Thomas J. Mariani, Ph.D.

Thomas J. Mariani, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester, NY 14642

Office: (585) 276-4616
Fax: (585) 276-2642

Journal Articles

Showing all 58 journal articles available.

2014 Oct 1
Bhattacharya S, Zhou Z, Yee M, Chu CY, Lopez AM, Lunger VA, Solleti SK, Resseguie E, Buczynski BW, Mariani TJ, O'Reilly MA. "The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator." American journal of physiology. Lung cellular and molecular physiology. 2014 Oct 1; 307(7):L516-23. Epub 2014 Aug 22.
2014 Sep 15
Qiu W, Rogers AJ, Damask A, Raby BA, Klanderman BJ, Duan QL, Tyagi S, Niu S, Anderson C, Cahir-McFarland E, Mariani TJ, Carey V, Tantisira KG. "Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis." Human molecular genetics. 2014 Sep 15; 23(18):5017-24. Epub 2014 Apr 25.
2013 Sep
Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK. "HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium." PLoS biology. 2013 Sep; 11(9):e1001665. Epub 2013 Sep 24.
2013 May 1
Mariani TJ, Martinez F. "Chronic obstructive pulmonary disease genomics: yesterday, discovering population biomarkers; tomorrow, defining disease clusters." American journal of respiratory and critical care medicine. 2013 May 1; 187(9):900-2.
2013 Apr
Bhattacharya S, Mariani TJ. "Systems biology approaches to identify developmental bases for lung diseases." Pediatric research. 2013 Apr; 73(4 Pt 2):514-22. Epub 2013 Jan 11.
2013 Apr
Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. "Molecular determinants of lung development." Annals of the American Thoracic Society. 2013 Apr; 10(2):S12-6.
2012 Nov
Scheible K, Secor-Socha S, Wightman T, Wang H, Mariani TJ, Topham DJ, Pryhuber G, Quataert S. "Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection." Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2012 Nov; 81(11):937-49. Epub 2012 Oct 01.
2012 Aug 15
Bhattacharya S, Go D, Krenitsky DL, Huyck HL, Solleti SK, Lunger VA, Metlay L, Srisuma S, Wert SE, Mariani TJ, Pryhuber GS. "Genome-wide transcriptional profiling reveals connective tissue mast cell accumulation in bronchopulmonary dysplasia." American journal of respiratory and critical care medicine. 2012 Aug 15; 186(4):349-58. Epub 2012 Jun 21.
2011 Sep
Himes BE, Klanderman B, Ziniti J, Senter-Sylvia J, Soto-Quiros ME, Avila L, Celedón JC, Lange C, Mariani TJ, Lasky-Su J, Hersh CP, Raby BA, Silverman EK, Weiss ST, Demeo DL. "Association of SERPINE2 with asthma." Chest. 2011 Sep; 140(3):667-74. Epub 2011 Mar 24.
2011 Jun 1
Hersh CP, Silverman EK, Gascon J, Bhattacharya S, Klanderman BJ, Litonjua AA, Lefebvre V, Sparrow D, Reilly JJ, Anderson WH, Lomas DA, Mariani TJ, . "SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development." American journal of respiratory and critical care medicine. 2011 Jun 1; 183(11):1482-9. Epub 2011 Feb 17.
2011
Reddy NM, Potteti HR, Mariani TJ, Biswal S, Reddy SP. "Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation." American journal of respiratory cell and molecular biology. 2011 45(6):1161-8. Epub 2011 Jun 09.
2011
Melen E, Kho AT, Sharma S, Gaedigk R, Leeder JS, Mariani TJ, Carey VJ, Weiss ST, Tantisira KG. "Expression analysis of asthma candidate genes during human and murine lung development." Respiratory research. 2011 12:86. Epub 2011 Jun 23.
2011
Bhattacharya S, Tyagi S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ. "Peripheral blood gene expression profiles in COPD subjects." Journal of clinical bioinformatics. 2011 1(1):12. Epub 2011 Apr 24.
2011
