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Andrew Samuelson, Ph.D.

Andrew Samuelson, Ph.D.

Contact

Office (585) 273-2409
Administrative (585) 273-1440

Research Lab

About Me

Faculty Appointments

Research Associate Professor - Department of Biomedical Genetics (SMD)

Credentials

Post-doctoral Training & Residency

Research Fellow, Department of Genetics, Harvard Medical School and Department of Molecular Biology, Massachusetts General Hospital 2002 - 2009

Research

Publications

Journal Articles

HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network

Maria I. Lazaro-Pena; Zachary C. Ward; Yang; Alexandra Strohm; Alyssa K. Merrill; Celia A. Soto; Andrew V. Samuelson1*.

Front. Aging. 2022; 3:861686.

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Lazaro-Pena M.I.; Cornwell A.B.; Samuelson A.V.

J Vis Exp. 2020; .

Analysis of Lifespan in C. elegans: Low- and High-Throughput Approaches.

Cornwell A.B.; Samuelson A.V.

Aging: Methods and Protocols. 2020; .

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan.

Cornwell AB, Llop JR, Salzman P, Thakar J, Samuelson AV

Journal of visualized experiments : JoVE.. 2018 June 29 (136)Epub 06/29/2018.

The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.

Das R, Melo JA, Thondamal M, Morton EA, Cornwell AB, Crick B, Kim JH, Swartz EW, Lamitina T, Douglas PM, Samuelson AV

PLoS genetics.. 2017 October 13 (10):e1007038. Epub 10/16/2017.

Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase.

Sasaki T, Lian S, Khan A, Llop JR, Samuelson AV, Chen W, Klionsky DJ, Kishi S

Autophagy.. 2017 February 13 (2):386-403. Epub 11/22/2016.

The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals.

Johnson DW, Llop JR, Farrell SF, Yuan J, Stolzenburg LR, Samuelson AV

PLoS genetics.. 2014 April 10 (4):e1004278. Epub 04/03/2014.

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation.

Sykiotis GP, Habeos IG, Samuelson AV, Bohmann D

Current opinion in clinical nutrition and metabolic care.. 2011 January 14 (1):41-8. Epub 1900 01 01.

Signaling Pathways that Regulate C. elegans Life Span

Ruvkun, G.; Samuelson, A.V.; Carr, C.E.; Curran, S.P.; and Shore, D.E.

Research and Perspectives in Endocrine Interactions. 2009; : 69-84.

Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.

Tworkowski KA, Chakraborty AA, Samuelson AV, Seger YR, Narita M, Hannon GJ, Lowe SW, Tansey WP

Proceedings of the National Academy of Sciences of the United States of America.. 2008 April 22105 (16):6103-8. Epub 04/14/2008.

Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc

Chakraborty A.A.; Tworkowski K.A.; Samuelson A.V.; Seger Y.R.; Narita M.; Hannon G.J.; Lowe S.W.; and Tansey W.P.

Proc. Natl. Acad. Sci. 2008; 105: 6103-8.

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.

Samuelson AV, Carr CE, Ruvkun G

Genes & development.. 2007 November 1521 (22):2976-94. Epub 1900 01 01.

Gene activities that mediate increased lifespan of C. elegans insulin-like signaling mutants

Samuelson A.V.; Carr C.E.; and Ruvkun G.

Genes and Development. 2007; 21: 2976-94.

Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.

Samuelson AV, Klimczak RR, Thompson DB, Carr CE, Ruvkun G

Cold Spring Harbor symposia on quantitative biology.. 2007 72 :489-97. Epub 1900 01 01.

p400 is required for E1A to promote apoptosis.

Samuelson AV, Narita M, Chan HM, Jin J, de Stanchina E, McCurrach ME, Narita M, Fuchs M, Livingston DM, Lowe SW

The Journal of biological chemistry.. 2005 June 10280 (23):21915-23. Epub 02/28/2005.

p400 is required for E1A to promote apoptosis

Samuelson A.V.; Narita M.; Chan H.M.; Jin J.; de Stanchina E.; McCurrach M.E.; Narita M.; Fuchs M.; Livingston D.M.; Lowe S.W.

J. Biol. Chem. 2005; 280: 21915-23.

E1A signaling to p53 involves the p19(ARF) tumor suppressor.

de Stanchina E, McCurrach ME, Zindy F, Shieh SY, Ferbeyre G, Samuelson AV, Prives C, Roussel MF, Sherr CJ, Lowe SW

Genes & development.. 1998 August 112 (15):2434-42. Epub 1900 01 01.

E1A signaling to p53 involves the p19(ARF) tumor suppressor

de Stanchina E.; McCurrach M.E.; Zindy F.; Shieh S.Y.; Ferbeyre G.; Samuelson A.V.; Prives C.; Roussel M.F.; Sherr C.J.; and Lowe S.W. (.

Genes and Development. 1998; 12: 2434-42.

Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins.

Samuelson AV, Lowe SW

Proceedings of the National Academy of Sciences of the United States of America.. 1997 October 2894 (22):12094-9. Epub 1900 01 01.

Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins

Samuelson A.V. and Lowe S.W.

Proc. Natl. Acad. Sci. 1997; 94: 12094-9.