Arshad Rahman, Ph.D.

Arshad Rahman, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-5948

Journal Articles

Showing all 56 journal articles available.

2013
Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A. "Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration." PloS one. 2013 8(3):e59965. Epub 2013 Mar 21.
2012 Nov
Bijli KM, Fazal F, Rahman A. "Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2." American journal of respiratory cell and molecular biology.. 2012 Nov; 47(5):660-8. Epub 2012 Jul 27.
2010 Jun 15
Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I. "Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells." Antioxidants & redox signaling.. 2010 Jun 15; 12(12):1355-69.
2009 Jul 31
Fazal F, Bijli KM, Minhajuddin M, Rein T, Finkelstein JN, Rahman A. "Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells." The Journal of biological chemistry.. 2009 Jul 31; 284(31):21047-56. Epub 2009 May 29.
2009 Apr
Rahman A, Fazal F. "Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration." Antioxidants & redox signaling.. 2009 Apr; 11(4):823-39.
2009 Feb 13
Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A. "Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells." The Journal of biological chemistry.. 2009 Feb 13; 284(7):4052-61. Epub 2008 Dec 13.
2008 Jul
Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. "VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2008 Jul; 22(7):2297-310. Epub 2008 Feb 08.
2008 May 23
Bijli KM, Fazal F, Minhajuddin M, Rahman A. "Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65." The Journal of biological chemistry.. 2008 May 23; 283(21):14674-84. Epub 2008 Mar 24.
2007 Feb 9
Fazal F, Minhajuddin M, Bijli KM, McGrath JL, Rahman A. "Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells." The Journal of biological chemistry.. 2007 Feb 9; 282(6):3940-50. Epub 2006 Dec 08.
2007 Feb
Bijli KM, Minhajuddin M, Fazal F, O'Reilly MA, Platanias LC, Rahman A. "c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells." American journal of physiology. Lung cellular and molecular physiology.. 2007 Feb; 292(2):L396-404. Epub 2006 Sep 29.
2006 Oct
Orrington-Myers J, Gao X, Kouklis P, Broman M, Rahman A, Vogel SM, Malik AB. "Regulation of lung neutrophil recruitment by VE-cadherin." American journal of physiology. Lung cellular and molecular physiology.. 2006 Oct; 291(4):L764-71. Epub 2006 Jun 16.
2006 Aug 15
Staversky RJ, Vitiello PF, Gehen SC, Helt CE, Rahman A, Keng PC, O'Reilly MA. "p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L)." Free radical biology & medicine.. 2006 Aug 15; 41(4):601-9. Epub 2006 May 23.
2006 Jun 9
Frey RS, Gao X, Javaid K, Siddiqui SS, Rahman A, Malik AB. "Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells." The Journal of biological chemistry.. 2006 Jun 9; 281(23):16128-38. Epub 2006 Mar 09.
2005 May 1
Minhajuddin M, Fazal F, Bijli KM, Amin MR, Rahman A. "Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells." The Journal of immunology : official journal of the American Association of Immunologists.. 2005 May 1; 174(9):5823-9.
2004 Nov
Rahman A, Anwar KN, Minhajuddin M, Bijli KM, Javaid K, True AL, Malik AB. "cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells." American journal of physiology. Lung cellular and molecular physiology.. 2004 Nov; 287(5):L1017-24. Epub 2004 Jul 09.
2004
Anwar KN, Fazal F, Malik AB, Rahman A. "RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65." The Journal of immunology : official journal of the American Association of Immunologists.. 2004 173(11):6965-72.
2003 Oct
Ong ES, Gao XP, Xu N, Predescu D, Rahman A, Broman MT, Jho DH, Malik AB. "E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeability." American journal of physiology. Lung cellular and molecular physiology.. 2003 Oct; 285(4):L879-88. Epub 2003 Jun 20.
2003 Sep 26
Paria BC, Malik AB, Kwiatek AM, Rahman A, May MJ, Ghosh S, Tiruppathi C. "Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells." The Journal of biological chemistry.. 2003 Sep 26; 278(39):37195-203. Epub 2003 Jul 10.
2003 Aug 29
Kambhampati S, Li Y, Verma A, Sassano A, Majchrzak B, Deb DK, Parmar S, Giafis N, Kalvakolanu DV, Rahman A, Uddin S, Minucci S, Tallman MS, Fish EN, Platanias LC. "Activation of protein kinase C delta by all-trans-retinoic acid." The Journal of biological chemistry.. 2003 Aug 29; 278(35):32544-51. Epub 2003 Jun 12.