Brehm JM, Hagiwara K, Tesfaigzi Y, Bruse S, Mariani TJ, Bhattacharya S, Boutaoui N, Ziniti JP, Soto-Quiros ME, Avila L, Cho MH, Himes B, Litonjua AA, Jacobson F, Bakke P, Gulsvik A, Anderson WH, Lomas DA, Forno E, Datta S, Silverman EK, Celedón JC. "Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease." Thorax. 2011 66(12):1085-90. Epub 2011 Sep 15.
2010 May
Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S. "Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation." American journal of respiratory cell and molecular biology. 2010 May; 42(5):524-36. Epub 2009 Jun 11.
2010 Apr 15
Srisuma S, Bhattacharya S, Simon DM, Solleti SK, Tyagi S, Starcher B, Mariani TJ. "Fibroblast growth factor receptors control epithelial-mesenchymal interactions necessary for alveolar elastogenesis." American journal of respiratory and critical care medicine. 2010 Apr 15; 181(8):838-50. Epub 2010 Jan 21.
2010 Feb 15
Sharma S, Tantisira K, Carey V, Murphy AJ, Lasky-Su J, Celedón JC, Lazarus R, Klanderman B, Rogers A, Soto-Quirós M, Avila L, Mariani T, Gaedigk R, Leeder S, Torday J, Warburton D, Raby B, Weiss ST. "A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma." American journal of respiratory and critical care medicine. 2010 Feb 15; 181(4):328-36. Epub 2009 Nov 19.
2010
Simon DM, Tsai LW, Ingenito EP, Starcher BC, Mariani TJ. "PPARgamma deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution." Respiratory research. 2010 11:69. Epub 2010 Jun 02.
2009 Oct
DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, Bueno R, Pillai SG, Lomas DA, Sparrow D, Shapiro SD, Criner GJ, Kim HP, Chen Z, Choi AM, Reilly J, Silverman EK. "Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene." American journal of human genetics. 2009 Oct; 85(4):493-502.
2009 Aug
Bhattacharya S; Mariani TJ. "Array of hope: expression profiling identifies disease biomarkers and mechanism." Biochem Soc Trans. 2009; 37(Pt 4): 855-862.
2009 Mar
Bhattacharya S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ. "Molecular biomarkers for quantitative and discrete COPD phenotypes." American journal of respiratory cell and molecular biology. 2009 Mar; 40(3):359-67. Epub 2008 Oct 10.
2009 Jan
Kho, A.T.; Bhattacharya, S.; Mecham, B.H.; Hong, J.; Kohane, I.S.; Mariani, T.J. "Expression profiles of the mouse lung identify a molecular signature of time-to-birth." Am J Respir Cell Mol Biol. 2009; 40(1): 47-57. Epub 2008 Jul 29.
2009
Kho, AT.; Bhattacharya, S; Tantisira, KG; Carey, VJ; Gaedigk R; Leeder JS; Kohane IS; Weiss ST; Mariani TJ. "Transcriptomic Analysis of Human Lung Development. Oct 8. [Epub ahead of print]". Am J Respir Crit Care Med. 2009; .
2009
Du R; Tantisira K; Carey V; Bhattacharya S; Metje S; Kho AT; Klanderman BJ; Gaedigk R; Lazarus R; Mariani TJ; Leeder JS; Weiss ST. "Platform dependence of inference on gene-wise and gene-set involvement in human lung development." BMC Bioinformatics. 2009; 10: 189.
2008 Sep 15
Planagumà A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE, Levy BD. "Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma." American journal of respiratory and critical care medicine. 2008 Sep 15; 178(6):574-82. Epub 2008 Jun 26.
2008 May
Reynolds SD, Zemke AC, Giangreco A, Brockway BL, Teisanu RM, Drake JA, Mariani T, Di PY, Taketo MM, Stripp BR. "Conditional stabilization of beta-catenin expands the pool of lung stem cells." Stem cells. 2008 May; 26(5):1337-46. Epub 2008 Mar 20.
2008 Jan
Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, Kobzik L. "Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility." American journal of respiratory cell and molecular biology. 2008 Jan; 38(1):57-67. Epub 2007 Jul 26.
2007 Oct 15
