Takahiro Takano, Ph.D.

Takahiro Takano, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 645
Rochester, NY 14642

Lab: (585) 275-3720
Administrative: (585) 275-9588
Fax: (585) 273-5561

Journal Articles

Showing all 49 journal articles available.

2014 Jan
Takano T, He W, Han X, Wang F, Xu Q, Wang X, Oberheim Bush NA, Cruz N, Dienel GA, Nedergaard M. "Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices." Glia.. 2014 Jan; 62(1):78-95. Epub 2013 Nov 06.
2013 Oct 30
Wang F, Smith NA, Xu Q, Goldman S, Peng W, Huang JH, Takano T, Nedergaard M. "Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 Oct 30; 33(44):17404-12.
2013 Sep
Langevin H, Fujita T, Bouffard N, Takano T, Koptiuch C, Badger G, Nedergaard M. "Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling." Journal of cellular physiology.. 2013 Sep; 228(9):1922-6.
2013 Jul
Thrane AS, Takano T, Thrane VR, Wang F, Peng W, Ottersen OP, Nedergaard M, Nagelhus EA. "In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013 Jul; 33(7):996-9. Epub 2013 Apr 24.
2013 Apr
Goldman N, Chandler-Militello D, Langevin HM, Nedergaard M, Takano T. "Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts." Cell calcium. 2013 Apr; 53(4):297-301. Epub 2013 Feb 22.
2013 Mar 7
Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M. "Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice." Cell stem cell.. 2013 Mar 7; 12(3):342-53.
2012 May 15
Wang F, Xu Q, Wang W, Takano T, Nedergaard M. "Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake." Proceedings of the National Academy of Sciences of the United States of America.. 2012 May 15; 109(20):7911-6. Epub 2012 Apr 30.
2012 Apr 17
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. "Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity." Proceedings of the National Academy of Sciences of the United States of America.. 2012 Apr 17; 109(16):6265-70. Epub 2012 Mar 15.
2012 Apr 3
Wang F, Smith NA, Xu Q, Fujita T, Baba A, Matsuda T, Takano T, Bekar L, Nedergaard M. "Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+." Science signaling. 2012 Apr 3; 5(218):ra26. Epub 2012 Apr 03.
2012 Mar 7
Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Garre JM, Tian GF, Bennett MV, Nedergaard M, Takano T. "Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2012 Mar 7; 32(10):3333-8.
2012 Jan 24
Torres A, Wang F, Xu Q, Fujita T, Dobrowolski R, Willecke K, Takano T, Nedergaard M. "Extracellular Ca²? acts as a mediator of communication from neurons to glia." Science signaling. 2012 Jan 24; 5(208):ra8. Epub 2012 Jan 24.
2012 Jan
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M. "Cultured astrocytes do not release adenosine during hypoxic conditions." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2012 Jan; 32(1):e1-7. Epub 2011 Oct 12.
2012
Takano T, Chen X, Luo F, Fujita T, Ren Z, Goldman N, Zhao Y, Markman JD, Nedergaard M. "Traditional acupuncture triggers a local increase in adenosine in human subjects." The journal of pain : official journal of the American Pain Society.. 2012 13(12):1215-23.
2011 Jan 11
Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Thrane VR, Enger R, Haj-Yasein NN, Skare O, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA. "Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema." Proceedings of the National Academy of Sciences of the United States of America.. 2011 Jan 11; 108(2):846-51. Epub 2010 Dec 27.
2010 Sep
Vates GE, Takano T, Zlokovic B, Nedergaard M. "Pericyte constriction after stroke: the jury is still out." Nature medicine.. 2010 Sep; 16(9):959; author reply 960.
2010 Jul
Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M. "Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture." Nature neuroscience.. 2010 Jul; 13(7):883-8. Epub 2010 May 30.
2009 Oct
Rempe DA, Takano T, Nedergaard M. "TR(I)Pping towards treatment for ischemia." Nature neuroscience.. 2009 Oct; 12(10):1215-6.
2009 Jul 28
Peng W, Cotrina ML, Han X, Yu H, Bekar L, Blum L, Takano T, Tian GF, Goldman SA, Nedergaard M. "Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury." Proceedings of the National Academy of Sciences of the United States of America.. 2009 Jul 28; 106(30):12489-93. Epub 2009 Jul 27.
2009 Mar 11
Oberheim NA, Takano T, Han X, He W, Lin JH, Wang F, Xu Q, Wyatt JD, Pilcher W, Ojemann JG, Ransom BR, Goldman SA, Nedergaard M. "Uniquely hominid features of adult human astrocytes." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2009 Mar 11; 29(10):3276-87.
2009 Mar
Takano T, Oberheim N, Cotrina ML, Nedergaard M. "Astrocytes and ischemic injury." Stroke; a journal of cerebral circulation.. 2009 Mar; 40(3 Suppl):S8-12. Epub 2008 Dec 08.
2009 Jan
Takano T, Nedergaard M. "Deciphering migraine." The Journal of clinical investigation.. 2009 Jan; 119(1):16-9.
2009
Wang X, Takano T, Nedergaard M. "Astrocytic Ca2+ Signaling: Mechanism and implications for functional brain imaging". Humana Press. 2009; .
2009
Wang X, Takano T, Nedergaard M. "Astrocytic calcium signaling: mechanism and implications for functional brain imaging." Methods in molecular biology.. 2009 489:93-109.
2009
Biswas T, Okunieff P, Schell MC, Smudzin T, Pilcher WH, Bakos RS, Vates GE, Walter KA, Wensel A, Korones DN, Milano MT. "Stereotactic radiosurgery for glioblastoma: retrospective analysis." Radiation oncology (London, England). 2009 4:11. Epub 2009 Mar 17.
2008 Mar 26
Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, Nedergaard M. "Loss of astrocytic domain organization in the epileptic brain." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 Mar 26; 28(13):3264-76.
2008 Jan 16
Lin JH, Lou N, Kang N, Takano T, Hu F, Han X, Xu Q, Lovatt D, Torres A, Willecke K, Yang J, Kang J, Nedergaard M. "A central role of connexin 43 in hypoxic preconditioning." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 Jan 16; 28(3):681-95.
2008 Jan
Bekar L, Libionka W, Tian GF, Xu Q, Torres A, Wang X, Lovatt D, Williams E, Takano T, Schnermann J, Bakos R, Nedergaard M. "Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor." Nature medicine.. 2008 Jan; 14(1):75-80. Epub 2007 Dec 23.
2007 Nov 7
Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M. "The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 Nov 7; 27(45):12255-66.
2007 Aug 28
Jaiswal JK, Fix M, Takano T, Nedergaard M, Simon SM. "Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes." Proceedings of the National Academy of Sciences of the United States of America.. 2007 Aug 28; 104(35):14151-6. Epub 2007 Aug 21.
2007 Jun
Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M. "Cortical spreading depression causes and coincides with tissue hypoxia." Nature neuroscience.. 2007 Jun; 10(6):754-62. Epub 2007 Apr 29.
2007 May
Takano T, Nedergaard M. "DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+." Cell calcium. 2007 May; 41(5):503-4. Epub 2006 Oct 19.
2007 Feb 1
Lin JH, Takano T, Arcuino G, Wang X, Hu F, Darzynkiewicz Z, Nunes M, Goldman SA, Nedergaard M. "Purinergic signaling regulates neural progenitor cell expansion and neurogenesis." Developmental biology.. 2007 Feb 1; 302(1):356-66. Epub 2006 Sep 16.
2007 Feb
Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. "Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease." Annals of the New York Academy of Sciences.. 2007 Feb; 1097:40-50.
