Research Bio
Dr. Schwarz is Professor of Orthopaedics and Associate Director of the
Center for Musculoskeletal Research at URMC. His laboratory focuses on
finding solutions to bone loss due to conditions such as rheumatoid
arthritis, infections, tumors that spread to bone, and bone destruction near
the implants used in reconstructive surgery.
Several genes are known to turn on the healing process in bone. Dr.
Schwarz's group loads these genes into harmless virus particles. The
particles are coated onto experimental bone implants to deliver therapeutic
genes to the area of reconstruction, thus improving bone healing. The
cartilage that lines joints in mice can be encouraged to heal more
completely when virus particles deliver therapeutic genes too.
An additional interest of Dr. Schwarz's lab is the use of magnetic resonance
imaging (MRI) and high resolution computed tomography (CT) scans to
visualize the formation of new blood vessels as patients heal.
2012 Mar
Takahata M, Awad HA, O'Keefe RJ, Bukata SV, Schwarz EM. "Endogenous tissue engineering: PTH therapy for skeletal repair." Cell and tissue research. 2012 Mar 0; 347(3):545-52. Epub 2011 May 31. |
2012 Feb
Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. "Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression." Journal of orthopaedic research : official publication of the
Orthopaedic Research Society. 2012 Feb 0; 30(2):325-33. Epub 2011 Aug 01. |
2011 Nov
Myakishev-Rempel M, Kuper J, Mintz B, Hutchinson S, Voris J, Zavislan K, Offley S, Nardia FB, Yaseen Z, Yen T, Zavislan JM, Maloney MD, Schwarz EM. "Investigation of the peak action wavelength of light-activated gene transduction." Gene therapy. 2011 Nov 0; 18(11):1043-51. Epub 2011 Apr 14. |
2011 Oct 10
Chiu YH, Mensah KA, Schwarz EM, Ju Y, Takahata M, Feng C, McMahon LA, Hicks DG, Panepento B, Keng PC, Ritchlin CT. "Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP)." Journal of bone and mineral research : the official journal of the
American Society for Bone and Mineral Research. 2011 Oct 10; Epub 2011 Oct 10. |
2011 Sep 28
Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA. "Delayed short course treatment with teriparatide (PTH(1-34) ) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction." Journal of bone and mineral research : the official journal of the
American Society for Bone and Mineral Research. 2011 Sep 28; Epub 2011 Sep 28. |