Hirakawa H, Pierce RA, Bingol-Karakoc G, Karaaslan C, Weng M, Shi GP, Saad A, Weber E, Mariani TJ, Starcher B, Shapiro SD, Cataltepe S. "Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury." American journal of respiratory and critical care medicine. 2007 Oct 15; 176(8):778-85. Epub 2007 Aug 02.
2007 May 15
Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR. "Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma." The Journal of immunology : official journal of the American Association of Immunologists. 2007 May 15; 178(10):6191-9.
2007
Simon DM, Mariani TJ. "Role of PPARs and Retinoid X Receptors in the Regulation of Lung Maturation and Development." PPAR research. 2007 2007:91240.
2007
Tantisira KG, Silverman ES, Mariani TJ, Xu J, Richter BG, Klanderman BJ, Litonjua AA, Lazarus R, Rosenwasser LJ, Fuhlbrigge AL, Weiss ST. "FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma." The Journal of allergy and clinical immunology. 2007 120(6):1285-91. Epub 2007 Nov 05.
2006 Jul
Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Tsai LW, Ingenito EP, Gonzalez F, Shapiro SD, Mariani TJ. "Epithelial cell PPAR[gamma] contributes to normal lung maturation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Jul; 20(9):1507-9. Epub 2006 May 23.
2006 Feb
Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. "The SERPINE2 gene is associated with chronic obstructive pulmonary disease." American journal of human genetics. 2006 Feb; 78(2):253-64. Epub 2005 Dec 15.
2006
Chu EK, Cheng J, Foley JS, Mecham BH, Owen CA, Haley KJ, Mariani TJ, Kohane IS, Tschumperlin DJ, Drazen JM. "Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells." American journal of respiratory cell and molecular biology. 2006 35(6):628-38. Epub 2006 Jun 22.
2005
Arikan, M.C.; Shapiro, S.D.; Mariani, T.J. "Induction of macrophage metalloelastase (MMP12) expression by statins." J Cellular Physiol. 2005; 204(1): 139-145.
2005
Ji, H.; Houghton, A.M.; Mariani, T.J.; Perera, S.; Kim, C.B.; Padera, R.; Tonon, G.; McNamara, K., Marconcini, L.A., Hezel, A., El-Bardeesy, N.; Bronson, R.T.; Sugarbaker, D.; Maser, R.S.; Shapiro, S.D.; Wong, K-K. "K-Ras activation generates an inflammatory response in lung tumors." Oncogene. 2005; 25: 2105-2112.
2005
Mariani, T.J.; Kaminski, N. "Gene expression studies in lung development and lung stem cell biology." Current Topics in Developmental Biology. 2005; 64: 57-71.
2005
Bhattacharya S, Mariani TJ. "Transformation of expression intensities across generations of Affymetrix microarrays using sequence matching and regression modeling." Nucleic acids research. 2005 33(18):e157. Epub 2005 Oct 13.
2004 Aug 11
Mecham BH, Wetmore DZ, Szallasi Z, Sadovsky Y, Kohane I, Mariani TJ. "Increased measurement accuracy for sequence-verified microarray probes." Physiological genomics. 2004 Aug 11; 18(3):308-15. Epub 2004 Aug 11.
2004
Mariani, T.J. "Regulation of alveogenesis by reciprocal proximo-distal fibroblast growth factor and retinoic acid signaling." Am J Resp Cell Mol Biol. 2004; 31(2 Suppl): S1-S81.
2004
Mecham BH, Klus GT, Strovel J, Augustus M, Byrne D, Bozso P, Wetmore DZ, Mariani TJ, Kohane IS, Szallasi Z. "Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements." Nucleic acids research. 2004 32(9):e74. Epub 2004 May 25.
2003 Feb
Mariani TJ, Budhraja V, Mecham BH, Gu CC, Watson MA, Sadovsky Y. "A variable fold change threshold determines significance for expression microarrays." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2003 Feb; 17(2):321-3. Epub 2002 Dec 03.
2002 Oct
"Chest 2002 Scientific Highlights. Abstracts of original investigations and case reports. 2-7 November 2002, San Diego, California, USA." Chest. 2002 Oct; 122(4 Suppl):1S-269S.
2002 Aug 1
Zelko IN, Mariani TJ, Folz RJ. "Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression." Free radical biology & medicine. 2002 Aug 1; 33(3):337-49.
