URMC Labs - Department of Pathology & Laboratory Medicine

Research Day

The Department's Research Day is an annual event that features poster presentations from house staff, graduate students and other trainees. The day concludes with the annual departmental dinner.

33rd Annual Research Day June 10, 2013

2013 Keynote lecture

Dr. Leonard M. Neckers, Ph.D.

HSP90: A Housekeeping Protein Co-opted by Cancer Cells

Neckers

Dr. Neckers received his Ph.D. from the University of Connecticut, completed postdoctoral training at the NIH, and joined the NCI in 1981. He became Chief of the Tumor Cell Biology Section, Medicine Branch, in 1988.

An early proponent of translational research, Dr. Neckers pioneered development of oligonucleotide-based therapeutic strategies. For the past twenty-five years, Dr. Neckers has been investigating the role of chaperone proteins in signal transduction and cancer. His identification of benzoquinone ansamycins as the first small molecule inhibitors of the molecular chaperone HSP90 uncovered the importance of this protein for the growth and survival of cancer cells and led directly to the first phase I clinical trial of an HSP90 antagonist as an anticancer agent. Using these drugs as bioprobes of Hsp90 function in cancer, Dr. Neckers uncovered the anticancer mechanism of action of Hsp90 inhibitors and he was the first to show that Hsp90 inhibition provides a novel approach to simultaneously attack multiple oncogenic signaling pathways. Dr. Neckers and his laboratory identified numerous oncogene clients of Hsp90, including v-Src, HER2, c-Raf, HIF-1, Bcr-Abl, Kit, and mutant p53. Based on his work, more than 200 Hsp90 clients have since been identified. Dr. Neckers continues to examine the pivotal role of Hsp90 in cancer cell survival, and participates in the ongoing translational development of Hsp90 inhibitors as novel anti-cancer agents.

Dr. Neckers’s current research explores the complex interplay between numerous HSP90 posttranslational modifications and chaperone function/drug sensitivity.

2013 Awards

PhD Program Award Recipients

Academic Excellence (1st yr student) – Chi-Wen Lo

Outstanding Contribution – Michael A. Moses

Outstanding Research Publication – Joanne Soong

TRAVEL AWARDS

Jonathan D. Cherry

Christopher Farnsworth

Rialnat AdeBisi Lawal

Bradley N. Mills

Michael A. Moses

2013 Presentations

1. Results of the National Association of Medical Examiners Clinical Pathology Survey.

Barker, Eric; Lopez, Lorraine; Jones, Rachael

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center

2. The Demographic Landscape of Forensic Pathology: Then and Now

Lorraine Lopez, Rachael Jones, Eric Barker

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center

3. Results of the National Association of Medical Examiners (NAME) Job Satisfaction Survey

Rachael Jones MD, Lorraine Lopez MD, Eric Barker MD

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center

4. Myocardial Immunopositivity for Complement C4d in Cases of Sudden Death in Hospitalized Patients

Rachael Jones MD, Leon Metlay MD, Bruce Goldman MD

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center

5. A Novel Transgenic Mouse Model of Ataxia-Telangiectasia Reveals a Correlation Between Gene Product Length and Disease Phenotype

Andrew Campbell1,2, Brittany Krupp2, Chris Pröschel2, Margot Mayer-Pröschel2

1Department of Pathology & Laboratory Medicine, 2Department of Biomedical Genetics, University of Rochester

6. Glymphatic Failure as a Pathogenic Mechanism for the Development of Craniectomy-Induced Syndrome of the Trephined

Benjamin A. Plog1,2,3, Clifford A. Pierre1,3, Hongyi Kang3, Jeffrey J. Iliff3,4, Rashid Deane3,4, G. Edward Vates3,4, Maiken Nedergaard3,4

1University of Rochester School of Medicine and Dentistry, Rochester, NY,  2Department of Pathology, University of Rochester Medical Center, Rochester, NY,  3Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY, 4Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY

7. Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Disease

Jonathan D. Cherry1, Bin Liu2, Jeffrey L. Frost2, Cynthia A. Lemere2, Jacqueline P. Williams3, John A. Olschowka4, M. Kerry O’Banion4

1 Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, 2 Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America, 4 Department of Neurobiology & Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America

8. Hypoxia and the Mitochondrial Unfolded Protein Response

Salvador Peña1, Teresa Sherman2, Andrew Wojtovich2, Sergiy Nadtochiy3, Cole Haynes4, Paul Brookes3, Keith Nehrke4

1 Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine; 2 Department of Nephrology, University of Rochester School of Medicine; 3 Department of Anesthesiology, University of Rochester School of Medicine; 4Cell Biology Program, Memorial Sloan-Kettering Cancer Center

