Research Bio
Dr. Katzman's research interests include placental pathology and development disorders, such as DiGeorge syndrome. He has begun investigating the ability to confirm morphologically diagnosed hydatidiform moles using fluorescent in situ hybridization (FISH) in cases where cytogenetic analysis on submitted tissue is unhelpful (no growth) or cannot be processed due to fixation. FISH could become an alternative diagnostic method for these specimens in our clinical laboratory. Dr. Katzman has also investigated the enigmatic "maternal floor infarction" in the placenta and is particularly interested in its identification as a possible etiology in recurrent first trimester losses.
Dr. Katzman developed an interest in DiGeorge syndrome and the deletion 22q11.2 spectrum while in pediatric pathology fellowship. He has studied a cohort of autopsied patients with congenital heart disease compiled in the Cardiac Registry of Boston Children's Hospital to identify a subpopulation with the 22q11.2 deletion. He used the polymerase chain reaction (PCR) to evaluate loss of heterozygosity (LOH) in this chromosome region for each patient. He hopes to confirm his data by performing FISH on the same cases and to develop a PCR assay for the 22q11.2 deletion as an alternative to the currently used clinical FISH assay.
2013 Apr 19
Katzman PJ, Oble DA. "Eosinophilic/T-cell Chorionic Vasculitis and Chronic Villitis Involve Regulatory T-cells and Often Occur Together." Pediatric and developmental pathology : the official journal of the
Society for Pediatric Pathology and the Paediatric Pathology Society. 2013 Apr 19; Epub 2013 Apr 19. |
2013 Mar 20
Katzman PJ. "Variable ALK protein and ALK gene staining in inflammatory myofibroblastic tumors." Pediatric and developmental pathology : the official journal of the
Society for Pediatric Pathology and the Paediatric Pathology Society. 2013 Mar 20; Epub 2013 Mar 20. |
2012 Nov 15
Curtin WM, Katzman PJ, Florescue H, Metlay LA. "Accuracy of signs of clinical chorioamnionitis in the term parturient." Journal of perinatology : official journal of the California
Perinatal Association. 2012 Nov 15; Epub 2012 Nov 15. |
2011
Katzman PJ, Shawn M, Oble D. "Immunohistochemical analysis reveals an influx of regulatory T cells and focal trophoblastic STAT-1 phosphorylation in chronic villitis of unknown etiology." Pediatric and developmental pathology : the official journal of the
Society for Pediatric Pathology and the Paediatric Pathology Society. 2011 14(4):284-93. Epub 2011 Feb 23. |
2010 May
Camacho N, Krakow D, Johnykutty S, Katzman PJ, Pepkowitz S, Vriens J, Nilius B, Boyce BF, Cohn DH. "Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia." American journal of medical genetics. Part A. 2010 May 0; 152A(5):1169-77. |
