Research Bio
Transmembrane proteins carry out critical functions in transporting ions and metabolites in an out of cells and organelles, in transducing extracellular signals into intracellular responses, in cell-cell recognition, and in catalyzing a variety of enzymatic reactions. They also constitute 20-30% of the protein coding potential of most genomes. However, the structures and molecular mechanisms of the function of membrane proteins remain much more poorly characterized than is the case for most soluble proteins. The Dumont laboratory focuses on understanding mechanisms of membrane protein function at the molecular level.
2011 Oct 4
Kang DC, Venkataraman PA, Dumont ME, Maloney PC. "Oligomeric state of the oxalate transporter, OxlT." Biochemistry. 2011 Oct 4; 50(39):8445-53. Epub 2011 Sep 08. |
2011 Jun 17
Mathew E, Bajaj A, Connelly SM, Sargsyan H, Ding FX, Hajduczok AG, Naider F, Dumont ME. "Differential interactions of fluorescent agonists and antagonists with the yeast G protein coupled receptor Ste2p." Journal of molecular biology. 2011 Jun 17; 409(4):513-28. Epub 2011 Apr 06. |
2010 Jun 22
Tantry SJ, Ding FX, Dumont ME, Becker JM, Naider FR. "Binding of fluorinated phenylalanine alpha-factor analogues to Ste2p: evidence for a cation-pi binding interaction between a peptide ligand and its cognate G protein-coupled receptor." Biochemistry. 2010 Jun 22; 49(24):5007-15. |
2010 Jun
Clark KM, Fedoriw N, Robinson K, Connelly SM, Randles J, Malkowski MG, Detitta GT, Dumont ME. "Purification of transmembrane proteins from Saccharomyces cerevisiae for X-ray crystallography." Protein expression and purification. 2010 Jun 0; 71(2):207-23. Epub 2010 Jan 04. |
2010
Shi S, Notenboom S, Dumont ME, Ballatori N. "Identification of human gene products containing Pro-Pro-x-Tyr (PY) motifs that enhance glutathione and endocytotic marker uptake in yeast." Cellular physiology and biochemistry : international journal of
experimental cellular physiology, biochemistry, and pharmacology. 2010 25(2-3):293-306. Epub 2010 Jan 12. |
