Eric M. Small, Ph.D.

Eric M. Small, Ph.D.

Contact Information

Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta, NY 14586

Office: (585) 276-9795
Lab: (585) 276-9847
Administrative: (585) 276-9800
Fax: (585) 276-9830

Professional Bio

Dr. Small earned his undergraduate degree from the University of Michigan in 1995. He then completed a Ph.D. in the laboratory of Dr. Paul Krieg at the University of Texas at Austin in 2003, where he defined transcriptional mechanisms that regulate the early stages of heart development. During subsequent post-doctoral training under Dr. Eric Olson at UTSW Medical Center at Dallas, he made contributions towards understanding the transcriptional mechanisms regulating cardiovascular development and remodeling using a combination of cell biological techniques and mouse genetics. Dr. Small was recruited to the University of Rochester Medical Center in 2011. His general research interests focus on understanding how a cell can interpret biomechanical and humoral signals and activate a discrete transcriptional program during development or in response to injury.

Research Bio

Research in the Small Lab is focused on understanding the molecular mechanisms that govern how a cell responds to its surroundings during development or following tissue injury. Specifically, we are interested in defining the gene regulatory circuits that are activated following cardiac injury, and how these circuits define a cellular response. To this end, we have three main projects based on gene regulation studies during tissue injury or remodeling:



1. One major component of wound healing, in dermal wounds or a damaged organ alike, is the proliferation and activation of fibroblasts, called "myofibroblasts". Activated myofibroblasts are contractile cells that promote wound closure due in part to the expression of smooth muscle contractile proteins and the deposition of high levels of extracellular matrix. My lab is dedicated to identifying the cellular source of these contractile fibroblasts in the heart and understanding the factors involved in their differentiation following injury.

2. Myocardin-related transcription factor (MRTF)-A is a ubiquitously expressed signal responsive transcriptional co-factor for serum response factor (SRF) that moves to the nucleus in response to various cues that promote F-actin polymerization. I have recently discovered an important role of MRTF-A during myofibroblast differentiation and scar formation following myocardial infarction. My lab is currently studying the mechanisms controlling MRTF activation during development or following cardiac injury, and identifying novel partners in these processes. MRTFs and myofibroblast differentiation are also intriguing therapeutic targets for the prevention or treatment of diseases characterized by inappropriate contractility or scar formation. Therefore, in an extension of this project, we are pursuing novel small molecule modifiers of MRTF activity and myofibroblast differentiation using cell biology and mouse models of wound healing.

3. I have recently identified a number of microRNAs that are activated by SRF and MRTF-A, some of which play a role in cardiovascular remodeling. We are interested in defining the importance of post-transcriptional regulation of gene expression by these microRNAs in tissue homeostasis. The main goal of this aim would be to discover novel cooperative interactions between seemingly unrelated microRNAs via regulation of common mRNAs or physiological pathways.

These projects utilize experimental approaches ranging from biochemical analyses, to cell biology, to mouse models of disease. It is hoped that the insight gained from answering these basic biological questions might lead to novel therapeutic strategies for the prevention or treatment of human disease.

Awards & Honors (Local)

Excellence in Postdoctoral Mentoring Award 2013
Scientist Development Grant | American Heart Association 2010 - 2014
Ruth L. Kirschstein NRSA Post-Doctoral Fellowship | National Institutes of Health 2004 - 2007
Best Poster Presentation Award | Weinstein Cardiovascular Conference 2002

Recent Journal Articles

Showing the 5 most recent journal articles. 21 available »

2013 Oct 15
Velasquez LS, Sutherland LB, Liu Z, Grinnell F, Kamm KE, Schneider JW, Olson EN, Small EM. "Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Oct 15; 110(42):16850-5. Epub 2013 Sep 30.
2013
Rod├ęs-Cabau J, Dauerman HL, Cohen MG, Mehran R, Small EM, Smyth SS, Costa MA, Mega JL, O'Donoghue ML, Ohman EM, Becker RC. "Antithrombotic treatment in transcatheter aortic valve implantation: insights for cerebrovascular and bleeding events." Journal of the American College of Cardiology.. 2013 62(25):2349-59. Epub 2013 Apr 10.
2012
Small EM. "The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation." Journal of cardiovascular translational research. 2012 5(6):794-804. Epub 2012 Aug 17.
2011 Sep 30
Miano JM, Small EM. "MicroRNA133a: a new variable in vascular smooth muscle cell phenotypic switching." Circulation research.. 2011 Sep 30; 109(8):825-7.
2011 Jan 20
Small EM, Olson EN. "Pervasive roles of microRNAs in cardiovascular biology." Nature. 2011 Jan 20; 469(7330):336-42.

Current Appointments

Assistant Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD) - Primary
Assistant Professor - Department of Pharmacology and Physiology (SMD)

Education

PhD | Molecular Biology | Univ Texas-Austin2003
BS | Cell and Molecular Biology | University of Michigan1995

Post-Doctoral Training & Residency

Hospital for Sick Children, Toronto, ON (Mentor: Benoit Bruneau) 2005
UT Southwestern Medical Center at Dallas, Dallas, TX (Mentor: Eric N. Olson) 2009