Paul Dunman, Ph.D.

Paul Dunman, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Journal Articles

Showing all 70 journal articles available.

2015 Apr
Eidem TM, Lounsbury N, Emery JF, Bulger J, Smith A, Abou-Gharbia M, Childers W, Dunman PM. "Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing." Antimicrobial agents and chemotherapy. 2015 Apr; 59(4):2016-28. Epub 2015 Jan 20.
2015 Apr
Mootz JM, Benson MA, Heim CE, Crosby HA, Kavanaugh JS, Dunman PM, Kielian T, Torres VJ, Horswill AR. "Rot is a key regulator of Staphylococcus aureus biofilm formation." Molecular microbiology. 2015 Apr; 96(2):388-404. Epub 2015 Feb 26.
Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ. "A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis." PloS one. 2015 10(6):e0129234. Epub 2015 Jun 22.
2014 Nov
Blanchard C, Barnett P, Perlmutter J, Dunman PM. "Identification of Acinetobacter baumannii serum-associated antibiotic efflux pump inhibitors." Antimicrobial agents and chemotherapy. 2014 Nov; 58(11):6360-70. Epub 2014 Aug 11.
2014 Oct 23
Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP. "Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus." Journal of medicinal chemistry. 2014 Oct 23; 57(20):8540-62. Epub 2014 Oct 06.
2014 Oct
Olson ME, Todd DA, Schaeffer CR, Paharik AE, Van Dyke MJ, B├╝ttner H, Dunman PM, Rohde H, Cech NB, Fey PD, Horswill AR. "Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization." Journal of bacteriology. 2014 Oct; 196(19):3482-93. Epub 2014 Jul 28.
Hanses F, Roux C, Dunman PM, Salzberger B, Lee JC. "Staphylococcus aureus gene expression in a rat model of infective endocarditis." Genome medicine. 2014 6(10):93. Epub 2014 Nov 03.
2013 Jan
Jacobs AC, Didone L, Jobson J, Sofia MK, Krysan D, Dunman PM. "Adenylate kinase release as a high-throughput-screening-compatible reporter of bacterial lysis for identification of antibacterial agents." Antimicrobial agents and chemotherapy. 2013 Jan; 57(1):26-36. Epub 2012 Oct 01.
2013 Jan
Brinkman CL, Bumgarner R, Kittichotirat W, Dunman PM, Kuechenmeister LJ, Weaver KE. "Characterization of the effects of an rpoC mutation that confers resistance to the Fst peptide toxin-antitoxin system toxin." Journal of bacteriology. 2013 Jan; 195(1):156-66. Epub 2012 Oct 26.
Kinkel TL, Roux CM, Dunman PM, Fang FC. "The Staphylococcus aureus SrrAB two-component system promotes resistance to nitrosative stress and hypoxia." mBio. 2013 4(6):e00696-13. Epub 2013 Nov 12.
2012 Aug
Anbalagan S, Dmitriev A, McShan WM, Dunman PM, Chaussee MS. "Growth phase-dependent modulation of Rgg binding specificity in Streptococcus pyogenes." Journal of bacteriology. 2012 Aug; 194(15):3961-71. Epub 2012 May 25.
2012 Jul
Caswell CC, Gaines JM, Ciborowski P, Smith D, Borchers CH, Roux CM, Sayood K, Dunman PM, Roop Ii RM. "Identification of two small regulatory RNAs linked to virulence in Brucella abortus 2308." Molecular microbiology. 2012 Jul; 85(2):345-60. Epub 2012 Jun 12.
2012 Jun
Morrison JM, Miller EW, Benson MA, Alonzo F, Yoong P, Torres VJ, Hinrichs SH, Dunman PM. "Characterization of SSR42, a novel virulence factor regulatory RNA that contributes to the pathogenesis of a Staphylococcus aureus USA300 representative." Journal of bacteriology. 2012 Jun; 194(11):2924-38. Epub 2012 Apr 06.
2012 Apr
Jacobs AC, Sayood K, Olmsted SB, Blanchard CE, Hinrichs S, Russell D, Dunman PM. "Characterization of the Acinetobacter baumannii growth phase-dependent and serum responsive transcriptomes." FEMS immunology and medical microbiology. 2012 Apr; 64(3):403-12. Epub 2012 Jan 23.
