Professional Bio
Dr. Cohen graduated cum laud from Lebanon Valley College before completing both his graduate and postdoctoral research at the University of Pennsylvania School of Medicine. Dr. Cohen's research is largely focused on understanding how intercellular signaling directs cardiac morphogenesis and how defect in this signaling contribute to human disease. Congenital heart defects are present in approximately 1% of newborn babies, 10% of stillborn fetuses and responsible for nearly 6% of deaths among children under one year of age. Furthermore heart disease is the leading cause of death among adults in the Western world.
A better understanding of the mechanisms underlying cardiac development will aid in the discovery of new methods to detect and treat congenital heart defects. Moreover since aberrant signaling by embryonic pathways is often associated with disease, this same information will also aid in the discovery of novel treatments for adult cardiomyopathy. Many of these new treatments are likely to involve using stem/progenitor cells to replace damaged cardiac tissues. However our ability to differentiate multi-potent stem cells into functional cardiomyocytes is still limited and further insight into the molecular cues that guide cardiac development will be necessary to reach the full potential of regenerative medicine.
Research Bio
Dr. Cohen graduated cum laud from Lebanon Valley College before completing both his graduate and postdoctoral research at the University of Pennsylvania School of Medicine. Dr. Cohen's research is largely focused on understanding how intercellular signaling directs cardiac morphogenesis and how defect in this signaling contribute to human disease. Congenital heart defects are present in approximately 1% of newborn babies, 10% of stillborn fetuses and responsible for nearly 6% of deaths among children under one year of age. Furthermore heart disease is the leading cause of death among adults in the Western world.
A better understanding of the mechanisms underlying cardiac development will aid in the discovery of new methods to detect and treat congenital heart defects. Moreover since aberrant signaling by embryonic pathways is often associated with disease, this same information will also aid in the discovery of novel treatments for adult cardiomyopathy. Many of these new treatments are likely to involve using stem/progenitor cells to replace damaged cardiac tissues. However our ability to differentiate multi-potent stem cells into functional cardiomyocytes is still limited and further insight into the molecular cues that guide cardiac development will be necessary to reach the full potential of regenerative medicine.
2012 Sep 18
Miller MF, Cohen ED, Baggs JE, Lu MM, Hogenesch JB, Morrisey EE. "Wnt ligands signal in a cooperative manner to promote foregut organogenesis." Proceedings of the National Academy of Sciences of the United States
of America. 2012 Sep 18; 109(38):15348-53. Epub 2012 Sep 04. |
2012 Jun
Cohen ED, Miller MF, Wang Z, Moon RT, Morrisey EE. "Wnt5a and Wnt11 are essential for second heart field progenitor development." Development (Cambridge, England). 2012 Jun 0; 139(11):1931-40. |
2011 Sep 2
Shen D, Li J, Lepore JJ, Anderson TJ, Sinha S, Lin AY, Cheng L, Cohen ED, Roberts JD, Dedhar S, Parmacek MS, Gerszten RE. "Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells." Circulation research. 2011 Sep 2; 109(6):616-28. Epub 2011 Jul 21. |
2011 Aug 15
Goss AM, Tian Y, Cheng L, Yang J, Zhou D, Cohen ED, Morrisey EE. "Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression." Developmental biology. 2011 Aug 15; 356(2):541-52. Epub 2011 Jun 16. |
2010 Aug
Yuan L, Wang T, Liu F, Cohen ED, Patel VV. "An evaluation of transmitral and pulmonary venous Doppler indices for assessing murine left ventricular diastolic function." Journal of the American Society of Echocardiography : official
publication of the American Society of Echocardiography. 2010 Aug 0; 23(8):887-97. Epub 2010 Jun 29. |
