BS:Pontificia Universidade Catolica (PUC-Rio) Physics (1989)
MS:Pontificia Universidade Catolica (PUC-Rio) Physics (1992)
PhD:Imperial College (Physics Department/Biophysics Section) (1997)
Postdoctoral Fellow - Yale University - Department of Physiology (1997-2000)
Postdoctoral Fellow- Mount Sinai School of Medicine - Department of Physiology and Biophysics (2000-2003)
2003-2004: Instructor - Mount Sinai School of Medicine - Department of Physiology and Biophysics
2004- : Assistant Professor - University of Rochester - Department of medicine - Cardiovascular Research Institute
We are interested in understanding the regulation of K+ channels by diverse G-protein signaling pathways in normal and pathological states. The major focus of our current work involves the regulation of the slow delayed rectifier-like current (IKs) in the heart and the pathogenesis of the Long QT (LQT1) syndrome. KCNQ1 is co-assembled with the KCNE1 gene product in the heart to produce IKs, which is one of the main currents responsible for myocyte repolarization. The most commonly inherited cardiac arrhythmia, long-QT1 (LQT1), is due to mutations in the KCNQ1 potassium channel. Stress and exercise are triggers known to precipitate arrhythmias, in particular for LQT1 patients.
Our research focus on the understanding of the regulation of IKs channels, their importance for heart function and the molecular mechanism by which their down-regulation leads to the LQT1 syndrome. In addition, we are interested in phospholipid regulation of ion channels. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an important membrane-delimited second messenger. It has been shown to be crucial for the activity of a number of transporters and ion channels. Several PIP2-sensitive channels have also been show to be regulated by physiological changes in PIP2 levels in the plasma membrane. Our laboratory is interested in the study of the crosstalk of PIP2 modulation with other common regulatory mechanisms of different ion channel families such as mechanosensitivity, voltage-gating and phosphorylation.
Mathias A, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Qi M, Shimizu W, Towbin JA, Michael Vincent G, Wilde AA, Zhang L, Goldenberg I. "Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome." Heart rhythm : the official journal of the Heart Rhythm Society.. 2013 May 0; 10(5):720-5. Epub 2013 Jan 29.
Mullally J, Goldenberg I, Moss AJ, Lopes CM, Ackerman MJ, Zareba W, McNitt S, Robinson JL, Benhorin J, Kaufman ES, Towbin JA, Barsheshet A. "Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations." Heart rhythm : the official journal of the Heart Rhythm Society.. 2013 Mar 0; 10(3):378-82. Epub 2012 Nov 19.
2012 Nov 20
Hoefen R, Reumann M, Goldenberg I, Moss AJ, O-Uchi J, Gu Y, McNitt S, Zareba W, Jons C, Kanters JK, Platonov PG, Shimizu W, Wilde AA, Rice JJ, Lopes CM. "In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models." Journal of the American College of Cardiology. 2012 Nov 20; 60(21):2182-91.
Costa J, Lopes CM, Barsheshet A, Moss AJ, Migdalovich D, Ouellet G, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. "Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome." Heart rhythm : the official journal of the Heart Rhythm Society.. 2012 Jun 0; 9(6):892-8. Epub 2012 Jan 28.
2012 Apr 24
Barsheshet A, Goldenberg I, O-Uchi J, Moss AJ, Jons C, Shimizu W, Wilde AA, McNitt S, Peterson DR, Zareba W, Robinson JL, Ackerman MJ, Cypress M, Gray DA, Hofman N, Kanters JK, Kaufman ES, Platonov PG, Qi M, Towbin JA, Vincent GM, Lopes CM. "Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to ?-blocker therapy in type 1 long-QT syndrome." Circulation. 2012 Apr 24; 125(16):1988-96. Epub 2012 Mar 28.