2012 Feb
Gardete S, Kim C, Hartmann BM, Mwangi M, Roux CM, Dunman PM, Chambers HF, Tomasz A. "Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300." PLoS pathogens. 2012 Feb; 8(2):e1002505. Epub 2012 Feb 02.
Annadurai S, Martinez R, Canney DJ, Eidem T, Dunman PM, Abou-Gharbia M. "Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA." Bioorganic & medicinal chemistry letters. 2012 22(24):7719-25. Epub 2012 Oct 03.
Eidem TM, Roux CM, Dunman PM. "RNA decay: a novel therapeutic target in bacteria." Wiley interdisciplinary reviews. RNA. 2012 3(3):443-54. Epub 2012 Feb 28.
2011 Nov
Truong-Bolduc QC, Dunman PM, Eidem T, Hooper DC. "Transcriptional profiling analysis of the global regulator NorG, a GntR-like protein of Staphylococcus aureus." Journal of bacteriology. 2011 Nov; 193(22):6207-14. Epub 2011 Sep 09.
2011 Oct
Roux CM, Demuth JP, Dunman PM. "Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex." Journal of bacteriology. 2011 Oct; 193(19):5520-6. Epub 2011 Jul 15.
2011 Oct
Lei MG, Cue D, Roux CM, Dunman PM, Lee CY. "Rsp inhibits attachment and biofilm formation by repressing fnbA in Staphylococcus aureus MW2." Journal of bacteriology. 2011 Oct; 193(19):5231-41. Epub 2011 Jul 29.
2011 Oct
Morrison JM, Dunman PM. "The modulation of Staphylococcus aureus mRNA turnover." Future microbiology. 2011 Oct; 6(10):1141-50.
2011 Sep
Anbalagan S, McShan WM, Dunman PM, Chaussee MS. "Identification of Rgg binding sites in the Streptococcus pyogenes chromosome." Journal of bacteriology. 2011 Sep; 193(18):4933-42. Epub 2011 Jul 15.
2011 Feb
Luong TT, Sau K, Roux C, Sau S, Dunman PM, Lee CY. "Staphylococcus aureus ClpC divergently regulates capsule via sae and codY in strain newman but activates capsule via codY in strain UAMS-1 and in strain Newman with repaired saeS." Journal of bacteriology. 2011 Feb; 193(3):686-94. Epub 2010 Dec 03.
Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, Dunman PM. "Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis." PLoS pathogens. 2011 7(2):e1001287. Epub 2011 Feb 10.
2010 Jan
Kuhn G, Koessler T, Melles DC, Francois P, Huyghe A, Dunman P, Vos MC, Zanetti G, Schrenzel J, van Belkum A, Blanc DS. "Comparative genomics of epidemic versus sporadic Staphylococcus aureus strains does not reveal molecular markers for epidemicity." Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2010 Jan; 10(1):89-96. Epub 2009 Oct 31.
Cue D, Lie MG, Luong TT, Kuechenmeister L, Dunman PM, O'Donnell S, Rowe S, O'Gara JP, Lee CY. "Rbf promote biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC." J. Bacteriol. 2010; 191(20):6363.
Jacobs AC, Hood I, Olson PD, Morrison J, Carson S, Sayood K, Iwen PC, Skaar EP, Dunman PM. "Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis. Infect. Immun." 2010; .
Hood I, Jacobs AC, Sayood K, Dunman PM, Skaar EP. "Acinetobacter baumannii regulates antibiotic resistance in response to extracellular NaCl." Antimicrob. Agents Chemother. 2010; 54(3):1029.
Torres VJ, Attia AS, Mason WJ, Hood MI, Corbin BD, Beasley FC, Anderson KL, Stauff DL, McDonald WH, Zimmerman LJ, Friedman DB, Heinrichs DE, Dunman PM, Skaar EP. "2010. Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia." Infect Immun. 2010; 78(4):1618.
Majerczyk CD, Dunman PM, Luong TT, Lee CY, Sadykov MR, Somerville GA, Bodi K, Sonenshein AL. "Direct targets of CodY in Staphylococcus aureus." J. Bacteriol. 2010; 192(11):2861.
