Associate Editor, Pain
Editorial Board, Journal of Pain
Editorial Board, Current Pain and Headache Reports
Professional Advisory Board, American Chronic Pain Association
Neuropathic Pain Advisory Council, Neuropathy Association
Zoster Working Group, Centers for Disease Control and Prevention
Special Government Employee, Food and Drug Administration
Director, Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), a public-private partnership with the Food and Drug Administration (http://www.acttion.org)
Methodologic aspects of analgesic clinical trials
Treatment and prevention of chronic pain
My current research focuses on methodologic aspects of acute and chronic pain clinical trials, especially identifying factors that increase the assay sensitivity of a trial to detect differences between an active and a control or comparison treatment. With funding from the US Food and Drug Administration (FDA), we are examining in large databases of acute and chronic pain trials the relationships between study methodologic features and study outcomes and placebo group responses, as well as comparing the responsiveness to treatment effects of different primary and secondary outcome measures. These studies and other efforts to improve the efficiency and informativeness of analgesic clinical trials are being conducted under the auspices of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership with the FDA, of which I serve as director.
In addition, in collaboration with Dennis Turk at the University of Washington, we are currently conducting a randomized clinical trial of tramadol, cognitive-behavior therapy, and health education alone and in combination for the treatment of fibromyalgia.
I have also been very interested in the identification of risk factors for the development of chronic neuropathic pain. One of our major results has been that patients with greater acute pain are more likely to develop chronic pain. This suggests that attenuating acute pain might prevent chronic pain, and an additional focus of my research has involved developing approaches to test this hypothesis.
1R01 AR059102-01A (9/1/11-7/31/16)
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
Combined behavioral and analgesic trial for fibromyalgia (COMBAT-FM)
Role: Principal Investigator
U01 FD004187-01 (9/15/11-8/31/16)
Food and Drug Administration
Analgesic clinical trial innovations, opportunities, and networks (ACTION)
Role: Principal Investigator
T32 NS007338 (7/1/90-6/30/15)
NIH/National Institute of Neurological Disorders and Stroke
Experimental therapeutics of neurological disease
Munch T, Dufka FL, Greene K, Smith SM, Dworkin RH, Rowbotham MC. "RReACT goes global: Perils and pitfalls of constructing a global open-access database of registered analgesic clinical trials and trial results." Pain.. 2014 Jul; 155(7):1313-7. Epub 2014 Apr 13.
Gauthier LR, Young A, Dworkin RH, Rodin G, Zimmermann C, Warr D, Librach SL, Moore M, Shepherd FA, Riddell RP, Macpherson A, Melzack R, Gagliese L. "Validation of the Short-Form McGill Pain Questionnaire-2 in Younger and Older People With Cancer Pain." The journal of pain : official journal of the American Pain Society.. 2014 Jul; 15(7):756-70. Epub 2014 Apr 26.
2014 Jun 30
Gewandter JS, McDermott MP, McKeown A, Smith SM, Williams MR, Hunsinger M, Farrar J, Turk DC, Dworkin RH. "Reporting of missing data and methods used to accommodate them in recent analgesic clinical trials: ACTTION systematic review and recommendations." Pain.. 2014 Jun 30; Epub 2014 Jun 30.
2014 Jun 20
Hershman DL, Lacchetti C, Dworkin RH, Lavoie Smith EM, Bleeker J, Cavaletti G, Chauhan C, Gavin P, Lavino A, Lustberg MB, Paice J, Schneider B, Smith ML, Smith T, Terstriep S, Wagner-Johnston N, Bak K, Loprinzi CL. "Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: american society of clinical oncology clinical practice guideline." Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2014 Jun 20; 32(18):1941-67. Epub 2014 Apr 14.
Hunsinger M, Smith SM, McKeown A, Parkhurst M, Gross RA, Lin AH, McDermott MP, Rappaport BA, Turk DC, Dworkin RH. "Disclosure of authorship contributions in analgesic clinical trials and related publications: ACTTION systematic review and recommendations." Pain.. 2014 Jun; 155(6):1059-63. Epub 2013 Dec 12.