Alan M. Grossfield, Ph.D.

Alan M. Grossfield, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 276-4193
Fax: (585) 275-6007

Lab Information

My lab's research is focused on understanding the stomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

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Research Bio

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Recent Journal Articles

Showing the 5 most recent journal articles. 36 available »

2014 Oct
Leioatts N, Suresh P, Romo TD, Grossfield A. "Structure-based simulations reveal concerted dynamics of GPCR activation." Proteins.. 2014 Oct; 82(10):2538-51. Epub 2014 Jun 09.
2014 Jun 17
Romo TD, Grossfield A. "How fast is your camera? Timescales for molecular motion and their role in restraining molecular dynamics." Biophysical journal.. 2014 Jun 17; 106(12):2549-51.
2014 Apr 15
Romo TD, Grossfield A. "Unknown unknowns: the challenge of systematic and statistical error in molecular dynamics simulations." Biophysical journal.. 2014 Apr 15; 106(8):1553-4.
2014 Mar
Kimura T, Vukoti K, Lynch DL, Hurst DP, Grossfield A, Pitman MC, Reggio PH, Yeliseev AA, Gawrisch K. "Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations." Proteins.. 2014 Mar; 82(3):452-65. Epub 2013 Oct 17.
2014 Jan 21
Leioatts N, Mertz B, Martinez-Mayorga K, Romo TD, Pitman MC, Feller SE, Grossfield A, Brown MF. "Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures." Biochemistry.. 2014 Jan 21; 53(2):376-85. Epub 2014 Jan 08.

Current Appointments

Associate Professor - Department of Biochemistry and Biophysics (SMD) - Primary