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Ph. D. (1995)
Columbia University
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Willis
Li
Associate Professor of Genetics
Primary Appointment:
Department
of Biomedical Genetics
GEBS Cluster Affiliation:
GGD Genetics, Genomics and Development
BMCB - Biochemistry, Molecular and Cell Biology
Li Lab Webpage
(under construction) |
Research:
Signal Transduction and
Epigenetic Regulation
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Contact Information:
E-Mail: Willis_Li@urmc.rochester.edu |
University of Rochester
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, New York 14642
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KMRB 2-9641
Phone: (585) 273-2408
Fax: (585) 273-1450 |
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Research
Overview
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Research Overview
My laboratory studies the molecular mechanisms and biological functions of signal transduction that underlies animal development and human diseases. We use Drosophila to study signaling by the JAK/STAT, receptor tyrosine kinase (RTK), Ras/Raf/MEK/ERK, and Dpp pathways. Our recent research focus is the epigenetic effects of signaling pathways.
- Biological functions of signaling pathways
- Molecular mechanisms of signal transduction
- Network signaling involving multiple pathways
See Li Lab webpage (under construction)
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Recent Publications
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Fan, X., Li, J., Hickey, G.W., Tsurumi, A., Larson, K., Guo, D, Yan, S.-J., Silver-Morse, L, and Li, W.X. (2008) Drosophila Raf activation is regulated by tyrosine 510 phosphorylation. PLoS Biology, in press.
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Shi, S., Larson, K., Guo, D., Lim, S.J., Dutta, P., Yan, S.J., and Li, W.X. (2008) Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. Nature Cell Biology 10, 489-96; Epub 2008 Mar 16
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Xing, Y., Shi, S., Le, L., Lee, C. A., Silver-Morse, L., and Li, W.X. (2007) Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila. PLoS Genetics 3(9):e151. Epub 2007 Jul 20. (Editor’s Pick of the Week).
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Mogila, V., Xia, F., and Li, W.X. (2006) An intrinsic cell-cycle checkpoint pathway mediated by MEK and ERK in Drosophila. Developmental Cell 11, 575-582. (commented in In This Issue).
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Li, J., and Li, W.X. (2006) Drosophila eIF4A as a negative regulator of Dpp/BMP signaling mediating Smad degradation. Nature Cell Biology 8, 1407-14; Epub 2006 Nov 19. (Commented in News and Views).
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Shi, S., Calhaun, H.C., Xia, F., Li, J., Le, L., and Li, W.X. (2006) JAK signaling globally counteracts heterochromatic gene silencing. Nature Genetics 38, 1071-6. Epub 2006 Aug 6. (Commented in News and Views).
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Li, W.X. (2005) Functions and Mechanisms of Receptor Tyrosine Kinase Torso Signaling: Lessons from Drosophila embryonic terminal development. Developmental Dynamics 232, 656-672.
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Li, J., Li, W.X., and Gelbart, W.M. (2005) A Genetic Screen for Maternal-effect Suppressors of decapentaplegic Identifies the eukaryotic translation initiation factor 4A in Drosophila. Genetics 171, 1629-41. Epub 2005 Jun 21.
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Li, W.X. (2004) Receptor tyrosine kinase signaling and primordial germ cell development. Cell Cycle 3, 249-251.
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Yan, S-J., Gu, Y., Li, W. X., and Fleming, R. J. (2004) Multiple signaling pathways and a selector protein sequentially regulate Drosophila wing development. Development, 131, 285-298.
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Li, J., Xia, F., and Li, W. X. (2003) Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila. Developmental Cell, 5, 787-798.
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Li, J., Li, W., Calhoun, H. C., Xia, F., Gao, F-B., and Li, W. X. (2003) Patterns and functions of STAT activation during Drosophila embryogenesis. Mechanisms of Development, 120, 1455-1468.
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Li, J., and Li, W. X. (2003). Drosophila gain-of-function mutant RTK Torso triggers ectopic Dpp and STAT signaling. Genetics 164, 247-258.
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Li, W. X., Agaisse, H., Mathey-Prevot, B., and Perrimon, N. (2002). Differential Requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. Development 129, 4241-4248.
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Baum, B., Li, W., and Perrimon, N. (2000). A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Current Biology 10, 964-73.
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Li, W., Noll, E., and Perrimon, N. (2000). Identification of autosomal regions involved in Drosophila Raf function. Genetics 156, 763-74.
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Li, W., Melnick, M., and Perrimon, N. (1998). Dual function of Ras in Raf activation. Development 125, 4999-5008.
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Li, W., Skoulakis, E. M., Davis, R. L., and Perrimon, N. (1997). The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner. Development 124, 4163-71.
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Li, W., and Perrimon, N. (1997). Specificity of receptor tyrosine kinase signaling pathways: lessons from Drosophila. Genetic Engineering 19, 167-82.
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Yu, Y., Li, W., Su, K., Yussa, M., Han, W., Perrimon, N., and Pick, L. (1997). The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz. Nature 385, 552-5.
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Li, W., Tully, T., and Kalderon, D. (1996). Effects of a conditional Drosophila PKA mutant on olfactory learning and memory. Learning & Memory 2, 320-33.
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Melendez, A., Li, W., and Kalderon, D. (1995). Activity, expression and function of a second Drosophila PKA catalytic subunit gene. Genetics 141, 1507-1520.
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Li, W., Ohlmeyer, J. T., Lane, M. E., and Kalderon, D. (1995). Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc development. Cell 80, 553-62.
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