Hironao Wakabayashi, M.D., Ph.D.

Hironao Wakabayashi, M.D., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Appointment: (585) 275-URMC (8762)

Professional Bio

Hironao Wakabayashi earned M.D. after 6 year education at Fukushima Medical School in Japan on 1988. In the Department of Pathology (II) at Fukushima Medical School he enrolled Ph.D. program. He studied on cancer invasion and metastasis and earned Ph.D. at 1992. He obtained postdoctoral training at University of Texas MD Anderson Cancer Center in Huston working on the same subject until he had an appointment as a Research Assistant Professor at The Institute for Molecular Medicine at Irvine, CA on 1996. Since 1999 he has been working as a Research Assistant Professor in the Department of Biochemistry and Biophysics at University of Rochester studying on the structural and functional analyses of blood coagulation factor VIII.

Patient Care Bio

Hemophilia A is a bleeding disease caused by deficiency or defect of a protein called blood coagulation factor VIII. Since 1992 recombinant factor VIII product was introduced, the periodical (very frequent) supplement of this protein by injection through vein has been a major therapeutic approach. Our research focuses on the development of new factor VIII product which has better activity. Consequently the frequency of injection as well as a risk of heavy bleeding incident would be reduced. Hemophilia A patients are usually a boy. Less injection would be very helpful to ease them.
I started my career as a pathologist and obtained a training of cell biology and protein chemistry. I have been working on current study for 8 years.

Patents

Enhanced Stability Factor VIII Following Mutation of Acidic Residues at the A2 Domain Interface

United States Serial NO.: 12/179,801
Filed Date: July 25, 2008
Title: Recombinant Factor VIII Having Increased Stability
Invented by: Philip Fay, Hironao Wakabayashi
Enhanced Stability Factor VIII Following Mutation of Acidic Residues at the A2 Domain Interface

United States Serial NO.: 2008319183
Filed Date: July 25, 2008
Title: Recombinant Factor VIII Having Increased Stability
Invented by: Philip Fay, Hironao Wakabayashi
Enhanced Stability Factor VIII Following Mutation of Acidic Residues at the A2 Domain Interface

United States Serial NO.: MX2010004813
Filed Date: July 25, 2008
Title: Recombinant Factor VIII Having Increased Stability
Invented by: Philip Fay, Hironao Wakabayashi
Enhanced Stability Factor VIII Following Mutation of Acidic Residues at the A2 Domain Interface

United States Serial NO.: 2010122052
Filed Date: July 25, 2008
Title: Recombinant Factor VIII Having Increased Stability
Invented by: Philip Fay, Hironao Wakabayashi
Enhanced Stability Factor VIII Following Mutation of Acidic Residues at the A2 Domain Interface

United States Serial NO.: ZA2010-03049
Filed Date: July 25, 2008
Title: Recombinant Factor VIII Having Increased Stability
Invented by: Philip Fay, Hironao Wakabayashi
Enhanced Stability Factor VIII Following Mutation of Acidic Residues at the A2 Domain Interface

United States Serial NO.: 13/691,474
Filed Date: November 30, 2012
Title: Recombinant Factor VIII Having Increased Stability
Invented by: Philip Fay, Hironao Wakabayashi
Enhanced Stability Factor VIII Following Mutation of Acidic Residues at the A2 Domain Interface

United States Serial NO.: 14/052,452
Filed Date: October 11, 2013
Title: Recombinant Factor VIII Having Increased Stability
Invented by: Philip Fay, Hironao Wakabayashi
Enhanced Stability Factor VIII Following Mutation of Acidic Residues at the A2 Domain Interface

United States Serial NO.: DE08782378.7
Filed Date: July 25, 2008
Title: Recombinant Factor VIII Having Increased Stability
Invented by: Philip Fay, Hironao Wakabayashi
Enhanced Stability Factor VIII Following Mutation of Acidic Residues at the A2 Domain Interface

United States Serial NO.: GB08782378.7
Filed Date: July 25, 2008
Title: Recombinant Factor VIII Having Increased Stability
Invented by: Philip Fay, Hironao Wakabayashi

Current Appointments

Research Assistant Professor - Department of Biochemistry and Biophysics (SMD) - Primary

Education

PhD | Pathology | Japan-Fukushima Med Coll1992
MD | Medicine | Japan-Fukushima Med Coll1988

Post-Doctoral Training & Residency

1992-1996 Postdoctoral Fellow, Department of Tumor Biology The University of Texas M. D. Anderson Cancer Center, Houston, Texas, U.S.A. 1996