Lymphoma Diagnostics at Wilmot There are several tests that may be used for the diagnosis of lymphoma. The results of these tests will help your doctors to determine where the lymphoma is located in the body and then tailor the best treatment plan for you or your loved one. Blood tests may be used to rule out other ailments that could be causing lymph nodes to swell or to determine the health of other organs in your body. Bone marrow aspiration and biopsy helps doctors to determine whether the disease has spread to the bone marrow. Cytogenetic studies look at the DNA within lymphoma cells to reveal changes in its chromosomes. Imaging tests such as X-rays, CT scans, PET scans and MRI may be used to help determine what parts of your body are affected by lymphoma. Immunophenotyping involves looking at cells gathered from lymph nodes to see what types of cancer cells are present. Lymph node biopsy involves taking a sample from a lymph node and having it examined by a pathologist. This test is used to determine whether you have lymphoma and if so, what type. Molecular genetic studies are used to identify specific genetic traits of lymphoma cells.