Alan M. Grossfield, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 276-4193
Fax: (585) 275-6007

Lab Description

My lab's research is focused on understanding the stomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

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Research Bio

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Recent Journal Articles

Showing the 5 most recent journal articles. 25 available »

2012 Mar 7
Olausson BE, Grossfield A, Pitman MC, Brown MF, Feller SE, Vogel A. "Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes." Journal of the American Chemical Society. 2012 Mar 7; 134(9):4324-31. Epub 2012 Feb 22.

2012 Feb
Horn JN, Sengillo JD, Lin D, Romo TD, Grossfield A. "Characterization of a potent antimicrobial lipopeptide via coarse-grained molecular dynamics." Biochimica et biophysica acta. 2012 Feb 0; 1818(2):212-8. Epub 2011 Jul 28.

2011 Aug
Romo TD, Bradney LA, Greathouse DV, Grossfield A. "Membrane binding of an acyl-lactoferricin B antimicrobial peptide from solid-state NMR experiments and molecular dynamics simulations." Biochimica et biophysica acta. 2011 Aug 0; 1808(8):2019-30. Epub 2011 Apr 06.

2011 Jul
Grossfield A. "Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations." Biochimica et biophysica acta. 2011 Jul 0; 1808(7):1868-78. Epub 2011 Apr 03.

2011 Jan
Romo TD, Grossfield A. "Validating and improving elastic network models with molecular dynamics simulations." Proteins. 2011 Jan 0; 79(1):23-34. Epub 2010 Sep 24.

Current Appointments

Assistant Professor - Department of Biochemistry and Biophysics (SMD) - Primary