Paul Spencer Brookes, Ph.D.

Paul Spencer Brookes, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 604
Rochester, NY 14642

Journal Articles

Showing all 38 journal articles available.

2006 Jul 1
Brookes PS, Freeman RS, Barone MC. "A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress"." Free radical biology & medicine.. 2006 Jul 1; 41(1):41-5. Epub 2006 Apr 01.
2006 May 1
Nadtochiy SM, Tompkins AJ, Brookes PS. "Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection." The Biochemical journal.. 2006 May 1; 395(3):611-8.
2006 Mar 15
Burwell LS, Nadtochiy SM, Tompkins AJ, Young S, Brookes PS. "Direct evidence for S-nitrosation of mitochondrial complex I." The Biochemical journal.. 2006 Mar 15; 394(Pt 3):627-34.
2006 Feb
Tompkins AJ, Burwell LS, Digerness SB, Zaragoza C, Holman WL, Brookes PS. "Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition." Biochimica et biophysica acta.. 2006 Feb; 1762(2):223-31. Epub 2005 Oct 21.
2005 Jul 15
Itoh S, Lemay S, Osawa M, Che W, Duan Y, Tompkins A, Brookes PS, Sheu SS, Abe J. "Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells." The Journal of biological chemistry.. 2005 Jul 15; 280(28):26383-96. Epub 2005 Apr 26.
2005 Jan 1
Brookes PS. "Mitochondrial H(+) leak and ROS generation: an odd couple." Free radical biology & medicine.. 2005 Jan 1; 38(1):12-23.
2005
Brand MD, Pakay JL, Ocloo A, Kokoszka J, Wallace DC, Brookes PS, Cornwall EJ. "The basal proton conductance of mitochondria depends on adenine nucleotide translocase content." The Biochemical journal.. 2005 392(Pt 2):353-62.
2004 Apr 15
Shiva S, Crawford JH, Ramachandran A, Ceaser EK, Hillson T, Brookes PS, Patel RP, Darley-Usmar VM. "Mechanisms of the interaction of nitroxyl with mitochondria." The Biochemical journal.. 2004 Apr 15; 379(Pt 2):359-66.
2004 Mar
Brookes PS. "Mitochondrial nitric oxide synthase." Mitochondrion. 2004 Mar; 3(4):187-204.
2004 Jan
Brookes PS, Darley-Usmar VM. "Role of calcium and superoxide dismutase in sensitizing mitochondria to peroxynitrite-induced permeability transition." American journal of physiology. Heart and circulatory physiology.. 2004 Jan; 286(1):H39-46. Epub 2003 Aug 21.
2004
Brookes, PS; Yoon, Y; Robotham, JL; Anders, MW; Sheu, SS. "Ca2+, ATP & ROS - a mitochondrial love/hate triangle". Am. J. Physiol. 2004; 287: 817-833. Link
2004
Shiva S, Moellering D, Ramachandran A, Levonen AL, Landar A, Venkatraman A, Ceaser E, Ulasova E, Crawford JH, Brookes PS, Patel RP, Darley-Usmar VM. "Redox signalling: from nitric oxide to oxidized lipids." Biochemical Society symposium. 2004 (71):107-20.
2003 Oct
Davies JE, Digerness SB, Goldberg SP, Killingsworth CR, Katholi CR, Brookes PS, Holman WL. "Intra-myocyte ion homeostasis during ischemia-reperfusion injury: effects of pharmacologic preconditioning and controlled reperfusion." The Annals of thoracic surgery.. 2003 Oct; 76(4):1252-8; discussion 1258.
2003 Aug 22
Brookes PS, Kraus DW, Shiva S, Doeller JE, Barone MC, Patel RP, Lancaster JR, Darley-Usmar V. "Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state." The Journal of biological chemistry.. 2003 Aug 22; 278(34):31603-9. Epub 2003 Jun 04.
2003 Jul 25
Barone MC, Darley-Usmar VM, Brookes PS. "Reversible inhibition of cytochrome c oxidase by peroxynitrite proceeds through ascorbate-dependent generation of nitric oxide." The Journal of biological chemistry.. 2003 Jul 25; 278(30):27520-4. Epub 2003 May 12.
2003 Jul
Venkatraman A, Shiva S, Davis AJ, Bailey SM, Brookes PS, Darley-Usmar VM. "Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide." Hepatology : official journal of the American Association for the Study of Liver Diseases.. 2003 Jul; 38(1):141-7.
2003 Apr
Digerness SB, Brookes PS, Goldberg SP, Katholi CR, Holman WL. "Modulation of mitochondrial adenosine triphosphate-sensitive potassium channels and sodium-hydrogen exchange provide additive protection from severe ischemia-reperfusion injury." The Journal of thoracic and cardiovascular surgery.. 2003 Apr; 125(4):863-71.
2002 Oct
Cooper CE, Patel RP, Brookes PS, Darley-Usmar VM. "Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species." Trends in biochemical sciences.. 2002 Oct; 27(10):489-92.
2002 Sep 15
Brookes PS, Levonen AL, Shiva S, Sarti P, Darley-Usmar VM. "Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species." Free radical biology & medicine.. 2002 Sep 15; 33(6):755-64.
2002 Aug
