Andrea Sant, Ph.D.

Andrea Sant, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 609
Rochester, NY 14642

Office: (585) 275-9798
Lab: (585) 273-5385

Journal Articles

Showing all 75 journal articles available.

2013 Aug 1
Nayak JL, Alam S, Sant AJ. "Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin." The Journal of immunology : official journal of the American Association of Immunologists.. 2013 Aug 1; 191(3):1001-5. Epub 2013 Jun 21.
2013 Jul 15
Tung J, Sant AJ. "Orchestration of CD4 T cell epitope preferences after multipeptide immunization." The Journal of immunology : official journal of the American Association of Immunologists.. 2013 Jul 15; 191(2):764-72. Epub 2013 Jun 14.
2013 Jan 15
Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ. "CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine." The Journal of infectious diseases.. 2013 Jan 15; 207(2):297-305. Epub 2012 Nov 12.
2013
Weilhammer DR, Blanchette CD, Fischer NO, Alam S, Loots GG, Corzett M, Thomas C, Lychak C, Dunkle AD, Ruitenberg JJ, Ghanekar SA, Sant AJ, Rasley A. "The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge." Biomaterials.. 2013 34(38):10305-18. Epub 2013 Sep 27.
2012 Aug
Nayak JL, Sant AJ. "Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host." Immunology. 2012 Aug; 136(4):425-36.
2012 Jul 30
Sant AJ, McMichael A. "Revealing the role of CD4(+) T cells in viral immunity." The Journal of experimental medicine.. 2012 Jul 30; 209(8):1391-5.
2012 May 1
Chaves FA, Lee AH, Nayak JL, Richards KA, Sant AJ. "The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 May 1; 188(9):4235-48. Epub 2012 Mar 30.
2012 Mar
Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H. "Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity." Molecular therapy : the journal of the American Society of Gene Therapy.. 2012 Mar; 20(3):652-60. Epub 2012 Jan 10.
2012
Richards KA, Chaves FA, Alam S, Sant AJ. "Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins." Vaccine.. 2012 31(1):219-25. Epub 2012 Oct 22.
2012
Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY. "Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization." PloS one. 2012 7(3):e34377. Epub 2012 Mar 23.
2012
Leddon SA, Sant AJ. "The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization." PloS one. 2012 7(10):e46952. Epub 2012 Oct 15.
2011 Jun
Richards KA, Chaves FA, Sant AJ. "The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity." Immunology. 2011 Jun; 133(2):246-56. Epub 2011 Mar 29.
2011 Mar
Nayak JL, Sant AJ. "T cell immunology for the clinician." The Pediatric infectious disease journal.. 2011 Mar; 30(3):248-50.
2011
Alam S, Sant AJ. "Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus." Journal of virology.. 2011 85(24):13310-21. Epub 2011 Oct 05.
2010 Nov 1
Richards KA, Topham D, Chaves FA, Sant AJ. "Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Nov 1; 185(9):4998-5002. Epub 2010 Oct 01.
2010 Aug
Leddon SA, Sant AJ. "Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules." Current opinion in organ transplantation. 2010 Aug; 15(4):505-11.
2010 May 10
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. "Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells." Virology.. 2010 May 10; 400(2):224-32. Epub 2010 Feb 25.
2010 Apr
Nayak JL, Richards KA, Chaves FA, Sant AJ. "Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins." Viral immunology.. 2010 Apr; 23(2):169-80.
2009 Jul
Richards KA, Chaves FA, Sant AJ. "Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus." Journal of virology.. 2009 Jul; 83(13):6566-77. Epub 2009 Apr 22.
2009 May 26
Weaver JM, Chaves FA, Sant AJ. "Abortive activation of CD4 T cell responses during competitive priming in vivo." Proceedings of the National Academy of Sciences of the United States of America.. 2009 May 26; 106(21):8647-52. Epub 2009 May 07.
2009
Weaver JM, Sant AJ. "Understanding the focused CD4 T cell response to antigen and pathogenic organisms." Immunologic research. 2009 45(2-3):123-43. Epub 2009 Feb 07.
2008 Sep 1
Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ. "Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Sep 1; 181(5):3039-48.
2008 May 12
Huang S, Gilfillan S, Kim S, Thompson B, Wang X, Sant AJ, Fremont DH, Lantz O, Hansen TH. "MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells." The Journal of experimental medicine.. 2008 May 12; 205(5):1201-11. Epub 2008 Apr 28.
2008 Mar
Bandyopadhyay A, Arneson L, Beeson C, Sant AJ. "The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function." Molecular immunology.. 2008 Mar; 45(5):1248-57. Epub 2007 Nov 05.
2008 Feb 15
Larkin J, Rankin AL, Picca CC, Riley MP, Jenks SA, Sant AJ, Caton AJ. "CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Feb 15; 180(4):2149-57.
2008 Feb 1
Menges PR, Jenks SA, Bikoff EK, Friedmann DR, Knowlden ZA, Sant AJ. "An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Feb 1; 180(3):1619-33.
2007 Sep
Gardiner A, Richards KA, Sant AJ, Arneson LS. "Conformation of MHC class II I-A(g7) is sensitive to the P9 anchor amino acid in bound peptide." International immunology. 2007 Sep; 19(9):1103-13.
2007 Jul
Richards KA, Chaves FA, Krafcik FR, Topham DJ, Lazarski CA, Sant AJ. "Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin." Journal of virology.. 2007 Jul; 81(14):7608-19. Epub 2007 May 16.
2007 Jun
Sant AJ, Chaves FA, Krafcik FR, Lazarski CA, Menges P, Richards K, Weaver JM. "Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design." Expert review of vaccines. 2007 Jun; 6(3):357-68.
2007 May
Chaves FA, Sant AJ. "Measurement of peptide dissociation from MHC class II molecules." Current protocols in immunology / edited by John E. Coligan ... [et al.]. 2007 May; Chapter 18:Unit 18.14.
2006 May 23
Chaves FA, Richards KA, Torelli A, Wedekind J, Sant AJ. "Peptide-binding motifs for the I-Ad MHC class II molecule: alternate pH-dependent binding behavior." Biochemistry.. 2006 May 23; 45(20):6426-33.
2006 May 15
Lazarski CA, Chaves FA, Sant AJ. "The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability." The Journal of experimental medicine.. 2006 May 15; 203(5):1319-28. Epub 2006 May 08.
2005 Oct
Sant AJ, Chaves FA, Jenks SA, Richards KA, Menges P, Weaver JM, Lazarski CA. "The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes." Immunological reviews. 2005 Oct; 207:261-78.
2005 Jul 1
McFarland BJ, Katz JF, Sant AJ, Beeson C. "Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein." Journal of molecular biology.. 2005 Jul 1; 350(1):170-83.
2005 Jul
Lazarski CA, Chaves FA, Jenks SA, Wu S, Richards KA, Weaver JM, Sant AJ. "The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance." Immunity.. 2005 Jul; 23(1):29-40.
2005 May
Chaves FA, Hou P, Wu S, Sant AJ. "Replacement of the membrane proximal region of I-A(d) MHC class II molecule with I-E-derived sequences promotes production of an active and stable soluble heterodimer without altering peptide-binding specificity." Journal of immunological methods.. 2005 May; 300(1-2):74-92.
2001 Jul 31
McFarland BJ, Katz JF, Beeson C, Sant AJ. "Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes." Proceedings of the National Academy of Sciences of the United States of America.. 2001 Jul 31; 98(16):9231-6. Epub 2001 Jul 24.
2001
Arneson LS, Katz JF, Liu M, Sant AJ. "Hydrogen bond integrity between MHC class II molecules and bound peptide determines the intracellular fate of MHC class II molecules." The Journal of immunology : official journal of the American Association of Immunologists.. 2001 167(12):6939-46.
2000 Sep 18
Nanda NK, Sant AJ. "DM determines the cryptic and immunodominant fate of T cell epitopes." The Journal of experimental medicine.. 2000 Sep 18; 192(6):781-8.
2000 Aug 15
Arneson LS, Peterson M, Sant AJ. "The MHC class II molecule I-Ag7 exists in alternate conformations that are peptide dependent." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Aug 15; 165(4):2059-67.
1999 Oct 1
McFarland BJ, Beeson C, Sant AJ. "Cutting edge: a single, essential hydrogen bond controls the stability of peptide-MHC class II complexes." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Oct 1; 163(7):3567-71.
1999 Sep