9. MKP-1 Effects o­­n HIF-1a in Glioblastoma Multiforme

Bradley N. Mills 1,2, Jeanne N. Hansen 1, and Marc W. Halterman 1,3,4

Center for Neural Development and Disease 1, Departments of Pathology and Laboratory Medicine 2, Neurology 3 and Pediatrics 4

10. ALK protein expression correlates with ALK rearrangement, but not increased ALK copy numbers in lung adenocarcinomas

Bing Ren,MD PhD; Loralee McMahon, MS; Qi Yang, Nancy Wang, PhD; M Anwar Iqbal, Ph.D; Paul Rothberg, PhD; Zongren Zhou, MD PhD; Faqian Li, MD PhD and Haodong Xu, MD PhD

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY USA

11. Squamous Cell Carcinoma Arising In a Peri-coccygeal Epithelial Inclusion Cyst with Adjacent Benign Notochordal Cell Tumor: First Case Report

Lorraine Lopez, Luke Schoeninger, David Zhou

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center

12. Shp2 as a potential therapeutic target in MET-responsive melanoma

Joanne Soong2,1 and Glynis Scott1,2

1Department of Dermatology and 2Pathology& Laboratory Medicine, University of Rochester School of Medicine.

13. Elucidating the Role of EVI1 in Leukemogenesis Using a Novel Mouse Model.

Michael P. Wilson1, Kristina M. Owens1, Yi Zhang1, and Archibald S. Perkins1.

1Department of Pathology and Laboratory Medicine

14. THE EVOLUTION OF ACUTE MYELOGENOUS LEUKEMIA STEM CELL PROPERTIES FOLLOWING TREATMENT AND PROGRESSION

Tzu-chieh Ho1,2, Mark W. LaMere2, Craig T. Jordan2, Michael W. Becker2

1Department of Pathology & Laboratory Medicine, 2The Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY

15. A Critical Role of Nonclassical MHC in Tumor Immune Evasion Revealed in vivo in the Amphibian Xenopus Model

Nikesha Haynes1,2 , Eva Stina Edholm1, PhD, Jacques Robert1, PhD

 1Department of Microbiology and Immunology; 2Department of Pathology & Laboratory Medicine

16. Epigallocatechin Gallate (EGCG) Elicits Stage-Specific Sensitivity in a Novel Human Prostate Cancer Progression Model

Michael A. Moses1, Ellen C. Henry2, William A. Ricke3, & Thomas A. Gasiewicz2

1Dept. of Pathology & Laboratory Medicine; 2Dept. of Environmental Medicine, University of Rochester; 3Dept. of Urology, University of Wisconsin-Madison

17. Adipose Tissue Provides a Unique Microenvironment for Primitive Leukemic Cells

Haobin Ye 1, 2 , John Ashton 3 , Marlene Balys 2 , Mohammad Minhajuddin 2 ,  Shanshan Pei 2 , Kevin Callahan 2 , Craig Jordan 2, 4

1Department of Pathology and Laboratory Medicine, 2James Wilmot Cancer Center, 3Genomics Research Center, 4Department of Medicine, Hematology/Oncology, University of Rochester, Rochester, NY;

18. Osteolineage Jagged1 is a critical component of the PTH activated hematopoietic stem and progenitor cell niche

Rialnat AdeBisi Lawal, Laura M. Calvi, MD.

The Wilmot Cancer Center; Department of Pathology & Laboratory Medicine; Endocrine Division, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY 14623

19. Investigation into a link between Ascl3 and endocrine cell specification

Pei-Lun Weng1, Catherine Ovitt2,3

1Department of Pathology & Laboratory Medicine, 2Department of Biomedical Genetics, 3Center for Oral Biology, University of Rochester School of Medicine and Dentistry

20. Identification of signals that regulate skeletal muscle stem cell quiescence.
Andrew Soroka, Alanna Klose, Wenxuan Liu, Joe Chakkalakal

Department of Pathology & Laboratory Medicine, University of Rochester School of Medicine and Dentistry

21. In vivo pharmacologic modulation of bone marrow microenvironmental signals promotes long-term hematopoietic stem cell function

Julianne N.P. Smith, MS1, Alexandra Goodman2, Laura M. Calvi, MD2 1Department of Pathology and Laboratory Medicine, 2Endocrine Division, Department of Medicine, University of Rochester School of Medicine and Dentistry

22. SDF-1 acutely promotes the physical association of megakaryocytes with marrow vascular endothelium and enhances the number of circulating platelets

Lisa M. Niswander1, 2, Jennifer L. McLaughlin2, Anne D. Koniski2, Kathleen E. McGrath2, and James Palis2

1Department of Pathology and Laboratory Medicine, 2Center for Pediatric Biomedical Research, Department of Pediatrics

23. The Role of Neurotrophin Signaling in Megakaryocyte Differentiation and Platelet Production

Ayse Kizilyer1, Michelle Kiebala2, Sanjay Maggirwar2

1Department of Pathology, 2Department of Microbiology and Immunology

24. Emergence and potential of hemogenic endothelium in the mammalian yolk sac

Jenna M. Frame1,2, Kathleen E. McGrath2, Katherine Fegan2, James Palis2

1,2Department of Pathology and Laboratory Medicine, 2Center for Pediatric Biomedical Research, Department of Pediatrics, URMC  

25. High Fat Diet Increases Bacterial Load and Osteolysis in a Model of Implant Associated Osteomyelitis

Christopher Farnsworth, Maynard, R., Varrone, J., Schwarz, E.M., Mooney, RA.

