Research Profile Journal Articles
Douglas Stuart Portman, Ph.D.

Douglas Stuart Portman, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 645
Rochester, NY 14642

Office: (585) 275-7414
Lab: (585) 275-7915
Fax: (585) 276-1947

Research Bio

Genetic Control of Sex Differences in Neurobiology and Disease

Though the existence of two sexes is a fundamental characteristic of nearly all animal species, the way biological sex brings about sex differences in the brain and behavior is poorly understood. Moreover, susceptibility to a host of human neurological and mental health disorders is strongly influenced by gender, but in most cases the biological bases for these differences remain opaque. Our research uses a simple, experimentally tractable model system--the small soil nematode C. elegans--to shed light on the genetic underpinnings of sex differences in neural development, behavior, and disease susceptibility.

For more information, please visit the lab website at: http://wormweb.urmc.rochester.edu/

Recent Journal Articles

Showing the 5 most recent journal articles. 16 available »

2012 Mar 21
Mowrey WR, Portman DS. "Sex differences in behavioral decision-making and the modulation of shared neural circuits." . 2012 Mar 21; 3(1):8. Epub 2012 Mar 21.
2011 Sep 14
Miller RM, Portman DS. "The Wnt/beta-catenin asymmetry pathway patterns the atonal ortholog lin-32 to diversify cell fate in a Caenorhabditis elegans sensory lineage." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Sep 14; 31(37):13281-91.
2011
Siehr MS, Koo PK, Sherlekar AL, Bian X, Bunkers MR, Miller RM, Portman DS, Lints R. "Multiple doublesex-related genes specify critical cell fates in a C. elegans male neural circuit." PloS one. 2011 6(11):e26811. Epub 2011 Nov 01.
2010 Jul
Hurd DD, Miller RM, Núñez L, Portman DS. "Specific alpha- and beta-tubulin isotypes optimize the functions of sensory Cilia in Caenorhabditis elegans." Genetics. 2010 Jul 0; 185(3):883-96. Epub 2010 Apr 26.
2010
Miller RM, Portman DS. "A latent capacity of the C. elegans polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5." Disease models & mechanisms. 2010 3(7-8):441-50. Epub 2010 Mar 11.

Current Appointments

Associate Professor - Department of Biomedical Genetics, Center for Neural Development & Disease (SMD) - Primary
Associate Professor - Department of Biology RC (RC)

Education

PhD | Molecular Biology and Genetics | Univ of Pennsylvania1995
BA with Honors, | Biochemistry | Univ of Pennsylvania1988