Bryant PW, Roos P, Ploegh HL, Sant AJ. "Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties." European journal of immunology.. 1999 Sep; 29(9):2729-39.
1999 Jun 1
Siemasko K, Eisfelder BJ, Stebbins C, Kabak S, Sant AJ, Song W, Clark MR. "Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Jun 1; 162(11):6518-25.
1999
McFarland BJ, Sant AJ, Lybrand TP, Beeson C. "Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers." Biochemistry.. 1999 38(50):16663-70.
1999
McFarland, B. J.; Sant, A. J.; Beeson, C.;. "Identification of two distinct structural transitions in the dissociation of peptides from class II proteins of the major histocompatibility complex". 1999; 121: 11225-11226. Link
1999
Sant AJ, Beeson C, McFarland B, Cao J, Ceman S, Bryant PW, Wu S. "Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange." Immunological reviews. 1999 172:239-53.
1998 Sep 15
Peterson M, Sant AJ. "The inability of the nonobese diabetic class II molecule to form stable peptide complexes does not reflect a failure to interact productively with DM." The Journal of immunology : official journal of the American Association of Immunologists.. 1998 Sep 15; 161(6):2961-7.
1998
Ceman S, Wu S, Jardetzky TS, Sant AJ. "Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal." The Journal of experimental medicine.. 1998 188(11):2139-49.
1997 Jun
Tan LJ, Ceman S, Chervonsky A, Rodriguez-Paris J, Steck TL, Sant AJ. "Late events in the intracellular sorting of major histocompatibility complex class II molecules are regulated by the 80-82 segment of the class II beta chain." European journal of immunology.. 1997 Jun; 27(6):1479-88.
1996 Nov 1
Katz JF, Stebbins C, Appella E, Sant AJ. "Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules." The Journal of experimental medicine.. 1996 Nov 1; 184(5):1747-53.
1996
Stebbins CC, Peterson ME, Suh WM, Sant AJ. "DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules." The Journal of immunology : official journal of the American Association of Immunologists.. 1996 157(11):4892-8.
1995 May 1
Zuckerman LA, Sant AJ, Miller J. "Identification of a unique costimulatory activity for murine T helper 1 T cell clones." The Journal of immunology : official journal of the American Association of Immunologists.. 1995 May 1; 154(9):4503-12.
1995 Apr
Chervonsky A, Sant AJ. "In the absence of major histocompatibility complex class II molecules, invariant chain is translocated to late endocytic compartments by autophagy." European journal of immunology.. 1995 Apr; 25(4):911-8.
1995 Jan 1
Stebbins CC, Loss GE, Elias CG, Chervonsky A, Sant AJ. "The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent." The Journal of experimental medicine.. 1995 Jan 1; 181(1):223-34.
1995
Ceman S, Sant AJ. "The function of invariant chain in class II-restricted antigen presentation." Seminars in immunology. 1995 7(6):373-87.
1994 Jul
Chervonsky AV, Gordon L, Sant AJ. "A segment of the MHC class II beta chain plays a critical role in targeting class II molecules to the endocytic pathway." International immunology. 1994 Jul; 6(7):973-82.
1994 Feb 15
Katz JF, Sant AJ. "T cell receptor recognition of MHC class II alloantigens is highly cell type dependent." The Journal of immunology : official journal of the American Association of Immunologists.. 1994 Feb 15; 152(4):1629-40.
1994 Feb
Sant AJ, Miller J. "MHC class II antigen processing: biology of invariant chain." Current opinion in immunology. 1994 Feb; 6(1):57-63.
1994
Sant AJ. "Endogenous antigen presentation by MHC class II molecules." Immunologic research. 1994 13(4):253-67.
1993 Jul 1
Loss GE, Elias CG, Fields PE, Ribaudo RK, McKisic M, Sant AJ. "Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways." The Journal of experimental medicine.. 1993 Jul 1; 178(1):73-85.
1993 Jun 15
Sant AJ. "Isotypic residues in the membrane proximal domain of MHC class II beta-chains control activation of CD4+ T cells." The Journal of immunology : official journal of the American Association of Immunologists.. 1993 Jun 15; 150(12):5299-310.
1993 Apr 15