Lan L, Cheng A, Dunman PM, Missiakas D, He C. "Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus." J. Bacteriol. 2010; 192(12):3068.
Wyatt MA, Wang W, Roux CM, Beasley FC, Heinrichs DE, Dunman PM, Magarvey NA. "Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence." Science. 2010; 6;329(5989):294-6.
Anderson KL, Roux CM, Olson MW, Luong TT, Lee CY, Olson R, Dunman PM. "Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover." FEMS immunology and medical microbiology. 2010 60(3):208-50. Epub 2010 Oct 06.
2009 Nov 3
Lu SH, Ni Tun MH, Mei ZJ, Chia GH, Lim X, Sow CH. "Improved hydrophobicity of carbon nanotube arrays with micropatterning." Langmuir : the ACS journal of surfaces and colloids. 2009 Nov 3; 25(21):12806-11.
2009 Aug
Sharma-Kuinkel BK, Mann EE, Ahn JS, Kuechenmeister LJ, Dunman PM, Bayles KW. "The Staphylococcus aureus LytSR two-component regulatory system affects biofilm formation." Journal of bacteriology. 2009 Aug; 191(15):4767-75. Epub 2009 Jun 05.
Chen PR, Nishida S, Poor CB, Cheng A, Bae T, Kuechenmeister L, Dunman PM, Missiakas D, He C. "A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus." Mol Microbiol. 2009; 71(1):198.
Kuechenmeister LJ, Anderson KL, Morrison JM, Dunman PM. "The use of molecular beacons to directly measure bacterial mRNA abundances and transcript degradation." J Microbiol Methods. 2009; 76(2):146-51.
Yang SJ, Xiong YQ, Dunman PM, Schrenzel J, Francois P, Peschel A, Bayer AS. "Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains." Antimicrob Agents Chemother. 2009; 53(6)2636-7.
Goering RV, Larsen AR, Skov R, Tenover FC, Anderson KL, Dunman PM. "Comparative genomic analysis of European community-associated methicillin-resistant Staphylococcus aureus (CC80-MRSA-IV) isolates by high-density microarray." Clin. Micro. Infection. 2009; 15(8):748.
Anderson KL, Dunman PM. "Messenger RNA Turnover Processes in Escherichia coli, Bacillus subtilis, and Emerging Studies in Staphylococcus aureus." International journal of microbiology. 2009 2009:525491. Epub 2009 Mar 05.
2008 Feb 15
Corbin BD, Seeley EH, Raab A, Feldmann J, Miller MR, Torres VJ, Anderson KL, Dattilo BM, Dunman PM, Gerads R, Caprioli RM, Nacken W, Chazin WJ, Skaar EP. "Metal chelation and inhibition of bacterial growth in tissue abscesses." Science. 2008 Feb 15; 319(5865):962-5.
2008 Jan
Handke LD, Rogers KL, Olson ME, Somerville GA, Jerrells TJ, Rupp ME, Dunman PM, Fey PD. "Staphylococcus epidermidis saeR is an effector of anaerobic growth and a mediator of acute inflammation." Infection and immunity. 2008 Jan; 76(1):141-52. Epub 2007 Oct 22.
Stauff DL, Bagaley D, Torres VJ, Joyce R, Anderson KL, Kuechenmeister L, Dunman PM, Skaar EP. "Staphylococcus aureus HrtA is an ATPase required for protection against heme toxicity and prevention of a transcriptional heme stress response." J. Bacteriol. 2008; 190(10):3588-96.
2007 Apr 19
Torres VJ, Stauff DL, Pishchany G, Bezbradica JS, Gordy LE, Iturregui J, Anderson KL, Dunman PM, Joyce S, Skaar EP. "A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence." Cell host & microbe. 2007 Apr 19; 1(2):109-19.
2006 Oct
Anderson KL, Roberts C, Disz T, Vonstein V, Hwang K, Overbeek R, Olson PD, Projan SJ, Dunman PM. "Characterization of the Staphylococcus aureus heat shock, cold shock, stringent, and SOS responses and their effects on log-phase mRNA turnover." Journal of bacteriology. 2006 Oct; 188(19):6739-56.