Brookes PS, Pinner A, Ramachandran A, Coward L, Barnes S, Kim H, Darley-Usmar VM. "High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes." Proteomics. 2002 Aug; 2(8):969-77.
2002 Jun 1
Brookes PS, Digerness SB, Parks DA, Darley-Usmar V. "Mitochondrial function in response to cardiac ischemia-reperfusion after oral treatment with quercetin." Free radical biology & medicine.. 2002 Jun 1; 32(11):1220-8.
2002 May 10
Lin TK, Hughes G, Muratovska A, Blaikie FH, Brookes PS, Darley-Usmar V, Smith RA, Murphy MP. "Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach." The Journal of biological chemistry.. 2002 May 10; 277(19):17048-56. Epub 2002 Feb 22.
2002 Feb 15
Brookes P, Darley-Usmar VM. "Hypothesis: the mitochondrial NO(*) signaling pathway, and the transduction of nitrosative to oxidative cell signals: an alternative function for cytochrome C oxidase." Free radical biology & medicine.. 2002 Feb 15; 32(4):370-4.
2002
Ramachandran A, Levonen AL, Brookes PS, Ceaser E, Shiva S, Barone MC, Darley-Usmar V. "Mitochondria, nitric oxide, and cardiovascular dysfunction." Free radical biology & medicine.. 2002 33(11):1465-74.
2002
Brookes PS, Shiva S, Patel RP, Darley-Usmar VM. "Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide." Methods in enzymology. 2002 359:305-19.
2001 Jun 19
Shiva S, Brookes PS, Patel RP, Anderson PG, Darley-Usmar VM. "Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase." Proceedings of the National Academy of Sciences of the United States of America.. 2001 Jun 19; 98(13):7212-7.
2001 Jan
Brookes PS, Zhang J, Dai L, Zhou F, Parks DA, Darley-Usmar VM, Anderson PG. "Increased sensitivity of mitochondrial respiration to inhibition by nitric oxide in cardiac hypertrophy." Journal of molecular and cellular cardiology.. 2001 Jan; 33(1):69-82.
2001
Levonen, A-L; Patel, RP; Brookes, P; Go, Y-M; Jo, H; Parthasarathy, S; Darley-Usmar, VM. "Mechanisms of cell signaling by nitric oxide and peroxynitrite: implications for the modulation of cellular oxidative and nitrosative stress". Antiox. Redox Signaling. (review). 2001; 3: 215-229. Link
2001
Dai L, Brookes PS, Darley-Usmar VM, Anderson PG. "Bioenergetics in cardiac hypertrophy: mitochondrial respiration as a pathological target of NO*." American journal of physiology. Heart and circulatory physiology.. 2001 281(6):H2261-9.
2000 Jul 7
Brookes PS, Salinas EP, Darley-Usmar K, Eiserich JP, Freeman BA, Darley-Usmar VM, Anderson PG. "Concentration-dependent effects of nitric oxide on mitochondrial permeability transition and cytochrome c release." The Journal of biological chemistry.. 2000 Jul 7; 275(27):20474-9.
1999 Mar 12
Brookes PS, Bolaños JP, Heales SJ. "The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct." FEBS letters.. 1999 Mar 12; 446(2-3):261-3.
1999 Feb 9
Heales SJ, Bolaños JP, Stewart VC, Brookes PS, Land JM, Clark JB. "Nitric oxide, mitochondria and neurological disease." Biochimica et biophysica acta.. 1999 Feb 9; 1410(2):215-28.
1998 May
Brookes PS, Land JM, Clark JB, Heales SJ. "Peroxynitrite and brain mitochondria: evidence for increased proton leak." Journal of neurochemistry.. 1998 May; 70(5):2195-202.
1998 Feb
Brookes PS, Buckingham JA, Tenreiro AM, Hulbert AJ, Brand MD. "The proton permeability of the inner membrane of liver mitochondria from ectothermic and endothermic vertebrates and from obese rats: correlations with standard metabolic rate and phospholipid fatty acid composition." Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 1998 Feb; 119(2):325-34.
1998
Changani, KK; Bell, JD; Brooks, KJ; Fuller, BJ; Taylor-Robinson, SD; Davidson, BR; Brookes, PS; Bates, TE. "Depression of liver mitochondrial complex II-linked respiration following cooling: beneficial effects of using a prostacyclin analogue during hypothermia". Cryo-Letters. 1998; 19: 71-78. Link
1997 Oct 13
Brookes PS, Land JM, Clark JB, Heales SJ. "Stimulation of glyceraldehyde-3-phosphate dehydrogenase by oxyhemoglobin." FEBS letters.. 1997 Oct 13; 416(1):90-2.
1997 Jan 15
Brookes PS, Rolfe DF, Brand MD. "The proton permeability of liposomes made from mitochondrial inner membrane phospholipids: comparison with isolated mitochondria." The Journal of membrane biology. 1997 Jan 15; 155(2):167-74.
1997
Brookes PS, Hulbert AJ, Brand MD. "The proton permeability of liposomes made from mitochondrial inner membrane phospholipids: no effect of fatty acid composition." Biochimica et biophysica acta.. 1997 1330(2):157-64.

