James F. Miller, Ph.D.

James F. Miller, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 609
Rochester, NY 14642

Office: (585) 275-9698
Lab: (585) 273-5383
Administrative: (585) 273-1400
Fax: (585) 273-2452

Journal Articles

Showing all 57 journal articles available.

2014
Sanchez-Lockhart M, Rojas AV, Fettis MM, Bauserman R, Higa TR, Miao H, Waugh RE, Miller J. "T cell receptor signaling can directly enhance the avidity of CD28 ligand binding." PloS one. 2014 9(2):e89263. Epub 2014 Feb 24.
2011
Sanchez-Lockhart M, Kim M, Miller J. "Cutting edge: A role for inside-out signaling in TCR regulation of CD28 ligand binding." The Journal of immunology : official journal of the American Association of Immunologists.. 2011 187(11):5515-9. Epub 2011 Nov 07.
2010 Sep 15
Cook KD, Miller J. "TCR-dependent translational control of GATA-3 enhances Th2 differentiation." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Sep 15; 185(6):3209-16. Epub 2010 Aug 09.
2009
Miller J, Baker C, Cook K, Graf B, Sanchez-Lockhart M, Sharp K, Wang X, Yang B, Yoshida T. "Two pathways of costimulation through CD28." Immunologic research. 2009 45(2-3):159-72. Epub 2009 Feb 13.
2008
Sanchez-Lockhart M, Graf B, Miller J. "Signals and sequences that control CD28 localization to the central region of the immunological synapse." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 181(11):7639-48.
2007 Aug 15
Arneson LS, Miller J. "The chondroitin sulfate form of invariant chain trimerizes with conventional invariant chain and these complexes are rapidly transported from the trans-Golgi network to the cell surface." The Biochemical journal.. 2007 Aug 15; 406(1):97-103.
2007 Aug 1
Graf B, Bushnell T, Miller J. "LFA-1-mediated T cell costimulation through increased localization of TCR/class II complexes to the central supramolecular activation cluster and exclusion of CD45 from the immunological synapse." The Journal of immunology : official journal of the American Association of Immunologists.. 2007 Aug 1; 179(3):1616-24.
2006 Apr 15
Sanchez-Lockhart M, Miller J. "Engagement of CD28 outside of the immunological synapse results in up-regulation of IL-2 mRNA stability but not IL-2 transcription." The Journal of immunology : official journal of the American Association of Immunologists.. 2006 Apr 15; 176(8):4778-84.
2005 Mar
Jenks SA, Eisfelder BJ, Miller J. "LFA-1 co-stimulation inhibits T(h)2 differentiation by down-modulating IL-4 responsiveness." International immunology. 2005 Mar; 17(3):315-23. Epub 2005 Feb 07.
2004 Aug 15
Sevilla LM, Comstock SS, Swier K, Miller J. "Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41." The Journal of immunology : official journal of the American Association of Immunologists.. 2004 Aug 15; 173(4):2586-93.
2004
Sanchez-Lockhart M, Marin E, Graf B, Abe R, Harada Y, Sedwick CE, Miller J. "Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signaling pathways." The Journal of immunology : official journal of the American Association of Immunologists.. 2004 173(12):7120-4.
2001 Nov 1
Abraham C, Miller J. "Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1." The Journal of immunology : official journal of the American Association of Immunologists.. 2001 Nov 1; 167(9):5193-201.
2001 Jun 15
Sevilla LM, Richter SS, Miller J. "Intracellular transport of MHC class II and associated invariant chain in antigen presenting cells from AP-3-deficient mocha mice." Cellular immunology.. 2001 Jun 15; 210(2):143-53.
2000 Jan 1
Jenks SA, Miller J. "Inhibition of IL-4 responses after T cell priming in the context of LFA-1 costimulation is not reversed by restimulation in the presence of CD28 costimulation." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Jan 1; 164(1):72-8.
1999 Sep 1
Ashman JB, Miller J. "A role for the transmembrane domain in the trimerization of the MHC class II-associated invariant chain." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Sep 1; 163(5):2704-12.
1999 Apr 15
Abraham C, Griffith J, Miller J. "The dependence for leukocyte function-associated antigen-1/ICAM-1 interactions in T cell activation cannot be overcome by expression of high density TCR ligand." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Apr 15; 162(8):4399-405.
1999 Feb 1
Sedwick CE, Morgan MM, Jusino L, Cannon JL, Miller J, Burkhardt JK. "TCR, LFA-1, and CD28 play unique and complementary roles in signaling T cell cytoskeletal reorganization." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Feb 1; 162(3):1367-75.
