Alan M. Grossfield, Ph.D.

Alan M. Grossfield, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 276-4193
Fax: (585) 275-6007

Lab Information

My lab's research is focused on understanding the stomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

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Research Bio

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Recent Journal Articles

Showing the 5 most recent journal articles. 41 available »

2015 Aug 18
Lin D, Grossfield A. "Thermodynamics of Micelle Formation and Membrane Fusion Modulate Antimicrobial Lipopeptide Activity." Biophysical journal. 2015 Aug 18; 109(4):750-9.
2015 Aug 4
Leioatts N, Romo TD, Danial SA, Grossfield A. "Retinal Conformation Changes Rhodopsin's Dynamic Ensemble." Biophysical journal. 2015 Aug 4; 109(3):608-17.
2015 May
Aytenfisu AH, Spasic A, Grossfield A, Stern H, Mathews DH. "99 Improving the amber RNA force field." Journal of biomolecular structure & dynamics. 2015 May; 33 Suppl 1:63.
2014 Oct 21
Lin D, Grossfield A. "Thermodynamics of antimicrobial lipopeptide binding to membranes: origins of affinity and selectivity." Biophysical journal. 2014 Oct 21; 107(8):1862-72.
2014 Oct
Leioatts N, Suresh P, Romo TD, Grossfield A. "Structure-based simulations reveal concerted dynamics of GPCR activation." Proteins. 2014 Oct; 82(10):2538-51. Epub 2014 Jun 09.

Current Appointments

Associate Professor - Department of Biochemistry and Biophysics (SMD) - Primary