Patricia J. Sime, M.D.

Patricia J. Sime, M.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester, NY 14642

Office: (585) 275-4161
Fax: (585) 273-1171


The biographical information for Patricia J. Sime, M.D. is not currently available.


Over-Trimethylation of 27-Lysine on Histone 3 in Human Idiopathic Pulmonary Fibrosis and Silica Mouse Model

United States Serial NO.: 13/126,875
Filed Date: November 2, 2009
Title: Methods of Diagnosing and Treating Fibrosis
Invented by: Xin Lin, Jia Guo, Steve Georas, Patricia Sime

Recent Journal Articles

Showing the 5 most recent journal articles. 93 available »

2015 Apr 23
Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I. "Disruption of SIRT1-mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease." American journal of respiratory cell and molecular biology. 2015 Apr 23; Epub 2015 Apr 23.
2015 Apr
Jones KM, Randtke EA, Howison CM, Cárdenas-Rodríguez J, Sime PJ, Kottmann MR, Pagel MD. "Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI." Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2015 Apr; 17(2):177-84.
2014 Jun 1
Lugade AA, Bogner PN, Thatcher TH, Sime PJ, Phipps RP, Thanavala Y. "Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection." The Journal of immunology : official journal of the American Association of Immunologists. 2014 Jun 1; 192(11):5226-35. Epub 2014 Apr 21.
2014 Jun
Thannickal VJ, Henke CA, Horowitz JC, Noble PW, Roman J, Sime PJ, Zhou Y, Wells RG, White ES, Tschumperlin DJ. "Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute." The American journal of pathology. 2014 Jun; 184(6):1643-51. Epub 2014 Apr 13.
2014 May 1
Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente LP, Rahman I. "SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism." American journal of physiology. Lung cellular and molecular physiology. 2014 May 1; 306(9):L816-28. Epub 2014 Mar 14.

Current Appointments

Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD) - Primary
Professor - Department of Environmental Medicine (SMD)
Professor - Department of Microbiology and Immunology (SMD)


Pulmonary Disease - American Board of Internal Medicine
Internal Medicine - American Board of Internal Medicine


MD | Medicine | UK-U Edinburgh Fac Med1988
BS | Pathology | UK-U Edinburgh Fac Med1984

Post-Doctoral Training & Residency

Fellowship in Pulmonary at Royal Infirmary of Edinburgh03/01/1998 - 09/30/1999
Fellowship in Pulmonary at Mcmaster Univ, Canada11/01/1993 - 02/28/1998
Fellowship in Pulmonary at Royal Infirmary of Edinburgh03/01/1992 - 11/01/1993
Residency in General Internal Medicine at Borders General Hospital03/01/1991 - 02/28/1992
Residency in General Internal Medicine at Western General Hospitals08/01/1989 - 02/28/1991
Internship in Internal Medicine/General Surgery at Royal Infirmary of Edinburgh08/01/1988 - 07/31/1989