RM. "Cellular and molecular mechanisms of radiation inhibition of restenosis. Part I: role of the macrophage and platelet-derived growth factor." International journal of radiation oncology, biology, physics.. 1998 Mar 1; 40(4):929-41.
1998
Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein J, Phipps RP. "Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis." Clinical immunology and immunopathology. 1998 89(3):222-30.
1998
Okunieff P, Wang X, Li M, Sabet H, Huang K, Grieg JR, Williams J, Rubin P, Ding I. "Chronic radiation bone toxicity is associated with decreased perfusion without elevation of circulating or soft tissue TGF beta or TNF alpha." Advances in experimental medicine and biology. 1998 454:325-33.
1997
Olschowka JA, Kyrkanides S, Harvey BK, O'Banion MK, Williams JP, Rubin P, Hansen JT. "ICAM-1 induction in the mouse CNS following irradiation." Brain, behavior, and immunity. 1997 11(4):273-85.
1996 Jun
Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R, Finkelstein JN. "Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation." Radiation research.. 1996 Jun; 145(6):762-7.
1995 Aug 30
Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. "A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis." International journal of radiation oncology, biology, physics.. 1995 Aug 30; 33(1):99-109.
1995 Jul
Sarac TP, Riggs PN, Williams JP, Feins RH, Baggs R, Rubin P, Green RM. "The effects of low-dose radiation on neointimal hyperplasia." Journal of vascular surgery.. 1995 Jul; 22(1):17-24.
1994 Apr
Rubin P, Gash DM, Hansen JT, Nelson DF, Williams JP. "Disruption of the blood-brain barrier as the primary effect of CNS irradiation." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 1994 Apr; 31(1):51-60.
1990 Apr
Coggle JE, Williams JP. "Experimental studies of radiation carcinogenesis in the skin: a review." International journal of radiation biology. 1990 Apr; 57(4):797-808.
1988 Aug
Charles MW, Williams JP, Coggle JE. "Skin carcinogenesis following uniform and nonuniform beta irradiation." Health physics.. 1988 Aug; 55(2):399-406.
1986
Hopewell JW, Coggle JE, Wells J, Hamlet R, Williams JP, Charles MW. "The acute effects of different energy beta-emitters on pig and mouse skin." British journal of radiology. Supplement. 1986 19:47-51.
1986
Williams JP, Coggle JE, Charles MW, Wells J. "Skin carcinogenesis in the mouse following uniform and non-uniform beta irradiation." British journal of radiology. Supplement. 1986 19:61-4.