2006 Sep 15
Tian GF, Takano T, Lin JH, Wang X, Bekar L, Nedergaard M. "Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain." Advanced drug delivery reviews. 2006 Sep 15; 58(7):773-87. Epub 2006 Aug 04.
2006 Jun
Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Kang J, Takano T, Nedergaard M. "Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo." Nature neuroscience.. 2006 Jun; 9(6):816-23. Epub 2006 May 14.
2006 Feb
Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, Nedergaard M. "Astrocyte-mediated control of cerebral blood flow." Nature neuroscience.. 2006 Feb; 9(2):260-7. Epub 2005 Dec 25.
2005 Nov 8
Takano T, Kang J, Jaiswal JK, Simon SM, Lin JH, Yu Y, Li Y, Yang J, Dienel G, Zielke HR, Nedergaard M. "Receptor-mediated glutamate release from volume sensitive channels in astrocytes." Proceedings of the National Academy of Sciences of the United States of America.. 2005 Nov 8; 102(45):16466-71. Epub 2005 Oct 27.
2005 Sep
Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J, Nedergaard M. "An astrocytic basis of epilepsy." Nature medicine.. 2005 Sep; 11(9):973-81. Epub 2005 Aug 14.
2005
Takano,T.; Kang,J.; Jaiswal,J. K.; Simon,S. M.; Lin,J. H.; Yu,Y.; Li,Y.; Yang,J.; Dienel,G.; Zielke,H. R.; Nedergaard,M. "Receptor-mediated glutamate release from volume sensitive channels in astrocytes". Proceedings of the National Academy of Sciences, U.S.A.. 2005; 102(45): 16466-16471.
2004 Aug
Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M. "P2X7 receptor inhibition improves recovery after spinal cord injury." Nature medicine.. 2004 Aug; 10(8):821-7. Epub 2004 Jul 18.
2004
Wang,X.; Arcuino,G.; Takano,T.; Lin,J.; Peng,W. G.; Wan,P.; Li,P.; Xu,Q.; Liu,Q. S.; Goldman,S. A.; Nedergaard,M. "P2X7 receptor inhibition improves recovery after spinal cord injury". Nature Medicine. 2004; 102(8): 821-827.
2003 Oct 8
Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M. "Signaling at the gliovascular interface." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 Oct 8; 23(27):9254-62.
2003 Jan 15
Lin JH, Yang J, Liu S, Takano T, Wang X, Gao Q, Willecke K, Nedergaard M. "Connexin mediates gap junction-independent resistance to cellular injury." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 Jan 15; 23(2):430-41.
2002 Sep
Nedergaard M, Takano T, Hansen AJ. "Beyond the role of glutamate as a neurotransmitter." Nature reviews. Neuroscience. 2002 Sep; 3(9):748-55.
2002 Jul 23
Arcuino G, Lin JH, Takano T, Liu C, Jiang L, Gao Q, Kang J, Nedergaard M. "Intercellular calcium signaling mediated by point-source burst release of ATP." Proceedings of the National Academy of Sciences of the United States of America.. 2002 Jul 23; 99(15):9840-5. Epub 2002 Jul 03.
2002 Jun 1
Lin JH, Takano T, Cotrina ML, Arcuino G, Kang J, Liu S, Gao Q, Jiang L, Li F, Lichtenberg-Frate H, Haubrich S, Willecke K, Goldman SA, Nedergaard M. "Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 Jun 1; 22(11):4302-11.
2002
Arcuino,G.; Lin,J. H.; Takano,T.; Liu,C.; Jiang,L.; Gao,Q.; Kang,J.; Nedergaard,M. "Intercellular calcium signaling mediated by point-source burst release of ATP;". Proceedings of the National Academy of Sciences, U.S.A.. 2002; 99(15): 9840-9845.
2001 Sep
Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M. "Glutamate release promotes growth of malignant gliomas." Nature medicine.. 2001 Sep; 7(9):1010-5.
2000 Oct 1
Zhang W, Couldwell WT, Song H, Takano T, Lin JH, Nedergaard M. "Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells." Cancer research.. 2000 Oct 1; 60(19):5395-400.

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