1998 Aug 25
Naujokas MF, Southwood S, Mathies SJ, Appella E, Sette A, Miller J. "T cell recognition of flanking residues of murine invariant chain-derived CLIP peptide bound to MHC class II." Cellular immunology.. 1998 Aug 25; 188(1):49-54.
1998 Apr 1
Zuckerman LA, Pullen L, Miller J. "Functional consequences of costimulation by ICAM-1 on IL-2 gene expression and T cell activation." The Journal of immunology : official journal of the American Association of Immunologists.. 1998 Apr 1; 160(7):3259-68.
1997 Oct
Fineschi B, Miller J. "Endosomal proteases and antigen processing." Trends in biochemical sciences.. 1997 Oct; 22(10):377-82.
1996 Oct 15
Fineschi B, Sakaguchi K, Appella E, Miller J. "The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain." The Journal of immunology : official journal of the American Association of Immunologists.. 1996 Oct 15; 157(8):3211-5.
1995 Oct 24
Fineschi B, Arneson LS, Naujokas MF, Miller J. "Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41." Proceedings of the National Academy of Sciences of the United States of America.. 1995 Oct 24; 92(22):10257-61.
1995 Sep
Naujokas MF, Arneson LS, Fineschi B, Peterson ME, Sitterding S, Hammond AT, Reilly C, Lo D, Miller J. "Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development." Immunity.. 1995 Sep; 3(3):359-72.
1995 Aug 15
Swier K, Miller J. "Invariant chain-independent antigen presentation depends primarily upon the pool of newly synthesized MHC class II molecules." The Journal of immunology : official journal of the American Association of Immunologists.. 1995 Aug 15; 155(4):1851-61.
1995 Jul 15
Swier K, Miller J. "Efficient internalization of MHC class II-invariant chain complexes is not sufficient for invariant chain proteolysis and class II antigen presentation." The Journal of immunology : official journal of the American Association of Immunologists.. 1995 Jul 15; 155(2):630-43.
1995 Jun
Arneson LS, Miller J. "Efficient endosomal localization of major histocompatibility complex class II-invariant chain complexes requires multimerization of the invariant chain targeting sequence." The Journal of cell biology.. 1995 Jun; 129(5):1217-28.
1995 May 1
Zuckerman LA, Sant AJ, Miller J. "Identification of a unique costimulatory activity for murine T helper 1 T cell clones." The Journal of immunology : official journal of the American Association of Immunologists.. 1995 May 1; 154(9):4503-12.
1995 Feb 1
Sette A, Southwood S, Miller J, Appella E. "Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II." The Journal of experimental medicine.. 1995 Feb 1; 181(2):677-83.
1994 Feb
Sant AJ, Miller J. "MHC class II antigen processing: biology of invariant chain." Current opinion in immunology. 1994 Feb; 6(1):57-63.
1994
Miller J. "Endosomal localization of MHC class II-invariant chain complexes." Immunologic research. 1994 13(4):244-52.
1993 Jul 30
Naujokas MF, Morin M, Anderson MS, Peterson M, Miller J. "The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44." Cell.. 1993 Jul 30; 74(2):257-68.
1993 Jan 15
Go C, Lancki DW, Fitch FW, Miller J. "Anergized T cell clones retain their cytolytic ability." The Journal of immunology : official journal of the American Association of Immunologists.. 1993 Jan 15; 150(2):367-76.
1993
Lenschow DJ, Su GH, Zuckerman LA, Nabavi N, Jellis CL, Gray GS, Miller J, Bluestone JA. "Expression and functional significance of an additional ligand for CTLA-4." Proceedings of the National Academy of Sciences of the United States of America.. 1993 90(23):11054-8.
1993
Anderson MS, Swier K, Arneson L, Miller J. "Enhanced antigen presentation in the absence of the invariant chain endosomal localization signal." The Journal of experimental medicine.. 1993 178(6):1959-69.
1992 Sep 1
Norton SD, Zuckerman L, Urdahl KB, Shefner R, Miller J, Jenkins MK. "The CD28 ligand, B7, enhances IL-2 production by providing a costimulatory signal to T cells." The Journal of immunology : official journal of the American Association of Immunologists.. 1992 Sep 1; 149(5):1556-61.
1992 Jun 18
Peterson M, Miller J. "Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41." Nature.. 1992 Jun 18; 357(6379):596-8.
1992 May 1
Go C, Miller J. "Differential induction of transcription factors that regulate the interleukin 2 gene during anergy induction and restimulation." The Journal of experimental medicine.. 1992 May 1; 175(5):1327-36.
1992 Mar 15