2006 Oct
Cassat J, Dunman PM, Murphy E, Projan SJ, Beenken KE, Palm KJ, Yang SJ, Rice KC, Bayles KW, Smeltzer MS. "Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390." Microbiology. 2006 Oct; 152(Pt 10):3075-90.
2006 Aug
Richardson AR, Dunman PM, Fang FC. "The nitrosative stress response of Staphylococcus aureus is required for resistance to innate immunity." Molecular microbiology. 2006 Aug; 61(4):927-39. Epub 2006 Jul 12.
2006 Apr
Roberts C, Anderson KL, Murphy E, Projan SJ, Mounts W, Hurlburt B, Smeltzer M, Overbeek R, Disz T, Dunman PM. "Characterizing the effect of the Staphylococcus aureus virulence factor regulator, SarA, on log-phase mRNA half-lives." Journal of bacteriology. 2006 Apr; 188(7):2593-603.
2006 Apr
Yang SJ, Dunman PM, Projan SJ, Bayles KW. "Characterization of the Staphylococcus aureus CidR regulon: elucidation of a novel role for acetoin metabolism in cell death and lysis." Molecular microbiology. 2006 Apr; 60(2):458-68.
Tenover, F., McDougal, L.K., Goering, R.V., Killgore, G., Projan, S.J., Patel, J.B., and P.M. Dunman. "Characterization of a strain of community-associatied methicillin-resistant Staphylococcus aureus widely disseminated in the United States." J. Clin. Microbiol. 2006; 44:108-118.
Luong, T.T, Dunman, P.M., Murphy, E., Projan, S.J. and C. Y. Lee. "Transcription profiling of mgrA regulon in Staphylococcus aureus." 2006; J. Bact. 188(5):1899-910.
2005 Apr
Truong-Bolduc QC, Dunman PM, Strahilevitz J, Projan SJ, Hooper DC. "MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus." Journal of bacteriology. 2005 Apr; 187(7):2395-405.
2005 Jan
Cassat JE, Dunman PM, McAleese F, Murphy E, Projan SJ, Smeltzer MS. "Comparative genomics of Staphylococcus aureus musculoskeletal isolates." Journal of bacteriology. 2005 Jan; 187(2):576-92.
Entenza, J.M., Moreillon, P., Dunman, P.M., Senn, M.M., Kormanec, J., Berger-Bachi, B., Projan, S.J., and M. Bischoff. "Role of sigmaB on the expression of cell-wall adhesions ClfA and FnbA of Staphylococcus aureus and contribution to infectivity in a rat model of experimental endocarditis." Infect. and Immun. 2005; 73(2):990-998.
McAleese, F., Murphy, E., Babinchak, T., Singh, G., Said-Salim, B., Kreiswirth, B., Dunman, P.M., O'Connell, J., Projan, S.J., and P.A. Bradford. "Use of ribotyping to retrospectively identify methicillin-resistant Staphylococcus aureus isolates from phase 3 clinical trials for Tigecycline that are genotypically related to community-associated isolates." 2005; 49(11): 4521-4529.
Bischoff, M., Dunman, P.M., Kormanec, J., Macapagal, D., Murphy, E., Mounts, W., Berger-Bachi, B. and S.J. Projan. "Microarray-based analysis of the Staphylococcus aureus sigmaB-regulon." J. Bact. 2004; 186(13): 4085-4099.
Beenken, K.E., Dunman, P.M., McAleese, F., Macapagal, D., Murphy, E., Projan, S.J., Francis, K., Kadurugamuwa, J., Blevins, J.S., and M.S. Smeltzer. "Global gene expression in Staphylococcus aureus biofilms." J. Bact. 2004; 186(14): 4665-4685.
Dunman, P.M., Mounts, W., McAleese, F., Immermann, F., Macapagal, D., Marsilio, E. McDougal, L., Tenover, F., Bradford, P.A., Petersen, P.J., Projan, S.J., and E. Murphy. "Genotyping Staphylococcus aureus using a Novel GeneChip-based approach." J. Clin. Micro. 2004; 42(9): 4275-4283.
