Conducting Cardiovascular Research in
Aab Cardiovascular Research Institute (CVRI) researchers are dedicated to understanding how the heart and blood vessels become susceptible to disease. Using state-of-the-art technologies, new treatments and diagnostic tests are being developed and analyzed for potential use in clinical cardiovascular medicine.
Cardiovascular Research Overview
The faculty of the CVRI focus on five areas of research in the cardiovascular system.
- Vascular and developmental biology
- Response to ischemic injury
- Electrophysiology and ion channels
- Molecular pharmacology and signal transduction
- Genetics of cardiovascular disease
The overall goal is to understand how the cardiovascular system develops and responds to physiological and pathological changes. Understanding these processes will provide insight into new therapeutic approaches to treat diseases such as hypertension, coronary artery disease, stroke, and atherosclerosis.
Four areas of research will be developed in the Center for Cardiovascular Research. These areas are vascular and developmental biology; ischemic injury, molecular pharmacology and signal transduction; and genetics of cardiovascular disease. The overall goal is to understand how the cardiovascular system develops and responds to physiological and pathological changes.
Gene Editing Technology Holds Huge Potential
A new gene editing technology known as CRISPR-Cas9 is taking the scientific community by storm. It is based on a system that bacteria use to defend themselves and their descendants against viruses that can make them sick (yes, bacteria can get sick). Over the last few years, researchers have used this system to precisely alter protein coding genes (genes that provide instructions for making proteins) in human cells, mice, rats, zebrafish, fruit flies and plants. In some cases, disease causing mutations in a protein have been corrected with CRISPR-Cas9, offering some hope for therapeutic intervention...read more
Wine Auction Funds for Cardiovascular Research Pilot Grants
The Aab Cardiovascular Research Institute (CVRI) now announces a competition for grants to fund pilot research projects. Funding for this award is made possible by generous donations to the 2013 Wine Auction, which raised over $1 M for cardiovascular research...read more
International MADS Box Conference
The first ever International MADS Box Conference (IMBC), organized by Joe Miano and Eric Small, was held in Canandaigua, July 10-13 at the Inn on the Lake.
More than 70 SRF/MEF2 investigators from USA, Canada, France, England, Ireland, Germany, Poland, Italy, and Japan attended the meeting. Keynote addresses by Dr. Richard Treisman and Dr. Eric Olson were among the meeting highlights, which featured two intense days of talks and posters. The conference was capped with some fine entertainment from Rochester’s own Michaela Davis and Chris Peltz. There was overwhelming enthusiasm to have another IMBC meeting in the future.
The Aab CVRI publishes a semi-annual newsletter called the "CVRI Beat." The newsletter includes a director's column and highlights such things as faculty profiles, recent publications and sponsored research grants.
Aab CVRI Grand Opening
URMC is pleased to name the Aab Cardiovascular Research Institute in honor of long-time friends, Richard and Jackie Aab, whose gift of $5 million is helping to transform our community.