Patricia M. White, Ph.D.

Patricia M. White, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester, NY 14642

Office: (585) 273-2340

Professional Bio

Dr. White received her bachelor's degree in Biology from the California Institute of Technology in Pasadena in 1989. She completed her Ph.D. degree in Developmental Biology, also at Caltech, in 2000, where she researched neural stem cells. She began post-doctoral work in hearing regeneration at the House Ear Institute, and joined the faculty at the University of Rochester Medical and Dental Center in 2010.



Dr. White's goal is to find a biological treatment to reverse noise-induced hearing loss through a better understanding of the function of different genes in the cochlea.

Research Bio

Scientific Goals



I want to realize the promise of developmental biology for human medicine. If we can define, describe, and understand the molecular mechanisms that regulate cell division and differentiation, then in principle, we can manipulate cells and tissues to rebuild damaged or diseased organs.

We have begun this process for human deafness, which impacts one quarter of adults over the age of 65. For many of these individuals, decades of noise exposure results in the progressive loss of mechanosensory hair cells, which detect sound vibration in the cochlea. In mammals, lost hair cells are not replaced; consequently, damage accumulates as people age. Surprisingly, when we tested the developmental capacities of nearby cells to divide and create new sensory cells, we found a latent ability for regeneration. My work here at Rochester centers on identifying what molecules regulate inner ear regeneration in mammals. My goal is to find a biological treatment for noise-induced hearing loss.

Awards & Honors (Local)

ARCS Scholar
Hearst Scholar

Recent Journal Articles

Showing the 5 most recent journal articles. 11 available »

2014
Savoy-Burke G, Gilels FA, Pan W, Pratt D, Que J, Gan L, White PM, Kiernan AE. "Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells." PloS one. 2014 9(9):e108160. Epub 2014 Sep 29.
2013 Nov 20
Gilels F, Paquette ST, Zhang J, Rahman I, White PM. "Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Nov 20; 33(47):18409-24.
2012 Mar 1
White PM, Stone JS, Groves AK, Segil N. "EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals." Developmental biology. 2012 Mar 1; 363(1):191-200. Epub 2012 Jan 02.
2006 Jun 22
White PM, Doetzlhofer A, Lee YS, Groves AK, Segil N. "Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells." Nature. 2006 Jun 22; 441(7096):984-7.
2006 May 26
Doetzlhofer A, White P, Lee YS, Groves A, Segil N. "Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea." Brain research. 2006 May 26; 1091(1):282-8. Epub 2006 Apr 17.

Current Appointments

Assistant Professor - Department of Neurobiology and Anatomy (SMD) - Primary
Assistant Professor - Department of Otolaryngology (SMD)

Education

PhD | Developmental Biology | California Inst of Tech2000
BS | Biology | California Inst of Tech1989

Post-Doctoral Training & Residency

House Ear Institute, Los Angeles, CA 2009