2002
Mariani, T.J.; Reed, J.J.; Shapiro, S.D. "Expression profiling of the developing mouse lung." Am. J. Resp. Cell Mol. Biol. 2002; 26: 541.
1999
Mariani TJ; Arikan MC; Pierce RA. "Lung fibroblast tropoelastin and a-smooth muscle actin expression is repressed by particulate-activated macrophage-derived TNFa in experimental granulomatous lung disease." Am J Resp Cell Mol.Biol. 1999; 21: 185-192.
1998 Jun
Mariani TJ, Sandefur S, Roby JD, Pierce RA. "Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury." Molecular biology of the cell. 1998 Jun; 9(6):1411-24.
1998 Jan
Mariani TJ, Dunsmore SE, Li Q, Ye X, Pierce RA. "Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells." The American journal of physiology. 1998 Jan; 274(1 Pt 1):L47-57.
1997
Mariani TJ, Sandefur S, Pierce RA. "Elastin in lung development." Experimental lung research. 1997 23(2):131-45.
1996 Jan
Mariani TJ, Roby JD, Mecham RP, Parks WC, Crouch E, Pierce RA. "Localization of type I procollagen gene expression in silica-induced granulomatous lung disease and implication of transforming growth factor-beta as a mediator of fibrosis." The American journal of pathology. 1996 Jan; 148(1):151-64.
1995 Oct
Mariani TJ, Crouch E, Roby JD, Starcher B, Pierce RA. "Increased elastin production in experimental granulomatous lung disease." The American journal of pathology. 1995 Oct; 147(4):988-1000.
1995 Jul
Schwartz E, Feinberg E, Lebwohl M, Mariani TJ, Boyd CD. "Ultraviolet radiation increases tropoelastin accumulation by a post-transcriptional mechanism in dermal fibroblasts." The Journal of investigative dermatology. 1995 Jul; 105(1):65-9.
1995
Boyd CD, Mariani TJ, Kim Y, Csiszar K. "The size heterogeneity of human lysyl oxidase mRNA is due to alternate polyadenylation site and not alternate exon usage." Molecular biology reports. 1995 21(2):95-103.
1995
Pierce RA, Mariani TJ, Senior RM. "Elastin in lung development and disease." Ciba Foundation symposium. 1995 192:199-212; discussion 212-4.
1993 May
Csiszar K, Mariani TJ, Gosin JS, Deak SB, Boyd CD. "A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene." Genomics. 1993 May; 16(2):401-6.
1992 Jun
Mariani TJ, Trackman PC, Kagan HM, Eddy RL, Shows TB, Boyd CD, Deak SB. "The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene)." Matrix (Stuttgart, Germany). 1992 Jun; 12(3):242-8.
1992 May
Deak SB, Ricotta JJ, Mariani TJ, Deak ST, Zatina MA, Mackenzie JW, Boyd CD. "The role of abnormal type III collagen in the development of common aneurysms." Journal of vascular surgery. 1992 May; 15(5):926-7.
1992 Apr
Deak SB, Ricotta JJ, Mariani TJ, Deak ST, Zatina MA, Mackenzie JW, Boyd CD. "Abnormalities in the biosynthesis of type III procollagen in cultured skin fibroblasts from two patients with multiple aneurysms." Matrix (Stuttgart, Germany). 1992 Apr; 12(2):92-100.

Books

2006
Mariani, T.J. "Developmental genetics of the pulmonary system". Principles of Developmental Genetics. Moody, S.A. San Diego, CA: Elsevier, 2006.
2006
Mariani, T.J.; Ramoni, M.F. "Microarray techniques and data in asthma and COPD". Lung Biology in Health and Disease. Postma, D.S.; Weiss, S.T. New York, NY: Informa Health Care, 2006. 75-104
2005
McLean, S.E.; Mecham, B.H.; Kelleher, C.M.; Mariani, T.J.; Mecham, R.P. "Extracellular matrix gene expression in developing mouse aorta". Extracellular Matrices and Development. Miner, J.H., Editor; Wassarman, P.M., Series Editor.. : Elsevier, 2005. 82-128
1999
Mariani, T.J.; Pierce, R.A. "Development of lung elastic matrix". Lung Development. Gaultier, G.I.; Bourbon, J.; Post, M. New York, NY: Oxford University Press, 1999. 28-45