Christoph Proschel, Ph.D.

Christoph Proschel, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, NY 14642

Office: (585) 273-5368
Lab: (585) 273-2416
Administrative: (585) 273-1440
Fax: (585) 273-1450

Lab Information

Visit Lab Website »


Research Bio

Within the context of our work on glial progenitor cells, we are now focusing on the role of astrocytes as critical modulators in response to injury or stress. The importance of understanding this process is emphasized by our discovery that the generation of mature astrocytes may be impaired in Vanishing White Matter leukodystrophy (Nat Med. 2005 Mar;11(3):277-83.).



The ability to study astrocyte development in normal and pathological conditions, provides a unique opportunity to test the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy in diseases of the central nervous system (CNS), such as traumatic injury (spinal cord and traumatic brain injury) and neurodegenerative diseases (Parkinsons Disease, Multiple sclerosis).

We have identified distinct astrocyte populations that demonstrate different functional properties with respect to their ability to promote injury repair upon transplantation into the injured nervous system. While one type shows little benefit and may even cause neuropathic pain syndrome, the other remodels the injured host tissue, enables axon outgrowth and extensive functional recovery (J Biol 2006 Apr 27, 5(3):7; J Biol 2008 Sep 19;7(7):245). As a prerequisite for the transition to the clinic we are analyzing the factors secreted by these astrocytes and have now derived homologous astrocyte populations from human precursor cells. (PLoS One. 2011 Mar 2;6(3)).

Awards & Honors (Local)

European Molecular Biology Organization, Practical Course: "Mouse Developmental Genetics" Course supervisor: Prof. P. Gruss Max-Planck Institute, Göttingen 1995
Scholarship of the University Würzburg: Postgraduate Studies Departments of Molecular Genetics and Neurobiology State University of New York, Albany, U.S.A. 1986 - 1987

Recent Journal Articles

Showing the 5 most recent journal articles. 24 available »

2014 Apr
Proschel C, Stripay JL, Shih CH, Munger JC, Noble MD. "Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons." EMBO molecular medicine.. 2014 Apr; 6(4):504-18. Epub 2014 Jan 29.
2013 May 2
Noble M, Mayer-Pröschel M, Pröschel C. "iOPs: a new tool for studying myelin pathologies?" Cell stem cell.. 2013 May 2; 12(5):503-4.
2011 Oct
Noble M, Davies JE, Mayer-Pröschel M, Pröschel C, Davies SJ. "Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2011 Oct; 8(4):677-93.
2011 Jan 7
Noble M, Pröschel C, Mayer-Pröschel M. "Oxidative-reductionist approaches to stem and progenitor cell function." Cell stem cell.. 2011 Jan 7; 8(1):1-2.
2011 Jan
Nout YS, Culp E, Schmidt MH, Tovar CA, Pröschel C, Mayer-Pröschel M, Noble MD, Beattie MS, Bresnahan JC. "Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats." Experimental neurology.. 2011 Jan; 227(1):159-71. Epub 2010 Oct 30.

Education

PhD | Molecular & Cellular Biology | LICR Univ. Colllege1995
M.Sc. | Immunology | Julius-Maximillian Univ.1990
BS | Biology | Julius-Maximillian Univ.1986

Post-Doctoral Training & Residency

Max-Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology Göttingen/Germany, Professor P. Gruss 1998
Postdoctoral Research Fellow, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City Research Project: Identification of Molecular Determinants of the Glial Cell Fate in Vertebrates: a potential role of GCM2 in CNS Gliogenesis 2000