Anderson MS, Miller J. "Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules." Proceedings of the National Academy of Sciences of the United States of America.. 1992 Mar 15; 89(6):2282-6.
1990 May 10
Peterson M, Miller J. "Invariant chain influences the immunological recognition of MHC class II molecules." Nature.. 1990 May 10; 345(6271):172-4.
1990 May
Simonis S, Miller J, Cullen SE. "Biosynthesis and intracellular transport of MHC class II molecules associated with a mutated, glycosaminoglycan-negative invariant chain." Molecular immunology.. 1990 May; 27(5):413-22.
1990 Mar 15
Pereira GM, Miller JF, Shevach EM. "Mechanism of action of cyclosporine A in vivo. II. T cell priming in vivo to alloantigen can be mediated by an IL-2-independent cyclosporine A-resistant pathway." The Journal of immunology : official journal of the American Association of Immunologists.. 1990 Mar 15; 144(6):2109-16.
1990 Feb 15
Tosato G, Miller J, Marti G, Pike SE. "Accessory function of interleukin-1 and interleukin-6: preferential costimulation of T4 positive lymphocytes." Blood.. 1990 Feb 15; 75(4):922-30.
1990 Jan 1
Miller J, Daitch L, Rath S, Selsing E. "Tissue-specific expression of allogeneic class II MHC molecules induces neither tissue rejection nor clonal inactivation of alloreactive T cells." The Journal of immunology : official journal of the American Association of Immunologists.. 1990 Jan 1; 144(1):334-41.
1989 Jul 1
McCoy KL, Miller J, Jenkins M, Ronchese F, Germain RN, Schwartz RH. "Diminished antigen processing by endosomal acidification mutant antigen-presenting cells." The Journal of immunology : official journal of the American Association of Immunologists.. 1989 Jul 1; 143(1):29-38.
1989 Feb
Storb U, Haasch D, Arp B, Sanchez P, Cazenave PA, Miller J. "Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences." Molecular and cellular biology.. 1989 Feb; 9(2):711-8.
1989
Simonis S, Miller J, Cullen SE. "The role of the Ia-invariant chain complex in the posttranslational processing and transport of Ia and invariant chain glycoproteins." The Journal of immunology : official journal of the American Association of Immunologists.. 1989 143(11):3619-25.
1988 Oct 1
Miller J, Ogden S, McMullen M, Andres H, Storb U. "The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns." The Journal of immunology : official journal of the American Association of Immunologists.. 1988 Oct 1; 141(7):2497-502.
1988 Mar
Miller J, Hatch JA, Simonis S, Cullen SE. "Identification of the glycosaminoglycan-attachment site of mouse invariant-chain proteoglycan core protein by site-directed mutagenesis." Proceedings of the National Academy of Sciences of the United States of America.. 1988 Mar; 85(5):1359-63.
1987
Saito T, Weiss A, Miller J, Norcross MA, Germain RN. "Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes." Nature.. 1987 325(7000):125-30.
1986 Nov 1
Miller J, Germain RN. "Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain." The Journal of experimental medicine.. 1986 Nov 1; 164(5):1478-89.
1986 Aug
Malek TR, Ashwell JD, Germain RN, Shevach EM, Miller J. "The murine interleukin-2 receptor: biochemical structure and regulation of expression." Immunological reviews. 1986 Aug; 92:81-101.
1986 Mar
Germain RN, Braunstein NS, Brown MA, Glimcher LH, Lechler RI, McCluskey J, Margulies DH, Miller J, Norcross MA, Paul WE. "Structure and function of murine class II major histocompatibility complex genes." The Mount Sinai journal of medicine, New York.. 1986 Mar; 53(3):194-201.
1985 Jun
Miller J, Malek TR, Leonard WJ, Greene WC, Shevach EM, Germain RN. "Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA." The Journal of immunology : official journal of the American Association of Immunologists.. 1985 Jun; 134(6):4212-7.
1982 Aug
Selsing E, Miller J, Wilson R, Storb U. "Evolution of mouse immunoglobulin lambda genes." Proceedings of the National Academy of Sciences of the United States of America.. 1982 Aug; 79(15):4681-5.
1982 Feb 4
Miller J, Selsing E, Storb U. "Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression." Nature.. 1982 Feb 4; 295(5848):428-30.
1981 Jun
Miller J, Bothwell A, Storb U. "Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III." Proceedings of the National Academy of Sciences of the United States of America.. 1981 Jun; 78(6):3829-33.
1979 Oct 30
Wilson R, Miller J, Storb U. "Rearrangement of immunoglobulin genes." Biochemistry.. 1979 Oct 30; 18(22):5013-21.

Books