2003 Jul 1
Deb DK, Sassano A, Lekmine F, Majchrzak B, Verma A, Kambhampati S, Uddin S, Rahman A, Fish EN, Platanias LC. "Activation of protein kinase C delta by IFN-gamma." The Journal of immunology : official journal of the American Association of Immunologists.. 2003 Jul 1; 171(1):267-73.
2003 May 30
Javaid K, Rahman A, Anwar KN, Frey RS, Minshall RD, Malik AB. "Tumor necrosis factor-alpha induces early-onset endothelial adhesivity by protein kinase Czeta-dependent activation of intercellular adhesion molecule-1." Circulation research.. 2003 May 30; 92(10):1089-97. Epub 2003 Apr 24.
2003
Babcock TA, Kurland A, Helton WS, Rahman A, Anwar KN, Espat NJ. "Inhibition of activator protein-1 transcription factor activation by omega-3 fatty acid modulation of mitogen-activated protein kinase signaling kinases." JPEN. Journal of parenteral and enteral nutrition.. 2003 27(3):176-80; discussion 181.
2002 Sep 6
Rahman A, True AL, Anwar KN, Ye RD, Voyno-Yasenetskaya TA, Malik AB. "Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells." Circulation research.. 2002 Sep 6; 91(5):398-405.
2002 Aug 15
Skidgel RA, Gao XP, Brovkovych V, Rahman A, Jho D, Predescu S, Standiford TJ, Malik AB. "Nitric oxide stimulates macrophage inflammatory protein-2 expression in sepsis." The Journal of immunology : official journal of the American Association of Immunologists.. 2002 Aug 15; 169(4):2093-101.
2002 May 17
Frey RS, Rahman A, Kefer JC, Minshall RD, Malik AB. "PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells." Circulation research.. 2002 May 17; 90(9):1012-9.
2002 Apr 26
Uddin S, Sassano A, Deb DK, Verma A, Majchrzak B, Rahman A, Malik AB, Fish EN, Platanias LC. "Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727." The Journal of biological chemistry.. 2002 Apr 26; 277(17):14408-16. Epub 2002 Feb 11.
2002 Apr 15
Gao XP, Standiford TJ, Rahman A, Newstead M, Holland SM, Dinauer MC, Liu QH, Malik AB. "Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice." The Journal of immunology : official journal of the American Association of Immunologists.. 2002 Apr 15; 168(8):3974-82.
2002 Apr
Xu N, Gao XP, Minshall RD, Rahman A, Malik AB. "Time-dependent reversal of sepsis-induced PMN uptake and lung vascular injury by expression of CD18 antagonist." American journal of physiology. Lung cellular and molecular physiology.. 2002 Apr; 282(4):L796-802.
2002 Feb 1
Fan J, Frey RS, Rahman A, Malik AB. "Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells." The Journal of biological chemistry.. 2002 Feb 1; 277(5):3404-11. Epub 2001 Nov 29.
2001 Sep 1
Gao X, Xu N, Sekosan M, Mehta D, Ma SY, Rahman A, Malik AB. "Differential role of CD18 integrins in mediating lung neutrophil sequestration and increased microvascular permeability induced by Escherichia coli in mice." The Journal of immunology : official journal of the American Association of Immunologists.. 2001 Sep 1; 167(5):2895-901.
2001 Aug
Rahman A, Anwar KN, Uddin S, Xu N, Ye RD, Platanias LC, Malik AB. "Protein kinase C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38 mitogen-activated protein kinase." Molecular and cellular biology.. 2001 Aug; 21(16):5554-65.
2001 Jun 22
Mehta D, Rahman A, Malik AB. "Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function." The Journal of biological chemistry.. 2001 Jun 22; 276(25):22614-20. Epub 2001 Apr 17.
2001 Jun 1
Yang M, Sang H, Rahman A, Wu D, Malik AB, Ye RD. "G alpha 16 couples chemoattractant receptors to NF-kappa B activation." The Journal of immunology : official journal of the American Association of Immunologists.. 2001 Jun 1; 166(11):6885-92.
2001 Jan
Kefer J, Rahman A, Anwar KN, Malik AB. "Decreased oxidant buffering impairs NF-kappaB activation and ICAM-1 transcription in endothelial cells." Shock.. 2001 Jan; 15(1):11-5.
2000 Oct
Rahman A, Anwar KN, Malik AB. "Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells." American journal of physiology. Cell physiology.. 2000 Oct; 279(4):C906-14.
2000 Aug 4
Xu N, Rahman A, Minshall RD, Tiruppathi C, Malik AB. "beta(2)-Integrin blockade driven by E-selectin promoter prevents neutrophil sequestration and lung injury in mice." Circulation research.. 2000 Aug 4; 87(3):254-60.
2000
True, A.L., Rahman, A., Malik, A.B. "Activation of NF-kB induced by H2O2 and TNFa in endothelial cells and effect on ICAM-1 expression." Am. J. Physiol: Lung Mol. Cell. Physiolol.. 2000; 279: L302-L311. Link
