Coeli M. Lopes, Ph.D.

Coeli M. Lopes, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Office: (585) 276-9784
Fax: (585) 276-9829
Lab: (585) 276-9834
Administrative: (585) 276-9800

Lab Information

The major focus of Dr. Lopes current work involves the regulation of the slow delayed rectifier-like current (IKs) in the heart and the pathogenesis of the Long QT (LQT1) syndrome.

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Professional Bio

EDUCATION



BS: PUC-Rio, Brazil; Physics (1989)
MS: PUC-Rio, Brazil; Biophysics (1992)
PhD: Imperial College, UK; Biophysics (1997)
Postdoctoral Fellow - Yale University - Department of Physiology (1997-2000)
Postdoctoral Fellow - Mount Sinai School of Medicine - Department of Physiology and Biophysics (2000-2003)

APPOINTMENTS
2003-2004: Instructor - Mount Sinai School of Medicine - Department of Physiology and Biophysics
2004-2012: Assistant Professor - University of Rochester - Department of medicine - Cardiovascular Research Institute
2013-now: Associate Professor (Research) - University of Rochester - Department of medicine - Cardiovascular Research Institute

Research Bio

We are interested in understanding the regulation of ion channels by diverse G-protein signaling pathways in normal and pathological states.



One major focus of our current work involves the changes in function and regulation of cardiac ion channels that lead to the pathogenesis of the Long QTsyndrome. Our work attempts to translate channel function and dysregulation at the cellular level to patient clinical phenotype and response to treatment.

A second focus of our current research is the study of the pathological remodeling of the slow delayed rectifier-like current (IKs) in heart failure. KCNQ1 is co-assembled with the KCNE1 gene product in the heart to produce IKs, which is one of the main currents responsible for myocyte repolarization. The most commonly inherited cardiac arrhythmia, long-QT1 (LQT1), is due to mutations in the KCNQ1 potassium channel. Heart disease is also known to decrease IKs currents. Our current research focus on stress signals caused by chronic stimulation of kinase signaling pathways, and their consequence for ion channel function and membrane trafficking. We explore possible novel antiarrhythmic treatments to reverse IKs pathological remodeling during heart failure.

Awards & Honors (National)

NIH reviewer ESTA Study Section 2013
AHA reviewer - Cardiac Electrophysiology Study Section 2012 - Present
Scientist Development Grant | American Heart Association 2004 - Present

Awards & Honors (Local)

Postdoctoral Fellowship American Heart Association 2002 - 2004
New York City Board Fellow Award American Heart Association 2002
PhD Scholarship Federal Agency for Post-Graduate Education (CAPES- Brazil) 1992 - 1996
Graduate Student Scholarship National Research Council (CNPq Brazil) 1990 - 1992
Outstanding Basic Science Student Award PUC-Rio 1987
Full Merit University Scholarship PUC-Rio 1986 - 1989
Outstanding Basic Science Student Award PUC-Rio 1986

Recent Journal Articles

Showing the 5 most recent journal articles. 30 available »

2013 May
Mathias A, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Qi M, Shimizu W, Towbin JA, Michael Vincent G, Wilde AA, Zhang L, Goldenberg I. "Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome." Heart rhythm : the official journal of the Heart Rhythm Society. 2013 May; 10(5):720-5. Epub 2013 Jan 29.
2013 Mar
Mullally J, Goldenberg I, Moss AJ, Lopes CM, Ackerman MJ, Zareba W, McNitt S, Robinson JL, Benhorin J, Kaufman ES, Towbin JA, Barsheshet A. "Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations." Heart rhythm : the official journal of the Heart Rhythm Society. 2013 Mar; 10(3):378-82. Epub 2012 Nov 19.
2012 Nov 20
Hoefen R, Reumann M, Goldenberg I, Moss AJ, O-Uchi J, Gu Y, McNitt S, Zareba W, Jons C, Kanters JK, Platonov PG, Shimizu W, Wilde AA, Rice JJ, Lopes CM. "In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models." Journal of the American College of Cardiology. 2012 Nov 20; 60(21):2182-91.
2012 Jun
Costa J, Lopes CM, Barsheshet A, Moss AJ, Migdalovich D, Ouellet G, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I. "Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome." Heart rhythm : the official journal of the Heart Rhythm Society. 2012 Jun; 9(6):892-8. Epub 2012 Jan 28.
2012 Apr 24
Barsheshet A, Goldenberg I, O-Uchi J, Moss AJ, Jons C, Shimizu W, Wilde AA, McNitt S, Peterson DR, Zareba W, Robinson JL, Ackerman MJ, Cypress M, Gray DA, Hofman N, Kanters JK, Kaufman ES, Platonov PG, Qi M, Towbin JA, Vincent GM, Lopes CM. "Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to ?-blocker therapy in type 1 long-QT syndrome." Circulation. 2012 Apr 24; 125(16):1988-96. Epub 2012 Mar 28.

Current Appointments

Research Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD) - Primary

Education

PhD | Biophysics | Imperial College1997
MS | Physics | Brazil-Pontificia Universidade Catolica1992
BS | Physics | Brazil-Pontificia Universidade Catolica1989