Loss GE, Sant AJ. "Invariant chain retains MHC class II molecules in the endocytic pathway." The Journal of immunology : official journal of the American Association of Immunologists.. 1993 Apr 15; 150(8 Pt 1):3187-97.
1991 Nov 1
McKisic MD, Sant AJ, Fitch FW. "Some cloned murine CD4+ T cells recognize H-2Ld class I MHC determinants directly. Other cloned CD4+ T cells recognize H-2Ld class I MHC determinants in the context of class II MHC molecules." The Journal of immunology : official journal of the American Association of Immunologists.. 1991 Nov 1; 147(9):2868-74.
1991 Oct 1
Sant AJ, Hendrix LR, Coligan JE, Maloy WL, Germain RN. "Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains." The Journal of experimental medicine.. 1991 Oct 1; 174(4):799-808.
1990 Jan 1
Lechler RI, Sant AJ, Braunstein NS, Sekaly R, Long E, Germain RN. "Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain." The Journal of immunology : official journal of the American Association of Immunologists.. 1990 Jan 1; 144(1):329-33.
1989 Jun 2
Sant AJ, Germain RN. "Intracellular competition for component chains determines class II MHC cell surface phenotype." Cell.. 1989 Jun 2; 57(5):797-805.
1988 Jan 1
Sant AJ, Zacheis M, Rumbarger T, Giacoletto KS, Schwartz BD. "Human Ia alpha- and beta-chains are sulfated." The Journal of immunology : official journal of the American Association of Immunologists.. 1988 Jan 1; 140(1):155-60.
1988
Germain RN, Sant AJ, Braunstein NS, Ronchese F. "The molecular basis of antigen presentation." Princess Takamatsu symposia. 1988 19:179-91.
1987 Nov
Sant AJ, Braunstein NS, Germain RN. "Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex alpha beta dimer expression." Proceedings of the National Academy of Sciences of the United States of America.. 1987 Nov; 84(22):8065-9.
1986 Nov 1
Giacoletto KS, Sant AJ, Bono C, Gorka J, O'Sullivan DM, Quaranta V, Schwartz BD. "The human invariant chain is the core protein of the human class II-associated proteoglycan." The Journal of experimental medicine.. 1986 Nov 1; 164(5):1422-39.
1985 Jul
Sant AJ, Cullen SE, Schwartz BD. "Biosynthetic relationships of the chondroitin sulfate proteoglycan with Ia and invariant chain glycoproteins." The Journal of immunology : official journal of the American Association of Immunologists.. 1985 Jul; 135(1):416-22.
1985 Jul
Sant AJ, Schwartz BD, Cullen SE. "Cellular distribution of the Ia-associated chondroitin sulfate proteoglycan." The Journal of immunology : official journal of the American Association of Immunologists.. 1985 Jul; 135(1):408-15.
1985
Sant AJ, Cullen SE, Giacoletto KS, Schwartz BD. "Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan." The Journal of experimental medicine.. 1985 162(6):1916-34.
1984 Mar
Sant AJ, Cullen SE, Schwartz BD. "Identification of a sulfate-bearing molecule associated with HLA class II antigens." Proceedings of the National Academy of Sciences of the United States of America.. 1984 Mar; 81(5):1534-8.
1983
Sant AJ, Schwartz BD, Cullen SE. "Identification of a new component in the murine Ia molecular complex." The Journal of experimental medicine.. 1983 158(6):1979-92.

Books

2006
Drake J; Sant AJ. "The Mechanics of Class II Processing: Establishment of a Class II Hierarchy". Immunodominance: The Choice of the Immune System. J Frelinger. : Wiley-VCH, 2006. 314
1994
Sant, AJ, Chervonsky, A, Dykhuizen, M, Katz, JF, Loss, GE, Stebbins, C, and LJ Tan. "Intracellular events regulating MHC Class II restricted antigen presentation". Antigen Processing and Presentation. S Pierce and R Humphreys. : Academic Press, 1994.
1988
Braunstein, NS, Ronchese, F, Sant, AJ, Schwartz, RH, Lechler, RI, and Germain, RN. "DNA-mediated gene transfer as a tool for analyzing la structure-function relationships and antigen presentation". Antigen Presenting Cells: Diversity, Differentiation and Regulation. : Alan R. Liss, Inc., 1988.
1988
Germain, RN, Braunstein, NS, Lechler, RI, Miller, J, Ronchese, F, and Sant, AJ. "la structure and immune recognition". Processing and Presentation of Antigens. B Pernis, S Silverstein, and H Vogel. : Academic Press NY, 1988.