Weinrick B, Dunman PM, McAleese F, Murphy E, Projan SJ, Fang Y, Novick RP. "Effect of mild acid on gene expression in Staphylococcus aureus." Journal of bacteriology. 2004 186(24):8407-23.
2003 Oct
Utaida S, Dunman PM, Macapagal D, Murphy E, Projan SJ, Singh VK, Jayaswal RK, Wilkinson BJ. "Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon." Microbiology. 2003 Oct; 149(Pt 10):2719-32.
Salim, B.S., Dunman, P.M., McAleese, F.M., Macapagal, D., McNamara, P.J., Staffan Arvidson, S., Projan, S.J., and B.N. Kreiswirth. "Global regulation of Staphylococcus aureus genes by Rot." J. Bact. 185(2):610-9. 2003; 185(2):610-9.
Livermore, D.M., Warner, M., Oakton, K.J., Hall, L.M.C., Enne, V.I., Projan, S.J., Dunman, P.M., Wooster, S.L., and G. Harrison. "Antibiotic resistance in bacteria from magpies (Pica pica) and rabbits (Oryctolagus cuniculus) from West Wales." Environ Microbiol. 2001; Oct; 3(10):658-61.
Dunman, P.M., Murphy, E., Haney, S., Palacios, D., Brown, E.L., Wu, S., Tucker-Kellog, G., Zagursky, R., Shlaes, D., and S. Projan. "Transcriptional profile analysis of the Staphylococcus aureus agr and sarA virulence loci." J Bact. 2001; 183(24):7341-53.
2000 Aug
Dunman PM, Ren L, Rahman MS, Palejwala VA, Murphy HS, Volkert MR, Humayun MZ. "Escherichia coli cells defective for the recN gene display constitutive elevation of mutagenesis at 3,N(4)-ethenocytosine via an SOS-induced mechanism." Molecular microbiology. 2000 Aug; 37(3):680-6.
1997 Jun
Wang G, Dunman PM, Humayun MZ. "Replication of M13 single-stranded DNA bearing a site-specific ethenocytosine lesion by Escherichia coil cell extracts." Cell research. 1997 Jun; 7(1):1-12.
1996 Nov
Rahman MS, Dunman PM, Wang G, Murphy HS, Humayun MZ. "Effect of UVM induction on mutation fixation at non-pairing and mispairing DNA lesions." Molecular microbiology. 1996 Nov; 22(4):747-55.
Murphy, H.S., Palejwala, V.A., Rahman, M.S., Dunman, P.M., Wang, G., and M.Z. Humayun. "Role of mismatch repair in the Escherichia coli UVM response." J. Bact. 1996; 178:6651-6657.
Wang, G., Palejwala, V.A., Dunman, P.M., Aviv, D.H., Murphy, H.S., Rahman, M.S., and M.Z. Humayun. "Alkylating agents induce UVM, a recA-independent inducible mutagenic phenomenon in Escherichia coli." Genetics. 1995; 141:813-823.
1994 Nov 4
Palejwala VA, Pandya GA, Bhanot OS, Solomon JJ, Murphy HS, Dunman PM, Humayun MZ. "UVM, an ultraviolet-inducible RecA-independent mutagenic phenomenon in Escherichia coli." The Journal of biological chemistry. 1994 Nov 4; 269(44):27433-40.
McAleese, F., Petersen, P., Ruzin, A., Dunman, P.M., Murphy, E., Projan, S.J., and P.A. Bradford. "A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory derived Staphylococcus aureus mutants to Tigecycline. Antimicrob." Agents Chemother. 49(5): 1865-71.


Dunman, P.M. and S.J. Projan.. "Expression Profiling Uses in Antibacterial Chemotherapy Development.". Microbial Genomics and Drug Discovery.. T.J. Dougherty and S.J. Projan. : Marcel Dekker Inc. New York., 2003.
Dunman, P.M. and S.J. Projan.. "The regulation of virulence in the Staphylococci.". Staphylococcal infection a. A. Honeyman, H. Friedman, and M. Bendinelli (ed.),. : Kluwer Academic/Plenum Publishers, New York., 2001.