Department of Pathology and Laboratory Medicine. Center for Musculoskeletal Research, University of Rochester

26. Evaluating the Mechanism of Action of Anti-Glucosaminidase Antibodies as a Passive Vaccine for Methicillin-Resistant Staphylococcus aureus (MRSA) Orthopaedic Infections

John J. Varrone1,2; John L. Daiss2; Karen L. de Mesy Bentley1; Stephen L. Kates2; Edward M. Schwarz1,2

1Department of Pathology & Laboratory Medicine, 2The Center for Musculoskeletal Research

27. Fibroblast specific deletion of TAK1 reduces adhesion formation during duringflexor tendonhealing.

Shi S1,2, Loiselle AE2, Jonason JH2, O’Keefe RJ2                                                                            1Department of Pathology, University of Rochester, Rochester, New York.  2Center for Musculoskeletal Research, University of Rochester, Rochester, New York.

28. Manipulating the NOTCH pathway to accelerate fracture repair

Cuicui Wang1,2, Jie Shen2, Kiminori Yukata2, Regis J. O’Keefe2, Matthew J. Hilton2

1Department of Pathology & Laboratory Medicine,2Center for Musculoskeletal Research

29. Doxycycline Mediated MMP Inhibition Blocks LH-induced Steroidogenesis and Promotes Cycling in a Mouse Model for Polycystic Ovary Syndrome

Allison Light1and Stephen R. Hammes2

1. University of Rochester, Department of Pathology and Laboratory Medicine, 2. University of Rochester, Department of Medicine, Division of Endocrinology and Metabolism

30. Selective Insulin Suppression of MMP-1, MMP-13 and ADAMTS-4 in osteoarthritic fibroblast-like synoviocytes

1Robert Hoff, Daisuke Hamada, Robert Maynard, Haobin Ye, Stephen L Kates, 2Matthew J Hilton, 2Michael J Zuscik, 1Robert A Mooney

1Department of Pathology & Laboratory Medicine,2Center for Musculoskeletal Research

31. The role of anti-serpin B13 antibodies in type 1 diabetes.

Chi-Wen Lo, Jan Czyzyk

Department of Pathology and Laboratory Medicine, University of Rochester

32. Selective iNOS inhibition increases the lymphatic pulse and drainage from arthritic joints in TNF-Tg mice

Yawen Ju, Ronald Wood, Lianping Xing, Christopher T. Ritchlin and Edward M. Schwarz

33. Pro-Resolving Lipid Mediator Resolvin D1 (RvD1) Inhibits Cigarette Smoke-Induced Airspace Enlargement in Mice.

Hsi-Min Hsiao1, Thomas, H Thatcher2, Charles N. Serhan3, Richard P. Phipps2,4, and Patricia J. Sime2,4.

1Department of Pathology and Laboratory Medicine, 2Division of Pulmonary and Critical Care Medicine, 3Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital, Harvard Institutes of Medicine and Harvard Medical School. 4Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry

34. Role of Epithelial Tissue Transglutaminase in the Development of Pulmonary Fibrosis

Amali P. Epa1, Keith C. Olsen2, Hsi-Min Hsiao1, Stephen J. Pollock3, Thomas H. Thatcher2, Richard P. Phipps1, 2, 3, and Patricia J. Sime1, 2, 3. 1Department of Pathology & Laboratory Medicine, 2Division of Pulmonary/Critical Care Medicine, 3Department of Environmental Medicine.

Differential Expression of Platelet P-selectin During Development

Massiel Chavez Stolla1, Jenny L McLaughlin2, Kathleen E. McGrath2, and James Palis2

1Department of Pathology, University of Rochester Medical Center, Rochester NY 14642

2Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Rochester NY 14642

The distribution of 25OHVitD2 and 25OHVitD3 in a patient population in

Rochester, NY

Moritz Stolla, Tai Kwong, Yan Zhang

Department of Pathology and Laboratory Medicine, University of Rochester

Medical Center, Strong Memorial Hospital, Rochester, NY

URMC Labs Test Index

A | B | C | D | E | F | G
H | I | J | K | L | M | N
O | P | Q | R | S | T | U
V | W | X | Y | Z