Books

2008
Brookes PS, Wojtovich AP, Burwell LS, Hoffman DL, Nadtochiy SM. "The interaction of mitochondrial membranes with reactive oxygen and nitrogen species". Free Radical Effects on Membranes. S Matalon, S Simon, D Benos. NY: Elsevier, 2008.
2008
Brookes PS, Hoffman DL. "Aging & Cardiac Ischemia: Mitochondrial Free Radical Considerations". Oxidative Stress in Aging: From Model Systems to Human Diseases. S Miwa, K Beckman, F Muller. NY: Springer Verlag, 2008.
2006
Shiva, S; Brookes, PS; Darley-Usmar, VM. "Methods for measuring the regulation of respiration by nitric oxide". Mitochondria - Methods in Cell Biology Series. Eds. L Pon and Eric Schon. San Diego: Press/Elsevier, 2006.
2005
Brookes, PS. "Mitochondrial production of oxidants and their role in the regulation of cellular processes". "Handbook of Neurochemistry and Molecular Neurobiology" "Brain Energy Metabolis. Eds. G. Gibson & G. Dienel. Kluwer: New York, 2005.
2000
Brookes, PS; Patel, RP; Levonen, A-L; Shiva, S; Moellering, D; Anderson, PG; Jo, H; Darley-Usmar, VM. "Cytoprotective mechanisms of nitric oxide: the role of cell signaling". Free Radicals in Chemistry, Biology and Medicine. (Eds. T. Yoshikawa, S. Toyokuni, Y. Yamamoto and Y. Niato.). London, UK: OICA International, 2000.
1996
Brookes, PS; Rolfe, DFS; Brand, MD. "Proton leak of mitochondrial inner membrane phospholipid liposomes". Biothermokinetics of the living cell. Eds. HV Westerhoff et al.. Amsterdam, NL: BTK Press, 1996. 3-10