Robert H. Dworkin, Ph.D.

Robert H. Dworkin, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 604
Rochester, NY 14642

Office: (585) 275-8214
Fax: (585) 244-7271

Professional Bio

Associate Editor, Pain
Editorial Board, Journal of Pain
Editorial Board, Current Pain and Headache Reports
Professional Advisory Board, American Chronic Pain Association
Neuropathic Pain Advisory Council, Neuropathy Association
Zoster Working Group, Centers for Disease Control and Prevention
Special Government Employee, Food and Drug Administration
Director, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the Food and Drug Administration (http://www.acttion.org)

Research Bio

Research Interests:
Methodologic aspects of analgesic clinical trials
Treatment and prevention of chronic pain
Neuropathic pain
Osteoarthritis



My current research focuses on methodologic aspects of acute and chronic pain clinical trials, especially identifying factors that increase the assay sensitivity of a trial to detect differences between an active and a control or comparison treatment. With funding from the US Food and Drug Administration (FDA), we are examining in large databases of acute and chronic pain trials the relationships between study methodologic features and study outcomes and placebo group responses, as well as comparing the responsiveness to treatment effects of different primary and secondary outcome measures. These studies and other efforts to improve the efficiency and informativeness of analgesic clinical trials are being conducted under the auspices of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the FDA, of which I serve as director.

In addition, in collaboration with Dennis Turk at the University of Washington, we are currently conducting a randomized clinical trial of tramadol, cognitive-behavior therapy, and health education alone and in combination for the treatment of fibromyalgia.

I have also been very interested in the identification of risk factors for the development of chronic neuropathic pain. One of our major results has been that patients with greater acute pain are more likely to develop chronic pain. This suggests that attenuating acute pain might prevent chronic pain, and an additional focus of my research has involved developing approaches to test this hypothesis.

Funding

HHSF223201400191C (9/30/14-9/29/17)
Food and Drug Administration
Analysis of FDA clinical trial data to improve assay sensitivity and informativeness of analgesic clinical trials
Role: Principal Investigator

U01 FD004187-01 (9/15/11-8/31/16)
Food and Drug Administration
Analgesic clinical trial innovations, opportunities, and networks (ACTION)
Role: Principal Investigator

1R01 AR059102-01A (9/1/11-7/31/16)
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Combined behavioral and analgesic trial for fibromyalgia (COMBAT-FM)
Role: Principal Investigator

T32 NS007338 (7/1/90-6/30/15)
NIH/National Institute of Neurological Disorders and Stroke
Experimental therapeutics of neurological disease
Role: Preceptor

Awards & Honors (National)

John and Emma Bonica Public Service Award | American Pain Society 2014
John J. Bonica Award | Eastern Pain Association 2011
Wilbert Fordyce Clinical Investigator Award | American Pain Society 2005

Recent Journal Articles

Showing the 5 most recent journal articles. 198 available »

2014 Nov 3
Dworkin RH, Laurie B B, Gewandter JS, Smith SM. "Reliability is Necessary but Far from Sufficient: How Might the Validity of Pain Ratings be Improved?" The Clinical journal of pain. 2014 Nov 3; Epub 2014 Nov 03.
2014 Oct 7
Dufka FL, Dworkin RH, Rowbotham MC. "How transparent are migraine clinical trials? Repository of Registered Migraine Trials (RReMiT)." Neurology. 2014 Oct 7; 83(15):1372-81. Epub 2014 Sep 05.
2014 Oct 2
Gewandter JS, McDermott MP, McKeown A, Smith SM, Pawlowski JR, Poli JJ, Rothstein D, Williams MR, Bujanover S, Farrar JT, Gilron I, Katz NP, Rowbotham MC, Turk DC, Dworkin RH. "Reporting of intention-to-treat analyses in recent analgesic clinical trials: ACTTION systematic review and recommendations." Pain. 2014 Oct 2; Epub 2014 Oct 02.
2014 Oct
Dworkin RH, McDermott MP. "Back to the future: The need to resolve analgesic efficacy in human immunodeficiency virus neuropathy." Pain. 2014 Oct; 155(10):1913-5. Epub 2014 Jul 24.
2014 Sep 3
Dworkin RH, Turk DC, Peirce-Sandner S, He H, McDermott MP, Hochberg MC, Jordan JM, Katz NP, Lin AH, Neogi T, Rappaport BA, Simon LS, Strand V. "Meta-analysis of assay sensitivity and study features in clinical trials of pharmacologic treatments for osteoarthritis pain." Arthritis & rheumatology. 2014 Sep 3; Epub 2014 Sep 03.

Current Appointments

Professor - Department of Anesthesiology (SMD) - Primary
Professor - Department of Neurology (SMD)
Professor - Department of Psychiatry (SMD)
Professor - Cancer Center
Professor - Center for Human Experimental Therapeutics

Education

PhD | Harvard University1977
BA | University of Pennsylvania1971