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PhD (1970)
University of Rochester
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Carol
K. Kellogg
Professor of Brain and Cognitive Sciences and of Pharmacology
and Physiology
Primary Appointment:
Brain and Cognitive
Sciences
GEBS Cluster Affiliations:
CRMP- Cell Regulation
and Molecular Pharmacology
NS
- Neuroscience
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Research:
GABAA Receptor and Neural Development |
Contact Information:
E-Mail: kellogg@bcs.rochester.edu |
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester, New York 14642
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Medical Center [room]
Phone: (716) [tele]
Fax: (716) [number] |
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Research
Overview
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My primary research interests are in developmental neurochemistry
and neuropharmacology. I am particularly interested in the role
that specific transmitters and their receptors may play in organization
of brain function. For the past several years, I have focused
on the roles of GABA and the GABAA receptor in the
organization of the brain for complex adaptive behaviors. GABA
is the major inhibitory transmitter in adult mammalian brains
and is difusely distributed. However, during early brain development,
GABA has depolarizing actions, and trophic effects have been
attributed to this substance. Using a variety of neurochemical,
neuroanatomical, physiological and behavioral methods, we have
evaluated the effect of early manipulation of the GABAA
receptor on neural and behavioral development. We have found
profound effects on a range of neural systems and adaptive responses
of a kind that are often not apparent until late in adolescence
(a developmental stage at which many clinical behavior disorders
appear). Several questions have been generated by these observations,
and these issues are currently being addressed:
- How do particular stressor-responsive systems change
during adolescent development and what is the underlying
trigger for the change?
- What responses are initiated in the brain at the time
of manipulation of GABAA receptors; in particular,
does manipulations of this receptor complex during in utero
development affect specific trophic factors?
- How do gonadal steroids interact with GABAA
receptors at different stages of development?
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Recent Publications
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- Kellogg, C.K. (1998).
- Early developmental modulations of GABAA receptor
function: Influence on adaptive responses, Perspectives
on Developmental Neurobiology, 5:219-234.
- Kellogg, C.K., Awatramani, G.B., and Piekut, D.T. (1998).
- Adolescent development alters stressor-induced fos immunoreactivity
in rat brain, Neuroscience, 83:681-689.
- Kellogg, C.K., Olson, V.G., Pleger, G.L. (1998).
- Neurosteroid action at the GABAA receptor
in fetal rat forebrain, Developmental Brain Research, 108:131-137.
- Kellogg, C.K., 1995.
- Perinatal benzodiazepine modulation of GABAA receptor
function: Influence on adaptive responses. In: Biological
Mechanisms and Perinatal Exposure to Drugs (P.V. Thodani,
ed.), NIDA Research Monograph, 158: 202-226.
- Kellogg, C.K., J.R. Inglefield, M.K. Taylor, Pleger,
G.L., 1993.
- Importance of hypothalamic function to stressor-induced
responsiveness of the GABAA receptor in the cerebral cortex:
A non-corticosterone influence. Brain Res., 609: 244-252.
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