1999 Nov
Lo SK, Rahman A, Xu N, Zhou MY, Nagpala P, Jaffe HA, Malik AB. "Neutrophil inhibitory factor abrogates neutrophil adhesion by blockade of CD11a and CD11b beta(2) integrins." Molecular pharmacology.. 1999 Nov; 56(5):926-32.
1999 May 1
Rahman A, Anwar KN, True AL, Malik AB. "Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 May 1; 162(9):5466-76.
1999 Mar
Rahman A, Bando M, Kefer J, Anwar KN, Malik AB. "Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription." Molecular pharmacology.. 1999 Mar; 55(3):575-83.
1998
Rahman, A., Kefer, J., Bando, M., Niles, W.D., Malik, A.B. "E-selectin expression in human endothelial cells by TNFa-induced oxidant generation and NF-kB activation." Am. J. Physiol.. 1998; 19: L533-L544. Link
1995 Aug 11
Roebuck KA, Rahman A, Lakshminarayanan V, Janakidevi K, Malik AB. "H2O2 and tumor necrosis factor-alpha activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter." The Journal of biological chemistry.. 1995 Aug 11; 270(32):18966-74.
1995 Jul
Rahman A, Malhotra P, Dhar R, Kewalramani T, Thimmapaya B. "Effect of single-base substitutions in the central domain of virus-associated RNA I on its function." Journal of virology.. 1995 Jul; 69(7):4299-307.
1994
Fazal, F., Rahman, A., Hadi, S.M. "Generation of superoxide anion and hydroxyl radical by methylglyoxal." Med. Sci. Res.. 1994; 22: 21-24. Link
1992 Apr
Said Ahmad M, Fazal F, Rahman A, Hadi SM, Parish JH. "Activities of flavonoids for the cleavage of DNA in the presence of Cu(II): correlation with generation of active oxygen species." Carcinogenesis.. 1992 Apr; 13(4):605-8.
1992 Apr
Rahman A, Fazal F, Greensill J, Ainley K, Parish JH, Hadi SM. "Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals and biological consequences of scission." Molecular and cellular biochemistry.. 1992 Apr; 111(1-2):3-9.
1991 Oct
Shahabuddin , Rahman A, Hadi SM. "Reaction of furfural and methylfurfural with DNA: use of single-strand-specific nucleases." Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.. 1991 Oct; 29(10):719-21.
1990 Nov
Fazal F, Rahman A, Greensill J, Ainley K, Hadi SM, Parish JH. "Strand scission in DNA by quercetin and Cu(II): identification of free radical intermediates and biological consequences of scission." Carcinogenesis.. 1990 Nov; 11(11):2005-8.
1990 Nov
Rahman A, Shahabuddin , Hadi SM, Parish JH. "Complexes involving quercetin, DNA and Cu(II)." Carcinogenesis.. 1990 Nov; 11(11):2001-3.
1990 Mar
Shahabuddin , Rahman A, Hadi SM. "Specificity of the in vitro interaction of methylfurfural with DNA." Mutagenesis. 1990 Mar; 5(2):131-6.
1990
Rahman A, Shahabuddin , Hadi SM. "Formation of strand breaks and interstrand cross-links in DNA by methylglyoxal." Journal of biochemical toxicology.. 1990 5(3):161-6.
1989 Oct
Rahman A, Shahabuddin , Hadi SM, Parish JH, Ainley K. "Strand scission in DNA induced by quercetin and Cu(II): role of Cu(I) and oxygen free radicals." Carcinogenesis.. 1989 Oct; 10(10):1833-9.
1989 Mar
Hadi SM, Shahabuddin , Rehman A. "Specificity of the interaction of furfural with DNA." Mutation research.. 1989 Mar; 225(3):101-6.
1986
Rizvi, R.Y., Uddin, S., Rahman, A., Hadi, S. M. "Effect of alkylation with streptozotocin on the secondary structure of DNA." Biosc. Rep.. 1986; 6: 557-564. Link
0
Bijli KM, Minhajuddin M, Fazal F, O'Reilly, MA, Platanias, LC, Rahman A. "c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells." Am J Physiol Lung Cell Mol Physiol. . Link
0
Fazal F, Minhajuddin M, Bijli KM, McGrath J, Rahman A. "Evidence for actin cytoskeleton-dependent and -independent RelA/p65 nuclear translocation in endothelial cells." J Biol Chem. . Link

Books

2007
Bijli KM, Rahman A. "NF-kapp B Signaling in Endothelium". Endothelial Biomedicine. Aird WC. : Cambridge University Press, 2007.
1996
Rahman A, Roebuck KA, Malik AB. "Transcriptional regulation of endothelial adhesion molecule gene expression by oxidants and cytokines.". Nitric Oxide and Radicals in the Pulmonary Vasculature. Proceedings of the VII. Weir EK, Archer SL, Reeves JT. New York, NY: Futura Publishing Co., 1996. 63-84
1993
Rahman A, Fazal F, Hadi SM. "Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals.". Glimpses in Plant Research XI: Medicinal Plants; New Vistas of Research-Part 2. Govil JN, Singh VK, Hashmi S. New Delhi, India: Today and Tomorrow's Printers and Publishers, 1993. 361-370